Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q

British Journal of Pharmacology

Volumn 163, Issue 5, 2011, Pages 1017-1033

  Yow, Tin T ^a   Pera, Elena ^a   Absalom, Nathan ^a   Heblinski, Marika ^b   Johnston, Graham Ar ^c   Hanrahan, Jane R ^a   Chebib, Mary ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c University of Sydney   (Australia)

Author keywords

flavonoid glycosides; flavonoids; G protein coupled inwardly rectifying potassium channels; G protein coupled receptor; naringin; tertiapin Q

Indexed keywords

ALANINE; AROMATIC AMINO ACID; AURANTIIN; CHLORIDE CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR3.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR3.2; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR3.4; POTASSIUM CHANNEL BLOCKING AGENT; TERTIAPIN Q; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; FEMALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP; XENOPUS;

ANIMALS; BEE VENOMS; BINDING SITES; BINDING, COMPETITIVE; CELLS, CULTURED; FLAVANONES; HUMANS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; RECOMBINANT PROTEINS; TRANSFECTION; XENOPUS LAEVIS;

EID: 79958796157     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01315.x     Document Type: Article

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