PI3K7-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 296, Issue 2, 2009, Pages

  Lim, Dae Hyun ^a   Cho, Jae Youn ^a   Song, Dae Jin ^a   Lee, Sang Yeub ^a   Miller, Marina ^a   Broide, David H ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Mucus; PSmad2 3; Smooth muscle; transforming growth factor 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; EOTAXIN; INTERLEUKIN 5; OVALBUMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ALLERGEN; ISOENZYME; PHOSPHATIDYLINOSITOL 3-KINASE GAMMA;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CONTROLLED STUDY; EOSINOPHIL; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; BRONCHUS HYPERREACTIVITY; C57BL MOUSE; CYTOLOGY; IMMUNOBLOTTING; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; PNEUMONIA; RESPIRATORY SYSTEM; SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALLERGENS; ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CCL11; EOSINOPHILS; IMMUNOBLOTTING; INTERLEUKIN-5; ISOENZYMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH; OVALBUMIN; PNEUMONIA; RESPIRATORY SYSTEM; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 59449099114     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90275.2008     Document Type: Article

References (33)

1. Alcorn J, Rinaldi L, Jaffe E, van Loon M, Bates J, Janssen-Heininger Y, Irvin C. Transforming growth factor-p1 suppresses airway hyperre-sponsiveness in allergic airway disease. Am J Respir Crit Care Med 176: 974-982, 2007.
2. Barnes P. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8: 183-192, 2008.
3. Broide D, Schwarze J, Tighe H, Gifford T, Nguyen MD, Malek S, Uden JV, Martin-Orozco E, Gelfand EW, Raz E. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hy-perresponsiveness in mice. J Immunol 161: 7054-7062, 1998.
4. Broide DH. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 121: 560-570, 2008.
5. Camps M, Ruckle T, Ji H, Ardissone V, Rintelen F, Shaw J, Ferrandi C, Chabert C, Gillieron C, Francon B, Martin T, Gretener D, Perrin D, Leroy D, Vitte PA, Hirsch E, Wymann MP, Cirillo R, Schwarz MK, Rommel C. Blockade of PI3Kβ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nature Med 11: 936-943, 2005.
6. Cantley LC. The phosphoinositide 3-kinase pathway. Science 296: 1655-1657, 2002.
7. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Friedman S, Broide DH. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 113: 551-560, 2004.
8. Doherty T, Broide D. Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol 19: 676-680, 2007.
9. Duan W, Dateles AM, Leung BP, Vlahos CJ, Wong WS. An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Int Immunopharm 5: 495-502, 2005.
10. Fattouh R, Midence G, Arias K, Johnson J, Walker T, Goncharova S, Souza K, Gregory R, Lonning S, Gauldie J, Jordana M. Transforming growth factor-β regulates house dust mite-induced allergic airway inflammation but not airway remodeling. Am J Respir Crit Care Med 177: 593-603, 2008.
11. Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, Barnes N, Robinson D, Kay AB. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 112: 1029-1036, 2003.
12. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 183: 195-201, 1996.
13. Fruman DA, Cantle LC. Phosphoinositide 3-kinase in immunological systems. Semin Immunol 14: 7-18, 2002.
14. Hoshino M, Nakamura Y, Sim JJ. Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax 53: 21-27, 1998.
15. Ito K, Caramori G, Adcock IM. Therapeutic potential of phosphatidyl-inositol 3-kinase inhibitors in inflammatory respiratory disease. J Pharm Exp Ther 321: 1-8, 2007.
16. Kwak YG, Song CH, Hwany PH, Kim JS, Lee KS, Lee YC. Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. J Clin Invest 111: 1083-1092, 2003.
17. Laffargue M, Calvez R, Finan P, Trifilieff A, Barbier M, Altruda F, Hirsch E, Wymann MP. Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function. Immunity 16: 441-451, 2002.
18. Le AV, Cho JY, Miller M, McElwain S, Golgotiu K, Broide DH. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J Immunol 178: 7310-7316, 2007.
19. Lee JJ, Dimina D, Macias MP, Ochkur SI, McGarry MP, O'Neill KR, Protheroe C, Pero R, Nguyen T, Cormier SA, Lenkiewicz E, Colbert D, Rinaldi L, Ackerman SJ, Irvin CG, Lee NA. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 305: 1773-1776, 2004.
20. Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD. Inhibition of phosphoinositide 3-kinase δ hyperresponsiveness in murine asthma model. FASEB J 20: 455-465, 2006.
21. Lim DH, Cho JY, Miller M, McElwain K, McElwain S, Broide DH. Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice. Am J Physiol Lung Cell Mol Physiol 291: L265-L271, 2006.
22. Liu Y, Shreder KR, Gai W, Corral S, Ferris DK, Rosenblum JS. Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem Biol 12: 99-107, 2005.
23. McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J Immunol 174: 5774-5780, 2005.
24. Medina-Tato DA, Ward SG, Watson ML. Phosphoinositide 3-kinase signaling in lung disease: leucocytes and beyond. Immunology 121: 448-461, 2007.
25. Myou S, Leff AR, Myo S, Boetticher E, Tong J, Meliton AY, Liu J, Munoz NM, Zhu X. Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. J Exp Med 198: 1573-1582, 2003.
26. Nashed BF, Zhang T, Al-Alwan M, Srinivasan G, Halayko AJ, Okkenhaug K, Vanhaesebroeck HayGlass KT, Marshall AJ. Role of the phosphoinositide 3-kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation. Eur J Immunol 37: 416-424, 2007.
27. Rommel C, Camps M, Ji H. PI3K8 and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 7: 191-201, 2007.
28. Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunol 24: 147-174, 2006.
29. Sasaki T, Irie-Sasaki J, Jones RG, Oliverira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM. Function of PI3K-γ in thymocyte development, T cell activation, and neutrophil migration. Science 287: 1040-1046, 2000.
30. Stokoe D. The phosphoinositide 3-kinase pathway and cancer. Exp Rev Mol Med 7: 1-22, 2005.
31. Thomas MJ, Smith A, Head DH, Miline L, Nichollas A, Pearce W, Vanhaesebroeck B, Wymann MP, Hirsch E, Trifilieff A, Walker C, Finan P, Westwick J. Airway inflammation: chemokine-induced neutro-philia and the class I phosphoinositide 3-kinases. Eur J Immunol 35: 1238-1291, 2005.
32. Xie S, Sukkar MB, Issa R, Khorasani NM, Chung KF. Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-β. Am J Physiol Lung Cell Mol Physiol 293: L245-L253, 2007.
33. Zhang M, Angata T, Cho JY, Miller M, Broide DH, Varki A. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood 109: 4280-4287, 2007.