Irving Page Lecture: 5-HT2A serotonin receptor biology: Interacting proteins, kinases and paradoxical regulation

Neuropharmacology

Volumn 61, Issue 3, 2011, Pages 348-354

  Roth, Bryan L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Antipsychotic; Caveolin; Functional selectivity; PDZ domain; Psychoactive; RSK2

Indexed keywords

AMPHETAMINE DERIVATIVE; ARACHIDONIC ACID; CAVEOLIN 1; CYCLIC AMP; DISC LARGE TUMOR SUPPRESSOR; EPLIVANSERIN; ESMIRTAZAPINE; G PROTEIN COUPLED RECEPTOR; GLEMANSERIN; KETANSERIN H 3; LYSERGIDE; NITRIC OXIDE; PHOSPHOLIPASE C; PIMAVANSERIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN ZO1; RADIOLIGAND; RETINA S ANTIGEN; S6 KINASE; SEROTONIN 2A RECEPTOR; SR 46349 B; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VOLINANSERIN; ALPHA 1 ADRENERGIC RECEPTOR; BINDING PROTEIN; ERGOLINE DERIVATIVE; LYSERGIDE H 3; PDZ PROTEIN; PROTEIN KINASE; PROTEIN KINASE C; PSYCHEDELIC AGENT; RECEPTOR INTERACTING PROTEIN; SEROTONIN 2C RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SPIPERONE H 3; TETRABENAZINE; TRYPTAMINE DERIVATIVE; UNINDEXED DRUG; VESICULAR MONOAMINE TRANSPORTER;

AMYGDALOID NUCLEUS; BINDING AFFINITY; BRAIN CORTEX; CELLULAR DISTRIBUTION; CORPUS STRIATUM; DRUG RECEPTOR BINDING; FATTY ACID SYNTHESIS; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS; LIGAND BINDING; NONHUMAN; NUCLEUS ACCUMBENS; OLFACTORY BULB; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PYRAMIDAL NERVE CELL; REVIEW; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CHEMICAL LABELING; CONFERENCE PAPER; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME REGULATION; GENE DELETION; HYPERALGESIA; INSOMNIA; ISOTOPE LABELING; MOLECULAR CLONING; NEUROPATHIC PAIN; PROTEIN ANALYSIS; PROTEIN INTERACTION; PSYCHOSIS; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM;

ANIMALS; HUMANS; NERVE TISSUE PROTEINS; NEURONS; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN 5-HT2 RECEPTOR AGONISTS; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; SIGNAL TRANSDUCTION;

EID: 79958152707     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.01.012     Document Type: Review

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100. B.L. Roth, D.L. Willins, K. Kristiansen, and W.K. Kroeze 5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5- hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function Pharmacol. Ther. 79 1998 231 257 (Pubitemid 28393877)
101. B.L. Roth, D.J. Sheffler, and W.K. Kroeze Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia Nat. Rev. Drug. Discov. 3 2004 353 359 (Pubitemid 38499762)
102. C.L. Schmid, K.M. Raehal, and L.M. Bohn Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo Proc. Natl. Acad. Sci. U S A 105 2008 1079 1084 (Pubitemid 351282084)
103. R. Schulz, M. Wuster, and A. Herz Supersensitivity to opioids following the chronic blockade of endorphin action by naloxone Naunyn Schmiedebergs Arch. Pharmacol. 306 1979 93 96 (Pubitemid 10236247)
104. M.R. Seggal, D. Qureshi, and R.A. Glennon Effect of 5-HT2-selective agonists on cat platelet aggregation Life Sci. 41 1987 1077 1081 (Pubitemid 17125224)
105. D.J. Sheffler, W.K. Kroeze, B.G. Garcia, A.Y. Deutch, S.J. Hufeisen, P. Leahy, J.C. Bruning, and B.L. Roth p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling Proc. Natl. Acad. Sci. U S A 103 2006 4717 4722
106. B. Sommer, L.M. Montano, V. Carbajal, E. Flores-Soto, A. Ortega, R. Ramirez-Oseguera, C. Irles, A.F. El-Yazbi, W.J. Cho, and E.E. Daniel Extraction of membrane cholesterol disrupts caveolae and impairs serotonergic (5-HT2A) and histaminergic (H1) responses in bovine airway smooth muscle: role of Rho-kinase Can. J. Physiol. Pharmacol. 87 2009 180 195
107. R.T. Strachan, D.J. Sheffler, B. Willard, M. Kinter, J.G. Kiselar, and B.L. Roth Ribosomal S6 kinase 2 directly phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling J. Biol. Chem. 284 2009 5557 5573
108. R.T. Strachan, J.A. Allen, D.J. Sheffler, and B.L. Roth p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling Biochemistry 49 2010 2657 2671
109. R.T. Strachan, N. Sciaky, M.R. Cronan, W.K. Kroeze, and B.L. Roth Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity Mol. Pharmacol. 77 2010 327 338
110. M. Teitler, S. Leonhardt, E.L. Weisberg, and B.J. Hoffman 4-[125I]-(2,5-dimethoxy)phenylisopropylamine and [3H]-ketanserin labeling of 5-hydroxytryptamine2 (5HT2) receptors in mammalian cells transfected witha rat 5HT2 cDNA: evidence for multiple states and not multiple 5HT2 receptor subtypes Mol. Pharmacol. 38 1990 594 598
111. M. Titeler, R.A. Lyon, and R.A. Glennon Radioligand binding evidence implicates the brain 5-HT2 receptor as a site-of-action for LSD and phenylisopropylamine hallucinogens Psychopharmacology 94 1988 213 216 (Pubitemid 18040697)
112. F. Touri, E. Welker, and B.M. Riederer Differential distribution of MAP1A isoforms in the adult mouse barrel cortex and comparison with the serotonin 5-HT2A receptor J. Chem. Neuroanat. 27 2004 99 108 (Pubitemid 38581105)
113. J.D. Urban, W.P. Clarke, M. von Zastrow, D.E. Nichols, B. Kobilka, H. Weinstein, J.A. Javitch, B.L. Roth, A. Christopoulos, P.M. Sexton, K.J. Miller, M. Spedding, and R.B. Mailman Functional selectivity and classical concepts of quantitative pharmacology J. Pharmacol. Exp. Ther. 320 2007 1 13 (Pubitemid 46025713)
114. T. Walsh, J.M. McClellan, S.E. McCarthy, A.M. Addington, S.B. Pierce, G.M. Cooper, A.S. Nord, M. Kusenda, D. Malhotra, A. Bhandari, S.M. Stray, C.F. Rippey, P. Roccanova, V. Makarov, B. Lakshmi, R.L. Findling, L. Sikich, T. Stromberg, B. Merriman, N. Gogtay, P. Butler, K. Eckstrand, L. Noory, P. Gochman, R. Long, Z. Chen, S. Davis, C. Baker, E.E. Eichler, P.S. Meltzer, S.F. Nelson, A.B. Singleton, M.K. Lee, J.L. Rapoport, M.C. King, and J. Sebat Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia Science 320 2008 539 543 (Pubitemid 351590668)
115. E.T. Weber, and R. Andrade Htr2a gene and 5-HT(2A) receptor expression in the cerebral cortex studied using genetically modified mice Front Neurosci 4 2010
116. D. Willins, A. Deutch, and B. Roth Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex Synapse 27 1997 79 82 (Pubitemid 27327604)
117. D.L. Willins, L. Alsayegh, S.A. Berry, J.R. Backstrom, E. Sanders-Bush, L. Friedman, N. Khan, and B.L. Roth Serotonergic antagonist effects on trafficking of serotonin 5-HT2A receptors in vitro and in vivo Ann. N. Y. Acad. Sci. 861 1998 121 127 (Pubitemid 29047708)
118. D. Willins, S. Berry, L. Alsayegh, J. Backstrom, E. Sanders-Bush, and B. Roth Clozapine and other 5-hydroxytryptamine2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine2A receptors in vitro and in vivo Neurosci 91 1999 599 606 (Pubitemid 29193269)
119. Z. Xia, J.A. Gray, B.A. Compton-Toth, and B.L. Roth A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction J. Biol. Chem. 278 2003 21901 21908 (Pubitemid 36792597)
120. Z. Xia, S.J. Hufeisen, J.A. Gray, and B.L. Roth The PDZ-binding domain is essential for the dendritic targeting of 5-HT(2A) serotonin receptors in cortical pyramidal neurons in vitro Neuroscience 122 2003 907 920 (Pubitemid 37485844)
121. R.S. Zukin, J.R. Sugarman, M.L. Fitz-Syage, E.L. Gardner, S.R. Zukin, and A.R. Gintzler Naltrexone-induced opiate receptor supersensitivity Brain Res. 245 1982 285 292 (Pubitemid 12038382)