Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 6952-6958

  Nakata, Eiji ^a   Yukimachi, Yoshihiro ^a   Kariyazono, Hirokazu ^a   Im, Seongwang ^a   Abe, Chiaki ^a   Uto, Yoshihiro ^a   Maezawa, Hiroshi ^b   Hashimoto, Toshihiro ^c   Okamoto, Yasuko ^c   Hori, Hitoshi ^a  

^a Graduate School   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Bioreductive activation; Fluorescent imaging; Fluorescent pH probe; Nitro reduction; Tumor hypoxia

Indexed keywords

10 (DIMETHYLAMINO) 3 [(4 NITROPHENYL)METHOXY] SPIRO [7H BENZO[C]XANTHENE 7,10(3'H) ISOBENZOFURAN] 3' ONE; 10 (DIMETHYLAMINO) 3 HYDROXY SPIRO[7H BENZO[C]XANTHENE 7,10(3'H) ISOBENZOFURAN] 3' ONE; FLUORESCENT DYE; UNCLASSIFIED DRUG; UTX 12; XANTHENE DERIVATIVE;

AEROBIC METABOLISM; ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL PH; CONTROLLED STUDY; DRUG SYNTHESIS; EMBRYO; FLUORESCENCE IMAGING; HYPOXIA; LIVER MICROSOME; NONHUMAN; PH MEASUREMENT; REDUCTION; TISSUE OXYGENATION; TUMOR; TUMOR CELL;

ANIMALS; BENZOPYRANS; CELL HYPOXIA; CELL LINE; DIAGNOSTIC IMAGING; DINITROBENZENES; DRUG DESIGN; FLUORESCENT DYES; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSOMES, LIVER; NEOPLASMS; OXIDATION-REDUCTION;

EID: 69949189653     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.037     Document Type: Article

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