Transition-state analysis of Trypanosoma cruzi uridine phosphorylase- catalyzed arsenolysis of uridine

Journal of the American Chemical Society

Volumn 133, Issue 25, 2011, Pages 9923-9931

  Silva, Rafael G ^a   Vetticatt, Mathew J ^a   Merino, Emilio F ^a,b   Cassera, Maria B ^a,b   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOND ORDERS; CODING SEQUENCES; COMPETITIVE KINETICS; DEOXYURIDINE; DISTRIBUTION PATTERNS; LEAVING GROUPS; NATURAL BOND ORBITAL ANALYSIS; NUCLEOSIDE PHOSPHORYLASE; PHOSPHOROLYSIS; SALVAGE PATHWAY; TRANSITION STATE STRUCTURE; TRANSITION-STATE; TRYPANOSOMA CRUZI;

BIOMOLECULES; CATALYSIS; CHEMICAL BONDS; DENSITY FUNCTIONAL THEORY; ESCHERICHIA COLI; ISOTOPES; NUCLEOPHILES; PHOSPHORYLATION;

ENZYME ACTIVITY;

ARSENIC ACID; HOMODIMER; NUCLEOPHILE; NUCLEOSIDE ANALOG; NUCLEOSIDE PHOSPHORYLASE; THYMIDINE; THYMIDINE DERIVATIVE; URIDINE; URIDINE PHOSPHORYLASE;

ARSENOLYSIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE OVEREXPRESSION; GENE SEQUENCE; GENOME; GEOMETRY; KINETIC ISOTOPE EFFECT; NONHUMAN; PHASE TRANSITION; TRYPANOSOMA CRUZI;

ARSENATES; BIOCATALYSIS; CLONING, MOLECULAR; KINETICS; MODELS, MOLECULAR; STATIC ELECTRICITY; TRYPANOSOMA CRUZI; URIDINE; URIDINE PHOSPHORYLASE;

EID: 79959503185     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2031294     Document Type: Article

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