The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase

Journal of Molecular Biology

Volumn 396, Issue 5, 2010, Pages 1244-1259

  Larson, Eric T ^a   Mudeppa, Devaraja G ^a   Gillespie, J Robert ^a   Mueller, Natascha ^a   Napuli, Alberto J ^a   Arif, Jennifer A ^a   Ross, Jenni ^a   Arakaki, Tracy L ^a   Lauricella, Angela ^b   DeTitta, George ^b   Luft, Joseph ^b   Zucker, Frank ^a   Verlinde, Christophe L M J ^a   Fan, Erkang ^a   Van Voorhis, Wesley C ^a   Buckner, Frederick S ^a   Rathod, Pradipsinh K ^a   Hol, Wim G J ^a   Merritt, Ethan A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Gene annotation; Nucleoside phosphorylase; Nucleotide metabolism; Pyrimidine salvage; Sleeping sickness

Indexed keywords

DIMER; MICROBIAL ENZYME; PURINE NUCLEOSIDE PHOSPHORYLASE; URIDINE PHOSPHORYLASE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; TRYPANOSOMA BRUCEI;

PROTOZOA; TRYPANOSOMA BRUCEI;

EID: 77649274213     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.01.013     Document Type: Article

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