High homocysteine serum levels in young male schizophrenia and bipolar patients and in an animal model

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 29, Issue 7, 2005, Pages 1181-1191

  Levine, Joseph ^a   Sela, Ben Ami ^b,c   Osher, Yamima ^a   Belmaker, R H ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Bipolar disorder; Cerebrospinal fluid; Cognitive impairment; Folate; Functional deterioration; Homocysteine; Mice; Schizophrenia; Vitamin B12

Indexed keywords

APOMORPHINE; HOMOCYSTEINE;

ANIMAL BEHAVIOR; BIPOLAR DISORDER; BLOOD LEVEL; CEREBROSPINAL FLUID ANALYSIS; CONCENTRATION RESPONSE; CONSENSUS; DIETARY INTAKE; HOSPITAL ADMISSION; HUMAN; HYPERHOMOCYSTEINEMIA; LEARNING; MAZE TEST; MEMORY; NEUROTOXICITY; NONHUMAN; PLASMA; REVIEW; RISK ASSESSMENT; RISK FACTOR; ROTAROD TEST; SCHIZOPHRENIA; SEX DIFFERENCE; SMOKING; STEREOTYPY; TASK PERFORMANCE;

ADOLESCENT; ADULT; AGE FACTORS; AGING; ANIMALS; BEHAVIOR, ANIMAL; BIPOLAR DISORDER; DISEASE MODELS, ANIMAL; HOMOCYSTEINE; HUMANS; MALE; MICE; MIDDLE AGED; SCHIZOPHRENIA; SEX FACTORS;

EID: 25644459164     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2005.06.029     Document Type: Review

References (60)

1. F.T. Antun, G.B. Burnett, A.J. Cooper, R.J. Daly, J.R. Smythies, and A.K. Zealley The effects of l-methionine (without MAOI) in schizophrenia J. Psychiatr. Res. 8 2 1971 63 71
2. APPI DSM-IV: Diagnostic and Statistical Manual of Psychiatric Disorders 1994 APPI Press Washington DC
3. J. Applebaum, H. Shimon, B.A. Sela, and J. Levine Plasma homocysteine levels in newly admitted schizophrenic patients J. Psychiatr. Res. 4 2004 413 416
4. H. Arai Biological markers for the clinical diagnosis of Alzheimer's disease Tohoku J. Exp. Med. 179 2 1996 65 79
5. A. Araki, and Y. Sako Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection J. Chromatogr. 422 1987 43 52
6. P.A. Berger, G.R. Elliott, E. Erdelyi, S.J. Watson, R.J. Wyatt, and J.D. Barchas Platelet methylene reductase activity in schizophrenia Arch. Gen. Psychiatry 34 7 1977 808 809
7. S. Bleich, A. Junemann, N. Von Ahsen, B. Lausen, K. Ritter, G. Beck, G.O. Naumann, and J. Kornhuber Homocysteine and risk of open-angle glaucoma J. Neural Transm. 109 12 2002 1499 1504
8. S. Bleich, B. Bandelow, K. Javaheripour, A. Muller, D. Degner, J. Wilhelm, U. Havemann-Reinecke, W. Sperling, E. Ruther, and J. Kornhuber Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism Neurosci. Lett. 335 3 2003 179 182
9. S.F. Choumenkovitch, J. Selhub, P.W. Wilson, J.I. Rader, I.H. Rosenberg, and P.F. Jacques Folic acid intake from fortification in United States exceeds predictions J. Nutr. 132 9 2002 2792 2798
10. L. Clark, S.D. Iversen, and G.M. Goodwin Sustained attention deficit in bipolar disorder Br. J. Psychiatry 180 2002 313 319 (Show)
11. S.M. Cohen, A. Nichols, R. Wyatt, and W. Pollin The administration of methionine to chronic schizophrenic patients: a review of ten studies Biol. Psychiatry 8 2 1974 209 225
12. A. Coppen, S. Chaudhry, and C. Swade Folic acid enhances lithium prophylaxis J. Affect. Disord. 10 1 1986 9 13 (Show: 5 10 20 50 100 200 500 Sort Author Journal Pub Date Text File)
13. C. Desouza, M. Keebler, D.B. McNamara, and V. Fonseca Drugs affecting homocysteine metabolism: impact on cardiovascular risk Drugs 62 4 2002 605 616
14. W. Duan, B. Ladenheim, R.G. Cutler, Kruman II, J.L. Cadet, and M.P. Mattson Dietary folate deficiency, elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease J. Neurochem. 80 1 2002 101 110
15. G.R. Elliott, K. Sutherland, E. Erdelyi, R.D. Ciaranello, J.D. Barchas, and R.J. Wyatt N5,10-methylenetetrahydrofolate reductase activity in autopsied brain parts of chronic schizophrenics and controls and in vitro tryptoline formation Biol. Psychiatry 13 6 1978 695 708 (Write to the Help Desk NCBI | NLM | NIH Department of Health and Human Services Privacy Statement | Freedom of Information Act | Disclaimer)
16. I.N. Ferrier, B.R. Stanton, T.P. Kelly, and J. Scott Neuropsychological function in euthymic patients with bipolar disorder Br. J. Psychiatry 175 1999 246 251 (Show)
17. J.M. Freeman, J.D. Finkelstein, and S.H. Mudd Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity N. Engl. J. Med. 292 10 1975 491 496
18. A. Friedman, D. Kaufer, J. Shemer, I. Hendler, H. Soreq, and I. Tur-Kaspa Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response Nat. Med. 2 12 1996 1382 1385
19. D. Galasko Cerebrospinal fluid biomarkers in Alzheimer disease: a fractional improvement? Arch. Neurol. 60 9 2003 1195 1196
20. D.L. Garver, R.L. Tamas, and J.A. Holcomb Elevated interleukin-6 in the cerebrospinal fluid of a previously delineated schizophrenia subtype Neuropsychopharmacology 28 8 2003 1515 1520
21. D.C. Glahn, S. Therman, M. Manninen, M. Huttunen, J. Kaprio, J. Lonnqvist, and T.D. Cannon Spatial working memory as an endophenotype for schizophrenia Biol. Psychiatry 53 7 2003 624 626
22. P.S. Godfrey, B.K. Toone, M.W. Carney, T.G. Flynn, T. Bottiglieri, M. Laundy, I. Chanarin, and E.H. Reynolds Enhancement of recovery from psychiatric illness by methylfolate Lancet 336 8712 1990 392 395
23. D.C. Goff, T. Bottiglieri, E. Arning, V. Shih, O. Freudenreich, A.E. Evins, D.C. Henderson, L. Baer, and J. Coyle Folate, homocysteine, and negative symptoms in schizophrenia Am. J. Psychiatry 161 9 2004 1705 1708
24. J.F. Goldberg, and M. Harrow Poor outcome bipolar disorders J.F. Goldberg M. Harrow Bipolar Disorders, Clinical Course and Outcome 1999 American Psychiatric Press Washington DC 1 19
25. T.E. Goldberg, and D.R. Weinberger Schizophrenia, training paradigms, and the Wisconsin card sorting test redux Schizophr. Res. 11 3 1994 291 296
26. I. Grundke-Iqbal, and K. Iqbal Tau pathology generated by overexpression of tau Am. J. Pathol. 155 6 1999 1781 1785
27. D.N. Kaluski, T.H. Tulchinsky, A. Haviv, Y. Averbuch, S. Rachmiel, E.M. Berry, and A. Leventhal Addition of essential micronutrients to foods-implication for public health policy in Israel Isr. Med. Assoc. J. 5 4 2003 277 280
28. N. Kozlovsky, R.H. Belmaker, and G. Agam Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients Am. J. Psychiatry 157 5 2000 831 833
29. N. Kozlovsky, W.T. Regenold, J. Levine, A. Rapoport, R.H. Belmaker, and G. Agam GSK-3beta in cerebrospinal fluid of schizophrenia patients J. Neural Transm. 111 8 2004 1093 1098 (Electronic publication 2004 Apr 27.)
30. Kruman II, C. Culmsee, S.L. Chan, Y. Kruman, Z. Guo, L. Penix, and M.P. Mattson Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity J. Neurosci. 20 18 2000 6920 6926
31. T. Kruse, H. Reiber, and V. Neuhoff Amino acid transport across the human blood-CSF barrier. An evaluation graph for amino acid concentrations in cerebrospinal fluid J. Neurol. Sci. 70 2 1985 129 138
32. J. Levine, Z. Stahl, B.A. Sela, S. Gavendo, V. Ruderman, and R.H. Belmaker Elevated homocysteine levels in young male patients with schizophrenia Am. J. Psychiatry 159 10 2002 1790 1792
33. J. Levine, G. Agam, B.A. Sela, D.L. Garver, E.F. Torrey, and R.H. Belmaker CSF homocysteine is not elevated in schizophrenia J. Neural Transm. 112 2 2005 297 302
34. S. Levy, M. Rachmilewitz, N. Grossowicz, Y. Reshef, and G. Izak Nutritional survey in an iron- and folate-deficient population Am. J. Clin. Nutr. 28 12 1975 1454 1457
35. B.K. Lipska, and D.R. Weinberger A neurodevelopmental model of schizophrenia: neonatal disconnection of the hippocampus Neurotox. Res. 4 5-6 2002 469 475
36. S.A. Lipton, W.K. Kim, Y.B. Choi, S. Kumar, D.M. D'Emilia, P.V. Rayudu, D.R. Arnelle, and J.S. Stamler Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor Proc. Natl. Acad. Sci. U. S. A. 94 11 1997 5923 5928
37. G.M. MacQueen, L.T. Young, T.M. Galway, and R.T. Joffe Backward masking task performance in stable, euthymic out-patients with bipolar disorder Psychol. Med. 31 7 2001 1269 1277
38. J.W. Muntjewerff, N. van der Put, T. Eskes, B. Ellenbroek, E. Steegers, H. Blom, and F. Zitman Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia Psychiatry Res. 121 1 2003 1 9
39. O. Nygard, S.E. Vollset, H. Refsum, I. Stensvold, A. Tverdal, J.E. Nordrehaug, M. Ueland, and G. Kvale Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study JAMA 274 19 1995 1526 1533
40. P. O'Callaghan, R. Meleady, T. Fitzgerald, and I. Graham Smoking and plasma homocysteine Eur. Heart J. 23 20 2002 1580 1586
41. Y. Osher, B.A. Sela, J. Levine, and R.H. Belmaker Elevated homocysteine levels in euthymic bipolar disorder patients showing functional deterioration Bipolar Disord. 6 1 2004 82 86
42. W. Pollin, P. Cardon, and S. Kety Effect of amino acid feedings in schizophrenic patients treated with iproniazid Science 133 1961 104 105
43. O.T. Preble, and E.F. Torrey Serum interferon in patients with psychosis Am. J. Psychiatry 142 10 1985 1184 1186
44. B. Regland, B.V. Johansson, and C.G. Gottfries Homocysteinemia and schizophrenia as a case of methylation deficiency J. Neural Transm. 98 2 1994 143 152
45. B. Regland, B.V. Johansson, B. Grenfeldt, L.T. Hjelmgren, and M. Medhus Homocysteinemia is a common feature of schizophrenia J. Neural Transm. 100 2 1995 165 169
46. B. Regland, T. Germgard, C.G. Gottfries, B. Grenfeldt, and A.C. Koch-Schmidt Homozygous thermolabile methylenetetrahydrofolate reductase in schizophrenia-like psychosis J. Neural Transm. 104 8-9 1997 931 941
47. P.S. Sachdev, M. Valenzuela, X.L. Wang, J.C. Looi, and H. Brodaty Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals Neurology 58 10 2002 1539 1541
48. J. Selhub Homocysteine metabolism Annu. Rev. Nutr. 19 1999 217 246
49. D.J. Selkoe Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease Trends Neurosci. 16 10 1993 403 409
50. J.M. Serot, M.C. Bene, and G.C. Faure CSF homocysteine, CSF folates and choroid plexus Neurobiol. Aging 24 4 2003 627 628 (discussion 629)
51. S. Seshadri, A. Beiser, J. Selhub, P.F. Jacques, I.H. Rosenberg, R.B. D'Agostino, P.W. Wilson, and P.A. Wolf Plasma homocysteine as a risk factor for dementia and Alzheimer's disease N. Engl. J. Med. 346 7 2002 476 483
52. Z. Stahl, R.H. Belmaker, M. Friger, and J. Levine Nutritional and life style determinants of plasma homocysteine in schizophrenia patients Eur. Neuropsychopharmacol. 15 3 2005 291 295
53. M.C. Stuhlinger, R.K. Oka, E.E. Graf, I. Schmolzer, B.M. Upson, O. Kapoor, A. Szuba, M.R. Malinow, T.C. Wascher, O. Pachinger, and J.P. Cooke Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine Circulation 108 8 2003 933 938 (Electronic publication 2003 Aug 11)
54. E. Susser, A.S. Brown, E. Klonowski, R.H. Allen, and J. Lindenbaum Schizophrenia and impaired homocysteine metabolism: a possible association Biol. Psychiatry 44 2 1998 141 143
55. C.E. Teunissen, J. de Vente, H.W. Steinbusch, and C. De Bruijn Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid Neurobiol. Aging 23 4 2002 485 508
56. W.G. van Gorp, L. Altshuler, D.C. Theberge, J. Wilkins, and W. Dixon Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study Arch. Gen. Psychiatry 55 1 1998 41 46
57. C. Virgos, L. Martorell, J.M. Simo, J. Valero, L. Figuera, J. Joven, A. Labad, and E. Vilella Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: lack of association with schizophrenia NeuroReport 10 10 1999 2035 2038
58. P.P. Zandi, M.C. Carlson, B.L. Plassman, K.A. Welsh-Bohmer, L.S. Mayer, D.C. Steffens, and J.C. Breitner Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study JAMA 288 17 2002 2123 2129
59. J. Zhou, J. Moller, C.C. Danielsen, J. Bentzon, H.B. Ravin, R.C. Austin, and E. Falk Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice Arterioscler. Thromb. Vasc. Biol. 21 9 2001 1470 1476
60. J.K. Zubieta, P. Huguelet, R.L. O'Neil, and B.J. Giordani Cognitive function in euthymic bipolar I disorder Psychiatry Res. 102 1 2001 9 20