Proteolytic activation of pro-spätzle is required for the induced transcription of antimicrobial peptide genes in lepidopteran insects

Developmental and Comparative Immunology

Volumn 31, Issue 10, 2007, Pages 1002-1012

  Wang, Yang ^a   Cheng, Tingcai ^b   Rayaprolu, Subrahmanyam ^a   Zou, Zhen ^a   Xia, Qingyou ^b   Xiang, Zhonghuai ^b   Jiang, Haobo ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

^b SOUTHWEST UNIVERSITY   (China)

Author keywords

Bombyx mori; Cytokine processing; Gene regulation; Hemolymph protein; Insect immunity; M. sexta; Serine proteinase; Signal transduction

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; HYBRID PROTEIN; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT; SPATZLE 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DENATURATION; ESCHERICHIA COLI; FEMALE; GENE OVEREXPRESSION; GENE STRUCTURE; GENETIC TRANSCRIPTION; INSECT; LARVA; LEPIDOPTERA; MALE; MANDUCA SEXTA; MOLECULAR CLONING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; SILKWORM; TRANSCRIPTION INITIATION; UPREGULATION;

BOMBYX MORI; ESCHERICHIA COLI; HEXAPODA; MANDUCA SEXTA; MICROCOCCUS LUTEUS;

EID: 34447648523     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2007.01.001     Document Type: Article

References (20)

1. Morisato D., and Anderson K.V. Signaling pathways that establish the dorsal-ventral pattern of Drosophila embryo. Ann Rev Genet 29 (1995) 371-399
2. Wang L., and Ligoxygakis P. Pathogen recognition and signaling in the Drosophila innate immune response. Immunobiology 211 4 (2006) 251-261
3. Moussian B., and Roth S. Dorsoventral axis formation in the Drosophila embryo-shaping and transducing a morphogen gradient. Curr Biol 15 21 (2005) R887-R899
4. Ligoxygakis P., Pelte N., Hoffmann J.A., and Reichhart J.M. Activation of Drosophila toll during fungal infection by a blood serine protease. Science 297 5578 (2002) 114-116
5. Jang I.H., Chosa N., Kim S.H., Nam H.J., Lemaitre B., Ochiai M., et al. A spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Dev Cell 10 1 (2006) 45-55
6. Mulinari S., Hacker U., and Castillejo-Lopez C. Expression and regulation of spätzle-processing enzyme in Drosophila. FEBS Lett 580 22 (2006) 5406-5410
7. Kambris Z., Brun S., Jang I.H., Nam H.J., Romeo Y., Takahashi K., et al. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for toll activation. Curr Biol 16 8 (2006) 808-813
8. Xia Q., Zhou Z., Lu C., Cheng D., Dai F., Li B., et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science 306 5703 (2004) 1937-1940
9. Dunn P., and Drake D. Fate of bacteria injected into naïve and immunized larvae of the tobacco hornworm, M. sexta. J Invert Pathol 41 (1983) 77-85
10. Cheng T., Zhao P., Liu C., Xu P., Gao Z., Xia Q., et al. Structures, regulatory regions, and inductive expression patterns of antimicrobial peptide genes in the silkworm Bombyx mori. Genomics 87 3 (2006) 356-365
11. Lee E., Linder M.E., and Gilman A. Expression of G-protein alpha subunits in E. coli. Meth Enzymol 237 (1994) 146-164
12. Jiang H., Wang Y., Yu X.Q., and Kanost M.R. Prophenoloxidase-activating proteinase-2 from hemolymph of M. sexta. A bacteria-inducible serine proteinase containing two clip domains. J Biol Chem 278 6 (2003) 3552-3561
13. Wang Y., and Jiang H. Prophenoloxidase (proPO) activation in M. sexta: an analysis of molecular interactions among proPO, proPO-activating proteinase-3, and a cofactor. Insect Biochem Mol Biol 34 8 (2004) 731-742
14. Cherbas L., and Cherbas P. The arthropod initiator: the capsite consensus plays an important role in transcription. Insect Biochem Mol Biol 23 1 (1993) 81-90
15. Hultmark D. Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet 9 5 (1993) 178-183
16. DeLotto Y., and DeLotto R. Proteolytic processing of the Drosophila spätzle protein by easter generates a dimeric NGF-like molecule with ventralizing activity. Mech Dev 72 1-2 (1998) 141-148
17. Weber A.N., Moncrieffe M.C., Gangloff M., Imler J.L., and Gay N.J. Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila Toll pathway. J Biol Chem 280 24 (2005) 22793-22799
18. Zhu Y., Johnson T.J., Myers A.A., and Kanost M.R. Identification by subtractive suppression hybridization of bacteria-induced genes expressed in M. sexta fat body. Insect Biochem Mol Biol 33 5 (2003) 541-559
19. Christophides G.K., Zdobnov E., Barillas-Mury C., Birney E., Blandin S., Blass C., et al. Immunity-related genes and gene families in Anopheles gambiae. Science 298 5591 (2002) 159-165
20. Evans J., Aronstein K., Chen Y.P., Hetru C., Imler J.L., Jiang H., et al. Immune pathways and defense mechanisms in the honey bee, Apis mellifera. Insect Mol Biol 15 5 (2006) 645-656