The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy

Archives of Biochemistry and Biophysics

Volumn 497, Issue 1-2, 2010, Pages 35-42

  Renck, Daiana ^a   Ducati, Rodrigo G ^a   Palma, Mario S ^b   Santos, Diógenes S ^a   Basso, Luiz A ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Cancer chemotherapy; Fluorescence spectroscopy; Initial velocity; PH rate profiles; Product inhibition; Uridine phosphorylase kinetic mechanism

Indexed keywords

GLYCOSYLTRANSFERASE; PHOSPHATE; RECOMBINANT ENZYME; RIBOSE 1 PHOSPHATE; UNCLASSIFIED DRUG; URACIL; URIDINE; URIDINE PHOSPHORYLASE 1;

AMINO ACID SEQUENCE; ARTICLE; BINDING KINETICS; CATALYSIS; CONTROLLED STUDY; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ESCHERICHIA COLI; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; STEADY STATE;

CATALYSIS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; KINETICS; NEOPLASMS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; RIBOSEMONOPHOSPHATES; SUBSTRATE SPECIFICITY; URIDINE PHOSPHORYLASE;

EID: 77952554598     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2010.03.004     Document Type: Article

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