Role of the transient receptor potential vanilloid 1 in inflammation and sepsis

Journal of Inflammation Research

Volumn 4, Issue 1, 2011, Pages 67-81

  Devesa, Isabel ^a   Planells Cases, Rosa ^b   Fernández Ballester, Gregorio ^a   González Ros, José Manuel ^a   Ferrer Montiel, Antonio ^a   Fernández Carvajal, Asia ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

Analgesia; Capsaicin; Ion channel; Nociceptor; Pain; Transient receptor potential

Indexed keywords

CALCINEURIN 2B PHOSPHATASE; CALCITONIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CAPSAICIN; CHEMOKINE RECEPTOR CCR2; CYCLIC AMP DEPENDENT PROTEIN KINASE; INOSITOL 1,4,5 TRISPHOSPHATE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MEMBRANE PROTEIN; OLVANIL; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROSTACYCLIN; PROTEIN KINASE C; PROTEIN PIRT; PURINERGIC P2X3 RECEPTOR; RESINIFERATOXIN; SNARE PROTEIN; STEROID RECEPTOR COACTIVATOR 1; SUBSTANCE P; TRIPHOSPHOINOSITIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ACUTE ARTHRITIS; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; CANCER PAIN; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CHRONIC ARTHRITIS; COLITIS; CONTACT DERMATITIS; EVOKED RESPONSE; HEART PROTECTION; HUMAN; IMMUNOMODULATION; IMMUNOREACTIVITY; INFLAMMATION; LIVER PROTECTION; MOLECULAR WEIGHT; NOCICEPTIVE STIMULATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RENAL PROTECTION; REVIEW; SEPSIS; SIGNAL TRANSDUCTION; SKIN DISEASE; STIMULUS RESPONSE; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY;

EID: 79959488150     PISSN: None     EISSN: 11787031     Source Type: Journal    
DOI: 10.2147/JIR.S12978     Document Type: Review

References (187)

1. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature. 1997;389(6653):816-824.
2. Kedei N, Szabo T, Lile JD, et al. Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem. 2001;276(30):28613-28619.
3. Smith GD, Gunthorpe MJ, Kelsell RE, et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature. 2002;418(6894):186-190.
4. Liapi A, Wood JN. Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur J Neurosci. 2005; 22(4):825-834.
5. Rutter AR, Ma QP, Leveridge M, Bonnert TP. Heteromerization and colocalization of TrpV1 and TrpV2 in mammalian cell lines and rat dorsal root ganglia. Neuroreport. 2005;16(16):1735-1739.
6. Tominaga M, Tominaga T. Structure and function of TRPV1. Pflugers Arch. 2005;451(1):143-150.
7. Phelps CB, Procko E, Lishko PV, Wang RR, Gaudet R. Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin). 2007;1(3):148-151.
8. Phelps CB, Wang RR, Choo SS, Gaudet R. Differential regulation of RPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J Biol Chem. 2010;285(1): 731-740.
9. Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron. 2007;54(6):905-918.
10. Nagy I, Santha P, Jancso G, Urban L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur J Pharmacol. 2004;500(1-3):351-369.
11. Planells-Cases R, Valente P, Ferrer-Montiel A, Qin F, Szallasi A. Complex regulation of TRPV1 and related thermo-TRPs: Implications for therapeutic intervention. Adv Exp Med Biol. 2011;704:491-515.
12. Salazar H, Jara-Oseguera A, Hernandez-Garcia E, et al. Structural determinants of gating in the TRPV1 channel. Nat Struct Mol Biol. 2009;16(7):704-710.
13. Valente P, Garcia-Sanz N, Gomis A, et al. Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J. 2008;22(9):3298-3309.
14. Brauchi S, Orio P. Voltage sensing in thermo-TRP channels. Adv Exp Med Biol. 2011;704:517-530.
15. Garcia-Sanz N, Fernandez-Carvajal A, Morenilla-Palao C, et al. Identification of a tetramerization domain in the C terminus of the vanilloid receptor. J Neurosci. 2004;24(23):5307-5314.
16. Zhang F, Liu S, Yang F, Zheng J, Wang K. Identification of a tetrameric assembly domain in the C-terminus of heat-activated TRPV1 channels. J Biol Chem. 2011;286(17):15308-15316.
17. Kwak J, Wang MH, Hwang SW, Kim TY, Lee SY, Oh U. Intracellular ATP increases capsaicin-activated channel activity by interacting with nucleotide-binding domains. J Neurosci. 2000;20(22):8298-8304.
18. Voets T, Nilius B. Modulation of TRPs by PIPs. J Physiol. 2007; 582(Pt 3):939-944.
19. Cortright DN, Szallasi A. Biochemical pharmacology of the vanilloid receptor TRPV1. An update. Eur J Biochem. 2004;271(10): 1814-1819.
20. Latorre R, Vargas G, Orta G, Brauchi S. Voltage and temperature gating in thermoTRP channels. In: Liedtke W, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. London, UK: CRC Taylor and Francis; 2007.
21. Richardson JD, Vasko MR. Cellular mechanisms of neurogenic inflammation. J Pharmacol Exp Ther. 2002;302(3):839-845.
22. Ferrari LF, Bogen O, Levine JD. Nociceptor subpopulations involved in hyperalgesic priming. Neuroscience. 2010;165(3):896-901.
23. Chien LY, Cheng JK, Chu D, Cheng CF, Tsaur ML. Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity. J Neurosci. 2007;27(37):9855-9865.
24. Cavanaugh DJ, Chesler AT, Jackson AC, et al. TRPV1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci. 2011;31(13):5067-5077.
25. Mezey E, Toth ZE, Cortright DN, et al. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc Natl Acad Sci U S A. 2000;97(7):3655-3660.
26. Southall MD, Li T, Gharibova LS, Pei Y, Nicol GD, Travers JB. Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes. J Pharmacol Exp Ther. 2003;304(1):217-222.
27. Choi TY, Park SY, Jo JY, et al. Endogenous expression of TRPV1 channel in cultured human melanocytes. J Dermatol Sci. 2009;56(2):128-130.
28. Lazzeri M, Vannucchi MG, Zardo C, et al. Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder. Eur Urol. 2004;46(6):792-798.
29. Birder LA, Kanai AJ, de Groat WC, et al. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci U S A. 2001;98(23):13396-13401.
30. Heiner I, Eisfeld J, Halaszovich CR, et al. Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: Evidence for currents through long TRP channel 2 induced by ADPribose and NAD. Biochem J. 2003;371(Pt 3):1045-1053.
31. Stander S, Moormann C, Schumacher M, et al. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004;13(3): 129-139.
32. Chen CW, Lee ST, Wu WT, Fu WM, Ho FM, Lin WW. Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages. Br J Pharmacol. 2003;140(6):1077-1087.
33. Mohapatra DP, Wang SY, Wang GK, Nau C. A tyrosine residue in TM6 of the vanilloid receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents. Mol Cell Neurosci. 2003;23(2):314-324.
34. Ahern GP, Brooks IM, Miyares RL, Wang XB. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci. 2005;25(21):5109-5116.
35. Tominaga M, Caterina MJ, Malmberg AB, et al. Thecloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron. 1998; 21(3):531-543.
36. Garcia-Martinez C, Morenilla-Palao C, Planells-Cases R, Merino JM, Ferrer-Montiel A. Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties. J Biol Chem. 2000;275(42):32552-32558.
37. Nilius B, Talavera K, Owsianik G, Prenen J, Droogmans G, Voets T. Gating of TRP channels: A voltage connection? J Physiol. 2005;567 (Pt 1):35-44.
38. Cromer BA, McIntyre P. Painful toxins acting at TRPV1. Toxicon. 2008;51(2):163-173.
39. Alawi K, Keeble J. The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation. Pharmacol Ther. 2010;125(2): 181-195.
40. Liu B, Hui K, Qin F. Thermodynamics of heat activation of single capsaicin ion channels VR1. Biophys J. 2003;85(5):2988-3006.
41. Grandl J, Kim SE, Uzzell V, et al. Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci. 2010;13(6):708-714.
42. De Petrocellis L, Chu CJ, Moriello AS, Kellner JC, Walker JM, Di Marzo V. Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br J Pharmacol. 2004;143(2):251-256.
43. Rosenbaum T, Simon SA. TRPV1 receptors and signal transduction. In: Liedtke W, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. London, UK: CRC Taylor and Francis; 2007.
44. Movahed P, Jonsson BA, Birnir B, et al. Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. J Biol Chem. 2005;280(46):38496-38504.
45. Jung J, Hwang SW, Kwak J, et al. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J Neurosci. 1999;19(2): 529-538.
46. Jung J, Lee SY, Hwang SW, et al. Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J Biol Chem. 2002;277(46): 44448-44454.
47. Jordt SE, Julius D. Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell. 2002;108(3):421-430.
48. Gavva NR, Klionsky L, Qu Y, et al. Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem. 2004;279(19): 20283-20295.
49. Jordt SE, Tominaga M, Julius D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A. 2000;97(14):8134-8139.
50. 2+. Neuroscience. 2010;171(4):1109-1119.
51. Tousova K, Vyklicky L, Susankova K, Benedikt J, Vlachova V. Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites. Mol Cell Neurosci. 2005;30(2):207-217.
52. Ahern GP, Wang X, Miyares RL. Polyamines are potent ligands for the capsaicin receptor TRPV1. J Biol Chem. 2006;281(13):8991-8995.
53. Koplas PA, Rosenberg RL, Oxford GS. The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci. 1997;17(10):3525-3537.
54. Docherty RJ, Yeats JC, Bevan S, Boddeke HW. Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats. Pflugers Arch. 1996;431(6):828-837.
55. Moriyama T, Higashi T, Togashi K, et al. Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain. 2005;1:3.
56. Xue Q, Jong B, Chen T, Schumacher MA. Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. J Neurochem. 2007;101(1):212-222.
57. Bron R, Klesse LJ, Shah K, Parada LF, Winter J. Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol Cell Neurosci. 2003;22(1): 118-132.
58. Mohapatra DP, Nau C. Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J Biol Chem. 2003;278(50):50080-50090.
59. Rohacs T, Thyagarajan B, Lukacs V. Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol. 2008;37(2-3):153-163.
60. 2+/calmodulin modulates TRPV1 activation by capsaicin. J Gen Physiol. 2004;123 (1):53-62.
61. Bhave G, Gereau RW. Posttranslational mechanisms of peripheral sensitization. J Neurobiol. 2004;61(1):88-106.
62. Wirkner K, Hognestad H, Jahnel R, Hucho F, Illes P. Characterization of rat transient receptor potential vanilloid 1 receptors lacking the N-glycosylation site N604. Neuroreport. 2005;16(9):997-1001.
63. Jahnel R, Dreger M, Gillen C, Bender O, Kurreck J, Hucho F. Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line. Eur J Biochem. 2001;268(21):5489-5496.
64. Jin X, Morsy N, Winston J, Pasricha PJ, Garrett K, Akbarali HI. Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase. Am J Physiol Cell Physiol. 2004;287(2):C558-C563.
65. Planells-Cases R, Garcia-Sanz N, Morenilla-Palao C, Ferrer-Montiel A. Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia. Pflugers Arch. 2005;451(1):151-159.
66. Stanchev D, Blosa M, Milius D, et al. Cross-inhibition between native and recombinant TRPV1 and P2X(3) receptors. Pain. 2009;143(1-2): 26-36.
67. Lukacs V, Thyagarajan B, Varnai P, Balla A, Balla T, Rohacs T. Dual regulation of TRPV1 by phosphoinositides. J Neurosci. 2007;27(26): 7070-7080.
68. Kim AY, Tang Z, Liu Q, et al. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell. 2008;133(3): 475-485.
69. Zhang X, Li L, McNaughton PA. Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron. 2008;59(3):450-461.
70. Goswami C, Dreger M, Jahnel R, Bogen O, Gillen C, Hucho F. Identification and characterization of a Ca2+-sensitive interaction of the vanilloid receptor TRPV1 with tubulin. J Neurochem. 2004;91(5):1092-1103.
71. Morenilla-Palao C, Planells-Cases R, Garcia-Sanz N, Ferrer-Montiel A. Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J Biol Chem. 2004;279(24):25665-25672.
72. Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature. 1999;397(6714):69-72.
73. Lainez S, Valente P, Ontoria-Oviedo I, et al. GABAA receptor associated protein (GABARAP) modulates TRPV1 expression and channel function and desensitization. FASEB J. 2010;24(6):1958-1970.
74. Saunders CI, Fassett RG, Geraghty DP. Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death. Biochim Biophys Acta. 2009;1792(10):1019-1026.
75. Dray A. Inflammatory mediators of pain. Br J Anaesth. 1995;75(2): 125-131.
76. Schafers M, Sorkin L. Effect of cytokines on neuronal excitability. Neurosci Lett. 2008;437(3):188-193.
77. Abbadie C, Bhangoo S, De Koninck Y, Malcangio M, Melik-Parsadaniantz S, White FA. Chemokines and pain mechanisms. Brain Res Rev. 2009;60(1):125-134.
78. Schaible HG, von Banchet GS, Boettger MK, et al. The role of proinflammatory cytokines in the generation and maintenance of joint pain. Ann N Y Acad Sci. 2010;1193:60-69.
79. Ren K, Dubner R. Interactions between the immune and nervous systems in pain. Nat Med. 2010;16(11):1267-1276.
80. Gold MS, Gebhart GF. Nociceptor sensitization in pain pathogenesis. Nat Med. 2010;16(11):1248-1257.
81. D'Mello R, Dickenson AH. Spinal cord mechanisms of pain. Br J Anaesth. 2008;101(1):8-16.
82. Hill RG. Molecular basis for the perception of pain. Neuroscientist. 2001;7(4):282-292.
83. Engler A, Aeschlimann A, Simmen BR, et al. Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritis. Biochem Biophys Res Commun. 2007;359(4):884-888.
84. Cho WG, Valtschanoff JG. Vanilloid receptor TRPV1-positive sensory afferents in the mouse ankle and knee joints. Brain Res. 2008;1219:59-65.
85. Akbar A, Yiangou Y, Facer P, Walters JR, Anand P, Ghosh S. Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut. 2008;57(7):923-929.
86. Planells-Cases R, Ferrer-Montiel A. TRP channel trafficking. In: Liedtke W, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. London, UK: CRC Taylor and Francis; 2007.
87. Pabbidi RM, Cao DS, Parihar A, Pauza ME, Premkumar LS. Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons. Mol Pharmacol. 2008;73(3):995-1004.
88. Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ. P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron. 2002;36(1):57-68.
89. Zhang X, Huang J, McNaughton PA. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J. 2005;24(24):4211-4223.
90. Bonnington JK, McNaughton PA. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J Physiol. 2003;551(Pt 2):433-446.
91. Stein AT, Ufret-Vincenty CA, Hua L, Santana LF, Gordon SE. Phosphoinositide 3-kinase binds to TRPV1 and mediates NGFstimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol. 2006;128(5):509-522.
92. Van Buren JJ, Bhat S, Rotello R, Pauza ME, Premkumar LS. Sensitization and translocation of TRPV1 by insulin and IGF-I. Mol Pain. 2005;1:17.
93. Lilja J, Laulund F, Forsby A. Insulin and insulin-like growth factor type-I up-regulate the vanilloid receptor-1 (TRPV1) in stably TRPV1-expressing SH-SY5Y neuroblastoma cells. J Neurosci Res. 2007;85(7):1413-1419.
94. Camprubi-Robles M, Planells-Cases R, Ferrer-Montiel A. Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors. FASEB J. 2009;23(11):3722-3733.
95. Miller RJ, Jung H, Bhangoo SK, White FA. Cytokine and chemokine regulation of sensory neuron function. Handb Exp Pharmacol. 2009;194:417-449.
96. Hensellek S, Brell P, Schaible HG, Brauer R, Segond von BG. The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci. 2007;36(3):381-391.
97. Khan AA, Diogenes A, Jeske NA, Henry MA, Akopian A, Hargreaves KM. Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin. Neuroscience. 2008;155(2):503-509.
98. Hagenacker T, Czeschik JC, Schafers M, Busselberg D. Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor-necrosis-factor-alpha. Brain Res Bull. 2010;81(1):157-163.
99. Hu Y, Gu Q, Lin RL, Kryscio R, Lee LY. Calcium transient evoked by TRPV1 activators is enhanced by tumor necrosis factor-alpha in rat pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol. 2010;299(4):L483-L492.
100. Constantin CE, Mair N, Sailer CA, et al. Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. J Neurosci. 2008;28(19):5072-5081.
101. Russell FA, Fernandes ES, Courade JP, Keeble JE, Brain SD. Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase- 2 signalling. Pain. 2009;142(3):264-274.
102. Cheng JK, Ji RR. Intracellular signaling in primary sensory neurons and persistent pain. Neurochem Res. 2008;33(10):1970-1978.
103. Garrison SL, Stucky CL. The dynamic TRPA1 channel: A suitable pharmacological pain target? Curr Pharm Biotechnol. April 5, 2011. [Epub ahead of print].
104. Kobayashi K, Fukuoka T, Obata K, et al. Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J Comp Neurol. 2005;493(4):596-606.
105. Trevisani M, Siemens J, Materazzi S, et al. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007;104(33):13519-13524.
106. Obata K, Katsura H, Mizushima T, et al. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest. 2005;115(9):2393-2401.
107. Obreja O, Rathee PK, Lips KS, Distler C, Kress M. IL-1 beta potentiates heat-activated currents in rat sensory neurons: Involvement of IL-1RI, tyrosine kinase, and protein kinase C. FASEB J. 2002;16(12):1497-1503.
108. Obreja O, Biasio W, Andratsch M, et al. Fast modulation of heatactivated ionic current by proinflammatory interleukin 6 in rat sensory neurons. Brain. 2005;128(Pt 7):1634-1641.
109. Andratsch M, Mair N, Constantin CE, et al. A key role for gp130 expressed on peripheral sensory nerves in pathological pain. J Neurosci. 2009;29(43):13473-13483.
110. Cesare P, McNaughton P. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc Natl Acad Sci U S A. 1996;93(26):15435-15439.
111. Mizumura K, Koda H, Kumazawa T. Evidence that protein kinase C activation is involved in the excitatory and facilitatory effects of bradykinin on canine visceral nociceptors in vitro. Neurosci Lett. 1997;237(1):29-32.
112. Mizumura K, Sugiura T, Katanosaka K, Banik RK, Kozaki Y. Excitation and sensitization of nociceptors by bradykinin: What do we know? Exp Brain Res. 2009;196(1):53-65.
113. Tominaga M, Wada M, Masu M. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci U S A. 2001;98(12):6951-6956.
114. Kajihara Y, Murakami M, Imagawa T, Otsuguro K, Ito S, Ohta T. Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons. Neuroscience. 2010;166(1):292-304.
115. Schnizler K, Shutov LP, Van Kanegan MJ, et al. Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. J Neurosci. 2008;28(19):4904-4917.
116. Zhang N, Inan S, Cowan A, et al. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci U S A. 2005;102(12):4536-4541.
117. Jung H, Toth PT, White FA, Miller RJ. Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem. 2008;104(1):254-263.
118. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience. 1988;24(3):739-768.
119. Jancsó G. NeuroImmune biology. Neruogenic Inflammation in Health and Disease. Amsterdam, The Netherlands: Elsevier; 2009.
120. Geppetti P, Holzer P. Neurogenic Inflammation. Boca Raton, FL: CRC Press; 1996.
121. Maggi CA. Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog Neurobiol. 1995;45(1):1-98.
122. Maggi CA, Meli A. The sensory-efferent function of capsaicinsensitive sensory neurons. Gen Pharmacol. 1988;19(1):1-43.
123. Kichko TI, Reeh PW. TRPV1 controls acid- and heat-induced calcitonin gene-related peptide release and sensitization by bradykinin in the isolated mouse trachea. Eur J Neurosci. 2009;29(9):1896-1904.
124. Price TJ, Louria MD, Candelario-Soto D, et al. Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF or BDNF: Effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion. BMC Neurosci. 2005;6:4.
125. Than M, Nemeth J, Szilvassy Z, Pinter E, Helyes Z, Szolcsanyi J. Systemic anti-inflammatory effect of somatostatin released from capsaicin-sensitive vagal and sciatic sensory fibres of the rat and guinea-pig. Eur J Pharmacol. 2000;399(2-3):251-258.
126. Helyes Z, Szabo A, Nemeth J, et al. Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat. Arthritis Rheum. 2004;50(5):1677-1685.
127. Adcock JJ. TRPV1 receptors in sensitisation of cough and pain reflexes. Pulm Pharmacol Ther. 2009;22(2):65-70.
128. Fernandes ES, Russell FA, Spina D, et al. A distinct role for TRPA1, in addition to TRPV1, in TNFalpha-induced inflammatory hyperalgesia and CFA-induced mono-arthritis. Arthritis Rheum. 2011; 63(3):819-829.
129. Keeble J, Russell F, Curtis B, Starr A, Pinter E, Brain SD. Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation. Arthritis Rheum. 2005;52(10):3248-3256.
130. Ghilardi JR, Rohrich H, Lindsay TH, et al. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci. 2005;25(12):3126-3131.
131. Goblirsch MJ, Zwolak P, Clohisy DR. Advances in understanding bone cancer pain. J Cell Biochem. 2005;96(4):682-688.
132. Nagae M, Hiraga T, Yoneda T. Acidic microenvironment created by osteoclasts causes bone pain associated with tumor colonization. J Bone Miner Metab. 2007;25(2):99-104.
133. Mach DB, Rogers SD, Sabino MC, et al. Origins of skeletal pain:Sensory and sympathetic innervation of the mouse femur. Neuroscience. 2002;113(1):155-166.
134. Peters CM, Ghilardi JR, Keyser CP, et al. Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain. Exp Neurol. 2005;193(1):85-100.
135. Shinoda M, Ogino A, Ozaki N, et al. Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain. J Pain. 2008;9(8): 687-699.
136. Buddenkotte J, Steinhoff M. Pathophysiology and therapy of pruritus in allergic and atopic diseases. Allergy. 2010;65(7):805-821.
137. Shim WS, Oh U. Histamine-induced itch and its relationship with pain. Mol Pain. 2008;4:29.
138. Imamachi N, Park GH, Lee H, et al. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A. 2009;106(27): 11330-11335.
139. Denda M, Tsutsumi M. Roles of transient receptor potential proteins (TRPs) in epidermal keratinocytes. Adv Exp Med Biol. 2011; 704:847-860.
140. Shim WS, Tak MH, Lee MH, et al. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci. 2007;27(9):2331-2337.
141. Bolli R, Abdel-Latif A. No pain, no gain: The useful function of angina. Circulation. 2005;112(23):3541-3543.
142. Harada N, Okajima K, Yuksel M, Isobe H. Contribution of capsaicinsensitive sensory neurons to antithrombin-induced reduction of ischemia/reperfusion-induced liver injury in rats. Thromb Haemost. 2005;93(1):48-56.
143. Mizutani A, Okajima K, Murakami K, et al. Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats. Anesthesiology. 2009;110(2):361-369.
144. Banvolgyi A, Palinkas L, Berki T, et al. Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model. J Neuroimmunol. 2005;169(1-2):86-96.
145. Sibaev A, Massa F, Yuce B, et al. CB1 and TRPV1 receptors mediate protective effects on colonic electrophysiological properties in mice. J Mol Med. 2006;84(6):513-520.
146. Ward SM, Bayguinov J, Won KJ, Grundy D, Berthoud HR. Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J Comp Neurol. 2003;465(1):121-135.
147. Massa F, Sibaev A, Marsicano G, Blaudzun H, Storr M, Lutz B. Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis. J Mol Med. 2006;84(2):142-146.
148. Abraham E, Matthay MA, Dinarello C, et al. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation. Crit Care Med. 2000;28(1):232-235.
149. Vincent JL, Martinez EO, Silva E. Evolving concepts in sepsis definitions. Crit Care Clin. 2009;25(4):665-675, vii.
150. Ulloa L, Tracey KJ. The "cytokine profile": A code for sepsis. Trends Mol Med. 2005;11(2):56-63.
151. Sriskandan S, Altmann DM. The immunology of sepsis. J Pathol. 2008;214(2):211-223.
152. Ulloa L, Brunner M, Ramos L, Deitch EA. Scientific and clinical challenges in sepsis. Curr Pharm Des. 2009;15(16):1918-1935.
153. Thornberry NA. Caspases: Key mediators of apoptosis. Chem Biol. 1998;5(5):R97-R103.
154. Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol. 2006;6(11):813-822.
155. Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A. Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol. 2005;78(2):325-337.
156. Shimaoka M, Park EJ. Advances in understanding sepsis. Eur J Anaesthesiol Suppl. 2008;42:146-153.
157. Brogden KA, Guthmiller JM, Salzet M, Zasloff M. The nervous system and innate immunity: The neuropeptide connection. Nat Immunol. 2005;6(6):558-564.
158. Joyce CD, Fiscus RR, Wang X, Dries DJ, Morris RC, Prinz RA. Calcitonin gene-related peptide levels are elevated in patients with sepsis. Surgery. 1990;108(6):1097-1101.
159. Arnalich F, Sanchez JF, Martinez M, et al. Changes in plasma concentrations of vasoactive neuropeptides in patients with sepsis and septic shock. Life Sci. 1995;56(2):75-81.
160. Beer S, Weighardt H, Emmanuilidis K, et al. Systemic neuropeptide levels as predictive indicators for lethal outcome in patients with postoperative sepsis. Crit Care Med. 2002;30(8):1794-1798.
161. Foreman JC, Jordan CC, Oehme P, Renner H. Structure-activity relationships for some substance P-related peptides that cause wheal and flare reactions in human skin. J Physiol. 1983;335:449-465.
162. Brain SD, Newbold P, Kajekar R. Modulation of the release and activity of neuropeptides in the microcirculation. Can J Physiol Pharmacol. 1995;73(7):995-998.
163. Harzenetter MD, Novotny AR, Gais P, Molina CA, Altmayr F, Holzmann B. Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER. J Immunol. 2007;179(1):607-615.
164. Numao T, Agrawal DK. Neuropeptides modulate human eosinophil chemotaxis. J Immunol. 1992;149(10):3309-3315.
165. Levite M, Cahalon L, Hershkoviz R, Steinman L, Lider O. Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin. J Immunol. 1998;160(2):993-1000.
166. Fox FE, Kubin M, Cassin M, et al. Calcitonin gene-related peptide inhibits proliferation and antigen presentation by human peripheral blood mononuclear cells: Effects on B7, interleukin 10, and interleukin 12. J Invest Dermatol. 1997;108(1):43-48.
167. Crossman D, McEwan J, MacDermot J, MacIntyre I, Dollery CT. Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells. Br J Pharmacol. 1987;92(4):695-701.
168. Okajima K, Harada N. Regulation of inflammatory responses by sensory neurons: Molecular mechanism(s) and possible therapeutic applications. Curr Med Chem. 2006;13(19):2241-2251.
169. Gomes RN, Castro-Faria-Neto HC, Bozza PT, et al. Calcitonin generelated peptide inhibits local acute inflammation and protects mice against lethal endotoxemia. Shock. 2005;24(6):590-594.
170. Reinshagen M, Flamig G, Ernst S, et al. Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury. J Pharmacol Exp Ther. 1998;286(2):657-661.
171. Suto B, Bagoly T, Borzsei R, et al. Surgery and sepsis increase somatostatin-like immunoreactivity in the human plasma. Peptides. 2010;31(6):1208-1212.
172. Berg RM, Strauss GI, Tofteng F, et al. Circulating levels of vasoactive eptides in patients with acute bacterial meningitis. Intensive Care Med. 2009;35(9):1604-1608.
173. Bryant P, Shumate M, Yumet G, Lang CH, Vary TC, Cooney RN. Capsaicin-sensitive nerves regulate the metabolic response to abdominal sepsis. J Surg Res. 2003;112(2):152-161.
174. Demirbilek S, Ersoy MO, Demirbilek S, et al. Small-dose capsaicin reduces systemic inflammatory responses in septic rats. Anesth Analg. 2004;99(5):1501-1507.
175. Kim CS, Kawada T, Kim BS, et al. Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages. Cell Signal. 2003;15(3):299-306.
176. Wang Y, Novotny M, Quaiserova-Mocko V, Swain GM, Wang DH. TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. Am J Physiol Regul Integr Comp Physiol. 2008;294(5):R1517-R1523.
177. Ang SF, Moochhala SM, Bhatia M. Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Crit Care Med. 2010;38(2):619-628.
178. De Winter BY, Bredenoord AJ, Van NL, et al. Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: Role of CGRP and TRPV1 receptors. Eur J Pharmacol. 2009;615(1-3): 177-184.
179. Murai M, Tsuji F, Nose M, et al. SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo. Eur J Pharmacol. 2008;588(2-3):309-315.
180. Tsuji F, Murai M, Oki K, et al. Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation. J Pharmacol Sci. 2010;112(4):487-490.
181. Clark N, Keeble J, Fernandes ES, et al. The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin. FASEB J. 2007;21(13):3747-3755.
182. Guptill V, Cui X, Khaibullina A, et al. Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis. Anesthesiology. March 4, 2011. [Epub ahead of print].
183. Helyes Z, Pozsgai G, Borzsei R, et al. Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat. Peptides. 2007;28(9):1847-1855.
184. Orliac ML, Peroni RN, Abramoff T, Neuman I, Podesta EJ, Adler-Graschinsky E. Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats. Eur J Pharmacol. 2007;566(1-3):145-152.
185. Huttemeier PC, Ritter EF, Benveniste H. Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats. Am J Physiol. 1993;265(2 Pt 2):H767-H769.
186. Iida T, Shimizu I, Nealen ML, Campbell A, Caterina M. Attenuated fever response in mice lacking TRPV1. Neurosci Lett. 2005;378(1):28-33.
187. Dogan MD, Patel S, Rudaya AY, Steiner AA, Szekely M, Romanovsky AA. Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor. Br J Pharmacol. 2004;143(8):1023-1032.