The NMDA receptor/nitric oxide pathway: A target for the therapeutic and toxic effects of lithium

Trends in Pharmacological Sciences

Volumn 32, Issue 7, 2011, Pages 420-434

  Ghasemi, Mehdi ^a,b   Dehpour, Ahmad Reza ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUTAMIC ACID; LITHIUM; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OUABAIN;

AMINO ACID TRANSPORT; ANIMAL BEHAVIOR; BIPOLAR DISORDER; CLONIC SEIZURE; DIABETES INSIPIDUS; DRUG ANTAGONISM; DRUG MECHANISM; DRUG POTENTIATION; DRUG TARGETING; HUMAN; IRRITABLE COLON; LEARNING; LOW DRUG DOSE; MEMORY; MEMORY DISORDER; MOOD DISORDER; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; POLYDIPSIA; POLYURIA; PREPULSE INHIBITION; PRIORITY JOURNAL; REVIEW; SCHIZOAFFECTIVE PSYCHOSIS; SEXUAL DYSFUNCTION; SIGNAL TRANSDUCTION; STARTLE REFLEX;

ANIMALS; HUMANS; LITHIUM; NITRIC OXIDE; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION;

EID: 79959792795     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2011.03.006     Document Type: Review

References (239)

1. R. Machado-Vieira The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders Neuroscientist 15 2009 525 539
2. P. Skolnick Glutamate-based antidepressants: 20 years on Trends Pharmacol. Sci. 30 2009 563 569
3. G. Wegener, and V. Volke Nitric oxide synthase inhibitors as antidepressants Pharmaceuticals 3 2010 273 299
4. S.L. Narsapur, and G.J. Naylor Methylene blue. A possible treatment for manic depressive psychosis J. Affect. Disord. 5 1983 155 161 (Pubitemid 13120409)
5. G.J. Naylor A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis Biol. Psychiatry 21 1986 915 920 (Pubitemid 16037297)
6. G.J. Naylor Methylene blue in mania Biol. Psychiatry 24 1988 941 942 (Pubitemid 19004170)
7. G.D. da Silva Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in mice Neuroreport 11 2000 3699 3702
8. S.Y. Inan Dual effects of nitric oxide in the mouse forced swimming test: possible contribution of nitric oxide-mediated serotonin release and potassium channel modulation Pharmacol. Biochem. Behav. 77 2004 457 464 (Pubitemid 38296804)
9. H.-G. Bernstein Nitric oxide synthase-containing neurons in human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics Neuroscience 83 1998 867 875 (Pubitemid 28068907)
10. B. Karolewicz Low nNOS protein in the locus coeruleus in major depression J. Neurochem. 91 2004 1057 1066 (Pubitemid 39587444)
11. E. Suzuki Elevated plasma nitrate levels in depressive states J. Affect. Disord. 63 2001 221 224 (Pubitemid 32200517)
12. M. Yanik The role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorder Eur. Arch. Psychiatry Clin. Neurosci. 254 2004 43 47 (Pubitemid 39310548)
13. H.S. Gergerlioglu Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment Prog. Neuropsychopharmacol. Biol. Psychiatry 31 2007 697 702 (Pubitemid 46467046)
14. S. Hashioka Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide Exp. Neurol. 206 2007 33 42 (Pubitemid 46935120)
15. S. Nonaka Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx Proc. Natl. Acad. Sci. U.S.A. 95 1998 2642 2647 (Pubitemid 28145996)
16. S. Nonaka Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine J. Pharmacol. Exp. Ther. 286 1998 539 547 (Pubitemid 28318031)
17. G. Nowak Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims Brain Res. 675 1995 157 164
18. S. Maruta Effects of intraperitoneally injected lithium, imipramine and diazepam on nitrate levels in rat amygdala Psych. Clin. Neurosci. 59 2005 358 361 (Pubitemid 40897210)
19. A.R. Karimollah Inhibition by lithium of the nitrergic relaxation of rat anococcygeus muscle Nitric Oxide 20 2009 31 38
20. H. Sadeghipour Effect of chronic lithium administration on endothelium-dependent relaxation of rat corpus cavernosum: the role of nitric oxide and cyclooxygenase pathways BJU Int. 99 2007 177 182 (Pubitemid 44915643)
21. D.-M. Chuang Neuroprotective effects of lithium in cultured cells and animal models of diseases Bipolar Disord. 4 2002 129 136 (Pubitemid 34411275)
22. H. Prast, and A. Philippu Nitric oxide as modulator of neuronal function Prog. Neurobiol. 64 2001 51 68 (Pubitemid 32201889)
23. P. Skolnick Antidepressants for the new millennium Eur. J. Pharmacol. 375 1999 31 40 (Pubitemid 29317590)
24. M. Ghasemi NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test J. Psychopharmacol. 24 2010 585 594
25. M. Ghasemi Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test Eur. Neuropsychopharmacol. 18 2008 323 332 (Pubitemid 351381351)
26. M. Ghasemi A role for nitrergic system in the antidepressant-like effects of chronic lithium treatment in the mouse forced swimming test Behav. Brain Res. 200 2009 76 82
27. B.H. Harvey Affective disorders and nitric oxide: a role in pathways to relapse and refractoriness? Human Psychopharmacol. 11 1996 309 319 (Pubitemid 26258871)
28. J. Karatinos The nitric oxide pathway: potential implications for treatment of neuropsychiatric disorders Clin. Neuropharmacol. 18 1995 482 499
29. J.F. Dixon Lithium stimulates glutamate "release" and inositol 1,4,5-trisphosphate accumulation via activation of the N-methyl-D-aspartate receptor in monkey and mouse cerebral cortex slices Proc. Natl. Acad. Sci. U.S.A. 91 1994 8358 8362
30. J.F. Dixon, and L.E. Hokin Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex Proc. Natl. Acad. Sci. U.S.A. 95 1998 8363 8368 (Pubitemid 28326118)
31. L.E. Hokin A novel action of lithium: stimulation of glutamate release and inositol 1,4,5 trisphosphate accumulation via activation of the N-methyl-D-aspartate receptor in monkey and mouse cerebral cortex slices Adv. Enzyme Regul. 36 1996 229 244 (Pubitemid 27065713)
32. T. Antonelli Differential effects of acute and short-term lithium administration on dialysate glutamate and GABA levels in the frontal cortex of the conscious rat Synapse 38 2000 355 362
33. S.D. Friedman Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder Biol. Psychiatry 56 2004 340 348 (Pubitemid 39164519)
34. P. Ahluwalia Brain GABAergic and dopaminergic systems following lithium treatment and withdrawal Prog. Neuropsychopharmacol. 5 1981 527 530 (Pubitemid 12157199)
35. S. Shibuya-Tayoshi Lithium effects on brain glutamatergic and GABAergic systems of healthy volunteers as measured by proton magnetic resonance spectroscopy Prog. Neuropsychopharmacol. Biol. Psychiatry 32 2008 249 256
36. R. Bernasconi, and P. Martin Effects of antiepiletic drugs on the GABA turnover rate [abstract 251] Naunyn. Schmiedebergs Arch. Pharmacol. 307 1979 R63
37. Z. Gottesfeld Effect of lithium and other alkali metals on brain chemistry and behavior. I. Glutamic acid and GABA in brain regions Psychopharmacologia 45 1976 239 242
38. S. Weiss Kainate receptors coupled to the evoked release of [3H]-gamma-aminobutyric acid from striatal neurons in primary culture: potentiation by lithium ions Mol. Pharmacol. 38 1990 229 236 (Pubitemid 20255309)
39. + enhances GABAergic inputs to granule cells in the rat hippocampal dentate gyrus Neuropharmacology 46 2004 638 646
40. N. Motohashi GABA receptor alterations after chronic lithium administration. Comparison with carbamazepine and sodium valproate Prog. Neuropsychopharmacol. Biol. Psychiatry 16 1992 571 579
41. N. Motohashi GABAB receptors are up-regulated by chronic treatment with lithium or carbamazepine. GABA hypothesis of affective disorders? Eur. J. Pharmacol. 166 1989 95 99 (Pubitemid 19183818)
42. O. Hetmar Decreased number of benzodiazepine receptors in frontal cortex of rat brain following long-term lithium treatment J. Neurochem. 41 1983 217 221 (Pubitemid 13067779)
43. A. Maggi, and S.J. Enna Regional alterations in rat brain neurotransmitter systems following chronic lithium treatment J. Neurochem. 34 1980 888 892 (Pubitemid 10134187)
44. V. Gundersen Co-localization of excitatory and inhibitory transmitters in the brain Acta Neurol. Scand. Suppl. 188 2008 29 33 (Pubitemid 351595270)
45. M.G. Darlison Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies Trends Neurosci. 15 1992 469 474
46. S. Nonaka, and D.M. Chuang Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats Neuroreport 9 1998 2081 2084 (Pubitemid 28300570)
47. R. Hashimoto Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation J. Neurochem. 80 2002 589 597 (Pubitemid 34809967)
48. J. Ma, and G.Y. Zhang Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia Neurosci. Lett. 348 2003 185 189 (Pubitemid 36980663)
49. J. Ma Lithium suppressed Tyr-402 phosphorylation of proline-rich tyrosine kinase (Pyk2) and interactions of Pyk2 and PSD-95 with NR2A in rat hippocampus following cerebral ischemia Neurosci. Res. 49 2004 357 362 (Pubitemid 38953852)
50. M. Basselin Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats Neuropsychopharmacology 31 2006 1659 1674 (Pubitemid 44106697)
51. C.D. Bown Attenuation of N-methyl-D-aspartate-mediated cytoplasmic vacuolization in primary rat hippocampal neurons by mood stabilizers Neuroscience 117 2003 949 955 (Pubitemid 36332312)
52. N.B. Karkanias, and R.L. Papke Subtype-specific effects of lithium on glutamate receptor function J. Neurophysiol. 81 1999 1506 1512 (Pubitemid 29262483)
53. N. Sourial-Bassillious Glutamate-mediated calcium signaling: A potential target for lithium action Neuroscience 161 2009 1126 1134
54. J.J. Valdés, and O.I. Weeks Estradiol and lithium chloride specifically alter NMDA receptor subunit NR1 mRNA and excitotoxicity in primary cultures Brain Res. 1268 2009 1 12
55. F. Kapczinski Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder Expert Rev. Neurother. 8 2008 1101 1113 (Pubitemid 351962077)
56. I. Kiprianova Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat J. Neurosci. Res. 56 1999 21 27 (Pubitemid 29190612)
57. D. Lindholm Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity Eur. J. Neurosci. 5 1993 1455 1464 (Pubitemid 23325228)
58. B. Cheng, and M.P. Mattson NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults Brain Res. 640 1994 56 67 (Pubitemid 24086531)
59. A.G. Estevez Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor J. Neurosci. 18 1998 3708 3714 (Pubitemid 28225678)
60. T. Fukumoto Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain Psychopharmacology (Berl) 158 2001 100 106
61. R. Hashimoto Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity Neuropharmacology 43 2002 1173 1179 (Pubitemid 36009371)
62. G. Bagetta Lithium and tacrine increase the expression of nitric oxide synthase mRNA in the hippocampus of rat Biochem. Biophys. Res. Commun. 197 1993 1132 1139 (Pubitemid 24042740)
63. S. Kanba Lithium ions have a potent and selective inhibitory effect on cyclic GMP formation stimulated by neurotensin, angiotensin II and bradykinin Eur. J. Pharmacol. 126 1986 111 116 (Pubitemid 16014739)
64. S. Kanba Lithium ions inhibit function of low- but not high-affinity muscarinic receptors of murine neuroblastoma cells (clone N1E-115) Psychopharmacology (Berl) 86 1985 413 416 (Pubitemid 15042304)
65. F. Shintani Inhibition by lithium of cyclic GMP formation without inhibition of nitric oxide generation in the mouse neuroblastoma cell (N1E-115) Neuropsychopharmacology 11 1994 119 124 (Pubitemid 24334067)
66. B.H. Harvey Evidence that lithium induces a glutamatergic: nitric oxide-mediated response in rat brain Neurochem. Res. 19 1994 469 474 (Pubitemid 24286616)
67. B. Harvey Lithium modulation of cortical cyclic nucleotides: evidence for the Yin-Yang hypothesis Eur. J. Pharmacol. 175 1990 129 136 (Pubitemid 20030150)
68. O.A. Reneerkens Selective phosphodiesterase inhibitors: a promising target for cognition enhancement Psychopharmacology (Berl) 202 2009 419 443
69. K. Esposito Phosphodiesterase genes and antidepressant treatment response: a review Ann. Med. 41 2009 177 185
70. C.B. Brink Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies J. Neural Transm. 115 2008 117 125
71. B. Harvey Absence of an effect of the lithium-induced increase in cyclic GMP on the cyclic GMP-stimulated phosphodiesterase (PDE II). Evidence for cyclic AMP-specific hydrolysis Neurochem. Res. 18 1993 1095 10100
72. H. Anai Activation of hypothalamic neuronal nitric oxide synthase in lithium-induced diabetes insipidus rats Psychoneuroendocrinology 26 2001 1009 1020
73. H. Herken Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment Arch. Med. Res. 38 2007 247 252 (Pubitemid 46080553)
74. Y.C. Wei The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma J. Psychosom. Res. 66 2009 259 266
75. W.E. Chrapko Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder Biol. Psychiatry 56 2004 129 134 (Pubitemid 38844788)
76. M.L. Selley Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression J. Affect. Disord. 80 2004 249 256 (Pubitemid 38597148)
77. M.E. Ozcan Antioxidant enzyme activities and oxidative stress in affective disorders Int. Clin. Psychopharmacol. 19 2004 89 95 (Pubitemid 38316767)
78. G. Wegener Combined chronic treatment with citalopram and lithium does not modify the regional neurochemistry of nitric oxide in rat brain J. Physiol. Pharmacol. 55 2004 575 586 (Pubitemid 39318849)
79. G.M. MacQueen Course of illness, hippocampal function, and hippocampal volume in major depression Proc. Natl. Acad. Sci. U.S.A. 100 2003 1387 1392 (Pubitemid 36184011)
80. G. Wegener Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression Int. J. Neuropsychopharmacol. 13 2010 461 473
81. V. Mollace Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors Pharmacol. Rev. 57 2005 217 252 (Pubitemid 41043885)
82. M. Colasanti, and H. Suzuki The dual personality of NO Trends Pharmacol. Sci. 21 2000 249 252 (Pubitemid 30445251)
83. D.B. Miller, and J.P. O'Callaghan Depression, cytokines, and glial function Metabolism 54 2005 33 38 (Pubitemid 40546021)
84. D. Wang Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor Neurosci. Lett. 433 2008 59 64
85. M. Basselin Lithium modifies brain arachidonic and docosahexaenoic metabolism in rat lipopolysaccharide model of neuroinflammation J. Lipid Res. 51 2010 1049 1056
86. P. Schotte Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein J. Biol. Chem. 276 2001 25939 25945
87. D.L. Feinstein Potentiation of astroglial nitric oxide synthase type-2 expression by lithium chloride J. Neurochem. 71 1998 883 886 (Pubitemid 28480439)
88. C.J. Yuskaitis, and R.S. Jope Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity Cell Signal. 21 2009 264 273
89. D.A. Cousins The role of dopamine in bipolar disorder Bipolar. Disord. 11 2009 787 806
90. G. Wegener Increased extracellular serotonin level in rat hippocampus induced by chronic citalopram is augmented by subchronic lithium: neurochemical and behavioural studies in the rat Psychopharmacology (Berl) 166 2003 188 194 (Pubitemid 36313127)
91. K. Scheuch Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons Brain Res. 1307 2010 14 21
92. N. Haddjeri Increased tonic activation of rat forebrain 5-HT(1A) receptors by lithium addition to antidepressant treatments Neuropsychopharmacology 22 2000 346 356 (Pubitemid 30105763)
93. I. Hide, and S. Yamawaki Inactivation of presynaptic 5-HT autoreceptors by lithium in rat hippocampus Neurosci. Lett. 107 1989 323 326 (Pubitemid 20013257)
94. J.P. Redrobe, and M. Bourin Evidence of the activity of lithium on 5-HT1B receptors in the mouse forced swimming test: comparison with carbamazepine and sodium valproate Psychopharmacology (Berl) 141 1999 370 377 (Pubitemid 29190005)
95. O. Massot 5-HT1B receptors: a novel target for lithium. Possible involvement in mood disorders Neuropsychopharmacology 21 1999 530 541 (Pubitemid 29414798)
96. T. Mizuta, and T. Segawa Chronic effects of imipramine and lithium on postsynaptic 5-HT1A and 5-HT1B sites and on presynaptic 5-HT3 sites in rat brain Jpn. J. Pharmacol. 47 1988 107 113
97. S.J. Peroutka Serotonin receptor subtypes S.J. Peroutka, Basic and Clinical Aspects 1993 Wiley-Liss Publication 46 51
98. 1A agonist show neuroprotectant activity in rats and mice Eur. J. Pharmacol. 183 1990 1953 1954 (Pubitemid 20318743)
99. 2 agonist Synapse 1 1987 3 9 (Pubitemid 17114243)
100. J. Strosznajder Serotonin, a potent modulator of arachidonic acid turnover. Interaction with ghrtamatergic receptor in brain cortex Neurochem. Int. 25 1994 193 199 (Pubitemid 24273636)
101. 2+- and glutamatergic receptor-evoked arachidonic acid and NO/cGMP release in adult hippocampus Neurochem. Int. 28 1996 439 444
102. 1A receptor in modulating anxiety-related behaviors J. Neurosci. 30 2010 2433 2441
103. A. Stepien Serotonin 5HT1B/1D receptor agonists abolish NMDA receptor-evoked enhancement of nitric oxide synthase activity and cGMP concentration in brain cortex slices Cephalalgia 19 1999 859 865 (Pubitemid 30062574)
104. 3H-norepinephrine release from rat hippocampal slices Fed. Proc. 45 1986 681
105. R.P. Ebstein The effect of repeated electroconvulsive shock treatment and chronic lithium feeding on the release of norepinephrine from rat cortical vesicular preparations Cell. Mol. Neurobiol. 3 1983 191 201 (Pubitemid 14087312)
106. K. Fink, and M. Gothert Modulation of N-methyl-D-aspartate (NMDA)-stimulated noradrenaline release in rat brain cortex by presynaptic alpha 2-adrenoceptors Naunyn. Schmiedebergs Arch. Pharmacol. 348 1993 372 378 (Pubitemid 23297675)
107. A.C. Dolphin Long-term potentiation of the perforant path in vivo is associated with increased glutamate release Nature 297 1982 496 498 (Pubitemid 12007528)
108. T.V. Bliss Reduction of long-term potentiation in the dentate gyrus of the rat following selective depletion of monoamines J. Physiol. 334 1983 475 491 (Pubitemid 13176109)
109. E.D. Risby The mechanisms of action of lithium. II. Effects on adenylate cyclase activity and beta-adrenergic receptor binding in normal subjects Arch. Gen. Psychiatry 48 1991 513 524
110. L. Mann Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect Bipolar Disord. 11 2009 885 896
111. Y. Vulliemoz Alpha-2 adrenoceptor agonists decrease cyclic guanosine 3',5'-monophosphate in the mouse brain Anesthesiology 85 1996 544 550 (Pubitemid 26332607)
112. Y. Vulliemoz The nitric oxide-cGMP system of the locus coeruleus and the hypnotic action of alpha-2 adrenergic agonists Brain Res. 849 1999 169 174
113. R.F. O'Dea, and M. Zatz Catecholamine-stimulated cyclic GMP accumulation in the rat pineal: apparent presynaptic site of action Proc. Natl. Acad. Sci. U.S.A. 73 1976 3398 3402
114. L. Agullo, and A. Garcia Norepinephrine increases cyclic GMP in astrocytes by a mechanism dependent on nitric oxide synthesis Eur. J. Pharmacol. 206 1991 343 346
115. J.A. Ferrendelli Comparison of the effects of biogenic amines on cyclic GMP and cycle AMP levels in mouse cerebellum in vitro Brain Res. 84 1975 63 73
116. H. Corrodi The effect of lithium on cerebral monoamine neurons Psychopharmacologia 11 1967 345 353
117. E. Friedman, and S. Gershon Effect of lithium on brain dopamine Nature 243 1973 520 521
118. B.E. Leonard Changes in rat brain monoamine metabolism following the acute administration of lithium chloride in combination with antidepressant drugs Arch. Int. Pharmacodyn. Ther. 215 1975 202 207
119. J.E. Hesketh The effect of chronic lithium administration on dopamine metabolism in rat striatum Psychopharmacology (Berl) 56 1978 163 166 (Pubitemid 8287700)
120. M. Dziedzicka-Wasylewska, and K. Wedzony The effect of prolonged administration of lithium on the level of dopamine D2 receptor mRNA in the rat striatum and nucleus accumbens Acta Neurobiol. Exp. (Wars) 56 1996 29 34 (Pubitemid 26126124)
121. K. Kameda Effects of lithium on dopamine D2 receptor expression in the rat brain striatum J. Neural Transm. 108 2001 321 334 (Pubitemid 32703906)
122. A. Flemenbaum Lithium inhibition of norepinephrine and dopamine receptors Biol. Psychiatry 12 1977 563 572 (Pubitemid 8172043)
123. M. Schorderet Lithium inhibition of cyclic AMP accumulation induced by dopamine in isolated retinae of the rabbit Biochem. Pharmacol. 26 1977 167 170 (Pubitemid 8014741)
124. J.K. Rybakowski Dopamine D1 receptor gene polymorphism is associated with prophylactic lithium response in bipolar disorder Pharmacopsychiatry 42 2009 20 22
125. S.M. Nicola Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens Annu. Rev. Neurosci. 23 2000 185 215 (Pubitemid 30350042)
126. P. Calabresi Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors J. Neurosci. 17 1997 4536 4544 (Pubitemid 27246911)
127. 1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors J. Biol. Chem. 278 2003 20196 20202 (Pubitemid 36799216)
128. F.J. Lee Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor Cell 111 2002 219 230 (Pubitemid 35292442)
129. S. Sammut Phasic dopaminergic transmission increases NO efflux in the rat dorsal striatum via a neuronal NOS and a dopamine D(1/5) receptor-dependent mechanism Neuropsychopharmacology 31 2006 493 505 (Pubitemid 43276965)
130. D. Centonze Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity J. Neurosci. 23 2003 8506 8512 (Pubitemid 37158750)
131. D.J. Park, and A.R. West Regulation of striatal nitric oxide synthesis by local dopamine and glutamate interactions J. Neurochem. 111 2009 1457 1465
132. K.C. O'Donnell, and T.D. Gould The behavioral actions of lithium in rodent models: leads to develop novel therapeutics Neurosci. Biobehav. Rev. 31 2007 932 962 (Pubitemid 47299256)
133. J.P. Redrobe, and M. Bourin The effect of lithium administration in animal models of depression: a short review Fundam. Clin. Pharmacol. 13 1999 293 299 (Pubitemid 32260275)
134. T. Kato Animal models of bipolar disorder Neurosci. Biobehav. Rev. 31 2007 832 842 (Pubitemid 47285348)
135. J. Levine High homocysteine serum levels in young male schizophrenia and bipolar patients and in an animal model Prog. Neuropsychopharmacol. Biol. Psychiatry 29 2005 1181 1191 (Pubitemid 41383518)
136. J.C. DeMar Jr. One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats J. Lipid Res. 47 2006 172 180 (Pubitemid 43107460)
137. G.L. Gessa Sleep deprivation in the rat: an animal model of mania Eur. Neuropsychopharmacol. 5 Suppl. 1995 89 93 (Pubitemid 26017265)
138. E. Malatynska, and R.J. Knapp Dominant-submissive behavior as models of mania and depression Neurosci. Biobehav. Rev. 29 2005 715 737 (Pubitemid 40755462)
139. R.H. Belmaker, and Y. Bersudsky Lithium-pilocarpine seizures as a model for lithium action in mania Neurosci. Biobehav. Rev. 31 2007 843 849 (Pubitemid 47285351)
140. G.C. Ormandy Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats Exp. Neurol. 106 1989 172 180 (Pubitemid 19279483)
141. D.G. Fujikawa Neuroprotective effect of ketamine administered after status epilepticus onset Epilepsia 36 1995 186 195
142. S.L. Peterson Differential neuroprotective effects of the NMDA receptor-associated glycine site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus Neurotoxicology 25 2004 835 847 (Pubitemid 39013332)
143. J. Yang Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats J. Neurosci. 26 2006 406 410 (Pubitemid 43237103)
144. J.Z. Huo Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus Neurosci. Lett. 401 2006 266 270 (Pubitemid 43729516)
145. R. Li Lithium prevents ouabain-induced behavioral changes. Toward an animal model for manic depression Mol. Chem. Neuropathol. 31 1997 65 72 (Pubitemid 27328637)
146. R.W. Albers, and G.J. Siegel Membrane transport G.J. Siegel, Basic Neurochemistry 6 edn 1999 Lippincott-Raven Press 95 118
147. G.J. Lees, and W. Leong Brain lesions induced by specific and non-specific inhibitors of sodium-potassium ATPase Brain Res. 649 1994 225 233 (Pubitemid 24197216)
148. J. Sanchez-Prieto Characterization of the exocytotic release of glutamate from guinea-pig cerebral cortical synaptosomes J. Neurochem. 49 1987 58 64
149. M.A. Cousin Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain J. Neurochem. 64 1995 2097 2104
150. D. Fage Ouabain releases striatal polyamines in vivo independently of N-methyl-D-aspartate receptor activation J. Neurochem. 61 1993 261 265 (Pubitemid 23175909)
151. M.L. Brines, and R.J. Robbins Inhibition of alpha 2/alpha 3 sodium pump isoforms potentiates glutamate neurotoxicity Brain Res. 591 1992 94 102
152. M.G. Bersier, and G. Rodriguez de Lores Arnaiz Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus Neurochem. Res. 34 2009 1650 1657
153. B. Arts Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives Psychol. Med. 38 2008 771 785 (Pubitemid 351684591)
154. M.F. Joseph A quantitative and qualitative review of neurocognitive performance in pediatric bipolar disorder J. Child Adolesc. Psychopharmacol. 18 2008 595 605
155. J. Prickaerts Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania J. Neurosci. 26 2006 9022 9029 (Pubitemid 44319393)
156. I. Dewachter GSK3beta, a centre-staged kinase in neuropsychiatric disorders, modulates long term memory by inhibitory phosphorylation at serine-9 Neurobiol. Dis. 35 2009 193 200
157. M.R. Zarrindast Nitric oxide modulates state dependency induced by lithium in an inhibitory avoidance task in mice Behav. Pharmacol. 18 2007 289 295
158. T. Kleppisch, and R. Feil cGMP signalling in the mammalian brain: role in synaptic plasticity and behaviour Handb. Exp. Pharmacol. 2009 549 579
159. M. Rezayat N-methyl-D-aspartate receptors are involved in lithium-induced state-dependent learning in mice J. Psychopharmacol. 2009
160. H. Welzl Conditioned taste aversion as a learning and memory paradigm Behav. Brain Res. 125 2001 205 213 (Pubitemid 33000459)
161. Z. Cui Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout Eur. J. Neurosci. 22 2005 755 763 (Pubitemid 41192285)
162. ω-nitro-L-arginine methyl ester attenuates lithium-induced c-Fos, but not conditioned taste aversion, in rats Neurosci. Res. 50 2004 485 492 (Pubitemid 39572995)
163. N.J. Dun Nitric oxide synthase immunoreactivity in the rat pontine medullary neurons Neuroscience 59 1994 429 445 (Pubitemid 24098800)
164. B.M. Rabin Free radicals and taste aversion learning in the rat: nitric oxide, radiation and dopamine Prog. Neuropsychopharmacol. Biol. Psychiatry 20 1996 691 707 (Pubitemid 26236139)
165. M.A. Prendergast Nitric oxide synthase inhibition impairs spatial navigation learning and induces conditioned taste aversion Pharmacol. Biochem. Behav. 57 1997 347 352 (Pubitemid 27261432)
166. S.R. Vincent, and H. Kimura Histochemical mapping of nitric oxide synthase in the rat brain Neuroscience 46 1992 755 784
167. G. Wegener Nitric oxide modulates lithium-induced conditioned taste aversion Behav. Brain Res. 118 2001 195 200 (Pubitemid 32063381)
168. L. Brand Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement Eur. J. Pharmacol. 586 2008 205 211
169. M. Bjegovic, and M. Randic Effect of lithium ions on the release of acetylcholine from the cerebral cortex Nature 230 1971 587 588
170. M.B. Bowers Jr., and A. Rozitis Acetylcholine release from cortical brain slices of rats injected with lithium J. Pharm. Pharmacol. 22 1970 647
171. H.L. Haas, and R.W. Ryall An excitatory action of iontophoretically administered lithium on mammalian central neurones Br. J. Pharmacol. 60 1977 185 195 (Pubitemid 8115530)
172. J. Hirsch Effects of lithium chloride on peripheral acetylcholine release and brain acetylcholine levels in the guinea-pig Experientia 35 1979 91 92 (Pubitemid 9109879)
173. R.S. Jope Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine J. Neurochem. 49 1987 944 951 (Pubitemid 17123719)
174. E.S. Vizi Effect of lithium on acetylcholine release and synthesis Neuropharmacology 11 1972 521 530
175. M.M. Kraus, and H. Prast The nitric oxide system modulates the in vivo release of acetylcholine in the nucleus accumbens induced by stimulation of the hippocampal fornix/fimbria-projection Eur. J. Neurosci. 14 2001 1105 1112 (Pubitemid 35463754)
176. W. Perry Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania Biol. Psychiatry 50 2001 418 424 (Pubitemid 32885591)
177. M. Davis Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats Psychopharmacology (Berlin) 102 1990 1 4 (Pubitemid 20227519)
178. K. Umeda Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice Eur. J. Pharmacol. 553 2006 157 162 (Pubitemid 44779598)
179. J. Hu Inhibition of neuronal nitric oxide synthase by antipsychotic drugs Psychopharmacology (Berl) 114 1994 161 166 (Pubitemid 24150534)
180. A. Nel, and B.H. Harvey Haloperidol-induced dyskinesia is associated with striatal NO synthase suppression: reversal with olanzapine Behav. Pharmacol. 14 2003 251 255 (Pubitemid 36735159)
181. S. Sammut Dopamine D2 receptor-dependent modulation of striatal NO synthase activity Psychopharmacology (Berl) 191 2007 793 803 (Pubitemid 46355903)
182. C. Johansson Nitric oxide synthase inhibition blocks phencyclidine- induced behavioural effects on prepulse inhibition and locomotor activity in the rat Psychopharmacology (Berl) 131 1997 167 173 (Pubitemid 27261605)
183. J.L. Wiley Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition Neuropsychopharmacology 19 1998 86 94 (Pubitemid 28255217)
184. C. Salum Dopamine and nitric oxide interaction on the modulation of prepulse inhibition of the acoustic startle response in the Wistar rat Psychopharmacology (Berl) 185 2006 133 141 (Pubitemid 43363609)
185. A.C. Issy Nitric oxide modulation of methylphenidate-induced disruption of prepulse inhibition in Swiss mice Behav. Brain Res. 205 2009 475 481
186. K. Fejgin Nitric oxide signaling in the medial prefrontal cortex is involved in the biochemical and behavioral effects of phencyclidine Neuropsychopharmacology 33 2008 1874 1883 (Pubitemid 351832601)
187. T.M. McLeod Nitric oxide, stress, and depression Psychopharmacol. Bull. 35 2001 24 41
188. S.A. Goldman Lithium and neuroleptics in combination: is there enhancement of neurotoxicity leading to permanent sequelae? J. Clin. Pharmacol. 36 1996 951 962 (Pubitemid 26384486)
189. K. Boora Encephalopathy with combined lithium-risperidone administration Acta Psychiatr. Scand. 117 2008 394 395 discussion 396 (Pubitemid 351502442)
190. J.B. Kessel Neurotoxicity related to lithium and neuroleptic combinations? A retrospective review J. Psychiatry Neurosci. 17 1992 28 30 (Pubitemid 23135310)
191. C. Normann Delirium and persistent dyskinesia induced by a lithium-neuroleptic interaction Pharmacopsychiatry 31 1998 201 204 (Pubitemid 28505913)
192. D.N. Mendhekar Rabbit syndrome induced by combined lithium and risperidone Can. J. Psychiatry 50 2005 369 (Pubitemid 43175519)
193. W.J. Cohen, and N.H. Cohen Lithium carbonate, haloperidol, and irreversible brain damage JAMA 230 1974 1283 1287
194. C.W. Erwin Lithium carbonate and convulsive disorders Arch. Gen. Psychiatry 28 1973 646 648
195. A. Jus Influence of lithium carbonate on patients with temporal epilepsy Can. Psychiatr. Assoc. J. 18 1973 77 78
196. U. Roy, and B.P. Mukherjee Correlation of lithium effect on electroshock-induced seizure in rats with its concentration in brain and plasma Arch. Int. Pharmacodyn. Ther. 255 1982 81 88 (Pubitemid 12178929)
197. H. Honar Lithium inhibits the modulatory effects of morphine on susceptibility to pentylenetetrazole-induced clonic seizure in mice: involvement of a nitric oxide pathway Brain Res. 1029 2004 48 55 (Pubitemid 39463306)
198. J. Schmidt Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats Biomed. Biochim. Acta 45 1986 1167 1172 (Pubitemid 16010808)
199. G. Ferraro, and P. Sardo Nitric oxide and brain hyperexcitability In Vivo 18 2004 357 366 (Pubitemid 39069752)
200. L.V. Kalia NMDA receptors in clinical neurology: excitatory times ahead Lancet Neurol. 7 2008 742 755 (Pubitemid 351957932)
201. M. Ghasemi Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice Epilepsy Behav. 18 2010 171 178
202. A. Bahremand Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice Epilepsy Res. 89 2010 295 302
203. A. Bahremand Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway Epilepsy Behav. 18 2010 186 192
204. M. Ghasemi Inhibition of NMDA receptor/NO signaling blocked tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice Epilepsy Res. 91 2010 39 48
205. A. Ghasemi Administration of lithium and magnesium chloride inhibited tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice Epilepsy Behav. 19 2010 568 574
206. A.S. Kurt Lithium-induced nephrogenic diabetes insipidus J. Am. Board Fam. Pract. 12 1999 43 47
207. D.G. Waller, and J.G. Edwards Lithium and the kidney: an update Psychol. Med. 19 1989 825 831 (Pubitemid 20012248)
208. K. Thomsen Lithium-induced polyuria in rats Int. Pharmacopsychiatry 5 1970 233 241
209. J.Y. Summy-Long Central inhibition of nitric oxide synthase preferentially augments release of oxytocin during dehydration Neurosci. Lett. 152 1993 190 193 (Pubitemid 23149345)
210. M. Ghasemi Nitric oxide involvement in the effect of acute lithium administration on the nonadrenergic noncholinergic-mediated relaxation of rat gastric fundus Nitric Oxide 17 2007 152 159 (Pubitemid 47513852)
211. H. Shamshiri Antinociceptive effect of chronic lithium on visceral hypersensitivity in a rat model of diarrhea-predominant irritable bowel syndrome: The role of nitric oxide pathway J. Gastroenterol. Hepatol. 24 2009 672 680
212. F. Nejadkey Role of nitric oxide in the gastro-protective effect of lithium Pathophysiology 13 2006 85 89
213. Y.X. Wang Inhibition of nitric oxide, bradykinin, and prostaglandins in normal rats Hypertension 19 1992 II255 261
214. F. Iwata Role of EDRF in splanchnic blood flow of normal and chronic portal hypertensive rats Am. J. Physiol. 263 1992 G149 154
215. E. Masuda Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats Gastroenterology 108 1995 58 64
216. W.K. MacNaughton Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach Life Sci. 45 1989 1869 1876 (Pubitemid 19284677)
217. D. Aizenberg Lithium and male sexual function in affective patients Clin. Neuropharmacol. 19 1996 515 519 (Pubitemid 26391356)
218. H. Sadeghipour The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: improvement with l-arginine Eur. J. Pharmacol. 586 2008 300 305
219. H. Sadeghipour Effect of lithium on endothelium-dependent and neurogenic relaxation of rat corpus cavernosum: role of nitric oxide pathway Nitric Oxide 16 2007 54 63 (Pubitemid 44829960)
220. M. Ghasemi Lithium decreased endothelium-mediated, but not nonadrenergic noncholinergic, relaxation of guinea pig corpus cavernosum in vitro: a role for nitrergic system Fundam. Clin. Pharmacol. 25 2011 191 199
221. B. Afsharimani Effect of chronic lithium administration on endothelium-dependent relaxation of rat mesenteric bed: role of nitric oxide Can. J. Physiol. Pharmacol. 85 2007 1038 1046
222. A.R. Dehpour The effect of lithium on endothelial-dependent relaxation in rat isolated aorta Gen. Pharmacol. 26 1995 1003 1007
223. A.R. Dehpour Effect of chronic lithium administration on endothelium-dependent relaxation in rat aorta Clin. Exp. Pharmacol. Physiol. 27 2000 55 59 (Pubitemid 30104091)
224. T. Hiroi Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2 Pharmacogenomics J. 5 2005 102 111 (Pubitemid 40468117)
225. M. Schou Lithium in psychiatric therapy and prophylaxis J. Psychiatr. Res. 6 1968 67 95
226. P.C. Baastrup, and M. Schou Prophylactic lithium Lancet 1 1968 1419 1422
227. P.C. Baastrup, and M. Schou [Prophylactic action of lithium against recurrent depressions and manic-depressive psychosis] Nord. Med. 77 1967 180 187
228. P.C. Baastrup, and M. Schou Prophylactic lithium? Lancet 2 1968 349 350
229. M. Schou Normothymotics, "mood-normalizers": are lithium and the imipramine drugs specific for affective disorders? Br. J. Psychiatry 109 1963 803 809
230. M. Schou Therapeutic and prophylactic action of lithium against recurrent manic-depressive psychosis Act. Nerv. Super. (Praha) 9 1967 440
231. M. Schou The treatment of manic psychoses by the administration of lithium salts J. Neurol. Neurosurg. Psychiatry 17 1954 250 260
232. E. Stroemgren, and M. Schou LITHIUM TREATMENT OF MANIC STATES Postgrad. Med. 35 1964 83 86
233. S. Gershon Use of lithium salts in psychiatric disorders Dis. Nerv. Syst. 29 1968 51 55
234. S. Gershon Psychopharmacology of the lithium ion (twenty years after) Dis. Nerv. Syst. 31 1970 333 335
235. S. Gershon Lithium in mania Clin. Pharmacol. Ther. 11 1970 168 187
236. S. Gershon, and A. Yuwiler Lithium ion: a specific psychopharmacological approach to the treatment of mania J. Neuropsychiatr. 1 1960 229 241
237. G. Bagetta Systemic administration of lithium chloride and tacrine but not kainic acid augments citrulline content of rat brain Eur. J. Pharmacol. 294 1995 341 344 (Pubitemid 26015051)
238. P. Bhalla Potential of lithium to reduce aluminium-induced cytotoxic effects in rat brain Biometals 23 2009 197 206
239. Q. Du Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling Cancer Res. 66 2006 7024 7031 (Pubitemid 44197678)