Pyrophosphate interactions at the transition states of plasmodium falciparum and human orotate phosphoribosyltransferases

Journal of the American Chemical Society

Volumn 132, Issue 25, 2010, Pages 8787-8794

  Zhang, Yong ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; ISOTOPES; NUCLEOPHILES; QUANTUM THEORY;

ANOMERIC CARBON; BOND DISTANCE; CATALYTIC SITES; DIFFERENT SUBSTRATES; DIHEDRAL ANGLES; GEOMETRIC CONSTRAINT; INTRINSIC KINETICS; MONOPHOSPHATES; PHOSPHORIBOSYLTRANSFERASE; PLASMODIUM FALCIPARUM; QUANTUM CHEMICAL; REACTION COORDINATES; SLOW SUBSTRATE; TRANSITION STATE; TRANSITION STATE STRUCTURE;

SUBSTRATES;

NUCLEOPHILE; OROTATE PHOSPHORIBOSYLTRANSFERASE; OROTIC ACID; OROTIDINE; PHOSPHONOACETIC ACID; PYROPHOSPHATE; ENZYME INHIBITOR; PROTEIN BINDING; PYROPHOSPHORIC ACID DERIVATIVE; URIDINE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GEOMETRY; HUMAN; KINETIC ISOTOPE EFFECTS; NONHUMAN; PLASMODIUM FALCIPARUM; QUANTUM CHEMISTRY; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BIOCATALYSIS; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; KINETICS; METABOLISM; PROTEIN CONFORMATION; QUANTUM THEORY; STATIC ELECTRICITY;

BIOCATALYSIS; DIPHOSPHATES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; OROTATE PHOSPHORIBOSYLTRANSFERASE; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; QUANTUM THEORY; STATIC ELECTRICITY; URIDINE;

EID: 77953892029     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja102849w     Document Type: Article

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