메뉴 건너뛰기




Volumn 119, Issue 50, 1997, Pages 12069-12078

Transition state structure of the solvolytic hydrolysis of NAD+

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE;

EID: 0031576672     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja971316i     Document Type: Article
Times cited : (50)

References (103)
  • 19
    • 2642646043 scopus 로고    scopus 로고
    • note
    • X-Y, bond length between atoms X and Y; TS, transition state.
  • 61
    • 0041598305 scopus 로고
    • Quantum Chemistry Program Exchange, Department of Chemistry, University of Indiana: Bloomington, IN
    • Sims, L. B.; Burton, G. W.; Lewis, D. E. BEBOVIB-IV, QCPE No. 337; Quantum Chemistry Program Exchange, Department of Chemistry, University of Indiana: Bloomington, IN, 1977.
    • (1977) BEBOVIB-IV, QCPE No. 337
    • Sims, L.B.1    Burton, G.W.2    Lewis, D.E.3
  • 67
    • 2642713980 scopus 로고    scopus 로고
    • note
    • The angle between the C1′-H1′ bond and the normal to the plane defined by the atoms O4′, C1′, and C2′.
  • 72
    • 2642616057 scopus 로고    scopus 로고
    • note
    • + molecules per structure).
  • 73
    • 2642641961 scopus 로고    scopus 로고
    • note
    • + molecules), 2OHX, and ILDM.
  • 76
    • 0342781028 scopus 로고
    • Everse, J., Anderson, B., You, K.-S., Eds.; Academic Press: New York
    • Oppenheimer, N. J. In The pyridine nucleotide coenzymes; Everse, J., Anderson, B., You, K.-S., Eds.; Academic Press: New York, 1982; pp 51-89.
    • (1982) The Pyridine Nucleotide Coenzymes , pp. 51-89
    • Oppenheimer, N.J.1
  • 77
    • 0002574656 scopus 로고
    • Dolphin, D., Poulson, R., Avramovic, O., Eds.; Wiley-Interscience: New York
    • Oppenheimer, N. J. In Pyridine nucleotide coenzymes; Dolphin, D., Poulson, R., Avramovic, O., Eds.; Wiley-Interscience: New York, 1987; pp 185-230.
    • (1987) Pyridine Nucleotide Coenzymes , pp. 185-230
    • Oppenheimer, N.J.1
  • 84
    • 2642645251 scopus 로고    scopus 로고
    • note
    • 1.44.
  • 85
    • 2642617643 scopus 로고    scopus 로고
    • note
    • 298 K)].
  • 92
    • 2642679088 scopus 로고    scopus 로고
    • note
    • This is not chemically reasonable since it would require (unreasonably) that the leaving group be present, but not in the reaction coordinate. If the leaving group has diffused away, then the irreversible step has occurred and the correct reaction coordinate motion is unimolecular dissociation (above). For this reason, this mechanism will not be considered further.
  • 93
    • 2642672645 scopus 로고    scopus 로고
    • note
    • 15N EIE = 1.027 predicted here.
  • 94
  • 96
    • 2642672644 scopus 로고    scopus 로고
    • note
    • Although it could risk becoming circular logic to judge possible transition state models on the basis of the measured KIEs when one of the stated purposes of the study is to test the methods of modeling transition structures from KIEs, the magnitudes of the effects invoked here and in the next paragraph are large enough that the details of the model will not affect these arguments.
  • 98
    • 0039226889 scopus 로고
    • Cook, P. F., Ed.; CRC Press Inc.: Boca Raton, FL
    • Schramm, V. L. In Enzyme mechanism from isotope effects; Cook, P. F., Ed.; CRC Press Inc.: Boca Raton, FL, 1991; pp 367-388.
    • (1991) Enzyme Mechanism from Isotope Effects , pp. 367-388
    • Schramm, V.L.1
  • 103
    • 2642708214 scopus 로고    scopus 로고
    • note
    • If the water nucleophile is removed from the reaction coordinate, it becomes a solvating water.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.