Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Wu, Dongmei ^a   Qiu, Yifu ^a   Gao, Xiang ^b   Yuan, Xiao Bing ^a   Zhai, Qiwei ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR SUBSTRATE 2; LIOTHYRONINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; THYROXINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; GLUCOSE; INSULIN RECEPTOR SUBSTRATE; IRS2 PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE; SIRTUIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DEACETYLATION; ENERGY EXPENDITURE; FEMALE; FOREBRAIN; GENE; GENE OVEREXPRESSION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HIPPOCAMPUS; HYPOTHALAMUS; LIOTHYRONINE BLOOD LEVEL; LIPID METABOLISM; LIPID STORAGE; MALE; MOTOR DYSFUNCTION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PHYSICAL ACTIVITY; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIRT1 GENE; THYROXINE BLOOD LEVEL; UPREGULATION; WHITE ADIPOSE TISSUE; ANIMAL; BLOOD; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; FEMALE; GLUCOSE; HIPPOCAMPUS; INSULIN RECEPTOR SUBSTRATE PROTEINS; LIPID METABOLISM; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; PROSENCEPHALON; SIRTUIN 1; THYROXINE; TRIIODOTHYRONINE;

EID: 79959726080     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021759     Document Type: Article

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