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Volumn 26, Issue 4, 2011, Pages 475-487

DNA methylation in cancer development, diagnosis and therapy - Multiple opportunities for genotoxic agents to act as methylome disruptors or remediators

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 METHYLCYTOSINE; 5,6 DIHYDROAZACITIDINE; ANTINEOPLASTIC AGENT; AZACITIDINE; CARCINOGEN; DNA METHYLTRANSFERASE; DOXORUBICIN; EPIGALLOCATECHIN GALLATE; FAZARABINE; HYDRALAZINE; MERCAPTOPURINE; MG 98; MITOXANTRONE; N PHTHALOYLTRYPTOPHAN; PROCAINAMIDE; PROCAINE; ZEBULARINE;

EID: 79959744436     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/ger019     Document Type: Review
Times cited : (75)

References (137)
  • 1
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides, T. (2007) Chromatin modifications and their function. Cell, 128, 693-705.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 2
    • 4644312235 scopus 로고    scopus 로고
    • The role of RNA interference in heterochromatic silencing
    • DOI 10.1038/nature02875
    • Lippman, Z. and Martienssen, R. (2004) The role of RNA interference in heterochromatic silencing. Nature, 431, 364-370. (Pubitemid 39265677)
    • (2004) Nature , vol.431 , Issue.7006 , pp. 364-370
    • Lippman, Z.1    Martienssen, R.2
  • 3
    • 77249170184 scopus 로고    scopus 로고
    • Establishing, maintaining and modyfying DNA methylation patterns in plants and animals
    • Law, J. A. and Jacobsen, S. E. (2010) Establishing, maintaining and modyfying DNA methylation patterns in plants and animals. Nat. Rev. Genet., 11, 204-219.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 204-219
    • Law, J.A.1    Jacobsen, S.E.2
  • 4
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • Yu, W., Gius, D., Onyango, P., Muldoon-Jacobs, K., Karp, J., Feinberg, A. P. and Cui, H. (2008) Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature, 451, 202-206.
    • (2008) Nature , vol.451 , pp. 202-206
    • Yu, W.1    Gius, D.2    Onyango, P.3    Muldoon-Jacobs, K.4    Karp, J.5    Feinberg, A.P.6    Cui, H.7
  • 5
    • 35848962284 scopus 로고    scopus 로고
    • Transcription and RNAi in heterochromatic gene silencing
    • Buhler, M. and Moazed, D. (2007) Transcription and RNAi in heterochromatic gene silencing. Nat. Struct. Mol. Biol., 14, 1041-1048.
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 1041-1048
    • Buhler, M.1    Moazed, D.2
  • 6
    • 0347356348 scopus 로고    scopus 로고
    • Systematic identification of sense-antisense transcripts in mammalian cells
    • Rosok, O. and Sioud, M. (2004) Systematic identification of sense-antisense transcripts in mammalian cells. Nat. Biotechnol., 22, 104-108.
    • (2004) Nat. Biotechnol. , vol.22 , pp. 104-108
    • Rosok, O.1    Sioud, M.2
  • 7
    • 25444491234 scopus 로고    scopus 로고
    • DNA methylation and demethylation as targets for anticancer therapy
    • Szyf, M. (2005) DNA methylation and demethylation as targets for anticancer therapy. Biochemistry, 70, 533-549.
    • (2005) Biochemistry , vol.70 , pp. 533-549
    • Szyf, M.1
  • 9
    • 77649257687 scopus 로고    scopus 로고
    • Epigenome: Mapping in motion
    • Baker, M. (2010) Epigenome: mapping in motion. Nat. Methods., 7, 181-185.
    • (2010) Nat. Methods. , vol.7 , pp. 181-185
    • Baker, M.1
  • 10
    • 33645465003 scopus 로고    scopus 로고
    • Epigenetic therapy - A new developmnet in pharmacology
    • Peedicayil, J. (2006) Epigenetic therapy - a new developmnet in pharmacology. Indian J. Med. Res., 123, 17-24.
    • (2006) Indian J. Med. Res. , vol.123 , pp. 17-24
    • Peedicayil, J.1
  • 11
    • 33847262454 scopus 로고    scopus 로고
    • Epigenetic control of nuclear architecture
    • Espada, J. and Esteller, M. (2007) Epigenetic control of nuclear architecture. Cell. Mol. Life Sci., 64, 449-457.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 449-457
    • Espada, J.1    Esteller, M.2
  • 12
    • 0034625064 scopus 로고    scopus 로고
    • Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
    • Ramsahoye, B. H., Biniszkiewicz, D., Lyko, F., Clark, V., Bird, A. and Jaenisch, R. (2000) Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc. Natl Acad. Sci. USA., 97, 5237-5242.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 5237-5242
    • Ramsahoye, B.H.1    Biniszkiewicz, D.2    Lyko, F.3    Clark, V.4    Bird, A.5    Jaenisch, R.6
  • 13
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister, R., Pelizzola, M., Dowen, R. H. et al. (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature, 462, 315-322.
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2    Dowen, R.H.3
  • 14
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear base 5-hydroxymethylcytosine is present in Purkinje neurons and brain
    • Kriaucionis, S. and Heintz, N. (2009) The nuclear base 5-hydroxymethylcytosine is present in Purkinje neurons and brain. Science, 324, 929-930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 15
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani, M., Koh, K. P., Shen, Y. et al. (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science, 324, 930-935.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 16
    • 0016692220 scopus 로고
    • X inactivation, differentiation, and DNA methylation
    • Riggs, A. D. (1975) X inactivation, differentiation, and DNA methylation. Cytogenet. Cell Genet., 14, 9-25.
    • (1975) Cytogenet. Cell Genet. , vol.14 , pp. 9-25
    • Riggs, A.D.1
  • 17
    • 0016439429 scopus 로고
    • DNA modification mechanisms and gene activity during development
    • Holliday, R. and Pugh, J. E. (1975) DNA modification mechanisms and gene activity during development. Science, 187, 226-232.
    • (1975) Science , vol.187 , pp. 226-232
    • Holliday, R.1    Pugh, J.E.2
  • 18
    • 0142247187 scopus 로고    scopus 로고
    • Mammalian DNA (cytosine-5)methyltransferases and their expression
    • Pradhan, S. and Estève, P.-O. (2003) Mammalian DNA (cytosine-5)methyltransferases and their expression. Clin. Immunol., 109, 6-16.
    • (2003) Clin. Immunol. , vol.109 , pp. 6-16
    • Pradhan, S.1    Estève, P.-O.2
  • 20
    • 62049086288 scopus 로고    scopus 로고
    • PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
    • Zhao, Q., Rank, G., Tan, Y. T. et al. (2009) PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat. Struct. Mol. Biol., 16, 304-311.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 304-311
    • Zhao, Q.1    Rank, G.2    Tan, Y.T.3
  • 21
    • 19444361995 scopus 로고    scopus 로고
    • Genomic imprinting and methylation: Epigenetic canalization and conflict
    • Wilkins, J. F. (2005) Genomic imprinting and methylation: epigenetic canalization and conflict. Trends Genet, 21, 356-365.
    • (2005) Trends Genet , vol.21 , pp. 356-365
    • Wilkins, J.F.1
  • 22
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson, K. D. (2005) DNA methylation and human disease. Nat. Rev. Genet., 6, 597-610.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 23
    • 0037068378 scopus 로고    scopus 로고
    • DNA methylation in cancer
    • Jones, A. P. (2002) DNA methylation in cancer. Oncogene, 21, 5358-5360.
    • (2002) Oncogene , vol.21 , pp. 5358-5360
    • Jones, A.P.1
  • 25
    • 45449114804 scopus 로고    scopus 로고
    • The colorful history of active DNA demethylation
    • Ooi, S. K. T. and Bestor, T. H. (2008) The colorful history of active DNA demethylation. Cell, 133, 1145-1148.
    • (2008) Cell , vol.133 , pp. 1145-1148
    • Ooi, S.K.T.1    Bestor, T.H.2
  • 26
    • 26944485107 scopus 로고    scopus 로고
    • Preventing transcriptional gene silencing by active DNA demethylation
    • DOI 10.1016/j.febslet.2005.08.039, PII S0014579305010392, RNAi: Mechanisms, Biology and Applications
    • Kapoor, A., Agius, F. and Zhu, J.-K. (2005) Preventing transcriptional gene silencing by active DNA demethylation. FEBS Lett., 579, 5889-5898. (Pubitemid 41484134)
    • (2005) FEBS Letters , vol.579 , Issue.26 , pp. 5889-5898
    • Kapoor, A.1    Agius, F.2    Zhu, J.-K.3
  • 29
    • 77249148019 scopus 로고    scopus 로고
    • Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
    • Popp, C., Dean, W., Feng, S., Cokus, S. H., Andrews, S., Pellegrini, M., Jacobsen, S. E. and Reik, W. (2010) Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature, 463, 1101-1105.
    • (2010) Nature , vol.463 , pp. 1101-1105
    • Popp, C.1    Dean, W.2    Feng, S.3    Cokus, S.H.4    Andrews, S.5    Pellegrini, M.6    Jacobsen, S.E.7    Reik, W.8
  • 30
    • 77649104794 scopus 로고    scopus 로고
    • Reprogramming towards pluripotency requires AID-dependent DNA demethylation
    • Bhutani, N., Brady, J. J., Damian, M., Sacco, A., Corbel, S. Y. and Blau, H. M. (2010) Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature, 463, 1042-1047.
    • (2010) Nature , vol.463 , pp. 1042-1047
    • Bhutani, N.1    Brady, J.J.2    Damian, M.3    Sacco, A.4    Corbel, S.Y.5    Blau, H.M.6
  • 31
    • 33745898263 scopus 로고    scopus 로고
    • Mutagenic mechanisms in leukemia and cancer: A new concept cytosine lack could be as mutagenic as cytosine deamination
    • Parry, T. E. (2006) Mutagenic mechanisms in leukemia and cancer: a new concept cytosine lack could be as mutagenic as cytosine deamination. Leuk. Res., 30, 1079-1083.
    • (2006) Leuk. Res. , vol.30 , pp. 1079-1083
    • Parry, T.E.1
  • 32
    • 0029736819 scopus 로고    scopus 로고
    • Methylation inhibitors can increase the rate of cytosine deamination by cytosine-5-DNA methyltransferase
    • Zingg, J. M., Shen, J. C., Yang, A. S., Rapoport, H. and Jones, P. A. (1996) Methylation inhibitors can increase the rate of cytosine deamination by cytosine-5-DNA methyltransferase. Nucleic Acid Res., 24, 3267-3275.
    • (1996) Nucleic Acid Res. , vol.24 , pp. 3267-3275
    • Zingg, J.M.1    Shen, J.C.2    Yang, A.S.3    Rapoport, H.4    Jones, P.A.5
  • 33
    • 67449105689 scopus 로고    scopus 로고
    • DNA methylation at the C-5 position of cytosine by methyl radicals: A possible role for epigenetic change during carcinogenesis by environmental agents
    • Kasai, H. and Kawai, K. (2009) DNA methylation at the C-5 position of cytosine by methyl radicals: a possible role for epigenetic change during carcinogenesis by environmental agents. Chem. Res. Toxicol., 22, 984-989.
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 984-989
    • Kasai, H.1    Kawai, K.2
  • 34
    • 27944492002 scopus 로고    scopus 로고
    • Dynamic and reversibility of heterochromatic gene silencing in human disease
    • DOI 10.1038/sj.cr.7290337
    • Zardo, G., Fazi, F., Travaglini, L. and Nervi, C. (2005) Dynamic and reversibility of heterochromatic gene silencing in human disease. Cell Res., 15, 679-690. (Pubitemid 41673852)
    • (2005) Cell Research , vol.15 , Issue.9 , pp. 679-690
    • Zardo, G.1    Fazi, F.2    Travaglini, L.3    Nervi, C.4
  • 35
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • Klose, R. J. and Bird, A. P. (2006) Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci., 31, 89-187.
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 89-187
    • Klose, R.J.1    Bird, A.P.2
  • 36
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi, A., Park, I.-H., Wen, B. et al. (2009) Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat. Genet., 41, 1350-1353.
    • (2009) Nat. Genet. , vol.41 , pp. 1350-1353
    • Doi, A.1    Park, I.-H.2    Wen, B.3
  • 37
    • 66149100139 scopus 로고    scopus 로고
    • DNA methylation inhibits p53-mediated survivin repression
    • Nabilsi, N. H., Broaddus, R. R. and Loose, D. S. (2009) DNA methylation inhibits p53-mediated survivin repression. Oncogene, 28, 1-5.
    • (2009) Oncogene , vol.28 , pp. 1-5
    • Nabilsi, N.H.1    Broaddus, R.R.2    Loose, D.S.3
  • 38
    • 32544431582 scopus 로고    scopus 로고
    • Epigenetics and human disease: Translating basic biology into clinical applications
    • DOI 10.1503/cmaj.050774
    • Rodenhiser, D. and Mann, M. (2006) Epigenetics and human disease: translating basic biology into clinical applications. CMAJ, 3, 341-348. (Pubitemid 43235307)
    • (2006) Canadian Medical Association Journal , vol.174 , Issue.3 , pp. 341-348
    • Rodenhiser, D.1    Mann, M.2
  • 39
    • 0036324032 scopus 로고    scopus 로고
    • DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearragements
    • Erlich, M. (2002) DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearragements. J. Nutr., 132, 2424S-2429S.
    • (2002) J. Nutr. , vol.132
    • Erlich, M.1
  • 40
    • 7944230161 scopus 로고    scopus 로고
    • Epigenetic silencing mediated by CpG island methylation: Potential as a therapeutic target and as a biomarker
    • Teodoridis, J. M., Strathdee, G. and Brown, R. (2004) Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker. Drug Resist. Updat., 7, 267-278.
    • (2004) Drug Resist. Updat. , vol.7 , pp. 267-278
    • Teodoridis, J.M.1    Strathdee, G.2    Brown, R.3
  • 41
    • 0347622294 scopus 로고    scopus 로고
    • Targeting DNA methylation in cancer
    • Szyf, M. (2003) Targeting DNA methylation in cancer. Ageing Res. Rev., 2, 299-328.
    • (2003) Ageing Res. Rev. , vol.2 , pp. 299-328
    • Szyf, M.1
  • 42
    • 33644753715 scopus 로고    scopus 로고
    • The application of epigenetic modifiers on the treatment of prostate and bladder cancer
    • Zhang, Z., Karam, J., Frankel, E., Sagalowsky, A. and Hsieh, J.-T. (2006) The application of epigenetic modifiers on the treatment of prostate and bladder cancer. Urol. Oncol., 24, 152-160.
    • (2006) Urol. Oncol. , vol.24 , pp. 152-160
    • Zhang, Z.1    Karam, J.2    Frankel, E.3    Sagalowsky, A.4    Hsieh, J.-T.5
  • 43
    • 14644396228 scopus 로고    scopus 로고
    • Detection and interpretation of altered methylation patterns in cancer cells
    • Ushijima, T. (2005) Detection and interpretation of altered methylation patterns in cancer cells. Nat. Rev. Cancer, 5, 223-231.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 223-231
    • Ushijima, T.1
  • 45
    • 51649083501 scopus 로고    scopus 로고
    • A microRNA DNA methylation signature for human cancer metastasis
    • Lujambio, A., Calin, G. A., Villanueva, A. et al. (2008) A microRNA DNA methylation signature for human cancer metastasis. Proc. Natl Acad. Sci. USA., 105, 13556-13561.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13556-13561
    • Lujambio, A.1    Calin, G.A.2    Villanueva, A.3
  • 46
    • 7244221348 scopus 로고    scopus 로고
    • DNA methylation, cancer susceptibility, and nutrient interactions
    • Davies, C. D. (2004) DNA methylation, cancer susceptibility, and nutrient interactions. Exp. Biol. Med., 229, 988-995.
    • (2004) Exp. Biol. Med. , vol.229 , pp. 988-995
    • Davies, C.D.1
  • 48
    • 0036593394 scopus 로고    scopus 로고
    • Histone methyltransferases, diet nutrients and tumor suppressors
    • Huang, S. (2002) Histone methyltransferases, diet nutrients and tumor suppressors. Nat. Rev. Cancer, 2, 469-472.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 469-472
    • Huang, S.1
  • 49
    • 0034800283 scopus 로고    scopus 로고
    • Beneficial role for folate in the prevention of colorectal and breast cancer
    • Prinz-Langenohl, R., Fohr, I. and Pietrzik, K. (2001) Beneficial role for folate in the prevention of colorectal and breast cancer. Eur. J. Nutr., 40, 98-105.
    • (2001) Eur. J. Nutr. , vol.40 , pp. 98-105
    • Prinz-Langenohl, R.1    Fohr, I.2    Pietrzik, K.3
  • 50
    • 31544467532 scopus 로고    scopus 로고
    • Nutritional epigenetics: Impact of folate deficiency on DNA methylation and colon cancer susceptibility
    • Kim, Y.-I. (2005) Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J. Nutr., 135, 2703-2709.
    • (2005) J. Nutr. , vol.135 , pp. 2703-2709
    • Kim, Y.-I.1
  • 51
    • 33646790538 scopus 로고    scopus 로고
    • Assessing the effects of high methionine intake on DNA methylation
    • Waterland, R. A. (2006) Assessing the effects of high methionine intake on DNA methylation. J. Nutr., 136, 1706S-1710S.
    • (2006) J. Nutr. , vol.136
    • Waterland, R.A.1
  • 53
    • 58249098396 scopus 로고    scopus 로고
    • Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors
    • Vaissiere, T., Hung, R. J., Zaridze, D. et al. (2009) Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. Cancer Res., 69, 243-252.
    • (2009) Cancer Res. , vol.69 , pp. 243-252
    • Vaissiere, T.1    Hung, R.J.2    Zaridze, D.3
  • 54
    • 40649093505 scopus 로고    scopus 로고
    • The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas
    • Guz, J., Foksinski, M., Siomek, A., Gackowski, D., Rozalski, R., Dziaman, T., Szpila, A. and Olinski, R. (2008) The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas. Mutat. Res., 640, 170-173.
    • (2008) Mutat. Res. , vol.640 , pp. 170-173
    • Guz, J.1    Foksinski, M.2    Siomek, A.3    Gackowski, D.4    Rozalski, R.5    Dziaman, T.6    Szpila, A.7    Olinski, R.8
  • 55
    • 33847613305 scopus 로고    scopus 로고
    • Epigenetics and cancer: Towards an evaluation of the impact of environmental and dietary factors
    • Herceg, Z. (2007) Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors. Mutagenesis, 22, 91-103.
    • (2007) Mutagenesis , vol.22 , pp. 91-103
    • Herceg, Z.1
  • 56
    • 0033564902 scopus 로고    scopus 로고
    • DNA methylation
    • Singal, R. and Ginder, G. D. (1999) DNA methylation. Blood, 93, 4059-4070.
    • (1999) Blood , vol.93 , pp. 4059-4070
    • Singal, R.1    Ginder, G.D.2
  • 57
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird, P. W. (2003) The power and the promise of DNA methylation markers. Nat. Rev. Cancer, 3, 253-266.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 59
    • 55949113233 scopus 로고    scopus 로고
    • Use of DNA methylation for cancer detection: Promises and challenges
    • Zhu, J. and Yao, X. (2009) Use of DNA methylation for cancer detection: promises and challenges. Int. J. Biochem. Cell Biol., 41, 147-154.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 147-154
    • Zhu, J.1    Yao, X.2
  • 60
    • 0024365892 scopus 로고
    • Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
    • Greger, V., Passarge, E., Hopping, W., Messmer, E. and Horsthemke, B. (1989) Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum. Gen., 83, 155-158.
    • (1989) Hum. Gen. , vol.83 , pp. 155-158
    • Greger, V.1    Passarge, E.2    Hopping, W.3    Messmer, E.4    Horsthemke, B.5
  • 61
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones, A. P. and Baylin, S. B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, A.P.1    Baylin, S.B.2
  • 62
    • 31344466008 scopus 로고    scopus 로고
    • DNA methylation and gene silencing in cancer
    • Baylin, S. B. (2005) DNA methylation and gene silencing in cancer. Nat. Clin. Pract. Oncol., 2, S4-S11.
    • (2005) Nat. Clin. Pract. Oncol. , vol.2
    • Baylin, S.B.1
  • 63
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman, J. G., Merlo, A., Mao, L., Lapidus, R. G., Issa, J. P., Davidson, N. E., Sidransky, D. and Baylin, S. B. (1995) Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55, 4525-4530.
    • (1995) Cancer Res. , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 64
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation indicates a tumor suppressor role for p15 (INK4B)
    • Herman, J. G. (1996) Hypermethylation-associated inactivation indicates a tumor suppressor role for p15 (INK4B). Cancer Res., 56, 722-727.
    • (1996) Cancer Res. , vol.56 , pp. 722-727
    • Herman, J.G.1
  • 66
    • 0028072991 scopus 로고
    • Silencing of the VHL tumor suppressor gene by DNA methylation in renal carcinoma
    • Herman, J. G., Latif, F., Weng, Y. et al. (1994) Silencing of the VHL tumor suppressor gene by DNA methylation in renal carcinoma. Proc. Natl Acad. Sci. USA., 91, 9700-9704.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9700-9704
    • Herman, J.G.1    Latif, F.2    Weng, Y.3
  • 67
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman, J. G., Umar, A., Polyak, K. et al. (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl Acad. Sci. USA, 95, 6870-6875.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3
  • 68
    • 0028001087 scopus 로고
    • Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
    • Issa, J. P. (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat. Genet., 7, 536-540.
    • (1994) Nat. Genet. , vol.7 , pp. 536-540
    • Issa, J.P.1
  • 69
    • 0029759694 scopus 로고    scopus 로고
    • Hypermethylation of the myogenic gene Myf-3 in human breast carcinomas
    • Hahnel, R., Harvey, J. and Kay, P. (1996) Hypermethylation of the myogenic gene Myf-3 in human breast carcinomas. Anticancer Res., 16, 2111-2115. (Pubitemid 26270734)
    • (1996) Anticancer Research , vol.16 , Issue.4 A , pp. 2111-2115
    • Hahnel, R.1    Harvey, J.2    Kay, P.3
  • 71
  • 72
    • 33645775744 scopus 로고    scopus 로고
    • Cancer epigenome: A review
    • Dimitrijevic, B. (2005) Cancer epigenome: a review. Arch. Oncol., 13, 108-114.
    • (2005) Arch. Oncol. , vol.13 , pp. 108-114
    • Dimitrijevic, B.1
  • 73
    • 66149118937 scopus 로고    scopus 로고
    • The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer
    • Shah, R., Smith, P., Purdie, C., Quinlan, P., Baker, L., Aman, P., Thompson, A. M. and Crook, T. (2009) The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer. Br. J. Cancer., 100, 1687-1696.
    • (2009) Br. J. Cancer , vol.100 , pp. 1687-1696
    • Shah, R.1    Smith, P.2    Purdie, C.3    Quinlan, P.4    Baker, L.5    Aman, P.6    Thompson, A.M.7    Crook, T.8
  • 74
    • 67349175004 scopus 로고    scopus 로고
    • Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease
    • Mayor, R., Casadome, L., Azuara, D., Moreno, V., Clark, S. J., Capella, G. and Peinado, M. A. (2009) Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. Br. J. Cancer., 100, 1534-1539.
    • (2009) Br. J. Cancer , vol.100 , pp. 1534-1539
    • Mayor, R.1    Casadome, L.2    Azuara, D.3    Moreno, V.4    Clark, S.J.5    Capella, G.6    Peinado, M.A.7
  • 75
    • 67650077151 scopus 로고    scopus 로고
    • Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer
    • deVos, T., Tetzner, R., Model, F. et al. (2009) Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin. Chem., 55, 1337-1346.
    • (2009) Clin. Chem. , vol.55 , pp. 1337-1346
    • DeVos, T.1    Tetzner, R.2    Model, F.3
  • 76
    • 0038747956 scopus 로고    scopus 로고
    • Relevance of DNA methylation in the management of cancer
    • Esteller, M. (2003) Relevance of DNA methylation in the management of cancer. Lancet Oncol., 4, 351-358.
    • (2003) Lancet Oncol. , vol.4 , pp. 351-358
    • Esteller, M.1
  • 77
    • 27144509196 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
    • DOI 10.1093/jnci/dji311
    • Lyko, F. and Brown, R. (2005) DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J. Natl Cancer Inst., 97, 1498-1506. (Pubitemid 41631949)
    • (2005) Journal of the National Cancer Institute , vol.97 , Issue.20 , pp. 1498-1506
    • Lyko, F.1    Brown, R.2
  • 78
    • 34250638678 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors for cancer therapy
    • Brueckner, B., Kuck, D. and Lyko, F. (2007) DNA methyltransferase inhibitors for cancer therapy. Cancer J., 13, 17-22.
    • (2007) Cancer J. , vol.13 , pp. 17-22
    • Brueckner, B.1    Kuck, D.2    Lyko, F.3
  • 79
    • 0013773866 scopus 로고
    • 5-Azacytidine, a new, highly effective cancerostatic
    • Sorm, F., Piskala, A., Cihak, A. and Vesely, J. (1964) 5-Azacytidine, a new, highly effective cancerostatic. Experientia, 20, 202-203.
    • (1964) Experientia , vol.20 , pp. 202-203
    • Sorm, F.1    Piskala, A.2    Cihak, A.3    Vesely, J.4
  • 80
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • DOI 10.1158/0008-5472.CAN-04-2957
    • Brueckner, B., Boy, R. G., Siedlecki, P., Musch, T., Kliem, H. C., Zielenkiewicz, P., Suhai, S., Wiessler, M. and Lyko, F. (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res., 65, 6305-6311. (Pubitemid 40994416)
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 6305-6311
    • Brueckner, B.1    Boy, R.G.2    Siedlecki, P.3    Musch, T.4    Kliem, H.C.5    Zielenkiewicz, P.6    Suhai, S.7    Wiessler, M.8    Lyko, F.9
  • 84
    • 61749093379 scopus 로고    scopus 로고
    • Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo
    • Steele, N., Finn, P., Brown, R. and Plumb, J. A. (2009) Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo. Br. J. Cancer., 100, 758-763.
    • (2009) Br. J. Cancer. , vol.100 , pp. 758-763
    • Steele, N.1    Finn, P.2    Brown, R.3    Plumb, J.A.4
  • 85
    • 10644256532 scopus 로고    scopus 로고
    • Zebularine: A new drug for epigenetic therapy
    • Yoo, C. B., Cheng, J. C. and Jones, P. A. (2004) Zebularine: a new drug for epigenetic therapy. Biochem. Soc. Trans., 32, 910-912.
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 910-912
    • Yoo, C.B.1    Cheng, J.C.2    Jones, P.A.3
  • 86
    • 33846796029 scopus 로고    scopus 로고
    • Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells
    • Rao, S. P., Rechsteiner, M. P., Berger, C., Sigrist, J. A., Nadal, D. and Bernasconi, M. (2007) Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells. Mol. Cancer., 6, 3-8.
    • (2007) Mol. Cancer. , vol.6 , pp. 3-8
    • Rao, S.P.1    Rechsteiner, M.P.2    Berger, C.3    Sigrist, J.A.4    Nadal, D.5    Bernasconi, M.6
  • 87
    • 0036861629 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors: State of the art
    • Goffin, J. and Eisenhauer, E. (2002) DNA methyltransferase inhibitors: state of the art. Annal. Oncol., 13, 1699-1716.
    • (2002) Annal. Oncol. , vol.13 , pp. 1699-1716
    • Goffin, J.1    Eisenhauer, E.2
  • 88
    • 0345275879 scopus 로고    scopus 로고
    • Tea Polyphenol (-)-Epigallocatechin-3-Gallate Inhibits DNA Methyltransferase and Reactivates Methylation-Silenced Genes in Cancer Cell Lines
    • Fang, M. Z., Wang, Y., Ai, N., Hou, Z., Sun, Y., Lu, H., Welsh, W. and Yang, C. S. (2003) Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res., 63, 7563-7570. (Pubitemid 37466673)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 7563-7570
    • Fang, M.Z.1    Wang, Y.2    Ai, N.3    Hou, Z.4    Sun, Y.5    Lu, H.6    Welsh, W.7    Yang, C.S.8
  • 89
    • 33845969839 scopus 로고    scopus 로고
    • Dietary polyphenols may affect DNA methylation
    • Fang, M., Chen, D. and Yang, C. S. (2007) Dietary polyphenols may affect DNA methylation. J. Nutr., 137, 223S-228S.
    • (2007) J. Nutr. , vol.137
    • Fang, M.1    Chen, D.2    Yang, C.S.3
  • 90
    • 33644871227 scopus 로고    scopus 로고
    • Chromatin-modulating agents as epigenetic anticancer drugs - "The die is cast"
    • Konstantinopoulos, P. A. and Papavassiliou, A. G. (2006) Chromatin-modulating agents as epigenetic anticancer drugs - "the die is cast". Drug Discov. Today, 11, 91-93.
    • (2006) Drug Discov. Today , vol.11 , pp. 91-93
    • Konstantinopoulos, P.A.1    Papavassiliou, A.G.2
  • 91
    • 67650462249 scopus 로고    scopus 로고
    • DNA hypomethylation in the origin and pathogenesis of human diseases
    • Pogribny, I. P. and Beland, F. A. (2009) DNA hypomethylation in the origin and pathogenesis of human diseases. Cell. Mol. Life Sci., 66, 2249-2261.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 2249-2261
    • Pogribny, I.P.1    Beland, F.A.2
  • 92
    • 34249774303 scopus 로고    scopus 로고
    • Chromatin as a target for the DNA-binding anticancer drugs
    • Kundu, T. K. and Dasgupta, D. (eds.), Springer-Verlag, Berlin, Germany
    • Majumder, P., Pradhan, S. K., Devi, P. K., Pal, S. and Dasgupta, D. (2007) Chromatin as a target for the DNA-binding anticancer drugs. In Kundu, T. K. and Dasgupta, D. (eds.), Chromatin and disease, Springer-Verlag, Berlin, Germany, pp. 145-189.
    • (2007) Chromatin and Disease , pp. 145-189
    • Majumder, P.1    Pradhan, S.K.2    Devi, P.K.3    Pal, S.4    Dasgupta, D.5
  • 93
    • 54049123727 scopus 로고    scopus 로고
    • Outcry at scale of inheritance project
    • Pearson, H. (2008) Outcry at scale of inheritance project. Nature, 455, 845.
    • (2008) Nature , vol.455 , pp. 845
    • Pearson, H.1
  • 94
    • 2442680341 scopus 로고    scopus 로고
    • The value of DNA methylation analysis in basic, initial toxicity assessment
    • Watson, R. E., McKim, J. M., Cockerell, G. L. and Goodman, J. I. (2004) The value of DNA methylation analysis in basic, initial toxicity assessment. Toxicol. Sci., 79, 178-188.
    • (2004) Toxicol. Sci. , vol.79 , pp. 178-188
    • Watson, R.E.1    McKim, J.M.2    Cockerell, G.L.3    Goodman, J.I.4
  • 95
    • 67049107646 scopus 로고    scopus 로고
    • Determination of 5-methyl-2′-deoxycitidine in genomic DNA using high performance liquid chromatography-ultraviolet detection
    • Sandhu, J., Kaur, B., Armstrong, C., Talbot, C. J., Steward, W. P., Farmer, P. B. and Singh, R. (2009) Determination of 5-methyl-2′- deoxycitidine in genomic DNA using high performance liquid chromatography- ultraviolet detection. J. Chromatogr. B, 877, 1957-1961.
    • (2009) J. Chromatogr. B , vol.877 , pp. 1957-1961
    • Sandhu, J.1    Kaur, B.2    Armstrong, C.3    Talbot, C.J.4    Steward, W.P.5    Farmer, P.B.6    Singh, R.7
  • 97
    • 39449088572 scopus 로고    scopus 로고
    • Genome-wide approaches to studying chromatin modifications
    • Schones, D. E. and Zhao, K. (2008) Genome-wide approaches to studying chromatin modifications. Natl Rev. Genet., 9, 179-191.
    • (2008) Natl Rev. Genet. , vol.9 , pp. 179-191
    • Schones, D.E.1    Zhao, K.2
  • 99
    • 78049451947 scopus 로고    scopus 로고
    • Methods for genome-wide analysis of DNA methylation in intestinal tumors
    • Hahn, M. A. and Pfeifer, G. P. (2010) Methods for genome-wide analysis of DNA methylation in intestinal tumors. Mutat. Res., 693, 77-83.
    • (2010) Mutat. Res. , vol.693 , pp. 77-83
    • Hahn, M.A.1    Pfeifer, G.P.2
  • 100
    • 77249137168 scopus 로고    scopus 로고
    • Principle and challenges of genome-wide DNA methylation analysis
    • Laird, P. W. (2010) Principle and challenges of genome-wide DNA methylation analysis. Nat. Rev. Genet., 11, 191-203.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 101
    • 77957937011 scopus 로고    scopus 로고
    • Quantitative comparison of genome-wide DNA methylation mapping technologies
    • Bock, C., Tomazou, E. M., Brinkman, A. B. et al. (2010) Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat. Biotechnol, 28, 1106-1114.
    • (2010) Nat. Biotechnol , vol.28 , pp. 1106-1114
    • Bock, C.1    Tomazou, E.M.2    Brinkman, A.B.3
  • 102
    • 47849128445 scopus 로고    scopus 로고
    • The bisulfite genomic sequencing used in the analysis of epigenetic states, a technique in the emerging environmental genotoxicology research
    • Hayatsu, H. (2008) The bisulfite genomic sequencing used in the analysis of epigenetic states, a technique in the emerging environmental genotoxicology research. Mutat. Res., 659, 77-82.
    • (2008) Mutat. Res. , vol.659 , pp. 77-82
    • Hayatsu, H.1
  • 103
    • 78651280460 scopus 로고    scopus 로고
    • Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
    • Song, C.-X., Szulwach, K. E., Fu, Y. et al. (2010) Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol, 29, 68-72.
    • (2010) Nat. Biotechnol , vol.29 , pp. 68-72
    • Song, C.-X.1    Szulwach, K.E.2    Fu, Y.3
  • 104
    • 0037328344 scopus 로고    scopus 로고
    • A versatile method employing basic techniques of genetic engineering to study the ability of low molecular weight compounds to bind covalently with DNA in cell-free system
    • Bartoszek, A., Sielenko, A. and Wesiora, M. (2003) A versatile method employing basic techniques of genetic engineering to study the ability of low molecular weight compounds to bind covalently with DNA in cell-free system. Anal. Biochem., 313, 53-59.
    • (2003) Anal. Biochem. , vol.313 , pp. 53-59
    • Bartoszek, A.1    Sielenko, A.2    Wesiora, M.3
  • 105
    • 36448949036 scopus 로고    scopus 로고
    • DNA methylation analysis using CpG microarrays is impaired in benzopyrene exposed cells
    • Sadikovic, B., Andrews, J. and Rodenhiser, D. I. (2007) DNA methylation analysis using CpG microarrays is impaired in benzopyrene exposed cells. Toxicol. Appl. Pharamacol., 225, 300-309.
    • (2007) Toxicol. Appl. Pharamacol. , vol.225 , pp. 300-309
    • Sadikovic, B.1    Andrews, J.2    Rodenhiser, D.I.3
  • 106
    • 57549100476 scopus 로고    scopus 로고
    • Chemical approach toward efficient DNA methylation analysis
    • Okamoto, A. (2009) Chemical approach toward efficient DNA methylation analysis. Org. Biomol. Chem., 7, 21-26.
    • (2009) Org. Biomol. Chem. , vol.7 , pp. 21-26
    • Okamoto, A.1
  • 107
    • 0026808756 scopus 로고
    • Cytosine methylation can induce local distortions in the structure of duplex DNA
    • Hodges-Garcia, Y. and Hagerman, P. J. (1992) Cytosine methylation can induce local distortions in the structure of duplex DNA. Biochemistry, 31, 7595-7599.
    • (1992) Biochemistry , vol.31 , pp. 7595-7599
    • Hodges-Garcia, Y.1    Hagerman, P.J.2
  • 109
    • 0022459159 scopus 로고
    • Influence of DNA-binding drugs on chromatin condensation
    • Sen, D. and Crothers, D. M. (1986) Influence of DNA-binding drugs on chromatin condensation. Biochemistry, 25, 1503-1509.
    • (1986) Biochemistry , vol.25 , pp. 1503-1509
    • Sen, D.1    Crothers, D.M.2
  • 112
    • 0030479681 scopus 로고    scopus 로고
    • DNA modifying agents as a tools for studying chromatin structure
    • Millard, J. T. (1996) DNA modifying agents as a tools for studying chromatin structure. Biochimie, 78, 803-816.
    • (1996) Biochimie , vol.78 , pp. 803-816
    • Millard, J.T.1
  • 113
    • 0042473098 scopus 로고    scopus 로고
    • Preferential carcinogen - DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms
    • DOI 10.1021/bi034631s
    • Hu, W., Feng, Z. and Tang, M. S. (2003) Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms. Biochemistry, 42, 10012-10023. (Pubitemid 37012877)
    • (2003) Biochemistry , vol.42 , Issue.33 , pp. 10012-10023
    • Hu, W.1    Feng, Z.2    Tang, M.-S.3
  • 114
    • 0035477426 scopus 로고    scopus 로고
    • Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: Similarities with the p53 mutation spectrum in smoking-associated lung cancers
    • Yoon, J.-H., Smith, L. E., Feng, Z., Tang, M. S., Lee, C.-S. and Pfeifer, G. P. (2001) Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-related lung cancer. Cancer Res., 61, 7110-7117. (Pubitemid 32946502)
    • (2001) Cancer Research , vol.61 , Issue.19 , pp. 7110-7117
    • Yoon, J.-H.1    Smith, L.E.2    Feng, Z.3    Tang, M.-S.4    Lee, C.-S.5    Pfeifer, G.P.6
  • 115
    • 68549107689 scopus 로고    scopus 로고
    • Global and gene-specific promoter methylation changes are related toanti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals
    • Pavanello, S., Bollati, V., Pesatori, A. C., Kapka, L., Bolognesi, C., Bertazzi, P. A. and Baccarelli, A. (2009) Global and gene-specific promoter methylation changes are related toanti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals. Int. J. Cancer., 125, 1692-1697.
    • (2009) Int. J. Cancer , vol.125 , pp. 1692-1697
    • Pavanello, S.1    Bollati, V.2    Pesatori, A.C.3    Kapka, L.4    Bolognesi, C.5    Bertazzi, P.A.6    Baccarelli, A.7
  • 117
    • 67349121731 scopus 로고    scopus 로고
    • Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylchloranthrene and diethylnitrosamine
    • Liu, W.-b., Liu, J.-y., Ao, L., Zhou, Z.-y., Zhou, Z.-h., Cui, Z.-h., Yang, H. and Cao, J. (2009) Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylchloranthrene and diethylnitrosamine. Toxicol. Lett., 189, 5-13.
    • (2009) Toxicol. Lett. , vol.189 , pp. 5-13
    • Liu, W.-B.1    Liu, J.-Y.2    Ao, L.3    Zhou, Z.-Y.4    Zhou, Z.-H.5    Cui, Z.-H.6    Yang, H.7    Cao, J.8
  • 118
    • 33750038006 scopus 로고    scopus 로고
    • Benzo[a]pyren exposure disrupts DNA methylation and growth dynamics in breast cancer
    • Sadikovic, B. and Rodenhiser, D. (2006) Benzo[a]pyren exposure disrupts DNA methylation and growth dynamics in breast cancer. Toxicol. Appl. Pharamacol., 216, 456-468.
    • (2006) Toxicol. Appl. Pharamacol. , vol.216 , pp. 456-468
    • Sadikovic, B.1    Rodenhiser, D.2
  • 119
    • 0242318377 scopus 로고    scopus 로고
    • Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease
    • Zou, Y., Shell, S. M., Utzat, D. C., Luo, C., Yang, Z., Geacintov, N. E. and Basu, A. K. (2003) Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease. Biochemistry, 42, 12654-12661.
    • (2003) Biochemistry , vol.42 , pp. 12654-12661
    • Zou, Y.1    Shell, S.M.2    Utzat, D.C.3    Luo, C.4    Yang, Z.5    Geacintov, N.E.6    Basu, A.K.7
  • 120
    • 0037164719 scopus 로고    scopus 로고
    • DNA repair: Bioinformatics helps reverse methylation damage
    • Jiricny, J. (2002) DNA repair: bioinformatics helps reverse methylation damage. Current Biol., 12, R846-R848.
    • (2002) Current Biol. , vol.12
    • Jiricny, J.1
  • 122
    • 0028988834 scopus 로고
    • Selective recognition of the m5CpG dinucleotide sequence in DNA by mitomycin C for alkylation and cross-linking
    • Johnson, W. S., He, Q.-Y. and Tomasz, M. (1995) Selective recognition of the m5CpG dinucleotide sequence in DNA by mitomycin C for alkylation and cross-linking. Bioorg. Med. Chem., 3, 851-860.
    • (1995) Bioorg. Med. Chem. , vol.3 , pp. 851-860
    • Johnson, W.S.1    He, Q.-Y.2    Tomasz, M.3
  • 124
    • 0035844263 scopus 로고    scopus 로고
    • Cytosine methylation enhances mitoxantrone-DNA adduct formation at CpG nucleotides
    • Parker, B. S., Cutts, S. M. and Phillips, D. R. (2001) Cytosine methylation enhances mitoxantrone-DNA adduct formation at CpG nucleotides. J. Biol. Chem., 276, 15953-15960.
    • (2001) J. Biol. Chem. , vol.276 , pp. 15953-15960
    • Parker, B.S.1    Cutts, S.M.2    Phillips, D.R.3
  • 126
    • 0037069761 scopus 로고    scopus 로고
    • The interaction of cisplatin and analogues with DNA in reconstituted chromatin
    • Galea, A. M. and Murray, V. (2002) The interaction of cisplatin and analogues with DNA in reconstituted chromatin. Biochim. Biophys. Acta, 1579, 142-152.
    • (2002) Biochim. Biophys. Acta , vol.1579 , pp. 142-152
    • Galea, A.M.1    Murray, V.2
  • 127
    • 0021894582 scopus 로고
    • Adducts of the antitumor drug cis-diamminedichloroplatinum( II) with DNA: Formation, identification, and quantitation
    • Fichtinger-Schepman, A. M., van der Veer, J. L., den Hartog, J. H., Lohman, P. H. and Reedijk, J. (1985) Adducts of the antitumor drug cis-diamminedichloroplatinum( II) with DNA: formation, identification, and quantitation. Biochemistry, 29, 707-713.
    • (1985) Biochemistry , vol.29 , pp. 707-713
    • Fichtinger-Schepman, A.M.1    Van Der Veer, J.L.2    Den Hartog, J.H.3    Lohman, P.H.4    Reedijk, J.5
  • 128
    • 0034255355 scopus 로고    scopus 로고
    • The effect of chromatin structure of cisplatin damage in intact human cells
    • Davies, N. P., Hardman, L. C. and Murray, V. (2000) The effect of chromatin structure on cisplatin damage in intact human cells. Nucleic Acids Res., 28, 2954-2958. (Pubitemid 30599271)
    • (2000) Nucleic Acids Research , vol.28 , Issue.15 , pp. 2954-2958
    • Davies, N.P.1    Hardman, L.C.2    Murray, V.3
  • 129
    • 0031588541 scopus 로고    scopus 로고
    • 32P-postlabelling analysis of nucleobases involved in the formation DNA adducts by antitumor 1-nitroacridines
    • 32P- postlabelling analysis of nucleobases involved in the formation DNA adducts by antitumor 1-nitroacridines. Chem. Biol. Interact., 103, 131-139.
    • (1997) Chem. Biol. Interact. , vol.103 , pp. 131-139
    • Bartoszek, A.1    Dackiewicz, P.2    Konopa, J.3
  • 130
    • 0024388926 scopus 로고
    • Induction of DNA-protein crosslinks by antitumor 1-nitro-9-aminoacridines in L1210 leukemia cells
    • Woynarowski, J. M., McNamee, H., Szmigiero, L., Beerman, T. A. and Konopa, J. (1989) Induction of DNA-protein crosslinks by antitumor 1-nitro-9-aminoacridines in L1210 leukemia cells. Biochem. Pharmacol, 38, 4095-4101.
    • (1989) Biochem. Pharmacol , vol.38 , pp. 4095-4101
    • Woynarowski, J.M.1    McNamee, H.2    Szmigiero, L.3    Beerman, T.A.4    Konopa, J.5
  • 131
    • 0019352101 scopus 로고
    • Some properties of the irreversible complexes of nitracrine (Ledakrin, C-283) with polynucleotides
    • Gniazdowski, M., Ciesielska, E. and Szmigiero, L. (1981) Some properties of the irreversible complexes of nitracrine (Ledakrin, C-283) with polynucleotides. Chem. Biol. Interact, 355, 355-366.
    • (1981) Chem. Biol. Interact , vol.355 , pp. 355-366
    • Gniazdowski, M.1    Ciesielska, E.2    Szmigiero, L.3
  • 132
    • 20344407323 scopus 로고    scopus 로고
    • Epigenetic programming in the preimplantation rat embryo is disrupted by chronic parental cyclophosphamide exposure
    • Barton, T. S., Robaire, B. and Hales, F. H. (2005) Epigenetic programming in the preimplantation rat embryo is disrupted by chronic parental cyclophosphamide exposure. Proc. Natl Acad. Sci. USA, 102, 7865-7870.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 7865-7870
    • Barton, T.S.1    Robaire, B.2    Hales, F.H.3
  • 133
    • 0034989609 scopus 로고    scopus 로고
    • Understanding the genotoxicity of tamoxifen?
    • Phillips, D. H. (2001) Understanding the genotoxicity of tamoxifen? Carcinogenesis, 22, 839-849.
    • (2001) Carcinogenesis , vol.22 , pp. 839-849
    • Phillips, D.H.1
  • 134
    • 33747888143 scopus 로고    scopus 로고
    • Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: Implications for tamoxifen-induced hepatocarcinogenesis
    • DOI 10.1093/carcin/bgl050, Special Issue on Chronic Pain
    • Tryndyak, V. P., Muskhelishvili, L., Kovalchuk, O., Rodriguez-Juarez, R., Montgomery, B., Churchwell, M. I., Ross, S. A., Beland, F. A. and Pogribny, I. P. (2006) Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis, 27, 1713-1720. (Pubitemid 44288061)
    • (2006) Carcinogenesis , vol.27 , Issue.8 , pp. 1713-1720
    • Tryndyak, V.P.1    Muskhelishvili, L.2    Kovalchuk, O.3    Rodriguez-Juarez, R.4    Montgomery, B.5    Churchwell, M.I.6    Ross, S.A.7    Beland, F.A.8    Pogribny, I.P.9
  • 136
    • 38649121719 scopus 로고    scopus 로고
    • Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    • Yauk, C., Polyzos, A., Rowan-Caroll, A. et al. (2008) Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc. Natl Acad. Sci. USA, 105, 605-610.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 605-610
    • Yauk, C.1    Polyzos, A.2    Rowan-Caroll, A.3
  • 137
    • 0347379799 scopus 로고    scopus 로고
    • Epigenetic theories of cancer initiation
    • Jaffe, L. A. (2003) Epigenetic theories of cancer initiation. Adv. Cancer Res., 30, 209-230.
    • (2003) Adv. Cancer Res. , vol.30 , pp. 209-230
    • Jaffe, L.A.1


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