Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide

Experimental Neurology

Volumn 206, Issue 1, 2007, Pages 33-42

  Hashioka, Sadayuki ^a,b   Klegeris, Andis ^b   Monji, Akira ^a   Kato, Takahiro ^a   Sawada, Makoto ^c   McGeer, Patrick L ^b   Kanba, Shigenobu ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Antidepressants; cAMP; Lithium chloride; Microglia; PKA; SQ 22536

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ANTIDEPRESSANT AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FLUVOXAMINE; GAMMA INTERFERON; IMIPRAMINE; INTERLEUKIN 6; LITHIUM CHLORIDE; NITRIC OXIDE; NORADRENALIN UPTAKE INHIBITOR; REBOXETINE; SEROTONIN UPTAKE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; ENZYME INHIBITION; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIMANIC AGENTS; ANTIVIRAL AGENTS; BRAIN; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEPRESSIVE DISORDER; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INTERFERON TYPE II; INTERLEUKIN-6; LITHIUM CHLORIDE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROTRANSMITTER UPTAKE INHIBITORS; NITRIC OXIDE; UP-REGULATION;

EID: 34250648917     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2007.03.022     Document Type: Article

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