Prophenoloxidase (proPO) activation in Manduca sexta: An analysis of molecular interactions among proPO, proPO-activating proteinase-3, and a cofactor

Insect Biochemistry and Molecular Biology

Volumn 34, Issue 8, 2004, Pages 731-742

  Wang, Yang ^a   Jiang, Haobo ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Clip domain; Hemolymph; Insect immunity; Melanization; PAP, proPO activating proteinase; PPAE, proPO activating enzyme; proPO and PO, prophenoloxidase and phenoloxidase; Serine proteinase; Serine proteinase homolog; SPH, serine proteinase homolog

Indexed keywords

CATECHOL OXIDASE; ENZYME PRECURSOR; PRO PHENOL OXIDASE ACTIVATING PROTEINASE; PRO PHENOLOXIDASE; PRO-PHENOL OXIDASE ACTIVATING PROTEINASE; PRO-PHENOLOXIDASE; SERINE PROTEINASE;

ANIMAL; ARTICLE; CHEMISTRY; COENZYME; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYMOLOGY; HEMOLYMPH; ISOLATION AND PURIFICATION; KINETICS; LEPIDOPTERA; METABOLISM; PROTEIN BINDING; SEQUENCE HOMOLOGY;

ANIMALS; CATECHOL OXIDASE; COENZYMES; ENZYME ACTIVATION; ENZYME PRECURSORS; HEMOLYMPH; KINETICS; MANDUCA; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY;

INSECTA; MANDUCA SEXTA; NICOTIANA TABACUM;

EID: 3242719716     PISSN: 09651748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ibmb.2004.03.008     Document Type: Article

References (21)

1. Ashida M., Brey P.T. Recent advances on the research of the insect prophenoloxidase cascade. Brey P.T., Hultmark D. Molecular Mechanisms of Immune Responses in Insects. 1998;135-172 Chapman & Hall, London
2. Dunn P., Drake D. Fate of bacteria injected into naive and immunized larvae of the tobacco hornworm, Manduca sexta. J. Invertebr. Pathol. 41:1983;77-85
3. Gillespie J.P., Kanost M.R., Trenczek T. Biological mediators of insect immunity. Ann. Rev. Entomol. 42:1997;611-643
4. Ji C., Wang Y., Ross J., Jiang H. Expression and in vitro activation of Manduca sexta prophenoloxidase-activating proteinase-2 precursor (proPAP-2) from baculovirus-infected insect cells. Protein Express. Purif. 29:2003;235-243
5. Jiang H., Kanost M.R. The clip-domain family of serine proteinases in arthropods. Insect Biochem. Mol. Biol. 30:2000;95-105
6. Jiang H., Wang Y., Ma C., Kanost M.R. Subunit composition of pro-phenol oxidase from Manduca sexta: molecular cloning of subunit proPO-p1. Insect Biochem. Mol. Biol. 27:1997;835-850
7. Jiang H., Wang Y., Kanost M.R. Pro-phenol oxidase activating proteinase from an insect, Manduca sexta: a bacteria-inducible protein similar to Drosophila easter. Proc. Natl. Acad. Sci. USA. 95:1998;12220-12225
8. Jiang H., Wang Y., Yu X.-Q., Kanost M.R. Prophenoloxidase-activating proteinase-2 (PAP-2) from hemolymph of Manduca sexta: a bacteria-inducible serine proteinase containing two clip domains. J. Biol. Chem. 278:2003a;3552
9. Jiang H., Wang Y., Yu X.-Q., Zhu Y., Kanost M.R. Prophenoloxidase- activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs. Insect Biochem. Mol. Biol. 33:2003b;1049-1060
10. Kanost M.R., Jiang H., Wang Y., Yu X., Ma C., Zhu Y. Hemolymph proteinases in immune responses of Manduca sexta. Beck G., Sugumaran M., Cooper E. Phylogenetic Perspective of the Vertebrate Immune System. Adv. Exp. Med. Biol. 484:2001;319-328 Plenum, New York
11. Kim M.S., Baek M.J., Lee M.H., Park J.W., Lee S.Y., Söderhäll K., Lee B.L. A new easter-type serine protease cleaves a masquerade-like protein during prophenoloxidase activation in Holotrichia diomphalia larvae. J. Biol. Chem. 277:2002;39999-40004
12. Lavine M.D., Strand M.R. Insect hemocytes and their role in immunity. Insect Biochem. Mol. Biol. 32:2002;1295-1309
13. Lee S.Y., Kwon T.H., Hyun J.H., Choi J.S., Kawabata S., Iwanaga S., Lee B.L. In vitro activation of pro-phenol-oxidase by two kinds of pro-phenol-oxidase-activating factors isolated from hemolymph of coleopteran, Holotrichia diomphalia larvae. Eur. J. Biochem. 254:1998;50-57
14. 2+ in coleopteran and Tenebrio molitor larvae. Eur J. Biochem. 269:2002;4375-4383
15. Nappi A.J., Vass E. Cytotoxic reactions associated with insect immunity. Beck G., Sugumaran M., Cooper E. Phylogenetic Perspective of the Vertebrate Immune System. Adv. Exp. Med. Biol. 484:2001;329-348 Plenum, New York
16. Satoh D., Horii A., Ochiai M., Ashida M. Prophenoloxidase-activating enzyme of the silkworm, Bombyx mori: purification, characterization and cDNA cloning. J. Biol. Chem. 274:1999;7441-7453
17. Söderhäll K., Cerenius L. Role of the prophenoloxidase- activating system in invertebrate immunity. Curr. Opin. Immunol. 10:1998;23-28
18. Sugumaran M. Roles of the insect cuticle in immunity. Söderhäll K., Iwanaga S., Vasta G.R. New Directions in Invertebrate Immunology. 1996;355-374 SOS Publications, Fair Haven, NJ
19. Wang R., Lee S.Y., Cerenius L., Söderhäll K. Properties of the prophenoloxidase activating enzyme of the freshwater crayfish, Pacifastacus leniusculus. Eur. J. Biochem. 268:2001;895-902
20. Yu X., Kanost M.R. Immulectin-2, a lipopolysaccharide-specific lectin from an insect, Manduca sexta, is induced in response to gram-negative bacteria. J. Biol. Chem. 275:2000;37373-37381
21. Yu X., Jiang H., Wang Y., Kanost M.R. Nonproteolytic serine proteinase homologs are involved in phenoloxidase activation in the tobacco hornworm, Manduca sexta. Insect Biochem. Mol. Biol. 33:2003;197-208