Analysis of the antinociceptive effect of the flavonoid myricitrin: Evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 2, 2006, Pages 789-796

  Meotti, Flavia Carla ^a   Luiz, Ana Paula ^b   Pizzolatti, Moacir Geraldo ^b   Kassuya, Cândida A L ^b   Calixto, João B ^b   Santos, Adair R S ^b  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ANALGESIC AGENT; ARGININE; BRADYKININ; CAPSAICIN; FLAVONOID; GLUTAMIC ACID; MYRICETIN 3 RHAMNOSIDE; NALOXONE; NITRIC OXIDE; OPIATE ANTAGONIST; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HYPERALGESIA; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VISCERAL PAIN; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANALGESICS, NON-NARCOTIC; ANIMALS; ARGININE; BLOTTING, WESTERN; FEMALE; FLAVONOIDS; HYPERALGESIA; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MOTOR ACTIVITY; NITRIC OXIDE; PAIN; PAIN MEASUREMENT; PROTEIN KINASE C; RATS; RATS, WISTAR;

EID: 31144471480     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.092825     Document Type: Article

References (40)

1. Abacioglu N, Tunctan B, Cakici I, Akbulut E, Uludag O, and Kanzik I (2001) The role of L-arginine/nitric oxide pathway in the antinociceptive activity of pyridoxine in mouse. Arzneimittelforschung 51:832-838.
2. Agrawal PK (1989) Studies in Organic Chemistry 39: Carbon-13 NMR of Flavonoids, Elsevier Science Publishers, New York.
3. Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Rémésy C, Chap H, and Payrastre B (1997) Relationship between flavonoid structure and inhibition of phosphatidylinositol-3 kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 53:1649-1657.
4. Beirith A, Santos AR, and Calixto JB (2002) Mechanisms underlying the nociception and paw edema caused by injection of glutamate into the mouse paw. Brain Res 924:219-228.
5. Birt DF, Hendrich S, and Wang W (2001) Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90:157-177.
6. Calixto JB, Campos MM, Otuki MF, and Santos ARS (2004) Anti-inflammatory compounds of plant origin: II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Plant Med 70:93-103.
7. Calixto JB, Kassuya CAL, André E, and Ferreira J (2005) Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions. Pharmacol Ther 106:179-208.
8. Calixto JB, Otuki MF, and Santos ARS (2003) Anti-inflammatory compounds of plant origin: I. Action on arachidonic acid pathway, nitric oxide and nuclear factor κB (NFκB). Plant Med 69:973-983.
9. Chen YC, Yang LL, and Lee TJF (2000) Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kB activation. Biochem Pharmacol 59:1445-1457.
10. Clifford AJ, Ebeler SE, Ebeler JD, Bills ND, Hinrichs SH, Teissedre PL, and Waterhouse AL (1996) Delayed tumor onset in transgenic mice fed an amino acid-based diet supplemented with red wine solids. Am J Clin Nutr 64:748-756.
11. Collier HOJ, Dinneen JC, Johnson CA, and Schneider C (1968) The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 32:295-310.
12. De Campos RP, Santos ARS, Vaz ZR, Pinheiro TR, Pizzolatti MG, Cechinel-Filho V, Delle Monache F, Yunes RA, and Calixto JB (1997) Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala ciparissias (Polygalaceae). Life Sci 61:1619-1630.
13. Edenharder R and Grünhage D (2003) Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. Mutat Res 540:1-18.
14. Ferrándiz ML, Bustos G, Payá M, Gunasegaran R, and Alcaraz MJ (1994) Hispidulin protection against hepatotoxicity induced by bromobenzene in mice. Life Sci 55:145-150.
15. Ferreira J, Silva GL, and Calixto JB (2004) Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice. Br J Pharmacol 141:787-794.
16. Ferreira J, Trichês KM, Medeiros R, and Calixto JB (2005) Mechanisms involved in the nociception produced by peripheral protein kinase C activation in mice. Pain 117:171-181.
17. Gamet-Payrastre L, Manenti S, Gratacap MP, Tulliez J, Chap H, and Payrastre B (1999) Flavonoids and the inhibition of PKC and PI 3-kinase. Gen Pharmacol 32:279-286.
18. Harborne JB (1989) Methods in plant biochemistry, in General Procedures and Measurement of Total Phenolics (Dey PM and Harborne JB eds) pp 1- 28, Academic Press, London, UK.
19. Havsteen BH (2002) The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96:67-202.
20. Holzer P (1991) Capsaicin as a tool for studying sensory neuron functions. Adv Exp Med Biol 298:3-16.
21. Ikeda Y, Ueno A, Naraba H, and Ohishi S (2001) Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. Life Sci 69:2911-2919.
22. Jancsó G, Király E, and Jancsó-Gávor A (1977) Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature (Lond) 270:741-743.
23. Julius D and Basbaum AI (2001) Molecular mechanisms of nociception. Nature (Lond) 413:203-210.
24. Khasar SG, McCarter G, and Levine JD (1999) Epinephrine produces a β-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat receptors. J Neurophysiol 81:1104-1112.
25. Kimira M, Arai Y, Shimoi K, and Watanabe S (1998) Japanese intake of flavonoids and isoflavonoids from foods. J Epidemiol 8:168-175.
26. Ma J, Luo XD, Protiva P, Yang H, Ma C, Basile MJ, Weinstein IB, and Kennelly EJ (2003) Bioactive novel polyphenols from the fruit of Manilkara zapota (Sapodilla). J Nat Prod 66:983-986.
27. Ma J, Yang H, Basile MJ, Kennelly and EJ (2004) Analysis of polyphenolic antioxidants from the fruits of three Pouteria species by selected ion monitoring liquid chromatography-mass spectrometry. J Agric Food Chem 52:5873-5878.
28. Murota K and Terao J (2003) Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch Biochem Biophys 417:12-17.
29. Premkumar LS and Ahern GP (2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature (Lond) 408:985-989.
30. Ramelet AA (2000) Pharmacologic aspects of a phlebotropic drug in CVI-associated edema. Angiology 51:19-23.
31. Randall LO and Selitto JJ (1957) A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 111:409-419.
32. Rodrigues AL, da Silva GL, Mateussi AS, Fernandes ES, Miguel OG, Yunes RA, Calixto JB, and Santos ARS (2002) Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci 70:1347-1358.
33. Santos ARS, Vedana EM, and De Freitas GA (1998) Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. Inflamm Res 47:302-307.
34. Schmeda-Hirschmann G, Theoduloz C, Franco L, Ferro E, and Arias AR (1987) Preliminary pharmacological studies on Eugenia uniflora leaves: xanthine oxidase inhibitory activity. J Ethnopharmacol 21:183-186.
35. Siebel JS, Beirith A, and Calixto JB (2004) Evidence for the involvement of metabotropic glutamatergic, neurokinin 1 receptor pathways and protein kinase C in the antinociceptive effect of dipyrone in mice. Brain Res 1003:61-67.
36. Tsacheva I, Rostan J, Iossifova T, Vogler B, Odjakova M, Navas H, Kostova I, Kojouharova M, and KrausW(2004) Complement inhibiting properties of dragon's blood from Croton draco. Z Naturforsch 59:528-532.
37. Vaz ZR, Filho VC, Yunes RA, and Calixto JB (1996) Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice. J Pharmacol Exp Ther 278:304-312.
38. Xagorari A, Roussos C, and Papapetrpoulos A (2002) Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Br J Pharmacol 136:1058-1064.
39. Yasukawa K, Takido M, Takeuchi M, Sato Y, Nitta K, and Nakagawa S (1990) Inhibitory effects of flavonol glycosides on 12-O-tetradecanoylphorbol-13- acetate-induced tumor promotion. Chem Pharm Bull 38:774-776.
40. Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109-110.