A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain

Neuropsychopharmacology

Volumn 26, Issue 5, 2002, Pages 634-642

  Nichols, Charles D ^a   Sanders Bush, Elaine ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA microarray; Hallucinogen; LSD; mRNA; Prefrontal cortex; Serotonin receptor

Indexed keywords

GLUTAMIC ACID; LYSERGIDE; PSYCHEDELIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; CYTOSKELETON; DRUG EFFECT; DRUG MECHANISM; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; MALE; MAMMAL; MOLECULAR DYNAMICS; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 2; GENE EXPRESSION; GENES, FOS; GENES, IMMEDIATE-EARLY; HALLUCINOGENS; I-KAPPA B PROTEINS; IMMEDIATE-EARLY PROTEINS; LYSERGIC ACID DIETHYLAMIDE; MALE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0036199782     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(01)00405-5     Document Type: Article

References (39)

1. Visual phenomenology of the LSD Flashback
2. Serotonin and hallucinogens
3. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release
4. Microarray-based analysis of early development in Xenopus laevis
5. Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation
6. Agonist-directed signaling of serotonin 5-HT2C receptors: Differences between serotonin and lysergic acid diethylamide (LSD)
7. Gene expression of NOR-1, a neuron-derived orphan receptor, is inducible in neuronal and other cell lineages in culture
8. Serotonin, schizophrenia and antipsychotic drug action
9. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
10. Lysergic acid diethylamide, but not its nonhallucinogenic congeners, is a potent serotonin 5HT1C receptor agonist
11. Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: Multiple gene products and coregulation with the proto- oncogene c-fos
12. Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons
13. Lsd: The bridge from human to animal
14. Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro
15. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory
16. mRNA differential display reveals Krox-20 as a neural plasticity- regulated gene in the rat hippocampus
17. 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
18. Homer proteins regulate coupling of group I metabatropic glutamate receptors to N-type calcium and M-type potassium channels
19. c-Fos as a transcription factor: A stressful (re)view from a functional map
20. Effects of hallucinogens on locomotor and investigatory activity and patterns: Influence of 5-HT2A and 5-HT2C receptors
21. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
22. Treatment of alcoholism using psychedelic drugs: A review of the program of research
23. Expression of the putative transcription factor NOR-1 in the nervous, the endocrine and the immune systems and the developing brain of the rat
24. The NGFI-B subfamily of the nuclear receptor superfamily
25. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1
26. The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors
27. Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells
28. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3- kinase-stimulated signaling pathway
29. Serotonergic regulation of mRNA expression of Arc, an immediate early gene selectively localized at neuronal dendrites
30. Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain
31. Presence of NF-kappaB-like and IkappaB-like immunoreactivities in postsynaptic densities
32. 2A/2C receptor activation is differentially regulated in four regions of rat brain
33. Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens
34. The "chip" as a specific genetic tool
35. LSD and structural analogs: Pharmacological evaluation at D1 dopamine receptors
36. NGFI-B and nor1 mRNAs are upregulated in brain reward pathways by drugs of abuse: Different effects in Fischer and Lewis rats
37. Addictionprone Lewis but not Fischer rats develop compulsive running that coincides with downregulation of nerve growth factor inducible-B and neuron-derived orphan receptor 1
38. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
39. Homer: A link between neural activity and glutamate receptor function