-
2
-
-
31344450167
-
Methylation inhibitor therapy in the treatment of myelodysplastic syndrome
-
Silverman, L. R. & Mufti, G. J. Methylation inhibitor therapy in the treatment of myelodysplastic syndrome. Nature Clin. Pract. Oncol. 2, S12-S23 (2005).
-
(2005)
Nature Clin. Pract. Oncol.
, vol.2
-
-
Silverman, L.R.1
Mufti, G.J.2
-
3
-
-
18244384738
-
Azacitidine
-
Issa, J.-P. J., Kantarjian, H. M. & Kirkpatrick, P. Azacitidine. Nature Rev. Drug Discov. 4, 275-276 (2005).
-
(2005)
Nature Rev. Drug Discov.
, vol.4
, pp. 275-276
-
-
Issa, J.-P.J.1
Kantarjian, H.M.2
Kirkpatrick, P.3
-
5
-
-
0018860957
-
Cellular differentiation, cytidine analogues and DNA methylation
-
Jones, P. A. & Taylor, S. M. Cellular differentiation, cytidine analogues and DNA methylation. Cell 20, 85-93 (1980).
-
(1980)
Cell
, vol.20
, pp. 85-93
-
-
Jones, P.A.1
Taylor, S.M.2
-
6
-
-
0004959517
-
Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta globin gene complex
-
Charache, S. et al. Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta globin gene complex. Proc. Natl Acad. Sci. USA 80, 4842-4846 (1983).
-
(1983)
Proc. Natl Acad. Sci. USA
, vol.80
, pp. 4842-4846
-
-
Charache, S.1
-
7
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment
-
Daskalakis, M. et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment. Blood 100, 2957-2964 (2002).
-
(2002)
Blood
, vol.100
, pp. 2957-2964
-
-
Daskalakis, M.1
-
8
-
-
33750534233
-
-
FDA labelling information [online]
-
FDA labelling information [online], (2006).
-
(2006)
-
-
-
9
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a Phase III randomized study
-
Kantarjian, H. et al. Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a Phase III randomized study. Cancer 106, 1794-1803 (2006).
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
-
10
-
-
17444452612
-
Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
-
Wijermans, P. et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients. J. Clin. Oncol. 18, 956-962 (2000).
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 956-962
-
-
Wijermans, P.1
-
11
-
-
13444256401
-
Efficacy of lenalidomide in myelodysplastic syndromes
-
List, A. et al. Efficacy of lenalidomide in myelodysplastic syndromes. N. Engl. J. Med. 352, 549-557 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 549-557
-
-
List, A.1
-
12
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
-
Silverman, L. R. et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B. J. Clin. Oncol. 20, 2429-2440 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2429-2440
-
-
Silverman, L.R.1
-
13
-
-
0037092962
-
Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: A Cancer and Leukemia Group B study
-
Kornblith, A. B. et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: A Cancer and Leukemia Group B study. J. Clin. Oncol. 20, 2441-2452 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2441-2452
-
-
Kornblith, A.B.1
-
14
-
-
33745714230
-
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
-
Gore, S. D. et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res. 66, 6361-6369 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 6361-6369
-
-
Gore, S.D.1
-
15
-
-
45749096371
-
Results of a randomized study of three schedules of low-dose decitabine in higher risk myelodysplastic syndrome and chronic myelomonocytic leukemia
-
1 Aug (doi: blood-2006-05-021162v1)
-
Kantarjian, H. et al. Results of a randomized study of three schedules of low-dose decitabine in higher risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 1 Aug 2006 (doi: blood-2006-05-021162v1).
-
(2006)
Blood
-
-
Kantarjian, H.1
-
16
-
-
85117737422
-
Phase I/II study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
-
1 Aug (doi: blood-2006-03-009142v1)
-
Garcia-Manero, G. et al. Phase I/II study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia. Blood 1 Aug 2006 (doi: Blood-2006-03-009142v1).
-
(2006)
Blood
-
-
Garcia-Manero, G.1
-
17
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
Cameron, E. E. et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Genet. 21, 103-107 (1999).
-
(1999)
Nature Genet.
, vol.21
, pp. 103-107
-
-
Cameron, E.E.1
-
18
-
-
33750509694
-
-
(Aplastic Anemia & MDS International Foundation, Annapolis, Maryland)
-
Myelodysplastic Syndromes: Basic Explanations 1-19 (Aplastic Anemia & MDS International Foundation, Annapolis, Maryland, 2005).
-
(2005)
Myelodysplastic Syndromes: Basic Explanations
, pp. 1-19
-
-
-
19
-
-
33750499152
-
-
IMS Health, IMS MIDAS MAT (June)
-
IMS Health, IMS MIDAS MAT (June 2006).
-
(2006)
-
-
|