Small-dose capsaicin reduces systemic inflammatory responses in septic rats

Anesthesia and Analgesia

Volumn 99, Issue 5, 2004, Pages 1501-1507

  Demirbilek, Semra ^a,b   Ersoy, M Ozcan ^a   Demirbilek, Savas ^a   Karaman, Abdurrahman ^a   Gürbüz, Necla ^a   Bayraktar, Nihayet ^a   Bayraktar, Mehmet ^a  

^a INONU UNIVERSITY   (Turkey)

^b INONU UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; INTERLEUKIN 10; INTERLEUKIN 6; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HEART; LIVER; LOW DRUG DOSE; LUNG; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; ANTIOXIDANTS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CECUM; FEMALE; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-6; LIGATION; LYSOSOMES; MACROPHAGES; MALONDIALDEHYDE; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SUPEROXIDE DISMUTASE; TISSUE DISTRIBUTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 6444243612     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000132975.02854.65     Document Type: Article

References (24)

1. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29: 1303-10.
2. Bone RC. The pathogenesis of sepsis. Ann Intern Med 1991;115: 457-69.
3. Zeni F, Freeman B, Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med 1997;25:1095-100.
4. Arndt P, Abraham E. Immunological therapy of sepsis: experimental therapies. Intensive Care Med 2001;27:104-15.
5. Buck SH, Bulks TF. The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev 1986;38: 179-226.
6. Joe B, Lokesh BR. Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages. Lipids 1997;32:1173-80.
7. Hwang TL, Yang JT, Lau YT. Arginine-nitric oxide pathway in plasma membrane of rat hepatocytes during early and late sepsis. Crit Care Med 199927:137-41.
8. Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock: a review of laboratory models and a proposal. J Surg Res 1980; 29:189-201.
9. Esplugues JV, Whittle BJR. Morphine potentiation of ethanol-induced gastric mucosal damage in the rat: role of local sensory afferent neurons. Gastroenterology 1990;98:82-9.
10. 15N] nitrate in biological fluids. Anal Biochem 1982;126:131-8.
11. Bories PN, Bories C. Nitrate determination in biological fluids by an enzymatic one-step assay with nitrate reductase. Clin Chem 1995;41:904-7.
12. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of Superoxide dismutase. Clin Chem 1988;34:497-500.
13. Lowry DH, Rosenbrough NJ, Far AL, Randall RJ. Protein measurement with folin phenol reaction. J Biol Chem 1951;193: 265-71.
14. Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Biochem Biophys Acta 1977;20:271-8.
15. Macdonald J, Galley HF, Webster NR. Oxidative stress and gene expression in sepsis. Br J Anaesth 2003;90:221-32.
16. Joe B, Lokesh BR. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim Biophys Acta 1994;1224: 255-63.
17. Kogure K, Goto S, Nishimura M, et al. Mechanism of potent antiperoxidative effect of capsaicin. Biochim Biophys Acta 2002; 1573:84-92.
18. Kirkeboen KA, Strand OA. The role of nitric oxide in sepsis: san overview. Acta Anaesthesiol Scand 1999;43:275-88.
19. Feuerstein G, Willette R, Aiyar N. Clinical perspectives of calcitonin gene related peptide pharmacology. Can J Physiol Pharmacol 1995;73:1070-4.
20. Monneret G, Arpin M, Venet F, et al. Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils. Intensive Care Med 2003;29:923-8.
21. Szallasi A, Blumberg PM. Vanilloid receptors: new insights enhance potential as a therapeutic target. Pain 1996;68:195-208.
22. Liu C, Chen M, Wang X. Calcitonin gene-related peptide inhibits LPS-induced IL-12 release from mouse peritoneal macrophages, mediated by the cAMP pathway. Immunology 2000; 101:61-7.
23. Torii H, Hosoi J, Beissert S, et al. Regulation of cytokine expression in macrophages and the Langerhans cell-like line XS52 by calcitonin gene-related peptide. J Leukoc Biol 1997;61:216-23.
24. Feng Y, Tang Y, Guo J, Wang X. Inhibition of LPS-induced TNF-alpha production by calcitonin gene-related peptide in cultured mouse peritoneal macrophages. Life Sci 1997;61: PL281-7.