-
1
-
-
0036897810
-
An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: Evidence that TNF alpha upregulates 5-HT2A-mediated contraction
-
Adner M, Rose AC, Zhang Y, Sward K, Benson M, Uddman R, Shankley NP, and Cardell LO (2002) An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNF alpha upregulates 5-HT2A-mediated contraction. Br J Pharmacol 137:971-982.
-
(2002)
Br J Pharmacol
, vol.137
, pp. 971-982
-
-
Adner, M.1
Rose, A.C.2
Zhang, Y.3
Sward, K.4
Benson, M.5
Uddman, R.6
Shankley, N.P.7
Cardell, L.O.8
-
2
-
-
0034666165
-
Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway - lack of evidence for STAT 6 involvement
-
Ceponis PJ, Botelho F, Richards CD, and Mckay DM (2000) Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway - lack of evidence for STAT 6 involvement. J Biol Chem 275:29132-29137.
-
(2000)
J Biol Chem
, vol.275
, pp. 29132-29137
-
-
Ceponis, P.J.1
Botelho, F.2
Richards, C.D.3
Mckay, D.M.4
-
3
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies SP, Reddy H, Caivano M, and Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105.
-
(2000)
Biochem J
, vol.351
, pp. 95-105
-
-
Davies, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
4
-
-
3042795833
-
Modulation of calcium signaling by interleukin-13 in human airway smooth muscle - role of CD38/cyclic adenosine diphosphate ribose pathway
-
Deshpande DA, Dogan S, Walseth TF, Miller SM, Amrani Y, Panettieri RA, and Kannan MS (2004) Modulation of calcium signaling by interleukin-13 in human airway smooth muscle - role of CD38/cyclic adenosine diphosphate ribose pathway. Am J Respir Cell Mol Biol 31:36-42.
-
(2004)
Am J Respir Cell Mol Biol
, vol.31
, pp. 36-42
-
-
Deshpande, D.A.1
Dogan, S.2
Walseth, T.F.3
Miller, S.M.4
Amrani, Y.5
Panettieri, R.A.6
Kannan, M.S.7
-
5
-
-
15944425792
-
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
-
Duan W, Aguinaldo Datiles AM, Leung BP, Vlahos CJ, and Wong WS (2005) An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Int Immunopharmacol 5:495-502.
-
(2005)
Int Immunopharmacol
, vol.5
, pp. 495-502
-
-
Duan, W.1
Aguinaldo Datiles, A.M.2
Leung, B.P.3
Vlahos, C.J.4
Wong, W.S.5
-
6
-
-
13644257561
-
IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle
-
Eum SY, Maghni K, Tolloczko B, Eidelman DH, and Martin JG (2005) IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 288:L576-L584.
-
(2005)
Am J Physiol Lung Cell Mol Physiol
, vol.288
-
-
Eum, S.Y.1
Maghni, K.2
Tolloczko, B.3
Eidelman, D.H.4
Martin, J.G.5
-
7
-
-
0035508451
-
Effect of wortmannin on human eosinophil responses in vitro and on bronchial inflammation and airway hyperresponsiveness in guinea pigs in vivo
-
Ezeamuzie CI, Sukumaran J, and Philips E (2001) Effect of wortmannin on human eosinophil responses in vitro and on bronchial inflammation and airway hyperresponsiveness in guinea pigs in vivo. Am J Respir Crit Care Med 164:1633-1639.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 1633-1639
-
-
Ezeamuzie, C.I.1
Sukumaran, J.2
Philips, E.3
-
8
-
-
22144478395
-
Bronchospasm and its biophysical basis in airway smooth muscle
-
Fredberg JJ (2004) Bronchospasm and its biophysical basis in airway smooth muscle. Respir Res 5:2.
-
(2004)
Respir Res
, vol.5
, pp. 2
-
-
Fredberg, J.J.1
-
9
-
-
0032545433
-
Requirement for IL-13 independently of IL-4 in experimental asthma
-
Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, et al. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282:2261-2263.
-
(1998)
Science
, vol.282
, pp. 2261-2263
-
-
Grünig, G.1
Warnock, M.2
Wakil, A.E.3
Venkayya, R.4
Brombacher, F.5
Rennick, D.M.6
Sheppard, D.7
Mohrs, M.8
Donaldson, D.D.9
Locksley, R.M.10
-
10
-
-
0036088040
-
IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
-
Grunstein MM, Hakonarson H, Leiter J, Chen M, Whelan R, Grunstein JS, and Chuang S (2002) IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 282:L520-L528.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.282
-
-
Grunstein, M.M.1
Hakonarson, H.2
Leiter, J.3
Chen, M.4
Whelan, R.5
Grunstein, J.S.6
Chuang, S.7
-
11
-
-
4444322559
-
Synthesis of IL-13 by human B lymphocytes: Regulation and role in IgE production
-
Hajoui O, Janani R, Tulic M, Joubert P, Ronis T, Hamid Q, Zheng H, and Mazer BD (2004) Synthesis of IL-13 by human B lymphocytes: Regulation and role in IgE production. J Allergy Clin Immunol 114:657-663.
-
(2004)
J Allergy Clin Immunol
, vol.114
, pp. 657-663
-
-
Hajoui, O.1
Janani, R.2
Tulic, M.3
Joubert, P.4
Ronis, T.5
Hamid, Q.6
Zheng, H.7
Mazer, B.D.8
-
12
-
-
0037393323
-
IL-13 receptors and signaling pathways: An evolving web
-
Hershey GK (2003) IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 111:677-690.
-
(2003)
J Allergy Clin Immunol
, vol.111
, pp. 677-690
-
-
Hershey, G.K.1
-
13
-
-
33947358942
-
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
-
Ito K, Caramori G, and Adcock IM (2007) Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. J Pharmacol Exp Ther 321:1-8.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 1-8
-
-
Ito, K.1
Caramori, G.2
Adcock, I.M.3
-
14
-
-
33746806220
-
ANG II enhances contractile responses via PI3-kinase p110 delta pathway in aortas from diabetic rats with systemic hyperinsulinemia
-
Kobayashi T, Hayashi Y, Taguchi K, Matsumoto T, and Kamata K (2006) ANG II enhances contractile responses via PI3-kinase p110 delta pathway in aortas from diabetic rats with systemic hyperinsulinemia. Am J Physiol Heart Circ Physiol 291:H846-H853.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.291
-
-
Kobayashi, T.1
Hayashi, Y.2
Taguchi, K.3
Matsumoto, T.4
Kamata, K.5
-
15
-
-
0035987319
-
Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
-
Kumar RK, Herbert C, Yang M, Koskinen AM, McKenzie AN, and Foster PS (2002) Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin Exp Allergy 32:1104-1111.
-
(2002)
Clin Exp Allergy
, vol.32
, pp. 1104-1111
-
-
Kumar, R.K.1
Herbert, C.2
Yang, M.3
Koskinen, A.M.4
McKenzie, A.N.5
Foster, P.S.6
-
16
-
-
0036344597
-
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
-
Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, and Erle DJ (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8:885-889.
-
(2002)
Nat Med
, vol.8
, pp. 885-889
-
-
Kuperman, D.A.1
Huang, X.2
Koth, L.L.3
Chang, G.H.4
Dolganov, G.M.5
Zhu, Z.6
Elias, J.A.7
Sheppard, D.8
Erle, D.J.9
-
17
-
-
0037382808
-
Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
-
Kwak YG, Song CH, Yi HK, Hwang PH, Kim JS, Lee KS, and Lee YC (2003) Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. J Clin Invest 111:1083-1092.
-
(2003)
J Clin Invest
, vol.111
, pp. 1083-1092
-
-
Kwak, Y.G.1
Song, C.H.2
Yi, H.K.3
Hwang, P.H.4
Kim, J.S.5
Lee, K.S.6
Lee, Y.C.7
-
18
-
-
0035402376
-
Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
-
Laporte JC, Moore PE, Baraldo S, Jouvin MH, Church TL, Schwartzman IN, Panettieri RA Jr, Kinet JP, and Shore SA (2001) Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells. Am J Respir Crit Care Med 164:141-148.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 141-148
-
-
Laporte, J.C.1
Moore, P.E.2
Baraldo, S.3
Jouvin, M.H.4
Church, T.L.5
Schwartzman, I.N.6
Panettieri Jr, R.A.7
Kinet, J.P.8
Shore, S.A.9
-
19
-
-
33645827963
-
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
-
Lee KS, Lee HK, Hayflick JS, Lee YC, and Puri KD (2006) Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J 20:455-465.
-
(2006)
FASEB J
, vol.20
, pp. 455-465
-
-
Lee, K.S.1
Lee, H.K.2
Hayflick, J.S.3
Lee, Y.C.4
Puri, K.D.5
-
21
-
-
0036644701
-
Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells
-
Lordan JL, Bucchieri F, Richter A, Konstantinidis A, Holloway JW, Thornber M, Puddicombe SM, Buchanan D, Wilson SJ, Djukanovic R, et al. (2002) Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells. J Immunol 169:407-414.
-
(2002)
J Immunol
, vol.169
, pp. 407-414
-
-
Lordan, J.L.1
Bucchieri, F.2
Richter, A.3
Konstantinidis, A.4
Holloway, J.W.5
Thornber, M.6
Puddicombe, S.M.7
Buchanan, D.8
Wilson, S.J.9
Djukanovic, R.10
-
22
-
-
0035851213
-
2+ channels
-
2+ channels. Circ Res 89:692-699.
-
(2001)
Circ Res
, vol.89
, pp. 692-699
-
-
Macrez, N.1
Mironneau, C.2
Carricaburu, V.3
Quignard, J.F.4
Babich, A.5
Czupalla, C.6
Nurnberg, B.7
Mironneau, J.8
-
23
-
-
34447095246
-
Phosphoinositide 3-kinase signalling in lung disease: Leucocytes and beyond
-
Medina-Tato DA, Ward SG, and Watson ML (2007) Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond. Immunology 121:448-461.
-
(2007)
Immunology
, vol.121
, pp. 448-461
-
-
Medina-Tato, D.A.1
Ward, S.G.2
Watson, M.L.3
-
24
-
-
2342622638
-
Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea
-
Moffatt JD, Cocks TM, and Page CP (2004) Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea. Br J Pharmacol 141:1159-1166.
-
(2004)
Br J Pharmacol
, vol.141
, pp. 1159-1166
-
-
Moffatt, J.D.1
Cocks, T.M.2
Page, C.P.3
-
25
-
-
33947729717
-
Role of the phosphoinositide 3-kinase p110 delta in generation of type 2 cytokine responses and allergic airway inflammation
-
Nashed BF, Zhang T, Al-Alwan M, Srinivasan G, Halayko AJ, Okkenhaug K, Vanhaesebroeck B, HayGlass KT, and Marshall AJ (2007) Role of the phosphoinositide 3-kinase p110 delta in generation of type 2 cytokine responses and allergic airway inflammation. Eur J Immunol 37:416-424.
-
(2007)
Eur J Immunol
, vol.37
, pp. 416-424
-
-
Nashed, B.F.1
Zhang, T.2
Al-Alwan, M.3
Srinivasan, G.4
Halayko, A.J.5
Okkenhaug, K.6
Vanhaesebroeck, B.7
HayGlass, K.T.8
Marshall, A.J.9
-
26
-
-
33644674205
-
Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: A moderator of arterial hypercontractility
-
Northcott CA, Hayflick J, and Watts SW (2005) Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractility. Clin Exp Pharmacol Physiol 32:851-858.
-
(2005)
Clin Exp Pharmacol Physiol
, vol.32
, pp. 851-858
-
-
Northcott, C.A.1
Hayflick, J.2
Watts, S.W.3
-
27
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110 delta PI 3-kinase mutant mice
-
Okkenhaug K, Bilancio A, Farjot G, Priddle H, Sancho S, Peskett E, Pearce W, Meek SE, Salpekar A, Waterfield MD, et al. (2002) Impaired B and T cell antigen receptor signaling in p110 delta PI 3-kinase mutant mice. Science 297:1031-1034.
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
Priddle, H.4
Sancho, S.5
Peskett, E.6
Pearce, W.7
Meek, S.E.8
Salpekar, A.9
Waterfield, M.D.10
-
28
-
-
0036126726
-
The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness
-
Rizzo CA, Yang R, Greenfeder S, Egan RW, Pauwels RA, and Hey JA (2002) The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness. J Allergy Clin Immunol 109:404-409.
-
(2002)
J Allergy Clin Immunol
, vol.109
, pp. 404-409
-
-
Rizzo, C.A.1
Yang, R.2
Greenfeder, S.3
Egan, R.W.4
Pauwels, R.A.5
Hey, J.A.6
-
29
-
-
34547098368
-
Insulin increases the expression of contractile phenotypic markers in airway smooth muscle
-
Schaafsma D, McNeill KD, Stelmack GL, Gosens R, Baarsma HA, Dekkers BG, Frohwerk E, Penninks JM, Sharma P, Ens KM, et al. (2007) Insulin increases the expression of contractile phenotypic markers in airway smooth muscle. Am J Physiol Cell Physiol 293:C429-C439.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Schaafsma, D.1
McNeill, K.D.2
Stelmack, G.L.3
Gosens, R.4
Baarsma, H.A.5
Dekkers, B.G.6
Frohwerk, E.7
Penninks, J.M.8
Sharma, P.9
Ens, K.M.10
-
30
-
-
25444487989
-
The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells
-
Syed F, Panettieri RA Jr, Tliba O, Huang C, Li K, Bracht M, Amegadzie B, Griswold D, Li L, and Amrani Y (2005) The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells. Respir Res 6:9.
-
(2005)
Respir Res
, vol.6
, pp. 9
-
-
Syed, F.1
Panettieri Jr, R.A.2
Tliba, O.3
Huang, C.4
Li, K.5
Bracht, M.6
Amegadzie, B.7
Griswold, D.8
Li, L.9
Amrani, Y.10
-
31
-
-
0942265661
-
Phosphatidylinositol 3-kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and -dependent pathways
-
Su XL, Smolock EM, Marcel KN, and Moreland RS (2004) Phosphatidylinositol 3-kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and -dependent pathways. Am J Physiol Heart Circ Physiol 286:H657-H666.
-
(2004)
Am J Physiol Heart Circ Physiol
, vol.286
-
-
Su, X.L.1
Smolock, E.M.2
Marcel, K.N.3
Moreland, R.S.4
-
32
-
-
1642545168
-
IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
-
Tliba O, Deshpande D, Chen H, Van Besien C, Kannan M, Panettieri RA Jr and Amrani Y (2003) IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 140:1159-1162.
-
(2003)
Br J Pharmacol
, vol.140
, pp. 1159-1162
-
-
Tliba, O.1
Deshpande, D.2
Chen, H.3
Van Besien, C.4
Kannan, M.5
Panettieri Jr, R.A.6
Amrani, Y.7
-
33
-
-
0034911881
-
Synthesis and function of 3-phosphorylated inositol lipids
-
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, and Waterfield MD (2001) Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 70:535-602.
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 535-602
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Ahmadi, K.3
Timms, J.4
Katso, R.5
Driscoll, P.C.6
Woscholski, R.7
Parker, P.J.8
Waterfield, M.D.9
-
34
-
-
0035888013
-
Critical Role for IL-13 in the development of allergen-induced airway hyperreactivity
-
Walter DM, McIntire JJ, Berry G, McKenzie ANJ, Donaldson DD, DeKruyff RH, and Umetsu DT (2001) Critical Role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 167:4668-4675.
-
(2001)
J Immunol
, vol.167
, pp. 4668-4675
-
-
Walter, D.M.1
McIntire, J.J.2
Berry, G.3
McKenzie, A.N.J.4
Donaldson, D.D.5
DeKruyff, R.H.6
Umetsu, D.T.7
-
35
-
-
0027056309
-
Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases
-
Ward SG, Reif K, Ley S, Fry MJ, Waterfield MD, and Cantrell DA (1992) Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases. J Biol Chem 267:23862-23869.
-
(1992)
J Biol Chem
, vol.267
, pp. 23862-23869
-
-
Ward, S.G.1
Reif, K.2
Ley, S.3
Fry, M.J.4
Waterfield, M.D.5
Cantrell, D.A.6
-
36
-
-
9644281044
-
Interleukin-13 in asthma pathogenesis
-
Wills-Karp M (2004) Interleukin-13 in asthma pathogenesis. Immunol Rev 202:175-190.
-
(2004)
Immunol Rev
, vol.202
, pp. 175-190
-
-
Wills-Karp, M.1
-
37
-
-
0030946256
-
Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29
-
Wright K, Ward SG, Kolios G, and Westwick J (1997) Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29. J Biol Chem 272:12626-12633.
-
(1997)
J Biol Chem
, vol.272
, pp. 12626-12633
-
-
Wright, K.1
Ward, S.G.2
Kolios, G.3
Westwick, J.4
-
38
-
-
0034755167
-
Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin
-
Yang M, Hogan SP, Henry PJ, Matthaei KI, McKenzie ANJ, Young IG, Rothenberg ME, and Foster PS (2001) Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol 25:522-530.
-
(2001)
Am J Respir Cell Mol Biol
, vol.25
, pp. 522-530
-
-
Yang, M.1
Hogan, S.P.2
Henry, P.J.3
Matthaei, K.I.4
McKenzie, A.N.J.5
Young, I.G.6
Rothenberg, M.E.7
Foster, P.S.8
-
39
-
-
0033560126
-
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
-
Zhu Z, Homer RJ, Wang ZD, Chen QS, Geba GP, Wang JM, Zhang Y, and Elias JA (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103:779-788.
-
(1999)
J Clin Invest
, vol.103
, pp. 779-788
-
-
Zhu, Z.1
Homer, R.J.2
Wang, Z.D.3
Chen, Q.S.4
Geba, G.P.5
Wang, J.M.6
Zhang, Y.7
Elias, J.A.8
|