Dose-related steady states of fat loss in long-term leptin-treated ob/ob mice: Leptin resistance or desensitization versus counterregulatory signaling

Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology

Volumn 175, Issue 7, 2005, Pages 487-497

  Eiden, Sandra ^a   Simon, Eckhart ^a   Schmidt, Ingrid ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Anorexigenic; Energy balance; Energy expenditure; Orexigenic

Indexed keywords

INSULIN; LEPTIN;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BLOOD; BODY COMPOSITION; DOSE RESPONSE; DRUG EFFECT; DRUG RESISTANCE; EATING; ENERGY METABOLISM; FEEDBACK SYSTEM; MALE; MOUSE; MOUSE MUTANT; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; BODY COMPOSITION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; EATING; ENERGY METABOLISM; FEEDBACK; INSULIN; LEPTIN; MALE; MICE; MICE, OBESE; OBESITY; SIGNAL TRANSDUCTION; WEIGHT LOSS;

EID: 27544513168     PISSN: 01741578     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00360-005-0009-z     Document Type: Article

References (51)

1. Ahima RS, Flier JS (2000) Leptin. Annu Rev Physiol 62:413-437
2. Ahima RS, Osei SY (2001) Molecular regulation of eating behavior: new insights and prospects for therapeutic strategies. Trends Mol Med 7:205-213
3. Berthoud HR (2002) Multiple neural systems controlling food intake and body weight. Neurosci Biobehav Rev 26:393-428
4. Cohen P, Yang G, Yu X, Soukas AA, Wolfish CS, Friedman JM, Li C (2005). Induction of leptin receptor expression in the liver by leptin and food deprivation. J Biol Chem 280:10034-10039
5. Coleman DL (1973) Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9:294-298
6. Döring H, Schwarzer K, Nuesslein-Hildesheim B, Schmidt I (1998) Leptin selectively increases energy expenditure of food-restricted lean mice. Int J Obes Relat Metab Disord 22:82-88
7. Eiden S, Preibisch G, Schmidt I (2001) Leptin responsiveness of juvenile rats: proof of leptin function within the physiological range. J Physiol 530:131-139
8. Eiden S, Doering H, Schmidt I (2002) Developmental and food-access-dependent changes in effector systems activated by leptin. Pflugers Arch 445:366-374
9. El-Hashimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS (2000) Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105:1827-1832
10. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395:763-770
11. Frühbeck G, Gómez-Ambrosi J (2001) Rationale for the existence of additional adipostatic hormones. FASEB J 15:1996-2006
12. Frühbeck G, Gómez-Ambrosi J, Muruzábal FJ, Burrell MA (2001) The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol 280:E827-847
13. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
14. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM (1997) Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 94:8878-8883
15. Harris RBS, Zhou J, Weigle DS, Kuijper JL (1997) Recombinant leptin exchanges between parabiosed mice but does not reach equilibrium. Am J Physiol 272:R1800-1808, 1997
16. Harris RBS, Zhou J, Redmann SM Jr, Smagin GN, Smith SR, Rodgers E, Zachwieja JJ (1998) A leptin dose-response study in obese (ob/ob) and lean ( + /?) mice. Endocrinology 139:8-19
17. Himms-Hagen J (1985) Food restriction increases torpor and improves brown adipose tissue thermogenesis in ob/ob mice. Am J Physiol 248:E531-539
18. Himms-Hagen J (1999) Physiological roles of the leptin endocrine system: differences between mice and humans. Crit Rev Clin Lab Sci 36:575-655
19. Hwa JJ, Fawzi AB, Graziano MP, Ghibaudi L, Williams P, Van Heek M, Davis H, Rudinski M, Sybertz E, Strader CD (1997) Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice. Am J Physiol 272:R1204-1209
20. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS (1999) Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20:68-100
21. Kennedy GC (1953) The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond 140:578-592
22. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72-76
23. Leibel RL (2002) The role of leptin in the control of body weight. Nutr Rev 60:S15-S19
24. Levin BE, Routh VH (1996) Role of the brain in energy balance and obesity. Am J Physiol 271:R491-500
25. Levin N, Nelson C, Gurney A, Vandlen R, De Sauvage F (1996) Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 93:1726-1730
26. Levin BE, Dunn-Meynell AA, Banks WA (2004) Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol 286:R143-150
27. Lin L, Martin R, Schaffhauser AO, York DA (2001) Acute changes in the response to peripheral leptin with alteration in the diet composition. Am J Physiol 280:R504-509
28. Martin RL, Perez E, He Y-J, Dawson Jr R, Millard WJ (2000) Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein downregulation. Metabolism Clin Exp 49:1479-1484
29. Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV (1999) Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology 140:4551-4557
30. Murphy JE, Zhou S, Giese K, Williams LT, Escobedo JA, Dwarki VJ (1997) Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin. Proc Natl Acad Sci USA 94:13921-13926
31. Novin D (1983) The integration of visceral information in the control of feeding. J Auton Nerv Syst 9:233-246
32. Ott V, Fasshauer M, Dalski A, Meier B, Perwitz N, Klein HH, Tschöp M, Klein J (2002) Direct peripheral effects of ghrelin include suppression of adiponectin expression. Horm Metab Res 34:640-645
33. Pelleymounter MA (1997) Leptin and the physiology of obesity. Curr Pharm Des 3:85-98
34. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
35. Pelleymounter MA, Cullen MJ, Healy D, Hecht R, Winters D, McCaleb M (1998) Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice. Am J Physiol 275:R950-959
36. Qiu J, Ogus S, Lu R, Chehab FF (2001) Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age. Endocrinology 142:348-358
37. Rafael J, Herling AW (2000) Leptin effect in ob/ob mice under thermoneutral conditions depends not necessarily on central satiation. Am J Physiol 278:R790-795
38. Riediger T, Schmid HA, Lutz TA, Simon E (2002) Amylin and glucose co-activate area postrema neurons of the rat. Neurosci Lett 328:121-124
39. Riediger T, Traebert M, Schmid HA, Scheel C, Lutz TA, Scharrer E (2003) Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus. Neurosci Lett 341:151-155
40. Sahu A (2002) Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones. J Neuroendocrinol 14:796-804
41. Scarpace PJ, Matheny M, Pollock BH, Tümer N (1997) Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol 273:E226-230
42. Scarpace PJ, Matheny M, Zhang Y, Shek EW, Prima V, Zolotukhin S, Tuemer N (2002a) Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology 143:3026-3035
43. Scarpace PJ, Matheny M, Zhang Y, Tuemer N, Frase CD, Shek EW, Hong B, Prima V, Zolotukhin S (2002b) Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacol 42:548-561
44. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (1999) Central nervous system control of food intake. Nature 404:661-671
45. Schwartz MW, Woods SC, Seeley RJ, Barsh GS, Baskin DG, Leibel RL (2003) Is the energy homeostasis system inherently biased toward weight gain? Diabetes 52:232-238
46. Stehling O, Döring H, Nuesslein-Hildesheim B, Olbort M, Schmidt I (1997) Leptin does not reduce body fat content but augments cold defense abilities in thermoneutrally reared rat pups. Pflugers Arch 434:694-697
47. Tang-Christensen M, Havel PJ, Jacobs RR, Larsen PJ, Cameron JL (1999) Central administration of leptin inhibits food intake and activates the sympathetic nervous system in Rhesus macaques. J Clin Endocrinol Metab 84:711-717
48. Vernon RG, Denis RGP, Sorensen A (2001) Signals of adiposity. Domest Anim Endocrinol 21:197-214
49. Webb GP, Jagot SA, Jakobson ME (1982) Fasting-induced torpor in mus musculus and its implications in the use of murine models for human obesity studies. Comp Biochem Physiol 72:211-219
50. Woods SC, Seeley RJ (2000) Adiposity signals and the control of energy homeostasis. Nutrition 16:894-902
51. Zhang Y, Procenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432