Chemokines and pain mechanisms

Brain Research Reviews

Volumn 60, Issue 1, 2009, Pages 125-134

  Abbadie, Catherine ^a   Bhangoo, Sonia ^b   De Koninck, Yves ^c   Malcangio, Marzia ^d   Melik Parsadaniantz, Stéphane ^e   White, Fletcher A ^f  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE QUÉBEC   (Canada)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e HÔPITAL SAINT ANTOINE   (France)

^f LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Cathepsin S; CCR2; CX3CR1; Fractalkine; MCP 1; Neuropathy; Pain

Indexed keywords

CATHEPSIN S; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; MONOCYTE CHEMOTACTIC PROTEIN 1;

ASTROCYTE; CELL FUNCTION; CHRONIC PAIN; GLIA CELL; HUMAN; MICROGLIA; NOCICEPTION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL GANGLION; UPREGULATION;

ANIMALS; CATHEPSINS; CHEMOKINE CCL2; CHEMOKINES; GANGLIA, SPINAL; HUMANS; NOCICEPTORS; PAIN; POSTERIOR HORN CELLS; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 63649140837     PISSN: 01650173     EISSN: 18726321     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2008.12.002     Document Type: Review

References (53)

1. Abbadie C. Chemokines, chemokine receptors and pain. Trends Immunol. 26 (2005) 529-534
2. Abbadie C., Lindia J.A., Cumiskey A.M., Peterson L.B., Mudgett J.S., Bayne E.K., DeMartino J.A., MacIntyre D.E., and Forrest M.J. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7947-7952
3. Barclay J., Clark A.K., Ganju P., Gentry C., Patel S., Wotherspoon G., Buxton F., Song C., Ullah J., Winter J., Fox A., Bevan S., and Malcangio M. Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain 130 (2007) 225-234
4. Beggs S., and Salter M.W. Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury. Brain Behav. Immun. 21 (2007) 624-633
5. Bhangoo S., Ren D., Miller R.J., Henry K.J., Lineswala J., Hamdouchi C., Li B., Monahan P.E., Chan D.M., Ripsch M.S., and White F.A. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Mol. Pain 3 (2007) 38
6. Brodmerkel C.M., Huber R., Covington M., Diamond S., Hall L., Collins R., Leffet L., Gallagher K., Feldman P., Collier P., Stow M., Gu X., Baribaud F., Shin N., Thomas B., Burn T., Hollis G., Yeleswaram S., Solomon K., Friedman S., Wang A., Xue C.B., Newton R.C., Scherle P., and Vaddi K. Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. J. Immunol. 175 8 (2005) 5370-5378 (Oct 15)
7. Charo I.F., and Ransohoff R.M. The many roles of chemokines and chemokine receptors in inflammation. N. Engl. J. Med. 354 (2006) 610-621
8. Clark A.K., Gentry C., Bradbury E.J., McMahon S.B., and Malcangio M. Role of spinal microglia in rat models of peripheral nerve injury and inflammation. Eur. J. Pain 11 (2007) 223-230
9. Clark A.K., Yip P.K., Grist J., Gentry C., Staniland A.A., Marchand F., Dehvari M., Wotherspoon G., Winter J., Ullah J., Bevan S., and Malcangio M. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 10655-10660
10. Colburn R.W., Rickman A.J., and DeLeo J.A. The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp. Neurol. 157 (1999) 289-304
11. Coull J.A., Beggs S., Boudreau D., Boivin D., Tsuda M., Inoue K., Gravel C., Salter M.W., and De Koninck Y. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438 (2005) 1017-1021
12. Dansereau M.A., Gosselin R.D., Pohl M., Pommier B., Mechighel P., Mauborgne A., Rostene W., Kitabgi P., Beaudet N., Sarret P., and Melik-Parsadaniantz S. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. J. Neurochem. 106 2 (2008) 757-769
13. De Koninck Y. Altered chloride homeostasis in neurological disorders: a new target. Curr. Opin. Pharmacol. 7 (2007) 93-99
14. Echeverry S., Shi X.Q., and Zhang J. Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain 135 (2008) 37-47
15. Fu K.Y., Light A.R., Matsushima G.K., and Maixner W. Microglial reactions after subcutaneous formalin injection into the rat hind paw. Brain Res. 825 (1999) 59-67
16. Garton K.J., Gough P.J., Blobel C.P., Murphy G., Greaves D.R., Dempsey P.J., and Raines E.W. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J. Biol. Chem. 276 (2001) 37993-38001
17. Haynes S.E., Hollopeter G., Yang G., Kurpius D., Dailey M.E., Gan W.B., and Julius D. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat. Neurosci. 9 (2006) 1512-1519
18. Honda S., Sasaki Y., Ohsawa K., Imai Y., Nakamura Y., Inoue K., and Kohsaka S. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 21 (2001) 1975-1982
19. Huang D.R., Wang J., Kivisakk P., Rollins B.J., and Ransohoff R.M. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193 (2001) 713-726
20. Hughes D.I., Scott D.T., Riddell J.S., and Todd A.J. Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models. J. Neurosci. 27 (2007) 2035-2044
21. Jung H., Toth P.T., White F.A., and Miller R.J. Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J. Neurochem. 104 (2008) 254-263
22. Kelder W., McArthur J.C., Nance-Sproson T., McClernon D., and Griffin D.E. Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia. Ann. Neurol. 44 (1998) 831-835
23. Kobayashi K., Yamanaka H., Fukuoka T., Dai Y., Obata K., and Noguchi K. P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain. J. Neurosci. 28 (2008) 2892-2902
24. Lindia J.A., McGowan E., Jochnowitz N., and Abbadie C. Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain. J. Pain 6 (2005) 434-438
25. Malcangio M., Ramer M.S., Jones M.G., and McMahon S.B. Abnormal substance P release from the spinal cord following injury to primary sensory neurons. Eur. J. Neurosci. 12 (2000) 397-399
26. Marchand F., Perretti M., and McMahon S.B. Role of the immune system in chronic pain. Nat. Rev. Neurosci. 6 (2005) 521-532
27. Menetski J., Mistry S., Lu M., Mudgett J.S., Ransohoff R.M., Demartino J.A., Macintyre D.E., and Abbadie C. Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses. Neuroscience 149 (2007) 706-714
28. Mildner A., Schmidt H., Nitsche M., Merkler D., Hanisch U.K., Mack M., Heikenwalder M., Bruck W., Priller J., and Prinz M. Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat. Neurosci. 10 (2007) 1544-1553
29. Milligan E.D., Zapata V., Chacur M., Schoeniger D., Biedenkapp J., O, Connor K.A., Verge G.M., Chapman G., Green P., Foster A.C., Naeve G.S., Maier S.F., and Watkins L.R. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. Eur. J. Neurosci. 20 (2004) 2294-2302
30. Oh S.B., Tran P.B., Gillard S.E., Hurley R.W., Hammond D.L., and Miller R.J. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J. Neurosci. 21 (2001) 5027-5035
31. Raghavendra V., Tanga F., and DeLeo J.A. Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J. Pharmacol. Exp. Ther. 306 (2003) 624-630
32. Rancan M., Otto V.I., Hans V.H., Gerlach I., Jork R., Trentz O., Kossmann T., and Morganti-Kossmann M.C. Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats. J. Neurosci. Res. 63 (2001) 438-446
33. Rebenko-Moll N.M., Liu L., Cardona A., and Ransohoff R.M. Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details. Curr. Opin. Immunol. 18 (2006) 683-689
34. Salter M.W., De Koninck Y., and Henry J.L. Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn. Prog. Neurobiol. 41 (1993) 125-156
35. Scholz J., and Woolf C.J. The neuropathic pain triad: neurons, immune cells and glia. Nat. Neurosci. 10 (2007) 1361-1368
36. Scholz J., Abele A., Marian C., Haussler A., Herbert T.A., Woolf C.J., and Tegeder I. Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats. Pain 138 1 (2008) 130-142
37. Song L., and Pachter J.S. Monocyte chemoattractant protein-1 alters expression of tight junction-associated proteins in brain microvascular endothelial cells. Microvasc. Res. 67 (2004) 78-89
38. Soulet D., and Rivest S. Bone-marrow-derived microglia: myth or reality?. Curr. Opin. Pharmacol. 8 4 (2008) 508-518
39. Stamatovic S.M., Keep R.F., Kunkel S.L., and Andjelkovic A.V. Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J. Cell Sci. 116 (2003) 4615-4628
40. Sun J.H., Yang B., Donnelly D.F., Ma C., and Lamotte R.H. MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. J. Neurophysiol. 96 5 (2006) 2189-2199
41. Tanaka T., Minami M., Nakagawa T., and Satoh M. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain. Neurosci. Res. 48 (2004) 463-469
42. Thacker M.A., Clark A.K., Bishop T., Grist J., Yip P.K., Moon L.D., Thompson S.W., Marchand F., and McMahon S.B. CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur. J. Pain (2008) (Electronic publication ahead of print) (Jun 11)
43. Tozaki-Saitoh H., Tsuda M., Miyata H., Ueda K., Kohsaka S., and Inoue K. P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. J. Neurosci. 28 (2008) 4949-4956
44. Tsuda M., Shigemoto-Mogami Y., Koizumi S., Mizokoshi A., Kohsaka S., Salter M.W., and Inoue K. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424 (2003) 778-783
45. Tsuda M., Inoue K., and Salter M.W. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci. 28 (2005) 101-107
46. Verge G.M., Milligan E.D., Maier S.F., Watkins L.R., Naeve G.S., and Foster A.C. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur. J. Neurosci. 20 (2004) 1150-1160
47. Wallace V.C., Cottrell D.F., Brophy P.J., and Fleetwood-Walker S.M. Focal lysolecithin-induced demyelination of peripheral afferents results in neuropathic pain behavior that is attenuated by cannabinoids. J. Neurosci. 23 (2003) 3221-3233
48. Watkins L.R., and Maier S.F. Glia: a novel drug discovery target for clinical pain. Nat. Rev. Drug Discov. 2 (2003) 973-985
49. White F.A., Sun J., Waters S.M., Ma C., Ren D., Ripsch M., Steflik J., Cortright D.N., Lamotte R.H., and Miller R.J. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 14092-14097
50. Zhang J., and De Koninck Y. Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J. Neurochem. 97 (2006) 772-783
51. Zhang J., Shi X.Q., Echeverry S., Mogil J.S., De Koninck Y., and Rivest S. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J. Neurosci. 27 (2007) 12396-12406
52. Zhuang Z.Y., Gerner P., Woolf C.J., and Ji R.R. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114 (2005) 149-159
53. Zhuang Z.Y., Kawasaki Y., Tan P.H., Wen Y.R., Huang J., and Ji R.R. Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. Brain Behav. Immun. 21 (2007) 642-651