Second-sphere amino acids contribute to transition-state structure in bovine purine nucleoside phosphorylase

Biochemistry

Volumn 47, Issue 8, 2008, Pages 2577-2583

  Li, Lei ^a   Luo, Minkui ^a   Ghanem, Mahmoud ^a   Taylor, Erika A ^a,b   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b WESLEYAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CRYSTALLOGRAPHY; ENZYME ACTIVITY; ISOTOPES; REACTION KINETICS;

BOVINES; COMPUTATIONAL CHEMISTRY; TRANSITION STATES;

AMINO ACIDS;

ARGININE; ASPARAGINE; GLYCINE; ISOTOPE; LYSINE; PURINE NUCLEOSIDE PHOSPHORYLASE; THREONINE; VALINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; COW; CRYSTAL STRUCTURE; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CATALYTIC DOMAIN; CATTLE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PURINE-NUCLEOSIDE PHOSPHORYLASE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSITION TEMPERATURE;

BOVINAE;

EID: 39749099953     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7021365     Document Type: Article

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