Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin A, a P-glycoprotein modulator

Journal of Agricultural and Food Chemistry

Volumn 50, Issue 23, 2002, Pages 6669-6674

  Tsai, Tung Hu ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Blood brain barrier; Cyclosporin A; Disposition; Hepatobiliary excretion; Microdialysis; Naringin; P glycoprotein; Pharmacokinetics

Indexed keywords

AURANTIIN; CYCLOSPORIN; CYCLOSPORIN A; FLAVONE DERIVATIVE; GLYCOPROTEIN P;

ACTIVE TRANSPORT; ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BILE; BILIARY EXCRETION; BLOOD BRAIN BARRIER; BODY FLUID; BRAIN LEVEL; CHEMISTRY; CHROMATOGRAPHY; CONTROLLED STUDY; DIALYSATE; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG INTERACTION; DRUG LIVER LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; LIVER; MALE; MICRODIALYSIS; NONHUMAN; RAT; RAT STRAIN; TISSUE DISTRIBUTION;

ANIMALS; BILE; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BRAIN CHEMISTRY; CHROMATOGRAPHY; CYCLOSPORINE; DRUG INTERACTIONS; FLAVANONES; FLAVONOIDS; KINETICS; LIVER; MALE; MICRODIALYSIS; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0037032180     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf020603p     Document Type: Article

References (30)

1. Ueng, Y. F.; Chang, Y. L.; Oda, Y.; Park, S. S.; Liao, J. F.; Lin, M. F.; Chen, C. F. In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver. Life Sci. 1999, 65, 2591-2602.
2. Ameer, B.; Weintraus, R. A. Drug interactions with grapefruit juice. Clin. Pharmacokinet. 1997, 31, 103-121.
3. Davies, M. I. A review of microdialysis sampling for pharmacokinetic applications. Anal. Chim. Acta 1999, 379, 227-249.
4. De Lange, E. C. M.; Danhof, M.; De Boer, A. G.; Breimer, D. D. Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the bloodbrain barrier. Brain Res. Rev. 1997, 25, 27-49.
5. Tossman, U.; Ungerstedt, U. Microdialysis in the study of extracellular levels of amino acids in the rat brain. Acta Physiol. Scand. 1986, 128, 9-14.
6. Zetterstrom, T.; Sharp, T.; Marsden, C. A.; Ungerstedt, U. In vivo measurement of dopamine and its metabolites by intracerebral dialysis: changes after d-amphetamine. J. Neurochem. 1983, 41, 1769-1773.
7. Stenken, J. A.; Lunte, C. E.; Southard, M. Z.; Stahle, L. Factors that influence microdialysis recovery. Comparison of experimental and theoretical microdialysis recoveries in rat liver. J. Pharm. Sci. 1997, 86, 958-966.
8. Johansen, M. J.; Newman, R. A.; Madden, T. The use of microdialysis in pharmacokinetics and pharmacodynamics. Pharmacotherapy 1997, 17, 464-481.
9. Scott, D. O.; Sorenson, L. R.; Steele, K. L.; Puckett, D. L.; Lunte, C. E. In vivo microdialysis sampling for pharmacokinetic investigations. Pharm. Res. 1991, 8, 389-392.
10. Stahle, L. In Techniques in the Behavioral and Neural Science; Robinson, T. E., Justice, J. B., Eds.; Elsevier: Amsterdam, 1991; Vol. 7, pp 155-174.
11. Fuhr, U.; Klittich, K.; Staib, A. H. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br. J. Clin. Pharmacol. 1993, 35, 431-436.
12. Scambia, G.; Ranelletti, F. O.; Panici, P. B.; De Vincenzo, R.; Bonanno, G.; Ferrandina, G.; Piantelli, M.; Bussa, S.; Rumi, C.; Cianfriglia, M. Quercetinpotentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother. Pharmacol. 1994, 34, 459-464.
13. Fuhr, U.; Kummert, A. L. The fate of naringin in humans: A key to grapefruit juice-drug interactions? Clin. Pharmacol. Ther. 1995, 58, 365-373.
14. Tsai, T. H.; Chen, Y. F.; Chen, I. F.; Chen, C. F. Measurement of unbound caffeic acid in rat blood by on-line microdialysis coupled with liquid chromatography and its application to pharmacokinetic studies. J. Chromatogr. B 1999, 729, 119-125.
15. Tsai, T. H.; Shum, A. Y. C.; Chen, C. F. Enterohepatic circulation of chloramphenicol and its glucuronide in the rat by microdialysis using a hepato-duodenal shunt. Life Sci. 2000, 66, 363-370.
16. Scott, D. O.; Lunte, C. E. In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol. Pharm. Res. 1993, 10, 335-342.
17. Tsai, T. H.; Huang, C. T.; Shum, A. Y. C.; Chen, C. F. Pharmacokinetic and biliary excretion study of esculetin by microdialysis in rat. Life Sci. 1996, 65, 1647-1655.
18. Tsai, T. H.; Hung, L. C.; Chen, C. F. Biliary excretion of chloramphenicol and chloramphenicol glucuronide in rat by microdialysis. J. Pharm. Pharmacol. 1999, 51, 911-915.
19. Tsai, T. H. Pharmacokinetics of pefloxacin and its interaction with cyclosporin A, a P-glycoprotein modulator, in rat blood, brain and bile, using simultaneous microdialysis. Br. J. Pharmacol. 2001, 132, 1310-1316.
20. Tsai, T. H.; Lee, C. H.; Yeh, P. H. Effect of cyclosporin A, a P-glycoprotein modulator, on the disposition and biliary excretion of camptothecin using microdialysis. Br. J. Pharmacol. 2001, 134, 1245-1252.
21. Paxinos, G.; Watson, C. The Rat Brain in Stereotaxic Coordinates; Academic Press: San Diego, CA, 1986.
22. Tsai, T. H.; Chen, C. F. Simultaneous measurement of acetylcholine and monoamines by two serial on-line microdialysis systems: Effects of methamphetamine on neurotransmitters release from the striatum of freely moving rats. Neurosci. Lett. 1994, 166, 175-177.
23. Gabrielsson, J.; Weiner, D. Non-compartmental analysis. In Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications; Swedish Pharm. Press: Stockholm, 1994; pp 621-626.
24. Abanmi, N.; Zaghloul, I.; El Sayed, N.; Al-Khamis, K. I. Determination of naringin and its main active metabolite in human serum by high-performance liquid chromatography. Ther. Drug Monitor. 1996, 31, 158-163.
25. Hammarlund-Udenaes, M. The use of microdialysis in CNS drug delivery studies: Pharmacokinetic perspectives and results with analgesics and antiepileptics. Adv. Drug Del. Rev. 2000, 45, 283-294.
26. Schinkel, A. H.; Wagenaar, E.; Mol, C. A. A. M.; Van Deemter, L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological and activity of many drugs. J. Clin. Invest. 1996, 97, 2517-2524.
27. Davies, M. I.; Lunte, C. E. Simultaneous microdialysis sampling from multiple sites in the liver for the study of phenol metabolism. Life Sci. 1996, 59, 1001-1013.
28. 2+/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene. Int. Immunol. 1994, 6, 179-188.
29. Fuhr, U.; Maier-Bruggemann, A.; Blume, H.; Muck, W.; Unger, S.; Kuhlmann, J.; Huschka, C.; Zaigler, M.; Rietbrock, S.; Staib, A. H. Grapefruit juice increases oral nimodipine bioavailability. Int. J. Clin. Pharmacol. Ther. 1998, 36, 126-132.
30. Zhang, H.; Wong, C. W.; Coville, P. F.; Wanwimolruk, S. Effect of the grapefruit flavonoid naringin on pharmacokinetics of quinine in rats. Drug Metab. Drug Interact. 2000, 17, 351-363.