-
1
-
-
1842328604
-
-
Aand glycine receptors. Nature 389, 385-389 (1997).
-
Aand glycine receptors. Nature 389, 385-389 (1997).
-
-
-
-
2
-
-
0024535962
-
Ethanol inhibits NMDA-activated ion current in hippocampal neurons
-
Lovinger, D.M., White, G. & Weight, F.F. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243, 1721-1724 (1989).
-
(1989)
Science
, vol.243
, pp. 1721-1724
-
-
Lovinger, D.M.1
White, G.2
Weight, F.F.3
-
3
-
-
0032901484
-
Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes
-
Cardoso, R.A. et al. Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 289, 774-780 (1999).
-
(1999)
J. Pharmacol. Exp. Ther
, vol.289
, pp. 774-780
-
-
Cardoso, R.A.1
-
4
-
-
0030426270
-
Pharmacologic characteristics of potentiation of 5-HT3 receptors by alcohols and diethyl ether in NCB-20 neuroblastoma cells
-
Zhou, Q. & Lovinger, D.M. Pharmacologic characteristics of potentiation of 5-HT3 receptors by alcohols and diethyl ether in NCB-20 neuroblastoma cells. J. Pharmacol. Exp. Ther. 278, 732-740 (1996).
-
(1996)
J. Pharmacol. Exp. Ther
, vol.278
, pp. 732-740
-
-
Zhou, Q.1
Lovinger, D.M.2
-
6
-
-
0032568547
-
Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?
-
Wick, M.J. et al. Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc. Natl. Acad. Sci. USA 95, 6504-6509 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6504-6509
-
-
Wick, M.J.1
-
7
-
-
0033490206
-
G protein-coupled inwardly rectifying potassium channels are targets of alcohol action
-
Lewohl, J.M. et al. G protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat. Neurosci. 2, 1084-1090 (1999).
-
(1999)
Nat. Neurosci
, vol.2
, pp. 1084-1090
-
-
Lewohl, J.M.1
-
9
-
-
0029112894
-
Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia
-
Covarrubias, M., Vyas, T.B., Escobar, L. & Wei, A. Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia. J. Biol. Chem. 270, 19408-19416 (1995).
-
(1995)
J. Biol. Chem
, vol.270
, pp. 19408-19416
-
-
Covarrubias, M.1
Vyas, T.B.2
Escobar, L.3
Wei, A.4
-
10
-
-
0037422541
-
A pervasive mechanism for analgesia: Activation of GIRK2 channels
-
Blednov, Y.A., Stoffel, M., Alva, H. & Harris, R.A. A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc. Natl. Acad. Sci. USA 100, 277-282 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 277-282
-
-
Blednov, Y.A.1
Stoffel, M.2
Alva, H.3
Harris, R.A.4
-
11
-
-
0034920540
-
Potassium channels as targets for ethanol: Studies of G protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice
-
Blednov, Y.A., Stoffel, M., Chang, S.R. & Harris, R.A. Potassium channels as targets for ethanol: studies of G protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. J. Pharmacol. Exp. Ther. 298, 521-530 (2001).
-
(2001)
J. Pharmacol. Exp. Ther
, vol.298
, pp. 521-530
-
-
Blednov, Y.A.1
Stoffel, M.2
Chang, S.R.3
Harris, R.A.4
-
12
-
-
0028322077
-
Activation of the cloned muscarinic potassium channel by G protein βγ-subunits
-
Reuveny, E. et al. Activation of the cloned muscarinic potassium channel by G protein βγ-subunits. Nature 370, 143-146 (1994).
-
(1994)
Nature
, vol.370
, pp. 143-146
-
-
Reuveny, E.1
-
13
-
-
0028180952
-
Recombinant G protein βγ-subunits activate the muscarinic-gated atrial potassium channel
-
Wickman, K.D. et al. Recombinant G protein βγ-subunits activate the muscarinic-gated atrial potassium channel. Nature 368, 255-257 (1994).
-
(1994)
Nature
, vol.368
, pp. 255-257
-
-
Wickman, K.D.1
-
15
-
-
0028826886
-
Identification of domains conferring G protein regulation on inward rectifier potassium channels
-
Kunkel, M.T. & Peralta, E.G. Identification of domains conferring G protein regulation on inward rectifier potassium channels. Cell 83, 443-449 (1995).
-
(1995)
Cell
, vol.83
, pp. 443-449
-
-
Kunkel, M.T.1
Peralta, E.G.2
-
16
-
-
0032479052
-
-
+ channel activation. J. Biol. Chem. 273, 16946-16952 (1998).
-
+ channel activation. J. Biol. Chem. 273, 16946-16952 (1998).
-
-
-
-
17
-
-
0033617167
-
Identification of a potassium channel site that interacts with G protein βγ subunits to mediate agonist-induced signaling
-
He, C., Zhang, H., Mirshahi, T. & Logothetis, D.E. Identification of a potassium channel site that interacts with G protein βγ subunits to mediate agonist-induced signaling. J. Biol. Chem. 274, 12517-12524 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 12517-12524
-
-
He, C.1
Zhang, H.2
Mirshahi, T.3
Logothetis, D.E.4
-
18
-
-
0043237432
-
+ channel
-
+ channel. J. Biol. Chem. 278, 29174-29183 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 29174-29183
-
-
Ivanina, T.1
-
20
-
-
0034893726
-
Mutational analysis of ethanol interactions with G protein-coupled inwardly rectifying potassium channels
-
Hara, K., Lewohl, J.M., Yamakura, T. & Harris, R.A. Mutational analysis of ethanol interactions with G protein-coupled inwardly rectifying potassium channels. Alcohol 24, 5-8 (2001).
-
(2001)
Alcohol
, vol.24
, pp. 5-8
-
-
Hara, K.1
Lewohl, J.M.2
Yamakura, T.3
Harris, R.A.4
-
21
-
-
33746047139
-
Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1
-
Pegan, S., Arrabit, C., Slesinger, P.A. & Choe, S. Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. Biochemistry 45, 8599-8606 (2006).
-
(2006)
Biochemistry
, vol.45
, pp. 8599-8606
-
-
Pegan, S.1
Arrabit, C.2
Slesinger, P.A.3
Choe, S.4
-
22
-
-
0041819527
-
Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster
-
Kruse, S.W., Zhao, R., Smith, D.P. & Jones, D.N. Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster. Nat. Struct. Biol. 10, 694-700 (2003).
-
(2003)
Nat. Struct. Biol
, vol.10
, pp. 694-700
-
-
Kruse, S.W.1
Zhao, R.2
Smith, D.P.3
Jones, D.N.4
-
23
-
-
0037184996
-
Structural basis of inward rectification: Cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 Å resolution
-
Nishida, M. & MacKinnon, R. Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 Å resolution. Cell 111, 957-965 (2002).
-
(2002)
Cell
, vol.111
, pp. 957-965
-
-
Nishida, M.1
MacKinnon, R.2
-
24
-
-
14544298750
-
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification
-
Pegan, S. et al. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat. Neurosci. 8, 279-287 (2005).
-
(2005)
Nat. Neurosci
, vol.8
, pp. 279-287
-
-
Pegan, S.1
-
27
-
-
0031436257
-
Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants
-
Vivaudou, M. et al. Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants. J. Biol. Chem. 272, 31553-31560 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 31553-31560
-
-
Vivaudou, M.1
-
28
-
-
0033161908
-
-
+ channels by distinct PtdIns(4,5)P2 interactions. Nat. Cell Biol. 1, 183-188 (1999).
-
+ channels by distinct PtdIns(4,5)P2 interactions. Nat. Cell Biol. 1, 183-188 (1999).
-
-
-
-
31
-
-
0032546013
-
-
2and its stabilization by G βγ. Nature 391, 803-806 (1998).
-
2and its stabilization by G βγ. Nature 391, 803-806 (1998).
-
-
-
-
32
-
-
0036143966
-
Inhibition of N-methyl-d-aspartate receptors by straight-chain diols: Implications for the mechanism of the alcohol cutoff effect
-
Peoples, R.W. & Ren, H. Inhibition of N-methyl-d-aspartate receptors by straight-chain diols: implications for the mechanism of the alcohol cutoff effect. Mol. Pharmacol. 61, 169-176 (2002).
-
(2002)
Mol. Pharmacol
, vol.61
, pp. 169-176
-
-
Peoples, R.W.1
Ren, H.2
-
33
-
-
0029874974
-
-
Aand glutamate receptors: relation to in vivo effects. Br. J. Pharmacol. 118, 378-384 (1996).
-
Aand glutamate receptors: relation to in vivo effects. Br. J. Pharmacol. 118, 378-384 (1996).
-
-
-
-
34
-
-
0028300618
-
Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols
-
Ramaswamy, S., Eklund, H. & Plapp, B.V. Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols. Biochemistry 33, 5230-5237 (1994).
-
(1994)
Biochemistry
, vol.33
, pp. 5230-5237
-
-
Ramaswamy, S.1
Eklund, H.2
Plapp, B.V.3
-
35
-
-
0034665877
-
Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency
-
Svensson, S., Hoog, J.O., Schneider, G. & Sandalova, T. Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency. J. Mol. Biol. 302, 441-453 (2000).
-
(2000)
J. Mol. Biol
, vol.302
, pp. 441-453
-
-
Svensson, S.1
Hoog, J.O.2
Schneider, G.3
Sandalova, T.4
-
36
-
-
0028978520
-
Engineering yeast alcohol dehydrogenase. Replacing Trp54 by Leu broadens substrate specificity
-
Weinhold, E.G. & Benner, S.A. Engineering yeast alcohol dehydrogenase. Replacing Trp54 by Leu broadens substrate specificity. Protein Eng. 8, 457-461 (1995).
-
(1995)
Protein Eng
, vol.8
, pp. 457-461
-
-
Weinhold, E.G.1
Benner, S.A.2
-
37
-
-
39149094255
-
The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: Insights from structural studies of LUSH
-
Thode, A.B., Kruse, S.W., Nix, J.C. & Jones, D.N. The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: insights from structural studies of LUSH. J. Mol. Biol. 376, 1360-1376 (2008).
-
(2008)
J. Mol. Biol
, vol.376
, pp. 1360-1376
-
-
Thode, A.B.1
Kruse, S.W.2
Nix, J.C.3
Jones, D.N.4
-
38
-
-
0035119276
-
+ channel with backbone mutations in the selectivity filter
-
+ channel with backbone mutations in the selectivity filter. Nat. Neurosci. 4, 239-246 (2001).
-
(2001)
Nat. Neurosci
, vol.4
, pp. 239-246
-
-
Lu, T.1
-
39
-
-
34548386717
-
Crystal structure of a Kir3.1-prokaryotic Kir channel chimera
-
Nishida, M., Cadene, M., Chait, B.T. & MacKinnon, R. Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J. 26, 4005-4015 (2007).
-
(2007)
EMBO J
, vol.26
, pp. 4005-4015
-
-
Nishida, M.1
Cadene, M.2
Chait, B.T.3
MacKinnon, R.4
-
40
-
-
0035049090
-
Yeast screen for constitutively active mutant G protein-activated potassium channels
-
Yi, B.A., Lin, Y.F., Jan, Y.N. & Jan, L.Y. Yeast screen for constitutively active mutant G protein-activated potassium channels. Neuron 29, 657-667 (2001).
-
(2001)
Neuron
, vol.29
, pp. 657-667
-
-
Yi, B.A.1
Lin, Y.F.2
Jan, Y.N.3
Jan, L.Y.4
-
41
-
-
0034744617
-
Coupling G βγ-dependent activation to channel opening via pore elements in inwardly rectifying potassium channels
-
Sadja, R., Smadja, K., Alagem, N. & Reuveny, E. Coupling G βγ-dependent activation to channel opening via pore elements in inwardly rectifying potassium channels. Neuron 29, 669-680 (2001).
-
(2001)
Neuron
, vol.29
, pp. 669-680
-
-
Sadja, R.1
Smadja, K.2
Alagem, N.3
Reuveny, E.4
-
42
-
-
0036753545
-
+ channel by pivoted bending of a transmembrane segment
-
+ channel by pivoted bending of a transmembrane segment. Mol. Cell 10, 469-481 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 469-481
-
-
Jin, T.1
-
43
-
-
14044277646
-
Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function
-
Sarac, R. et al. Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function. J. Neurosci. 25, 1836-1846 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 1836-1846
-
-
Sarac, R.1
-
44
-
-
0038664388
-
Conformational rearrangements associated with the gating of the G protein-coupled potassium channel revealed by FRET microscopy
-
Riven, I., Kalmanzon, E., Segev, L. & Reuveny, E. Conformational rearrangements associated with the gating of the G protein-coupled potassium channel revealed by FRET microscopy. Neuron 38, 225-235 (2003).
-
(2003)
Neuron
, vol.38
, pp. 225-235
-
-
Riven, I.1
Kalmanzon, E.2
Segev, L.3
Reuveny, E.4
-
45
-
-
0032557490
-
Molecular basis for interactions of G protein βγ subunits with effectors
-
Ford, C.E. et al. Molecular basis for interactions of G protein βγ subunits with effectors. Science 280, 1271-1274 (1998).
-
(1998)
Science
, vol.280
, pp. 1271-1274
-
-
Ford, C.E.1
-
46
-
-
13444254031
-
Pertussis toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: Evidence for a heterotrimeric G protein-channel complex
-
Clancy, S.M. et al. Pertussis toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G protein-channel complex. Mol. Cell. Neurosci. 28, 375-389 (2005).
-
(2005)
Mol. Cell. Neurosci
, vol.28
, pp. 375-389
-
-
Clancy, S.M.1
-
47
-
-
0024520745
-
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
-
Ho, S.N., Hunt, H.D., Horton, R.M., Pullen, J.K. & Pease, L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59 (1989).
-
(1989)
Gene
, vol.77
, pp. 51-59
-
-
Ho, S.N.1
Hunt, H.D.2
Horton, R.M.3
Pullen, J.K.4
Pease, L.R.5
-
48
-
-
33747818007
-
CASTp: Computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues
-
Dundas, J. et al. CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Res. 34, W116-118 (2006).
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Dundas, J.1
-
49
-
-
0028773889
-
Volume changes on protein folding
-
Harpaz, Y., Gerstein, M. & Chothia, C. Volume changes on protein folding. Structure 2, 641-649 (1994).
-
(1994)
Structure
, vol.2
, pp. 641-649
-
-
Harpaz, Y.1
Gerstein, M.2
Chothia, C.3
|