Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats

Journal of Bone and Mineral Research

Volumn 26, Issue 7, 2011, Pages 1506-1516

  Iwaniec, Urszula T ^a   Boghossian, Stéphane ^b   Trevisiol, Cynthia H ^c   Wronski, Thomas J ^d   Turner, Russell T ^a   Kalra, Satya P ^b  

^a OREGON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c Oregon State University   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

CT; Histomorphometry; Obesity; Osteoblasts; Osteoclasts; Osteoporosis

Indexed keywords

GREEN FLUORESCENT PROTEIN; LEPTIN; PARVOVIRUS VECTOR; RECOMBINANT ADENO ASSOCIATED VIRUS VECTOR LEPTIN; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; BONE METABOLISM; BRAIN THIRD VENTRICLE; CANCELLOUS BONE; CONTROLLED STUDY; FEMALE; FEMUR; GENE THERAPY; HYPOTHALAMUS; LUMBAR VERTEBRA; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; NONHUMAN; OBESITY; OSTEOBLAST; PHENOTYPE; RAT; TIBIA; TREATMENT DURATION; WEIGHT GAIN;

ANIMALS; BONE AND BONES; BONE DEVELOPMENT; DEPENDOVIRUS; FEMALE; GENE THERAPY; GENETIC VECTORS; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINATION, GENETIC; TIME FACTORS; WEIGHT GAIN;

EID: 79959501415     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.365     Document Type: Article

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