Simple and highly efficient synthesis of 3′-deoxy-3′-[ 18F]fluorothymidine using nucleophilic fluorination catalyzed by protic solvent

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 34, Issue 9, 2007, Pages 1406-1409

  Lee, Sang Ju ^a   Oh, Seung Jun ^a   Chi, Dae Yoon ^b   Kil, Hee Seup ^b   Kim, Euy Nyong ^a   Ryu, Jin Sook ^a   Moon, Dae Hyuk ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Inha University   (South Korea)

Author keywords

18F FLT; Cell proliferation; Nucleophilic substitution; Protic solvent; Tumor

Indexed keywords

3' FLUOROTHYMIDINE; FLUORINE 18; TERT BUTYL ALCOHOL; TETRABUTYLAMMONIUM;

ARTICLE; CATALYSIS; DRUG PURIFICATION; DRUG SYNTHESIS; ELUTION; FLUORINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; ISOTOPE LABELING; RADIOCHEMISTRY; RADIOCHROMATOGRAPHY; REACTOR;

AUTOMATION; CELL PROLIFERATION; CHROMATOGRAPHY, THIN LAYER; DIDEOXYNUCLEOSIDES; FLUORINE RADIOISOTOPES; HALOGENATION; HUMANS; NEOPLASMS; QUALITY CONTROL; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; SOLVENTS; TEMPERATURE; TIME FACTORS;

EID: 34548162135     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-007-0391-8     Document Type: Article

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