Immunity in lepidopteran insects

Advances in Experimental Medicine and Biology

Volumn 708, Issue , 2010, Pages 181-204

  Jiang, Haobo ^a   Vilcinskas, Andreas ^b   Kanost, Michael R ^c  

^a OKLAHOMA STATE UNIVERSITY   (United States)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LYSOZYME; MELANIN; MONOPHENOL MONOOXYGENASE; NUCLEIC ACID; PLASMA PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROPHENOL OXIDASE; PROTEINASE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SPATZLE; UNCLASSIFIED DRUG;

ARTHROPOD LARVA; ARTICLE; BLOOD CELL; CATERPILLAR; CELL ADHESION; CELL ENCAPSULATION; CYTOLOGY; CYTOLYSIS; DROSOPHILA; ENZYME ACTIVATION; ENZYME INHIBITION; FUNCTIONAL GENOMICS; GRANULAR CELL; HEMOLYMPH; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOREGULATION; INFECTION; INNATE IMMUNITY; LEPIDOPTERA; MELANOGENESIS; NONHUMAN; PATTERN RECOGNITION; PHAGOCYTOSIS; PLASMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

HEXAPODA; LEPIDOPTERA;

EID: 79958161931     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-8059-5_10     Document Type: Article

References (264)

1. Faye I, Pye A, Rasmuson T et al. Insect immunity II. Simultaneous induction of antibacterial activity and selective synthesis of some hemolymph proteins in diapausing pupae of Hyalophora cecropia and Samia cynthia. Infect Immun 1975; 12:1426-38.
2. Powning RF, Davidson WJ. Studies on the insect bacteriolytic enzymes-II. Some physical and enzymatic properties of lysozyme from haemolymph of Galleriamellonella. Comp Biochem Physiol 1976; 55:221-28.
3. Hultmark D, Steiner H, Rasmuson T et al. Insect immunity. Purification and properties of three inducible bactericidal proteins from hemolymph of immunized pupae of Hyalophora cecropia. Eur J Biochem 1980; 106:7-16. (Pubitemid 10057882)
4. Steiner H, Hultmark D, Engstrom A et al. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 1981; 292:246-48. (Pubitemid 11001840)
5. Hultmark D, Engström A, Andersson K et al. Insect immunity. Attacins, a family of antibacterial proteins from Hyalophora cecropia. EMBO J 1983; 2:571-76.
6. Yoshida H, Ochai M, Ashida M. p-1,3 -Glucan receptor andpeptidoglycan receptor are present as separate entities within insect prophenoloxidase activating system. Biochem Biophys Res Commun 1986; 114:1177-83.
7. Kanost MR, Prasad SV, Wells MA. Primary structure of a member of the serpin superfamily of proteinase inhibitors from an insect, Manduca sexta. J Biol Chem 1989; 264:965-72.
8. Yoshida H, Kinoshita K, Ashida M. Purification of a peptidoglycan recognition protein from hemolymph of the silkworm, Bombyx mori. J Biol Chem 1996; 271:13854-60. (Pubitemid 26185431)
9. Ochiai M, Ashida M. Purification of a p-1,3-glucan recognition protein in the prophenoloxidase system from hemolymph of the silkworm, Bombyx mori. J Biol Chem 1998; 263:12056-62.
10. Kang D, Liu G, Lundström A et al. A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc Natl Acad Sci USA 1998; 95:10078-82. (Pubitemid 28415297)
11. Ashida M, Brey PT. Recent advances on the research of the insect prophenoloxidase cascade. In: Brey PT Hultmark D, eds. Molecular Mechanisms of Immune Responses in Insects. London:Chapman and Hall, 1998:135-72.
12. Lavine MD, Strand MR. Insect hemocytes and their role in immunity. Insect Biochem Mol Biol 2002; 32:1295-309.
13. Tanaka H, Ishibashi J, Fujita K et al. A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori. Insect Biochem Mol Biol 2008; 38:1087-110.
14. Stevens JM. Bactericidal activity of the blood of actively immunized wax moth larvae. Canadian J Microbiol 1962; 8:491-9.
15. Powning RF, Davidson WJ. Studies on the insect bacteriolytic enzymes-II. Some physical and enzymatic properties of lysozyme from haemolymph of Galleria mellonella. Comp Biochem Physiol 1976; 55:221-28.
16. Kanost MR, Jiang H, Yu XQ. Innate immune responses of a lepidopteran insect, Manduca sexta. Immunol Rev 2004; 198:97-105. (Pubitemid 38406938)
17. Jiang H. The biochemical basis of antimicrobial responses in Manduca sexta. Insect Science 2008; 15:53-66.
18. Kanost MR, Gorman MJ. Phenoloxidases in insect immunity. In: Beckage NE ed. Insect Immunology. San Diego: Elsevier, 2008:69-96.
19. Ragan EJ, An C, Jiang H et al. Roles of hemolymph proteins in antimicrobial defences of Manduca sexta. In: Insect Infection and Immunity. Reynolds S, Rolff J eds. Oxford University Press, 2009:34-48.
20. Dushay MS. Insect hemolymph clotting. Cell Mol Life Sci 2009; 66:2643-50.
21. Vilcinskas A. Lepidopterans as model mini-hosts for human pathogens and as a source forpeptide antibiotics. In: Goldsmith M and Marec F, eds. Molecular Biology and Genetics of the Lepidoptera Boca Raton:CRC Press, 2010:293-305.
22. Kanost MR, Nardi JB. Innate immune responses of Manduca sexta. In: Goldsmith M and Marec F, eds. Molecular Biology and Genetics of the Lepidoptera Boca Raton:CRC Press, 2010:271-291.
23. Mukherjee K, Altincicek B, Hain T et al. Galleria mellonella as a model system for studying Listeria pathogenesis. Appl Environ Microbiol. 2010; 76:310-7.
24. Mullett H, Ratcliffe NA, Rowley AF. The generation and characterization of anti-insect blood cell monoclonal antibodies. J. Cell Sci 1992; 105:93-100.
25. Willott E, Trenczek T, Thrower LW et al. Immunochemical identification of insect hemocyte populations: Monoclonal antibodies distinguish four major hemocyte types in Manduca sexta. Eur J Cell Biol 1994; 65:417-23.
26. Gardiner EM, Strand MR. Monoclonal antibodies bind distinct classes of hemocytes in the moth Pseudoplusia includens. J Insect Physiol 1999; 45:113-126. (Pubitemid 29052915)
27. Nardi JB, Pilas B, Bee CM et al. Neuroglian-positive plasmatocytes of Manduca sexta and the initiation of hemocyte attachment to foreign surfaces. Dev Comp Immunol 2006; 30:447-62. (Pubitemid 43202093)
28. Gardiner EM, Strand MR. Hematopoiesis in larval Pseudoplusia includens and Spodoptera frugiperda. Arch Insect Biochem Physiol 2000; 43:147-64.
29. Beetz S, Holthusen TK, Koolman J et al. Correlation of hemocyte counts with different developmental parameters during the last larval instar of the tobacco hornworm, Manduca sexta. Arch Insect Biochem Physiol 2008; 67:63-75. (Pubitemid 351220127)
30. Nardi JB. Embryonic origins of the two main classes of hemocytes-granular cells and plasmatocytes-in Manduca sexta. Dev Genes Evol 2004; 214:19-28. (Pubitemid 38196113)
31. Nardi JB, Pilas B, Ujhelyi E et al. Hematopoietic organs of Manduca sexta and hemocyte lineages. Dev Genes Evol 2003; 213(10):477-91. (Pubitemid 37369230)
32. Schmidt O, Söderhäll K, Theopold U et al. Role of adhesion in arthropod immune recognition. Annu Rev Entomol 2010; 55:485-504.
33. Dean P, Potter U, Richards EH et al. Hyperphagocytic haemocytes in Manduca sexta. J Insect Physiol 2004; 50:1027-36. (Pubitemid 40015498)
34. Nardi JB, Pilas B, Bee CM et al. Neuroglian-positive plasmatocytes of Manduca sexta and the initiation of hemocyte attachment to foreign surfaces. Dev Comp Immunol 2006; 30:447-62. (Pubitemid 43202093)
35. Nakatogawa S, Oda Y, Kamiya M et al. A novel peptide mediates aggregation and migration of hemocytes from an insect. CurrBiol 2009; 19:779-85.
36. Clark KD, Pech LL, Strand MR. Isolation and identification of a plasmatocyte-spreading peptide from the hemolymph of the lepidopteran insect Pseudoplusia includens. J Biol Chem 1997; 272:23440-7. (Pubitemid 27392487)
37. Wang Y, Jiang H, Kanost MR. Biological activity of Manduca sexta paralytic and plasmatocyte spreading peptide and primary structure of its hemolymph precursor. Insect Biochem Mol Biol 1999; 29:1075-86.
38. Strand MR, Hayakawa Y, Clark KD. Plasmatocyte spreading peptide (PSP1) and growth blocking peptide (GBP) are multifunctional homologs. J Insect Physiol 2000; 46:817-24. (Pubitemid 30196512)
39. Volkman BF, Anderson ME, Clark KD et al. Structure of the insect cytokine peptide plasmatocyte-spreading peptide 1 from Pseudoplusia includens. J Biol Chem 1999; 274:4493-6.
40. Matsumoto Y, Oda Y, Uryu M et al. Insect cytokine growth-blocking peptide triggers a termination system of cellular immunity by inducing its binding protein. J Biol Chem 2003; 278:38579-85. (Pubitemid 37221754)
41. Eleftherianos I, Xu M, Yadi H et al. Plasmatocyte-spreading peptide (PSP) plays a central role in insect cellular immune defenses against bacterial infection. J Exp Biol 2009; 212(Pt 12): 1840-8.
42. Stanley D. Prostaglandins and other eicosanoids in insects: Biological significance. Annu Rev Entomol 2006; 51:25-44. (Pubitemid 43107813)
43. Shrestha S, Kim Y. Various eicosanoids modulate the cellular and humoral immune responses of the beet armyworm, Spodoptera exigua. Biosci Biotechnol Biochem 2009; 73:2077-84.
44. Shrestha S, Kim Y. Eicosanoids mediate prophenoloxidase release from oenocytoids in the beet armyworm Spodoptera exigua. Insect Biochem Mol Biol 2008; 38:99-112. (Pubitemid 350216437)
45. Lavine MD, Strand MR. Haemocytes from Pseudoplusia includens express multiple alpha and beta integrin subunits. Insect Mol Biol 2003; 12:441-52. (Pubitemid 37207551)
46. Wiegand C, Levin D, Gillespie J et al. Monoclonal antibody MS 13 identifies a plasmatocyte membrane protein and inhibits encapsulation and spreading reactions of Manduca sexta hemocytes. Arch Insect Biochem Physiol 2000; 45:95-108.
47. Levin DM, Breuer LN, Zhuang S et al. A hemocyte-specific integrin required for hemocytic encapsulation in the tobacco hornworm, Manduca sexta. Insect Biochem Mol Biol 2005; 35:369-80. (Pubitemid 40440931)
48. Nardi JB, Zhuang S, Pilas B et al. Clustering of adhesion receptors following exposure of insect blood cells to foreign surfaces. J Insect Physiol 2005; 51:555-64. (Pubitemid 40717353)
49. Zhuang S, Kelo L, Nardi JB. An integrin-tetraspanin interaction required for cellular innate immune responses of an insect, Manduca sexta. J Biol Chem 2007; 282:22563-72. (Pubitemid 47267354)
50. Zhuang S, Kelo L, Nardi JB et al. Multiple alpha subunits of integrin are involved in cell-mediated responses of the Manduca immune system. Dev Comp Immunol 2008; 32:365-79. (Pubitemid 350296328)
51. Zhuang S, Kelo L, Nardi JB et al. Neuroglian on hemocyte surfaces is involved in homophilic and heterophilic interactions of the innate immune system of Manduca sexta. Dev Comp Immunol 2007; 31:1159-67. (Pubitemid 47593028)
52. Andersson K, Steiner H. Structure and properties of protein P4, the major bacteria-inducible protein in pupae of Hyalophora cecropia. Insect Biochem 1987; 17:133-40.
53. Sun SC, Lindstöm I, Boman HG et al. Hemolin: An insect immune protein belonging to the immunoglobulin superfamily. Science 1990; 250:1729-32. (Pubitemid 120031884)
54. Ladendorff NE, Kanost MR. Isolation and characterization of bacteria induced protein P4 from hemolymph of Manduca sexta. Arch Insect Biochem Physiol 1990; 15:33-41.
55. Ladendorff NE, Kanost MR. Bacteria-induced protein P4 (hemolin) from Manduca sexta: A member of the immunoglobulin superfamily which can inhibit hemocyte aggregation. Arch Insect Biochem Physiol 1991; 18:285-300.
56. Shin SW, Park SS, Park DS et al. Isolation and characterization of immune-related genes from the fall webworm, Hyphantria cunea, using PCR-based differential display and subtractive cloning. Insect Biochem Mol Biol 1998; 28:827-37.
57. Lee KY, Horodyski FM, Valaitis AP et al. Molecular characterization of the insect immune protein hemolin and its high induction during embryonic diapause in the gypsy moth, Lymantria dispar. Insect Biochem Mol Biol 2002; 32:1457-67.
58. Li W, Terenius O, Hirai M et al. Cloning, expression and phylogenetic analysis of hemolin, from the Chinese oak silk moth, Antheraea pernyi. Dev Comp Immunol 2005; 29:853-64. (Pubitemid 40835807)
59. Gandhe AS, Arunkumar KP, John SH et al. Analysis of bacteria-challenged wild silkmoth, Antheraea mylitta (Lepidoptera) transcriptome reveals potential immune genes. BMC Genomics 2006; 7:184.
60. Eum JH, Seo YR, Yoe SM et al. Analysis of the immune-inducible genes of Plutella xylostella using expressed sequence tags and cDNA microarray. Dev Comp Immunol 2007; 31:1107-20 (Pubitemid 47588406)
61. Bao Y, Yamano Y, Morishima I. Induction of hemolin gene expression by bacterial cell wall components in eri-silkworm, Samia cynthia ricini. Comp Biochem Physiol Part B 2007; 146:147-51. (Pubitemid 46177700)
62. Faye I, Kanost MR. Function and regulation of hemolin. In: Brey PT, HultmarkD eds. Molecular Mechanisms of Immune Responses in Insects. London: Chapman and Hall, 1998:173-88.
63. Gibson NJ, Tolbert LP. Activation of epidermal growth factor receptor mediates receptor axon sorting and extension in the developing olfactory system of the moth Manduca sexta. J Comp Neurol 2006; 495:554-72.
64. Chen CL, Lampe DJ, Robertson HM et al. Neuroglian is expressed on cells destined to form the prothoracic glands of Manduca embryos as they segregate from surrounding cells andrearrange during morphogenesis. DevBiol1997; 181:1-13. (Pubitemid 27079630)
65. Roxström-Lindquist K, Lindström-Dinnetz I, Olesen J et al. An intron enhancer activates the immunoglobulin-related hemolin gene in Hyalophora cecropia. Insect Mol Biol 2002; 11:505-15.
66. Yu XQ, Kanost MR. Developmental expression of Manduca sexta hemolin. Arch Insect Biochem Physiol 1999; 42:198-212. (Pubitemid 129551729)
67. Roxström-Lindquist K, Assefaw-Redda Y, Rosinska K et al. 20-hydroxyecdysone indirectly regulates hemolin gene expression in Hyalophora cecropia. Insect Mol Biol 2005; 14:645-52. (Pubitemid 44914746)
68. Terenius O. Hemolin-A lepidopteran anti-viral defense factor? Dev Comp Immunol 2008; 32:311-6. (Pubitemid 350296334)
69. Hirai M, Terenius O, Li W et al. Baculovirus and dsRNA induce hemolin, but no antibacterial activity in Antheraea pernyi. Insect Mol Biol 2004; 13:399-405. (Pubitemid 39048168)
70. Terenius O, Popham HJ, Shelby KS. Bacterial, but not baculoviral infections stimulate hemolin expression in noctuid moths. Dev Comp Immunol 2009; 33:1176-85.
71. Daffre S, Faye I. Lipopolysaccharide interaction with hemolin, an insect member of the Ig-superfamily. FEBS Lett 1997; 408:127-30. (Pubitemid 27226781)
72. Yu XQ, Kanost MR. Binding of hemolin to bacterial lipopolysaccharide and lipoteichoic acid. An immunoglobulin superfamily member from insects as a pattern-recognition receptor. Eur J Biochem 2002; 269:1827-34. (Pubitemid 34429664)
73. Zhao L, Kanost MR. In search of a function for hemolin, a hemolymph protein from the immunoglobulin superfamily. J Insect Physiol 1996; 42:73-9. (Pubitemid 126686203)
74. Bettencourt R, Lanz-Mendoza H, Lindquist KRR et al. Cell adhesion properties of hemolin, an insect immune protein in the Ig superfamily. Eur J Biochem 1997; 250:630-7. (Pubitemid 28022478)
75. Su XD, Gastinel LN, Vaughn DE et al. Crystal structure of hemolin: A horseshoe shape with implications for homophilic adhesion. Science 1998; 281:991-5. (Pubitemid 28399249)
76. Eleftherianos I, Gokcen F, Felfoldi G et al. The immunoglobulin family protein hemolin mediates cellular immune responses to bacteria in the insect Manduca sexta. Cellular Microbiol 2007; 9:1137-47. (Pubitemid 46547134)
77. Dziarski R, Gupta D. The peptidoglycan recognition proteins (PGRPs). Genome Biol 2006; 7:232.
78. Ochiai M, Ashida M. A pattern recognition protein for peptidoglycan. Cloning the cDNA and the gene of the silkworm, Bombyx mori. J Biol Chem 1999; 274:11854-8.
79. Yu XQ, Zhu YF, Ma C et al. Pattern recognition proteins in Manduca sexta plasma. Insect Biochem Mol Biol 2002; 32:1287-93.
80. Zhu Y, Johnson T, Kanost MR. Identification of differentially expressed genes in the immune response of the tobacco hornworm, Manduca sexta. Insect Biochem Mol Biol 2003; 33:541-59. (Pubitemid 36572719)
81. Zou Z, Najar F, Wang Y et al. Pyrosequence analysis of expressed sequence tags for Manduca sexta hemolymph proteins involved in immune responses. Insect Biochem Mol Biol 2008; 38:677-82.
82. Seitz V, Clermont A, Wedde M et al. Identification of immunorelevant genes from greater wax moth (Galleria mellonella) by a subtractive hybridization approach. Dev Comp Immunol 2003; 27:207-15. (Pubitemid 36187449)
83. Onoe H, Matsumoto A, Hashimoto K et al. Peptidoglycan recognition protein (PGRP) from eri-silkworm, Samia cynthia ricini; protein purification and induction of the gene expression. Comp Biochem Physiol B 2007; 147:512-19. (Pubitemid 46783662)
84. Hashimoto K, Mega K, Matsumoto Y et al. Three peptidoglycan recognition protein (PGRP) genes encoding potential amidase from eri-silkworm, Samia cynthia ricini. Comp Biochem Physiol B Biochem Mol Biol 2007; 148:322-8. (Pubitemid 47626034)
85. Coates BS, Sumerford DV, Hellmich RL et al. Mining an Ostrinia nubilalis midgut expressed sequence tag (EST) library for candidate genes and single nucleotide polymorphisms (SNPs). Insect Mol Biol 2008; 17:607-20.
86. Mellroth P, Karlsson J, Steiner H. A scavenger function for a Drosophila peptidoglycan recognition protein. J Biol Chem 2003; 278:7059-64. (Pubitemid 36800702)
87. Ragan EJ. Immune-related protein complexes and serpin-1 isoforms in Manduca sexta plasma. PhD Dissertation, Kansas State University. 2008.
88. Sumathipala N. Expression, purification and characterization of peptidoglycan recognition protein 1 from Manduca sexta (L.). MS Thesis, Oklahoma State University. 2009.
89. Eleftherianos I, Marokhazi J, Millichap PJ et al. Prior infection of Manduca sexta with nonpathogenic Escherichia coli elicits immunity to pathogenic Photorhabdus luminescens: Roles of immune-related proteins shown by RNA interference. Insect Biochem Mol Biol 2006; 36:517-25. (Pubitemid 43766973)
90. Eleftherianos I, Millichap PJ, ffrench-Constant RH et al. RNAi suppression of recognition protein mediated immune responses in the tobacco hornworm Manduca sexta causes increased susceptibility to the insect pathogen Photorhabdus. Dev Comp Immunol 2006; 30:1099-107. (Pubitemid 44108150)
91. Royet J, Dziarski R. Peptidoglycan recognition proteins: Pleiotropic sensors and effectors of antimicrobial defences. Nat Rev Microbiol 2007; 5:264-77. (Pubitemid 46443603)
92. Charroux B, Rival T, Narbonne-Reveau K et al. Bacterial detection by Drosophilapeptidoglycan recognition proteins. Microbes Infect 2009; 11:631-636.
93. OchiaiM,AshidaM.A pattern-recognition protein for p-1,3-glucan: The binding domain and the cDN A cloning of p-1,3-glucan recognition protein from the silkworm, Bombyx mori. J Biol Chem 2000; 275:4995-5002. (Pubitemid 30108896)
94. Ma C, Kanost MR. A p-l,3-glucan recognition protein from an insect, Manduca sexta, agglutinates microorganisms and activates the phenoloxidase cascade. J Biol Chem 2000; 275:7505-14. (Pubitemid 30159646)
95. Jiang H, Ma C, Lu ZQ et al p-l,3-glucan recognition protein-2 (pGRP-2) from Manduca sexta: An acute-phase protein that binds p-l,3-glucan and lipoteichoic acid to aggregate fungi and bacteria and stimulate prophenoloxidase activation. Insect Biochem Mol Biol 2004; 34:89-100. (Pubitemid 38157615)
96. Fabrick JA, Baker JE, Kanost MR. cDNA cloning, purification, properties and function of abeta-l,3-glucan recognition protein from a pyralid moth, Plodia interpunctella. Insect Biochem Mol Biol 2003; 33:579-94. (Pubitemid 36720116)
97. Fabrick JA, Baker JE, Kanost MR. Innate immunity in a pyralid moth: Functional evaluation of domains from a p-l,3-glucan recognition protein. J Biol Chem 2004; 279:26605-11. (Pubitemid 38798817)
98. Takahasi K, Ochiai M, Horiuchi M et al. Solution structure of the silkworm pGRP/GNBP3 N-terminal domain reveals the mechanism for p-1,3-glucan-specific recognition. Proc Natl Acad Sci USA 2009; 106:11679-84.
99. Wang Y, Jiang H. Interaction of p-1,3-glucan with its recognition protein activates hemolymph proteinase 14, an initiation enzyme of the prophenoloxidase activation system in Manduca sexta. J Biol Chem 2006; 281:9271-8. (Pubitemid 43864642)
100. Wang Y, Jiang H. Binding properties of the regulatory domains in Manduca sexta hemolymph proteinase-14, an initiation enzyme of the prophenoloxidase activation system. Dev Comp Immunol 2010; 34:316-22.
101. Lee WJ, Lee JD, Kravchenko VV et al. Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Proc Natl Acad Sci USA 1996; 93:7888-93. (Pubitemid 26277134)
102. Pauchet Y, Freitak D, Heidel-Fischer HM et al. Immunity or digestion: Glucanase activity in a glucan-binding protein family from Lepidoptera. J Biol Chem 2009; 284:2214-24.
103. Vasta GR, Quesenberry M, Ahmed H et al. C-type lectins and galectins mediate innate and adaptive immune functions: Their roles in the complement activation pathway. Dev Comp Immunol 1999; 23,401-20. (Pubitemid 29309616)
104. Koizumi N, Morozumi A, Imamura M et al. Lipopolysaccharide-binding proteins and their involvement in the bacterial clearance from the hemolymph of the silkworm Bombyx mori. Eur J Biochem 1997; 248:217-24. (Pubitemid 27356991)
105. Koizumi N, Imai Y, Morozumi A et al. Lipopolysaccharide-binding protein of Bombyx mori participates in a hemocyte-mediated defense reaction against Gram-negative bacteria. J Insect Physiol 1999; 45:853-9. (Pubitemid 29359838)
106. Shin SW, Park DS, Kim SC et al. Two carbohydrate recognition domains of Hyphantria cunea lectin bind to bacterial lipopolysaccharides through O-specific chain. FEBS Lett 2000; 467:70-4. (Pubitemid 30069545)
107. Yu XQ, Gan H, Kanost MR. Immulectin, an inducible C-type lectin from an insect, Manduca sexta, stimulates activation of plasma prophenol oxidase. Insect Biochem Mol Biol 1999; 29:585-97. (Pubitemid 29336938)
108. Yu XQ, Kanost MR. Immulectin-2, a lipopolysaccharide-specific lectin from an insect, Manduca sexta, is induced in response to Gram-negative bacteria. J Biol Chem 2000; 275:37373-81. (Pubitemid 32004840)
109. Yu XQ, Tracy ME, Ling E et al. A novel C-type immulectin-3 from Manduca sexta is translocated from hemolymph into the cytoplasm of hemocytes. Insect Biochem Mol Biol 2005; 35:285-95. (Pubitemid 40335940)
110. Yu XQ, Ling E, Tracy ME et al. Immulectin-4 from the tobacco hornworm Manduca sexta binds to lipopolysaccharide and lipoteichoic acid. Insect Mol Biol 2006; 15:119-28.
111. Watanabe A, Miyazawa S, Kitami M et al. Characterization of a novel C-type lectin, Bombyx mori multibinding protein, from the B. mori hemolymph. J Immunol 2006; 177:4594-604.
112. Kim SR, Lee KS, Kim I et al. cDNA sequence of a novel immulectin homologue from the silkworm, Bombyx mori. Int J Indust Entomol 2003; 6:99-102.
113. Takase H, Watanabe A, Yoshizawa Y et al. Identification and comparative analysis of three novel C-type lectins from the silkworm with functional implications in pathogen recognition. Dev Comp Immunol 2009; 33:789-800.
114. Chai LQ, Tian YY, Yang DT et al. Molecular cloning and characterization of a C-type lectin from the cotton bollworm, Helicoverpa armigera. Dev Comp Immunol 2008; 32:71-83.
115. Zou Z, Evans J, Lu Z et al. Comparative genome analysis of the Tribolium immune system. Genome Biol2007; 8:R177.
116. Yu XQ, Kanost MR. Manduca sexta lipopolysaccharide-specific immulectin-2 protects larvae from bacterial infection. Dev Comp Immunol 2003; 27:189-96. (Pubitemid 36184619)
117. Yu XQ, Kanost MR. Immulectin-2, a pattern recognition receptor that stimulates hemocyte encapsulation and melanization in the tobacco hornworm, Manduca sexta. Dev Comp Immunol 2004; 28:891-900. (Pubitemid 38746429)
118. Ling E, Yu XQ. Cellular encapsulation and melanization are enhanced by immulectins, pattern recognition receptors from the tobacco hornworm Manduca sexta. Dev Comp Immunol 2006; 30:289-99. (Pubitemid 41571269)
119. Van der Horst DJ, Roosendaal SD, Rodenburg KW. Circulatory lipid transport: Lipoprotein assembly and function from an evolutionary perspective. Mol Cell Biochem. 2009; 326:105-19.
120. Li D, Scherfer C, Korayem AM et al. Insect hemolymph clotting: Evidence for interaction between the coagulation system and the prophenoloxidase activating cascade. Insect Biochem Mol Biol 2002; 32:919-28. (Pubitemid 34753295)
121. Ma G, Hay D, Li D et al. Recognition and inactivation of LPS by lipophorin particles. Dev Comp Immunol 2006; 30:619-26.
122. Rahman MM, Ma G, Roberts HL et al. Cell-free immune reactions in insects. J Insect Physiol 2006; 52:754-62. (Pubitemid 43927803)
123. Kato Y, Motoi Y, Taniai K et al. Lipopolysaccharide-lipophorin complex formation in insect hemolymph: A common pathway of lipopolysaccharide detoxification both in insects and in mammals. Insect Biochem Mol Biol 1994; 24:547-55. (Pubitemid 2090290)
124. Dunphy G, Halwani A. Haemolymph proteins of larvae of Galleria mellonella detoxify endotoxins of the insect pathogenic bacteria Xenhorabdus nematophilus (Enterobacteriaceae). J Insect Physiol 1997; 43:1023-9. (Pubitemid 28010232)
125. Halwani AE, Niven DF, Dunphy GB. Apolipophorin-III and the interactions of lipoteichoic acids with the immediate immune responses of Galleria mellonella. J Invertebr Pathol 2000; 76:233-41. (Pubitemid 32045035)
126. Pratt CC, Weers PM. Lipopolysaccharide binding of an exchangeable apolipoprotein, apolipophorin III, from Galleria mellonella. Biol Chem 2004; 385:1113-9. (Pubitemid 39600322)
127. Kim HJ, Je HJ, Park SY et al. Immune activation of apolipophorin-III and its distribution in hemocyte from Hyphantria cunea. Insect Biochem Mol Biol 2004; 34:1011-23. (Pubitemid 39308546)
128. Leon LJ, Idangodage H, Wan CP et al. Apolipophorin III: Lipopolysaccharide binding requires helix bundle opening. Biochem Biophys Res Commun 2006; 348:1328-33. (Pubitemid 44291347)
129. Weisner A, Losen S, Kopacek P et al. Isolated apolipophorin III from Galleria mellonella stimulates the immune reaction of this insect. J Insect Physiol 1997; 43:383-91. (Pubitemid 27324693)
130. Halwani AE, Dunphy GB. Apolipophorin-III in Galleria mellonella potentiates hemolymph lytic activity. Dev Comp Immunol 1999; 23:563-70. (Pubitemid 29509746)
131. Iimura Y, Ishikawa H, Yamamoto K et al. Hemagglutinating properties of apolipophorin III from the hemolymph of Galleria mellonella larvae. Arch Insect Biochem Physiol 1998; 38:119-25. (Pubitemid 128681028)
132. Halwani AE, Niven DF, Dunphy GB. Apolipophorin-III in the greater wax moth, Galleria mellonella (Lepidoptera: Pyralidae). Arch Insect Biochem Physiol 2001; 48:135-43. (Pubitemid 33597327)
133. Whitten MM, Tew IF, Lee BL et al. A novel role for an insect apolipoprotein (apolipophorin III) in p-1,3-glucan pattern recognition and cellular encapsulation reactions. J Immunol 2004; 172:2177-85. (Pubitemid 38182364)
134. St. Leger RJ, Bidochka MJ, Roberts DW. Isoforms of the cuticle-degrading Pr1 proteinase and production of a metalloproteinase by Metarhizium anisopliae. Arch Biochem Biophys 1994; 313:1-7. (Pubitemid 24261082)
135. Fedhila S, Nel P, Lereclus D. The InhA2 metalloprotease of Bacillus thuringiensis strain 407 is required for pathogenicity in insects infected via the oral route. J Bacteriol. 2002; 184:3296-304. (Pubitemid 34568939)
136. Held KG, LaRock CN, D' Argenio D A et al. A metalloprotease secreted by the insect pathogen Photorhabdus luminescens induces melanization. Appl Environ Microbiol 2007; 73(23):7622-8.
137. Qazi SS, Khachatourians GG. Hydrated conidia of Metarhizium anisopliae release a family of metalloproteases. J Invertebr Pathol 2007; 95:48-59. (Pubitemid 46559956)
138. Griesch J, Wedde M, Vilcinskas A. Recognition and regulation of metalloproteinase activity in the haemolymph of Galleria mellonella: A new pathway mediating induction of humoral immune responses. Insect Biochem Mol Biol 2000; 30:461-72. (Pubitemid 30367030)
139. Altincicek B, Linder M, Linder D et al. Microbial metalloproteinases mediate sensing of invading pathogens and activate innate immune responses in the lepidopteran model host Galleria mellonella. Infect Immun 2007; 75:175-83. (Pubitemid 46047891)
140. Altincicek B, Berisha A, Mukherjee K et al. Identification of collagen IV derived danger/alarm signals in insect immunity by nanoLC-FTICRR MS. Biological Chemistry 2009; 390:1303-11.
141. Matzinger P. The danger model: A renewed sense of self. Science 2002; 296:301-05. (Pubitemid 34303674)
142. Vilcinskas A, Wedde M. Inhibition of Beauveria bassiana proteases and fungal development by inducible protease inhibitors in the haemolymph of Galleria mellonella larvae. Biocontrol Sci Technol 1997;7:591-601. (Pubitemid 28042849)
143. Clermont A, Wedde M, Seitz V et al. Cloning and expression of an inhibitor against microbial metalloproteinases from insects (IMPI) contributing to innate immunity. Biochem J 2004; 382:315-22. (Pubitemid 39141595)
144. Wedde M, Weise C, Nuck C et al. The insect metallo-proteinase inhibitor gene of the lepidopteran Galleria mellonella encodes two distinct inhibitors. Biol Chem 2007; 388:119-27. (Pubitemid 46090180)
145. Kim I, Kim SH, Lee YS et al. Immune stimulation in the silkworm, Bombyx mori L., by CpG oligodeoxy-nucleotides. Arch Insect Biochem Physiol 2004; 55:43-8. (Pubitemid 38592050)
146. Altincicek B, Stötzel S, Wygrecka M et al. Host-derived extracellular nucleic acids enhance innate immune responses, induce coagulation and prolong survival upon infection in insects. J Immunol 2008; 181:2705-12.
147. Lavine MD, Chen G, Strand MR. Immune challenge differentially affects transcript abundance of three antimicrobial peptides in hemocytes from the moth Pseudoplusia includens. Insect Biochem Mol Biol 2005; 35:1335-46. (Pubitemid 41606705)
148. Dunn PE, Bohnert TJ, Russell V. Regulation of antibacterial protein synthesis following infection and during metamorphosis of Manduca sexta. Ann N Y Acad Sci 1994; 712:117-30. (Pubitemid 24149570)
149. Gorman MJ, Kankanala P, Kanost MR. Bacterial challenge stimulates innate immune responses in extra-embryonic tissues of tobacco hornworm eggs. Insect Mol Biol 2004; 13:19-24. (Pubitemid 38237285)
150. Mohrig W, Messner B. Immunreaktionen bei Insekten. I. Lysozyme als grundlegender antibakterieller Faktor im humoralen Abwehrgeschehen. Biol Zentralbl 1968; 87:439-47.
151. Jolles J, Schoentgen F, Croizier G et al. Insect lysozymes from three species of Lepidoptera: Their structural relatedness to the C (chicken) type lysozyme. J Mol Evol 1979; 14:267-71.
152. Yu KH, Kim KN, Lee JH et al. Comparative study on characteristics of lysozymes from the hemolymph of three lepidopteran larvae, Galleria mellonella, Bombyx mori, Agrius convolvuli. Dev Comp Immunol 2002; 26:707-13. (Pubitemid 36157324)
153. Chapelle M, Girard PA, Cousserans F et al. Lysozymes and lysozyme-like proteins from the fall armyworm, Spodoptera frugiperda. Mol Immunol 2009; 47:261-9.
154. Wang WX, Wang YP, Deng XJ et al. Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis. J Insect Sci 2009; 9:17.
155. Vilcinskas A, Matha V. Effect of the entomopathogenic fungus Beauveria bassiana on humoral immune response of Galleria mellonella larvae (Lepidoptera: Pyralidae). Eur J Entomol 1997; 94:461-72. (Pubitemid 127556471)
156. Rao XJ, Ling E, Yu XQ. The role of lysozyme in the prophenoloxidase activation system of Manduca sexta: An in vitro approach. Dev Comp Immunol 2010; 34:264-71.
157. Hemmi H, Ishibashi J, Hara S et al. Solution structure of moricin, an antibacterial peptide, isolated from the silkworm Bombyx mori. FEBS Lett 2002; 518:33-8. (Pubitemid 34454959)
158. Dai H, Rayaprolu S, Gong Y et al. Solution structure, antibacterial activity and expression profile of Manduca sexta moricin. J Pept Sci 2008; 14:855-63.
159. Hara S, Yamakawa M. Moricin, a novel antibacterial peptide family isolated from the silkworm, Bombyx mori. Biochem J 1995; 310:651-56.
160. Brown S, Howard A, Kasprzak AB et al. The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella. Insect Biochem Mol Biol 2008; 38:201-12.
161. Kockum K, Faye I, Hofsten PV et al. Insect immunity. Isolation and sequence of two cDNA clones corresponding to acidic and basic attacins from Hyalophora cecropia. EMBO J 1984; 3:2071-75.
162. Axén A, Carlsson A, Engström A et al. Gloverin, an antibacterial protein from the immune hemolymph of Hyalophora pupae. Eur J Biochem 1997; 247:614-619. (Pubitemid 27308640)
163. Mrinal N, Nagaraju J. Intron loss is associated with gain of function in the evolution of the gloverin family of antibacterial genes in Bombyx mori. J Biol Chem 2008; 283:23376-87.
164. Kawaoka S, Katsuma S, Daimon T et al. Functional analysis of four Gloverin-like genes in the silkworm, Bombyx mori. Arch Insect Biochem Physiol 2008; 67:87-96. (Pubitemid 351220129)
165. Mackintosh JA, Gooley AA, Karuso PH et al. A gloverin-like antibacterial protein is synthesized in Helicoverpa armigera following bacterial challenge. Dev Comp Immunol 1998; 22:387-99. (Pubitemid 28317568)
166. Lundström A, Liu G, Kang D et al. Trichoplusia ni gloverin, an inducible immune gene encoding an antibacterial insect protein. Insect Biochem Mol Biol 2002; 32:795-801. (Pubitemid 34601761)
167. Seitz V, Clermont A, Wedde M et al. Identification of immunorelevant genes from greater wax moth (Galleria mellonella) by a subtractive hybridization approach. Dev Comp Immunol 2003; 27:207-15. (Pubitemid 36187449)
168. Wang Q, Liu Y, He HJ et al. Immune responses of Helicoverpa armigera to different kinds of pathogens. BMC Immunol 2010; 11:9.
169. Hara S, Yamakawa M. A novel antibacterial peptide family isolated from the silkworm, Bombyx mori. Biochem J 1995; 310:651-6.
170. Furukawa S, Taniai K, Ishibashi J et al. A novel member of lebocin gene family from the silkworm, Bombyx mori. Biochem Biophys Res Commun 1997; 238:769-74. (Pubitemid 27472650)
171. Liu G, Kang D, Steiner H. Trichoplusia ni lebocin, an inducible immune gene with a downstream insertion element. Biochem Biophys Res Commun 2000; 269:803-7. (Pubitemid 30440381)
172. Bao Y, Yamano Y, Morishima I. A novel lebocin-like gene from eri-silkworm, Samia cynthia ricini, that does not encode the antibacterial peptide lebocin. Comp Biochem Physiol B Biochem Mol Biol 2005; 140:127-31 (Pubitemid 40037896)
173. Rayaprolu S, Wang Y, Kanost MR et al. Functional analysis of four processing products from multiple precursors encoded by a lebocin-related gene from Manduca sexta. Dev Comp Immunol 2010; 34:638-47.
174. Bulet P, Stöcklin R, Menin L. Anti-microbial peptides: From invertebrates to vertebrates. Immunol Rev 2004; 198:169-84. (Pubitemid 38406943)
175. Lamberty M, Ades S, Uttenweiler-Joseph S et al. Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity. J Biol Chem 1999; 274:9320-6.
176. Lamberty M, Caille A, Landon C et al. Solution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activities. Biochemistry 2001; 40:11995-2003. (Pubitemid 32946541)
177. Mandrioli M, Bugli S, Saltini S et al. Molecular characterization of a defensin in the IZD-MB-0503 cell line derived from immunocytes of the insect Mamestra brassicae (Lepidoptera). Biol Cell 2003; 95:53-7. (Pubitemid 36621836)
178. Volkoff AN, Rocher J, d'Alencon E et al. Characterization and transcriptional profiles of three Spodoptera frugiperda genes encoding cysteine-rich peptides. A new class of defensin-like genes from lepidopteran insects? Gene 2003; 319:43-53. (Pubitemid 37346199)
179. Schuhmann B, Seitz, V, Vilcinskas A et al. Cloning and expression of gallerimycin, an antifungal peptide expressed in immune response by the greater wax moth, Galleria mellonella. Arch Insect Biochem Physiol 2003; 53:125-33. (Pubitemid 38592075)
180. Lee YS, Yun EK, Jang WS et al. Purification, cDNA cloning and expression of an insect defensin from the great wax moth, Galleria mellonella. Insect Mol Biol 2004; 13:65-72. (Pubitemid 38237289)
181. Seitz V, Clermont A, Wedde M et al. Identification of immunorelevant genes from greater wax moth (Galleria mellonella) by a subtractive hybridization approach. Dev Comp Immunol 2003; 27:207-15. (Pubitemid 36187449)
182. Girard P, Boublik Y, Wheat CW et al. X-tox: An atypical defensin derived family of immune-related proteins specific to Lepidoptera. Dev Comp Immunol 2008; 32:575-84. (Pubitemid 351172453)
183. Destoumieux-Garzon D, Brehelin M, Bulet P et al. Spodoptera frugiperda X-tox protein, an immune related defensin rosary, has lost the function of ancestral defensins. PLoS One 2009; 4(8):e6795.
184. Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Ann Rev Immunol 2007; 25:697-743. (Pubitemid 46697922)
185. Cheng TC, Zhang YL, Liu C et al. Identification and analysis of Toll-related genes in the domesticated silkworm, Bombyx mori. Dev Comp Immunol 2008; 32:464-75. (Pubitemid 351172443)
186. Ao JQ, Ling E, Yu XQ. A Toll receptor from Manduca sexta is in response to Escherichia coli infection. Mol Immunol 2008; 45:543-52. (Pubitemid 47332629)
187. Wang Y, Cheng T, Rayaprolu S et al. Proteolytic activation of pro-spätzle is required for the induced transcription of antimicrobial peptide genes in lepidopteran insects. Dev Comp Immunol 2007; 31:1002-12. (Pubitemid 47095006)
188. An C, Jiang H, Kanost MR. Proteolytic activation and function of the cytokine Spätzle in innate immune response of a lepidopteran insect, Manduca sexta. FEBS J 2010; 277:148-62.
189. An C, Ishibashi J, Ragan EJ et al. Functions of Manduca sexta hemolymph proteinases HP6 and HP8 in two innate immune pathways. J Biol Chem 2009; 284:19716-26.
190. Tanaka H, Yamamoto M, Moriyama Y et al. A novel Rel protein and shortened isoform that differentially regulate antibacterial peptide genes in the silkworm Bombyx mori. Biochim Biophys Acta 2005; 1730:10-21. (Pubitemid 41008608)
191. Tanaka H, Matsuki H, Furukawa S et al. Identification and functional analysis of Relish homologs in the silkworm, Bombyx mori. Biochim Biophys Acta 2007; 1769:559-68. (Pubitemid 47404658)
192. Tanaka H, Sagisaka A, Nakajima Y et al. Correlation of differential expression of silkworm antimicrobial peptide genes with different amounts of rel family proteins and their gene transcriptional activity. Biosci Biotechnol Biochem 2009; 73:599-606.
193. Furukawa S, Tanaka H, Ishibashi J et al. Functional characterization of a cactus homolog from the silkworm Bombyx mori. Biosci Biotechnol Biochem 2009; 73:2665-70.
194. Nappi AJ, Christensen BM. Melanogenesis and associated cytotoxic reactions: Applications to insect innate immunity. Insect Biochem Mol Biol 2005; 35:443-59. (Pubitemid 40440937)
195. Cerenius L, Lee BL, Söderhäll K. The proPO-system: Pros and cons for its role in invertebrate immunity. Trends Immunol 2008; 29:263-71.
196. Noguchi H, Tsuzuki S, Tanaka K et al. Isolation and characterization of a dopa decarboxylase cDNA and the induction of its expression by an insect cytokine, growth-blocking peptide in Pseudaletia separata. Insect Biochem Mol Biol 2003; 33:209-17. (Pubitemid 36154284)
197. Gorman MJ, An C, Kanost MR. Characterization of tyrosine hydroxylase from Manduca sexta. Insect Biochem Mol Biol 2007; 37:1327-37. (Pubitemid 47625986)
198. Hashimoto K, Yamano Y, Morishima I. Induction of tyrosine hydroxylase gene expression by bacteria in the fat body of eri-silkworm, Samia cynthia ricini. Comp Biochem Physiol B 2008; 149:501-6.
199. Zhao P, Li J, Wang Y et al. Broad-spectrum antimicrobial activity of the reactive compounds generated in vitro by Manduca sexta phenoloxidase. Insect Biochem Mol Biol 2007; 37:952-9. (Pubitemid 47187724)
200. Yasuhara Y, Koizumi Y, Katagiri C et al. Reexamination of properties of prophenoloxidase isolated from larval hemolymph of the silkworm Bombyx mori. Arch Biochem Biophys 1995; 320:14-23.
201. Jiang H, Wang Y, Ma C et al. Subunit composition of pro-phenol oxidase from Manduca sexta: Molecular cloning of subunit proPO-p1. Insect Biochem Mol Biol 1997; 27:835-50. (Pubitemid 28076513)
202. Burmester T. Origin and evolution of arthropod hemocyanins and related proteins. J Comp Physiol B 2002; 172:95-107. (Pubitemid 36064501)
203. Iwama R, Ashida M. Biosynthesis of prophenoloxidase in hemocytes of larval hemolymph of the silkworm, Bombyx mori. Insect Biochem 16:547-55.
204. Li Y, Wang Y, Jiang H et al. Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type-3 copper enzymes. Proc Natl Acad Sci USA 2009; 106:17001-5.
205. Krem MM, Di Cera E. Evolution of enzyme cascades from embryonic development to blood coagulation. Trends Biochem Sci 2002; 27:67-74. (Pubitemid 34164321)
206. Jiang H, Kanost MR. The clip-domain family of serine proteinases in arthropods. Insect Biochem Mol Biol 2000; 30:95-105. (Pubitemid 30096721)
207. Jiang H, Wang Y, Gu Y et al. Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph. Insect Biochem Mol Biol 2005; 35:931-43. (Pubitemid 41556955)
208. Jiang H, Wang Y, Kanost MR. Pro-phenol oxidase activating proteinase from an insect, Manduca sexta: A bacteria-inducible protein similar to Drosophila Easter. Proc Natl Acad Sci USA 1998; 95:12220-5. (Pubitemid 28483746)
209. Jiang H, Wang Y, Yu XQ et al. Prophenoloxidase-activating proteinase-2 from hemolymph of Manduca sexta. A bacteria-inducible serine proteinase containing two clip domains. J Biol Chem 2003; 278:3552-61. (Pubitemid 36801078)
210. Jiang H, Wang Y, Yu XQ et al. Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: A clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs. Insect Biochem Mol Biol 2003; 33:1049-60. (Pubitemid 37245063)
211. Gupta S, Wang Y, Jiang H. Purification and characterization of Manduca sexta prophenoloxidase -activating proteinase-1 (PAP-1), an enzyme involved in insect immune responses. Protein Exp Purif 2005a; 39:261-8. (Pubitemid 40084613)
212. Satoh D, Horii A, Ochiai M et al. Prophenoloxidase-activating enzyme of the silkworm, Bombyx mori: Purification, characterization and cDNA cloning. J Biol Chem 1999; 274:7441-53.
213. Huang R, Lu Z, Dai H et al. The solution structure of clip domains from Manduca sexta prophenoloxidase activating proteinase-2. Biochemistry 2007; 46:11431-9. (Pubitemid 47585489)
214. Yu XQ, Jiang H, Wang Y et al. Nonproteolytic serine proteinase homologs involved in phenoloxidase activation in the tobacco hornworm, Manduca sexta. Insect Biochem Mol Biol 2003; 33:197-208. (Pubitemid 36154283)
215. Wang Y, Jiang H. Prophenoloxidase (proPO) activation in Manduca sexta: An analysis of molecular interactions among proPO, proPO-activating proteinase-3 and a cofactor. Insect Biochem Mol Biol 2004; 34:731-42. (Pubitemid 38946540)
216. Gupta S, Wang Y, Jiang H. Manduca sexta prophenoloxidase (proPO) activation requires proPO-activating proteinase (PAP) and serine proteinase homologs (SPHs) simultaneously. Insect Biochem Mol Biol 2005; 35:241-8. (Pubitemid 40199581)
217. Ji C, Wang Y, Guo X et al. A pattern recognition serine proteinase triggers the prophenoloxidase activation cascade in the tobacco hornworm, Manduca sexta. J Biol Chem 2004; 279:34101-6. (Pubitemid 39318031)
218. Buchon N, Poidevin M, Kwon HM et al. A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proc Natl Acad Sci USA 2009; 106:12442-7.
219. Roh KB, Kim CH, Lee H et al. Proteolytic cascade for the activation of the insect toll pathway induced by the fungal cell wall component. J Biol Chem 2009; 284:19474-81.
220. Wang Y, Jiang H. Reconstitution of a branch of the Manduca sexta prophenoloxidase activation cascade in vitro: Snake-like hemolymph proteinase 21 (HP21) cleaved by HP 14 activates prophenoloxidase-activating proteinase-2 precursor. Insect Biochem Mol Biol 2007; 37:1015-25. (Pubitemid 47333361)
221. Gorman MJ, Wang Y, Jiang H et al. Manduca sexta hemolymph proteinase 21 activates prophenoloxidase-activating proteinase 3 in an insect innate immune response proteinase cascade. J Biol Chem 2007b; 282:11742-9. (Pubitemid 47100681)
222. Wang Y, Jiang H. A positive feedback mechanism in the Manduca sexta prophenoloxidase activation system. Insect Biochem Mol Biol 2008; 38:763-9.
223. Kanost MR. Serine proteinase inhibitors in arthropod immunity. Dev Comp Immunol 1999; 23:291-301. (Pubitemid 29309608)
224. Gettins PG. Serpin structure, mechanism and function. Chem Rev 2002; 102:4751-804.
225. Sasaki T, Kobayashi K. Isolation of two novel proteinase inhibitors from hemolymph of silkworm larva, Bombyx mori: Comparison with human serum proteinase inhibitors. J Biochem 1984; 95:1009-17.
226. Sasaki T. Patchwork-structure serpins from silkworm (Bombyx mori) larval hemolymph. Eur J Biochem 1991; 202:255-61.
227. Jiang H, Kanost MR. Characterization and functional analysis of 12 naturally occurring reactive site variants of serpin-1 from Manduca sexta. J Biol Chem 1997; 272:1082-7. (Pubitemid 27034602)
228. Gan H, Wang Y, Jiang H et al. A bacteria-induced, intracellular serpin in granular hemocytes of Manduca sexta. Insect Biochem Mol Biol 2001; 31:887-98. (Pubitemid 32666596)
229. Zhu Y, Wang Y, Gorman MJ et al. Manduca sexta serpin-3 regulates prophenoloxidase activation in response to infection by inhibiting prophenoloxidase-activating proteinases. J Biol Chem 2003b; 278:46556-64. (Pubitemid 37452229)
230. Tong Y, Kanost MR. Manduca sexta serpin-4 and serpin-5 inhibit the prophenol oxidase activation pathway: CDNA cloning, protein expression and characterization. J Biol Chem 2005; 280:14923-31. (Pubitemid 40562843)
231. Tong Y, Jiang H, Kanost MR. Identification of plasma proteases inhibited by Manduca sexta serpin-4 and serpin-5 and their association with components of the prophenol oxidase activation pathway. J Biol Chem 2005; 280:14932-42. (Pubitemid 40562844)
232. Wang Y, Jiang H. Purification and characterization of Manduca sexta serpin-6: A serine proteinase inhibitor that selectively inhibits prophenoloxidase-activating proteinase-3. Insect Biochem Mol Biol 2004; 34, 387-95. (Pubitemid 38431049)
233. Cherqui A, Cruz N, Simoes N. Purification and characterization of two serine protease inhibitors from the hemolymph of Mythimna unipuncta. Insect Biochem Mol Biol 2001; 31:761-9. (Pubitemid 32587298)
234. Chamankhah M, Braun L, Visal-Shah S et al. Mamestra configurata serpin-1 homologs: Cloning, localization and developmental regulation. Insect Biochem Mol Biol 2003; 33:355-69. (Pubitemid 36280557)
235. Zou Z, Zhao P, Weng H et al. A comparative analysis of serpin genes in the silkworm genome. Genomics 2009; 93:367-75.
236. Kanost MR. Serpins in a Lepidopteran insect, Manduca sexta. In: Silverman GA, Lomas DA eds. The Serpinopathies: Molecular and Cellular Aspects of Serpins and their Disorders. Hackensack, NJ: World Scientific Publishing. 2007:229-42.
237. Jiang H, Wang Y, Kanost MR. Mutually exclusive exon use and reactive center diversity in insect serpins. J Biol Chem 1994; 269:55-8. (Pubitemid 24026621)
238. Jiang H, Wang Y, Huang Y et al. Organization of serpin gene-1 from Manduca sexta: Evolution of a family of alternate exons encoding the reactive site loop. J Biol Chem 1996; 271:28017-23. (Pubitemid 26374605)
239. Hegedus DD, Erlandson M, Baldwin D et al. Differential expansion and evolution of the exon family encoding the Serpin-1 reactive centre loop has resulted in divergent serpin repertoires among the Lepidoptera. Gene 2008; 418:15-21.
240. Zheng YP, He WY, Béliveau C et al. Cloning, expression and characterization of four serpin-1 cDNA variants from the spruce budworm, Choristoneura fumiferana. Comp Biochem Physiol B Biochem Mol Biol 2009; 154:165-73.
241. Krüger O, Ladewig J, Köster K et al. Widespread occurrence of serpin genes with multiple reactive centre-containing exon cassettes in insects and nematodes. Gene 2002; 29:97-105. (Pubitemid 34876465)
242. ZouZ, Jiang H. Manduca sexta serpin-6 regulates immune serine proteinases PAP-3 and HP8. cDNA cloning, protein expression, inhibition kinetics and function elucidation. J Biol Chem 2005; 280:14341-8.
243. Freitak D, Wheat CW, Heckel DG et al. Immune system responses and fitness costs associated with consumption of bacteria in larvae of Trichoplusia ni. BMC Biol 2007; 5:56.
244. Freitak D, Heckel DG, Vogel H. Bacterial feeding induces changes in immune-related gene expression and has trans-generational impacts in the cabbage looper (Trichoplusia ni). Front Zool 2009a; 6:7.
245. Strand MR. Insect hemocytes and their role in immunity. In: Beckage, NE, ed. Insect Immunology. San Diego, CA: Academic Press. 2008:25-47.
246. St. LegerRJ, Charnley AK, Cooper RM. Cuticle-degrading enzymes of entomopathogenic fungi: Synthesis in culture on cuticle. J Invertebr Pathol 1986; 48:85-95.
247. Vilcinskas A, Matha V, Götz P. Effects of the entomopathogenic fungus Metarhizium anisopliae and its secondary metabolites on morphology and cy toskeleton of plasmatocy tes isolated from Galleria mellonella. J Insect Physiol 1997; 43:1149-59. (Pubitemid 28058860)
248. Vilcinskas A, Götz P. Parasitic fungi and their interactions with the insect immune system. Adv Parasitol 1999; 43:267-13.
249. Fiolka MJ. Immunosuppressive effect of cyclosporin A on insect humoral immune response. J Invertebr Pathol 2008; 98:287-92.
250. Gillespie J, Bailey A, Cobb B et al. Fungal elicitors of insect immune responses. Arch Insect Biochem Physiol 2000; 44:49-68.
251. Lord JC, Anderson S, Stanley DW. Eicosanoids mediate Manduca sexta cellular response to the fung pathogen Beauveria bassiana: A role for the lipoxygenase pathway. Arch Insect Biochem Physiol 200 51:46-54.
252. Bergin D, Reeves E, Renwick J et al. Superoxide production in Galleria mellonella hemocytes: Identificati of proteins homologous to the NADPH oxidase complex of human neutrophils. Infect Immun 200 73:4161-4170.
253. Ekengren S, Hultmark D. Drosophila cecropin as an antifungal agent. Insect Biochem Mol Biol 1999 29(11):965-72. (Pubitemid 29510663)
254. Langen G, Imani J, Altincicek B et al. Transgenic expression of gallerimycin, a novel antifungal inse defensin from the greater wax moth Galleria mellonella, confers resistance against pathogenic fungi tobacco. Biol Chem 2006; 387:549-57. (Pubitemid 44071457)
255. Wojda I, Kowalski P, Jakubowicz T. Humoral immune response of Galleria mellonella larvae after infecti by Beauveria bassiana under optimal and heat-shock conditions. J Insect Physiol 2009; 55:525-31.
256. Schmidt O. Insect immune recognition and suppression. In: Beckage, NE, ed. Insect Immunology. S Diego, CA: Academic Press. 2008; 271-294.
257. Clarke DJ. Photorhabdus: A model for the analysis of pathogenicity and mutualism. Cell Microbiol 200 10:2159-67.
258. Beckage NE. Parasitoid polydnaviruses and insect immunity. In: Beckage, NE, ed. Insect Immunolog San Diego, CA: Academic Press. 2008; 243-270.
259. Suderman RJ, Pruijssers AJ, Strand MR. Protein tyrosine phosphatase-H2 from a polydnavirus induc apoptosis of insect cells. J Gen Virol 2008; 89:1411-20.
260. Thoetkiattikul H, Beck MH, Strand MR. Inhibitor kappaB-like proteins from a polydnavirus inhi NF-kappaB activation and suppress the insect immune response. Proc Natl Acad Sci USA 200 102:11426-31.
261. LuZ,BeckMH, Wang Yet al. The viral proteinEgf1. 0isadualactivityinhibitorofprophenoloxidase-activati proteinases 1 and 3 from Manduca sexta. J Biol Chem 2008; 283:21325-33.
262. Sparks WO, Bartholomay LC, Bonning BC. Insect immunity to viruses. Beckage, NE Parasitoid polydnaviruses andinsect immunity. In: Beckage, NE, ed. Insect Immunology. San Diego, CA: Academ Press. 2008; 209242-270.
263. Clem RJ. Baculoviruses and apoptosis: A diversity of genes and responses. Curr Drug Targets 200 8:1069-74.
264. Shelby KS, Popham HJ. Plasma phenoloxidase of the larval tobacco budworm, Heliothis virescens, virucidal. J Insect Sci 2006; 6:1-12.