Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats

Osteoporosis International

Volumn 20, Issue 9, 2009, Pages 1529-1538

  Maddalozzo, G F ^a   Turner, R T ^a   Edwards, C H T ^b   Howe, K S ^a   Widrick, J J ^a   Rosen, C J ^c,d   Iwaniec, U T ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b Oregon State University   (United States)

^c Maine Medical Center Research Institute   (United States)

^d JACKSON LABORATORY   (United States)

Author keywords

Adipocyte; Bone formation; Osteoporosis; Sarcopenia; Skeletal muscle

Indexed keywords

ALCOHOL; LEPTIN; SOMATOMEDIN;

AGE DISTRIBUTION; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY WEIGHT; BONE DENSITY; BONE MARROW; BONE MASS; BONE MINERAL; BONE STRUCTURE; BONE TURNOVER; CALORIC INTAKE; CALORIC RESTRICTION; CANCELLOUS BONE; COMORBIDITY; CONTROLLED STUDY; DIET; FAST MUSCLE; LEAN BODY WEIGHT; LUMBAR VERTEBRA; MALE; MUSCLE MASS; NONHUMAN; OBESITY; OSSIFICATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SKELETON MALFORMATION; SLOW MUSCLE; TIBIA;

ADIPOSITY; ALCOHOL DRINKING; ANIMALS; BODY COMPOSITION; BONE DENSITY; CALORIC RESTRICTION; MALE; MUSCLES; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 68949200362     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-009-0836-y     Document Type: Article

References (48)

1. DA Chakkalakal 2005 Alcohol-induced bone loss and deficient bone repair Alcohol Clin Exp Res 29 12 2077 2090
2. RG Smart A Ogborne 2000 Drinking and heavy drinking by students in 18 countries Drug Alcohol Depend 60 3 315 318
3. SAMHSA (2003) Results from the 2002 National Survey on Drug Use and Health: national findings. Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD
4. A Zaborskis, et al 2006 Trends in drinking habits among adolescents in the Baltic countries over the period of transition: HBSC survey results, 1993-2002 BMC Public Health 6 67
5. Newes-Adeyi G et al (2005) Trends in underage drinking in the United States, 1991-2003. National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
6. Johnston LD, O'Malley PM, Bachman JG (2005) Monitoring the Future National Survey Results on Drug Use, 1975-2004, vol I: secondary school students. National Institute on Drug Abuse, Bethesda, MD
7. SE Foster, et al 2003 Alcohol consumption and expenditures for underage drinking and adult excessive drinking JAMA 289 8 989 995
8. RT Turner 2000 Skeletal response to alcohol Alcohol Clin Exp Res 24 11 1693 1701
9. RT Turner, et al 1988 Chronic alcohol treatment results in disturbed vitamin D metabolism and skeletal abnormalities in rats Alcohol Clin Exp Res 12 1 159 162
10. I Trounce, et al 1987 Chronic alcoholic proximal wasting: physiological, morphological and biochemical studies in skeletal muscle Aust N Z J Med 17 4 413 419
11. ME Reilly, et al 1998 Skeletal muscle ribonuclease activities in chronically ethanol-treated rats Alcohol Clin Exp Res 22 4 876 883
12. G Addolorato, et al 2000 Body composition changes induced by chronic ethanol abuse: evaluation by dual energy X-ray absorptiometry Am J Gastroenterol 95 9 2323 2327
13. DA Chakkalakal, et al 2002 Chronic ethanol consumption results in deficient bone repair in rats Alcohol Alcohol 37 1 13 20
14. KM Delahunty, et al 2006 Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition Endocrinology 147 8 3915 3923
15. JS Thomsen, et al 2005 Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies J Microsc 218 Pt 2 171 179
16. Baron R et al (1983) Processing of undecalcified bone specimens for bone histomorphometry. In: Recker RR (ed) Bone histomorphometry: techniques and interpretation. CRC, Boca Raton, FL, pp 13-35
17. AM Parfitt, et al 1987 Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee J Bone Miner Res 2 6 595 610
18. L Feinman 1989 Absorption and utilization of nutrients in alcoholism Alcohol Health Res World 13 3 207 210
19. HW Gruchow, et al 1985 Alcohol consumption, nutrient intake and relative body weight among US adults Am J Clin Nutr 42 2 289 295
20. CS Lieber 2005 Metabolism of alcohol Clin Liver Dis 9 1 1 35
21. MW Hamrick, et al 2008 Caloric restriction decreases cortical bone mass but spares trabecular bone in the mouse skeleton: implications for the regulation of bone mass by body weight J Bone Miner Res 23 870 878
22. M Elia 2000 Hunger disease Clin Nutr 19 6 379 386
23. B Burguera, et al 2001 Leptin reduces ovariectomy-induced bone loss in rats Endocrinology 142 8 3546 3553
24. XH Luo, et al 2006 Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway J Bone Miner Res 21 10 1648 1656
25. E Pravdova M Fickova 2006 Alcohol intake modulates hormonal activity of adipose tissue Endocr Regul 40 3 91 104
26. AE Handschin, et al 2007 Leptin increases extracellular matrix mineralization of human osteoblasts from heterotopic ossification and normal bone Ann Plast Surg 59 3 329 333
27. J Caetano-Lopes H Canhao JE Fonseca 2007 Osteoblasts and bone formation Acta Reumatol Port 32 2 103 110
28. J Cornish, et al 2002 Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo J Endocrinol 175 2 405 415
29. T Akune, et al 2004 PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors J Clin Invest 113 6 846 855
30. VR Preedy, et al 2001 Alcoholic skeletal muscle myopathy: definitions, features, contribution of neuropathy, impact and diagnosis Eur J Neurol 8 6 677 687
31. A Urbano-Marquez, et al 1989 The effects of alcoholism on skeletal and cardiac muscle N Engl J Med 320 7 409 415
32. TJ Preedy VR Peters 1990 Changes in protein, RNA and DNA and rates of protein synthesis in muscle-containing tissues of the mature rat in response to ethanol feeding: a comparative study of heart, small intestine and gastrocnemius muscle Alcohol Alcohol 25 5 489 498
33. MD Delp C Duan 1996 Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle J Appl Physiol 80 1 261 270
34. HW Sampson, et al 1996 Alcohol consumption inhibits bone growth and development in young actively growing rats Alcohol Clin Exp Res 20 8 1375 1384
35. HA Hogan, et al 1997 Alcohol consumption by young actively growing rats: a study of cortical bone histomorphometry and mechanical properties Alcohol Clin Exp Res 21 5 809 816
36. NOF (2002) America's bone health: the state of osteoporosis and low bone mass in our nation. National Osteoporosis Foundation, Washington (DC). National Osteoporosis Foundation, Washington, DC
37. Y Jiang, et al 1997 Long-term changes in bone mineral and biomechanical properties of vertebrae and femur in aging, dietary calcium restricted, and/or estrogen-deprived/-replaced rats J Bone Miner Res 12 5 820 831
38. RF Klein KA Fausti AS Carlos 1996 Ethanol inhibits human osteoblastic cell proliferation Alcohol Clin Exp Res 20 3 572 578
39. K Rojdmark S Brismar 2001 Decreased IGF-I bioavailability after ethanol abuse in alcoholics: partial restitution after short-term abstinence J Endocrinol Invest 24 7 476 482
40. CH Lang, et al 2004 IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats Am J Physiol Endocrinol Metab 286 6 E916 E926
41. JD Sibonga, et al 2007 Effects of parathyroid hormone (1-34) on tibia in an adult rat model for chronic alcohol abuse Bone 40 4 1013 1020
42. P Mezquita-Raya, et al 2001 Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women J Bone Miner Res 16 8 1408 1415
43. RT Turner JD Sibonga 2001 Effects of alcohol use and estrogen on bone Alcohol Res Health 25 4 276 281
44. GC Isaia 2005 Is leptin the link between fat and bone mass? J Endocrinol Invest. 28 10 Suppl 61 65
45. PB Rapuri 2000 Alcohol intake and bone metabolism in elderly women Am J Clin Nutr 72 5 1206 1213
46. O Ganry C Baudoin P Fardellone 2000 Effect of alcohol intake on bone mineral density in elderly women: the EPIDOS Study Epidemiologie de l'Osteoporose. Am J Epidemiol 151 8 773 780
47. FM Williams, et al 2005 The effect of moderate alcohol consumption on bone mineral density: a study of female twins Ann Rheum Dis 64 2 309 310
48. RT Turner, et al 2001 Moderate alcohol consumption and increased bone mineral density: potential ethanol and non-ethanol mechanisms J Bone Miner Res 16 3 589 594