메뉴 건너뛰기




Volumn 44, Issue 11, 1998, Pages 1128-1142

The molecular biology of serotonin receptors: Therapeutic implications for the interface of mood and psychosis

Author keywords

Drug design; Psychosis; Schizophrenia; Serotonin; Serotonin receptors; Serotonin(2A)

Indexed keywords

RECEPTOR SUBTYPE; SEROTONIN 1 RECEPTOR;

EID: 0032402417     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00132-2     Document Type: Review
Times cited : (121)

References (157)
  • 2
    • 0031006582 scopus 로고    scopus 로고
    • Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells
    • Aghajanian G.K., Marek G.J. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 36:1997;589-599.
    • (1997) Neuropharmacology , vol.36 , pp. 589-599
    • Aghajanian, G.K.1    Marek, G.J.2
  • 7
    • 0024440822 scopus 로고
    • Effect of neuroleptics on positive and negative symptoms and the deficit state
    • Angst J., Stassen H.H., Woggon B. Effect of neuroleptics on positive and negative symptoms and the deficit state. Psychopharmacology (Berl). 99:(suppl):1989;S41-S46.
    • (1989) Psychopharmacology (Berl) , vol.99 , Issue.SUPPL
    • Angst, J.1    Stassen, H.H.2    Woggon, B.3
  • 8
    • 0025924342 scopus 로고
    • 5-hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex
    • Araneda R., Andrade R. 5-hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience. 40:1991;399-412.
    • (1991) Neuroscience , vol.40 , pp. 399-412
    • Araneda, R.1    Andrade, R.2
  • 10
    • 0027506471 scopus 로고
    • The probable arrangement of the helices in G protein-coupled receptors
    • Baldwin J.M. The probable arrangement of the helices in G protein-coupled receptors. EMBO J. 12:1993;1693-1703.
    • (1993) EMBO J , vol.12 , pp. 1693-1703
    • Baldwin, J.M.1
  • 11
    • 0028227013 scopus 로고
    • Structure and function of receptors coupled to G proteins
    • Baldwin J.M. Structure and function of receptors coupled to G proteins. Curr Opin Cell Biol. 6:1994;180-190.
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 180-190
    • Baldwin, J.M.1
  • 12
    • 0031025764 scopus 로고    scopus 로고
    • Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate
    • Barak L.S., Ferguson S.S., Zhang J., Martenson C., Meyer T., Caron M.G. Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate. Mol Pharmacol. 51:1997;177-184.
    • (1997) Mol Pharmacol , vol.51 , pp. 177-184
    • Barak, L.S.1    Ferguson, S.S.2    Zhang, J.3    Martenson, C.4    Meyer, T.5    Caron, M.G.6
  • 14
    • 0029442597 scopus 로고
    • Altered glutamatergic and GABAergic mechanisms in the cingulate cortex of the schizophrenic brain
    • Benes F.M. Altered glutamatergic and GABAergic mechanisms in the cingulate cortex of the schizophrenic brain. Arch Gen Psychiatry. 52:1995;1015-1018.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 1015-1018
    • Benes, F.M.1
  • 15
    • 0029831429 scopus 로고    scopus 로고
    • Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptor occurs via the endosome pathway in vitro
    • Berry S.A., Shah M.C., Khan N., Roth B.L. Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptor occurs via the endosome pathway in vitro. Mol Pharmacol. 50:1996;306-313.
    • (1996) Mol Pharmacol , vol.50 , pp. 306-313
    • Berry, S.A.1    Shah, M.C.2    Khan, N.3    Roth, B.L.4
  • 17
    • 0028245619 scopus 로고
    • Molecular biology of 5-HT receptors
    • Boess F.G., Martin I.L. Molecular biology of 5-HT receptors. Neuropharmacology. 33:1994;275-317.
    • (1994) Neuropharmacology , vol.33 , pp. 275-317
    • Boess, F.G.1    Martin, I.L.2
  • 18
    • 0023772366 scopus 로고
    • Characterization and localization of a peripheral neural 5-hydroxytryptamine receptor subtype with a selective agonist, 3H-5-hydroxyindalpine
    • Branchek T., Mawe G., Gershon M.D. Characterization and localization of a peripheral neural 5-hydroxytryptamine receptor subtype with a selective agonist, 3H-5-hydroxyindalpine. J Neurosci. 8:1988;2582-2595.
    • (1988) J Neurosci , vol.8 , pp. 2582-2595
    • Branchek, T.1    Mawe, G.2    Gershon, M.D.3
  • 19
    • 0028081958 scopus 로고
    • The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat
    • Burnet P.W., Michelson D., Smith M.A., Gold P.W., Sternberg E.M. The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain Res. 638:1994;311-324.
    • (1994) Brain Res , vol.638 , pp. 311-324
    • Burnet, P.W.1    Michelson, D.2    Smith, M.A.3    Gold, P.W.4    Sternberg, E.M.5
  • 25
    • 0029091218 scopus 로고
    • Further evidence that fluoxetine interacts with a 5-HT2C receptor in glial cells
    • Chen Y., Peng L., Zhang X., Stolzenburg J.U., Hertz L. Further evidence that fluoxetine interacts with a 5-HT2C receptor in glial cells. Brain Res Bull. 38:1995;153-159.
    • (1995) Brain Res Bull , vol.38 , pp. 153-159
    • Chen, Y.1    Peng, L.2    Zhang, X.3    Stolzenburg, J.U.4    Hertz, L.5
  • 29
    • 0031021528 scopus 로고    scopus 로고
    • The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts
    • Chuprun J.K., Raymond J.R., Blackshear P.J. The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts. J Biol Chem. 272:1997;773-781.
    • (1997) J Biol Chem , vol.272 , pp. 773-781
    • Chuprun, J.K.1    Raymond, J.R.2    Blackshear, P.J.3
  • 32
    • 0021248714 scopus 로고
    • Selective 5-HT2 antagonists inhibit serotonin-stimulated phosphatidylinositol metabolism in cerebral cortex
    • Conn P.J., Sanders-Bush E. Selective 5-HT2 antagonists inhibit serotonin-stimulated phosphatidylinositol metabolism in cerebral cortex. Neuropharmacology. 23:1984;993-996.
    • (1984) Neuropharmacology , vol.23 , pp. 993-996
    • Conn, P.J.1    Sanders-Bush, E.2
  • 35
    • 0027377333 scopus 로고
    • Glial cell-specific expression of the serotonin 2 receptor gene: Selective reactivation of a repressed promoter
    • Ding D., Toth M., Zhou Y., Parks C., Hoffman B.J., Chenk T. Glial cell-specific expression of the serotonin 2 receptor gene Selective reactivation of a repressed promoter . Mol Brain Res. 20:1993;181-191.
    • (1993) Mol Brain Res , vol.20 , pp. 181-191
    • Ding, D.1    Toth, M.2    Zhou, Y.3    Parks, C.4    Hoffman, B.J.5    Chenk, T.6
  • 36
    • 0028340906 scopus 로고
    • Isolation and characterization of the rat 5-hydroxytryptamine type 2 receptor promoter: Constitutive and inducible activity in myometrial smooth muscle cells
    • Du Y.L., Wilcox B.D., Teitler M., Jeffrey J.J. Isolation and characterization of the rat 5-hydroxytryptamine type 2 receptor promoter Constitutive and inducible activity in myometrial smooth muscle cells . Mol Pharmacol. 45:1994;1125-1131.
    • (1994) Mol Pharmacol , vol.45 , pp. 1125-1131
    • Du, Y.L.1    Wilcox, B.D.2    Teitler, M.3    Jeffrey, J.J.4
  • 37
    • 0029031536 scopus 로고
    • Regulation of rat 5-hydroxytryptamine type 2 receptor gene activity: Identification of cis elements that mediate basal and 5-hydroxytryptamine-dependent gene activation
    • Du Y.L., Wilcox B.D., Jeffrey J.J. Regulation of rat 5-hydroxytryptamine type 2 receptor gene activity Identification of cis elements that mediate basal and 5-hydroxytryptamine-dependent gene activation . Mol Pharmacol. 47:1995;915-922.
    • (1995) Mol Pharmacol , vol.47 , pp. 915-922
    • Du, Y.L.1    Wilcox, B.D.2    Jeffrey, J.J.3
  • 38
    • 0002570174 scopus 로고    scopus 로고
    • Computerization of mutant data: The tinyGRAP mutant database
    • Edvardsen O, Kristiansen K (1997): Computerization of mutant data: The tinyGRAP mutant database. 7TM J 6:1-6.
    • (1997) 7TM J , vol.6 , pp. 1-6
    • Edvardsen, O.1    Kristiansen, K.2
  • 40
    • 0030460743 scopus 로고    scopus 로고
    • G-protein-coupled receptor regulation: Role of G-protein-coupled receptor kinases and arrestins
    • Ferguson S.S., Barak L.S., Zhang J., Caron M.G. G-protein-coupled receptor regulation Role of G-protein-coupled receptor kinases and arrestins . Can J Physiol Pharmacol. 74:1996;1095-1110.
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 1095-1110
    • Ferguson, S.S.1    Barak, L.S.2    Zhang, J.3    Caron, M.G.4
  • 41
    • 0021331447 scopus 로고
    • Fluperlapine in 104 schizophrenic patients. Open multicenter trial
    • Fischer-Cornelssen K.A. Fluperlapine in 104 schizophrenic patients. Open multicenter trial. Arzneimittelforschung. 34:1984;125-130.
    • (1984) Arzneimittelforschung , vol.34 , pp. 125-130
    • Fischer-Cornelssen, K.A.1
  • 42
    • 0022922087 scopus 로고
    • Fluperlapine vs haloperidol: A comparison of their neuroendocrinological profiles and the influence on serum lipids
    • Fleischhacker W.W., Stuppack C., Moser C., Schubert H., Hinterhuber H. Fluperlapine vs haloperidol A comparison of their neuroendocrinological profiles and the influence on serum lipids . Pharmacopsychiatry. 19:1986;111-114.
    • (1986) Pharmacopsychiatry , vol.19 , pp. 111-114
    • Fleischhacker, W.W.1    Stuppack, C.2    Moser, C.3    Schubert, H.4    Hinterhuber, H.5
  • 43
    • 0029073212 scopus 로고
    • Transcriptional control of the rat serotonin-2 receptor gene
    • Garlow S.J., Ciaranello R.D. Transcriptional control of the rat serotonin-2 receptor gene. Mol Brain Res. 31:1995;201-209.
    • (1995) Mol Brain Res , vol.31 , pp. 201-209
    • Garlow, S.J.1    Ciaranello, R.D.2
  • 45
    • 0028981915 scopus 로고
    • 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation
    • Garnovskaya M.N., Nebigil C.G., Arthur J.M., Spurney R.F., Raymond J.R. 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation. Mol Pharmacol. 48:1995;230-237.
    • (1995) Mol Pharmacol , vol.48 , pp. 230-237
    • Garnovskaya, M.N.1    Nebigil, C.G.2    Arthur, J.M.3    Spurney, R.F.4    Raymond, J.R.5
  • 46
    • 0029904963 scopus 로고    scopus 로고
    • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway
    • Garnovskaya M.N., van Biesen T., Hawe B., Casanas Ramos S., Lefkowitz R.J., Raymond J.R. Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. Biochemistry. 35:1996;13716-13722.
    • (1996) Biochemistry , vol.35 , pp. 13716-13722
    • Garnovskaya, M.N.1    Van Biesen, T.2    Hawe, B.3    Casanas Ramos, S.4    Lefkowitz, R.J.5    Raymond, J.R.6
  • 49
    • 0028324115 scopus 로고
    • Selective activation of inhibitory G-protein alpha-subunits by partial agonists of the human 5-HT1A receptor
    • Gettys T.W., Fields T.A., Raymond J.R. Selective activation of inhibitory G-protein alpha-subunits by partial agonists of the human 5-HT1A receptor. Biochemistry. 33:1994;4283-4290.
    • (1994) Biochemistry , vol.33 , pp. 4283-4290
    • Gettys, T.W.1    Fields, T.A.2    Raymond, J.R.3
  • 51
    • 0029770657 scopus 로고    scopus 로고
    • β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor
    • Goodman O., Krupnick J., Santini F., Gurevich V.V., Penn R.B., Gagnon A.W., et al. β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor. Nature. 383:1996;447-450.
    • (1996) Nature , vol.383 , pp. 447-450
    • Goodman, O.1    Krupnick, J.2    Santini, F.3    Gurevich, V.V.4    Penn, R.B.5    Gagnon, A.W.6
  • 53
    • 0023109563 scopus 로고
    • Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat
    • Gudelsky G.A., Koenig J.I., Simonovic M., Koyama T., Ohmori T., Meltzer H.Y. Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat. J Neural Transm. 68:1987;227-240.
    • (1987) J Neural Transm , vol.68 , pp. 227-240
    • Gudelsky, G.A.1    Koenig, J.I.2    Simonovic, M.3    Koyama, T.4    Ohmori, T.5    Meltzer, H.Y.6
  • 54
    • 0030902977 scopus 로고    scopus 로고
    • Identification and localization of a skeletal muscle serotonin 5-HT2A receptor coupled to the Jak/STAT pathway
    • Guillet-Deniau I., Burnol A.F., Girard J. Identification and localization of a skeletal muscle serotonin 5-HT2A receptor coupled to the Jak/STAT pathway. J Biol Chem. 272:1997;14825-14829.
    • (1997) J Biol Chem , vol.272 , pp. 14825-14829
    • Guillet-Deniau, I.1    Burnol, A.F.2    Girard, J.3
  • 57
    • 0030610194 scopus 로고    scopus 로고
    • 7) receptor isoforms in human and rat produced by alternative splicing: Species differences due to altered intron-exon organization
    • 7) receptor isoforms in human and rat produced by alternative splicing Species differences due to altered intron-exon organization . J Neurochem. 68:1997;1372-1381.
    • (1997) J Neurochem , vol.68 , pp. 1372-1381
    • Heidmann, D.E.A.1    Metcalf, M.A.2    Kohen, R.3    Hamblin, M.W.4
  • 58
    • 0024234855 scopus 로고
    • CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
    • Higgins D.G., Sharp P.M. CLUSTAL A package for performing multiple sequence alignment on a microcomputer . Gene. 73:1988;237-244.
    • (1988) Gene , vol.73 , pp. 237-244
    • Higgins, D.G.1    Sharp, P.M.2
  • 60
    • 0028450104 scopus 로고
    • Combinatorial libraries. Finding the needle in the haystack
    • Houghten R.A. Combinatorial libraries. Finding the needle in the haystack. Curr Biol. 4:1994;564-567.
    • (1994) Curr Biol , vol.4 , pp. 564-567
    • Houghten, R.A.1
  • 61
    • 0028183017 scopus 로고
    • International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
    • Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev. 46:1994;157-203.
    • (1994) Pharmacol Rev , vol.46 , pp. 157-203
    • Hoyer, D.1    Clarke, D.E.2    Fozard, J.R.3    Hartig, P.R.4    Martin, G.R.5    Mylecharane, E.J.6
  • 62
    • 0032213226 scopus 로고    scopus 로고
    • Estrogen, serotonin and mood disturbance: Where is the therapeutic bridge?
    • Joffe H., Cohen L.S. Estrogen, serotonin and mood disturbance Where is the therapeutic bridge? Biol Psychiatry. 44:1998;798-811.
    • (1998) Biol Psychiatry , vol.44 , pp. 798-811
    • Joffe, H.1    Cohen, L.S.2
  • 63
    • 0028009827 scopus 로고
    • Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines
    • Johnson M.P., Loncharich R.J., Baez M., Nelson D.L. Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines. Mol Pharmacol. 45:1994;277-286.
    • (1994) Mol Pharmacol , vol.45 , pp. 277-286
    • Johnson, M.P.1    Loncharich, R.J.2    Baez, M.3    Nelson, D.L.4
  • 64
    • 0028989764 scopus 로고
    • 2A receptors reveal conserved transmembrane homology to the human rather than rat sequence
    • 2A receptors reveal conserved transmembrane homology to the human rather than rat sequence . Biochim Biophys Acta. 1236:1995;201-206.
    • (1995) Biochim Biophys Acta , vol.1236 , pp. 201-206
    • Johnson, M.P.1    Baez, M.2    Kursar, J.D.3    Nelson, D.L.4
  • 65
    • 0023740032 scopus 로고
    • Molecular characterization of a functional cDNA encoding the serotonin 1c receptor
    • Julius D., MacDermott A.B., Axel R., Jessel T. Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science. 241:1988;558-564.
    • (1988) Science , vol.241 , pp. 558-564
    • Julius, D.1    MacDermott, A.B.2    Axel, R.3    Jessel, T.4
  • 67
    • 0031032418 scopus 로고    scopus 로고
    • Molecular cloning of a putative serotonin receptor gene from barnacle, Balanus amphitrite
    • Kawahara H., Isoai A., Shizuri Y. Molecular cloning of a putative serotonin receptor gene from barnacle, Balanus amphitrite. Gene. 184:1997;245-250.
    • (1997) Gene , vol.184 , pp. 245-250
    • Kawahara, H.1    Isoai, A.2    Shizuri, Y.3
  • 68
    • 0023643263 scopus 로고
    • An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins
    • Kobilka B.K., Frielle T., Collins S., Yang-Feng T., Kobilka T.S., Francke U., et al. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature. 329:1987;75-79.
    • (1987) Nature , vol.329 , pp. 75-79
    • Kobilka, B.K.1    Frielle, T.2    Collins, S.3    Yang-Feng, T.4    Kobilka, T.S.5    Francke, U.6
  • 71
    • 0030582072 scopus 로고    scopus 로고
    • Molecular modeling of serotonin, ketanserin, ritanserin and their 5-HT2C receptor interactions
    • Kristiansen K., Dahl S.G. Molecular modeling of serotonin, ketanserin, ritanserin and their 5-HT2C receptor interactions. Eur J Pharmacol. 306:1996;195-210.
    • (1996) Eur J Pharmacol , vol.306 , pp. 195-210
    • Kristiansen, K.1    Dahl, S.G.2
  • 72
    • 0001332489 scopus 로고
    • Molecular modeling of ketanserin and its interactions with the 5-HT2 receptor
    • Kristiansen K., Edvardsen O., Dahl S. Molecular modeling of ketanserin and its interactions with the 5-HT2 receptor. Med Chem Res. 3:1993;370-385.
    • (1993) Med Chem Res , vol.3 , pp. 370-385
    • Kristiansen, K.1    Edvardsen, O.2    Dahl, S.3
  • 73
    • 0029845242 scopus 로고    scopus 로고
    • A database of mutants and effects of site-directed mutagenesis experiments on G protein-coupled receptors
    • (Internet address;
    • Kristiansen K, Dahl SG, Edvardsen O (1996): A database of mutants and effects of site-directed mutagenesis experiments on G protein-coupled receptors. Proteins: Structure, Function and Genetics 26:81-94 (Internet address; http://www-grap.fagmed.uit.no/GRAP/homepage.html).
    • (1996) Proteins: Structure, Function and Genetics , vol.26 , pp. 81-94
    • Kristiansen, K.1    Dahl, S.G.2    Edvardsen, O.3
  • 76
    • 0030611392 scopus 로고    scopus 로고
    • Increase of 5-HT7 (serotonin-7) and 5-HT1A (serotonin-1A) receptor mRNA expression in rat hippocampus after adrenalectomy
    • Le Corre S., Sharp T., Young A.H., Harrison P.J. Increase of 5-HT7 (serotonin-7) and 5-HT1A (serotonin-1A) receptor mRNA expression in rat hippocampus after adrenalectomy. Psychopharmacology (Berl). 130:1997;368-374.
    • (1997) Psychopharmacology (Berl) , vol.130 , pp. 368-374
    • Le Corre, S.1    Sharp, T.2    Young, A.H.3    Harrison, P.J.4
  • 77
    • 0028881817 scopus 로고
    • Cloning and characterization of two related serotonergic receptors from the brain and reproductive system of Aplysia that activate phospholipase C
    • Li X.C., Giot J.F., Kuhl D., Hen R., Kandel E.R. Cloning and characterization of two related serotonergic receptors from the brain and reproductive system of Aplysia that activate phospholipase C. J Neurosci. 15:1995;7585-7591.
    • (1995) J Neurosci , vol.15 , pp. 7585-7591
    • Li, X.C.1    Giot, J.F.2    Kuhl, D.3    Hen, R.4    Kandel, E.R.5
  • 78
    • 0032213142 scopus 로고    scopus 로고
    • Hypothalamic serotonin in control of eating behavior, meal size, and body weight
    • Liebowitz S., Alexander J. Hypothalamic serotonin in control of eating behavior, meal size, and body weight. Biol Psychiatry. 44:1998;851-864.
    • (1998) Biol Psychiatry , vol.44 , pp. 851-864
    • Liebowitz, S.1    Alexander, J.2
  • 79
    • 0032145210 scopus 로고    scopus 로고
    • The spectrum of behaviors influenced by serotonin
    • Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry. 44:1998;151-162.
    • (1998) Biol Psychiatry , vol.44 , pp. 151-162
    • Lucki, I.1
  • 80
    • 0000587671 scopus 로고
    • The role of serotonin in depression
    • In: Bloom FE, Kupfer DG, editors. New York: Raven Press, pp.
    • Maes M, Meltzer HY (1995): The role of serotonin in depression. In: Bloom FE, Kupfer DG, editors. Psychopharmacology: A Fourth Generation of Progress. New York: Raven Press, pp.
    • (1995) Psychopharmacology: A Fourth Generation of Progress
    • Maes, M.1    Meltzer, H.Y.2
  • 81
    • 0027417002 scopus 로고
    • Regulation of high-conductance anion channels by G proteins and 5-HT1A receptors in CHO cells
    • Mangel A.W., Raymond J.R., Fitz J.G. Regulation of high-conductance anion channels by G proteins and 5-HT1A receptors in CHO cells. Am J Physiol. 264:1993;F490-F495.
    • (1993) Am J Physiol , vol.264
    • Mangel, A.W.1    Raymond, J.R.2    Fitz, J.G.3
  • 82
    • 0023248472 scopus 로고
    • Differential effects of a new dibenzo-epine neuroleptic compared with haloperidol. Results of an open and crossover study
    • Mann K., Bartels M., Gartner H.J., Schied H.W., Wagner W., Heimann H. Differential effects of a new dibenzo-epine neuroleptic compared with haloperidol. Results of an open and crossover study. Pharmacopsychiatry. 20:1987;155-159.
    • (1987) Pharmacopsychiatry , vol.20 , pp. 155-159
    • Mann, K.1    Bartels, M.2    Gartner, H.J.3    Schied, H.W.4    Wagner, W.5    Heimann, H.6
  • 83
    • 0032402426 scopus 로고    scopus 로고
    • The electrophysiology of prefrontal serotonin systems: Therapeutic implications for mood and psychosis
    • (current issue)
    • Marek GJ, Aghajanian G (1998): The electrophysiology of prefrontal serotonin systems: Therapeutic implications for mood and psychosis. Biol Psychiatry (current issue).
    • (1998) Biol Psychiatry
    • Marek, G.J.1    Aghajanian, G.2
  • 85
    • 0028179207 scopus 로고
    • 5-Hydroxytryptamine type 2A and 2C receptors linked to Na+/K+/Cl- cotransport
    • Mayer S.E., Sanders-Bush E. 5-Hydroxytryptamine type 2A and 2C receptors linked to Na+/K+/Cl- cotransport. Mol Pharmacol. 45:1994;991-996.
    • (1994) Mol Pharmacol , vol.45 , pp. 991-996
    • Mayer, S.E.1    Sanders-Bush, E.2
  • 86
    • 0011747973 scopus 로고
    • Clozapine: Clinical advantages and biological mechanisms
    • S.C. Schulz, & C. Tamminga. New York: Oxford University Press
    • Meltzer H.Y. Clozapine Clinical advantages and biological mechanisms . Schulz S.C., Tamminga C. Schizophrenia A Scientific Focus . 1989;302-309 Oxford University Press, New York.
    • (1989) Schizophrenia: A Scientific Focus , pp. 302-309
    • Meltzer, H.Y.1
  • 87
    • 0024466603 scopus 로고
    • Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values
    • Meltzer H.Y., Matsubara S., Lee J.-C. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther. 251:1989;238-246.
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 238-246
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.-C.3
  • 88
    • 0026607250 scopus 로고
    • Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat
    • Mendelson S.D., McEwen B.S. Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat. Neuroendocrinology. 55:1992;444-450.
    • (1992) Neuroendocrinology , vol.55 , pp. 444-450
    • Mendelson, S.D.1    McEwen, B.S.2
  • 90
    • 0025674262 scopus 로고
    • Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells
    • Middleton J.P., Raymond J.R., Whorton A.R., Dennis V.W. Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells. J Clin Invest. 86:1990;1799-1805.
    • (1990) J Clin Invest , vol.86 , pp. 1799-1805
    • Middleton, J.P.1    Raymond, J.R.2    Whorton, A.R.3    Dennis, V.W.4
  • 91
    • 0027481384 scopus 로고
    • Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
    • Monsma F.J., Shen Y., Ward R.P., Hamblin M.W., Sibley D.R. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 43:1993;320-327.
    • (1993) Mol Pharmacol , vol.43 , pp. 320-327
    • Monsma, F.J.1    Shen, Y.2    Ward, R.P.3    Hamblin, M.W.4    Sibley, D.R.5
  • 95
    • 0031068606 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans
    • Olde B., McCombie W.R. Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans. J Mol Neurosci. 8:1997;53-62.
    • (1997) J Mol Neurosci , vol.8 , pp. 53-62
    • Olde, B.1    McCombie, W.R.2
  • 100
    • 0030064015 scopus 로고    scopus 로고
    • The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1
    • Parks C.L., Shenk T. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J Biol Chem. 271:1996;4417-4430.
    • (1996) J Biol Chem , vol.271 , pp. 4417-4430
    • Parks, C.L.1    Shenk, T.2
  • 101
    • 0026343455 scopus 로고
    • A polymerase chain reaction mediated by a single primer: Cloning of genomic sequences adjacent to a serotonin receptor protein coding region
    • Parks C.L., Chang L.S., Shenk T. A polymerase chain reaction mediated by a single primer Cloning of genomic sequences adjacent to a serotonin receptor protein coding region . Nucl Acids Res. 19:1991;7155-7160.
    • (1991) Nucl Acids Res , vol.19 , pp. 7155-7160
    • Parks, C.L.1    Chang, L.S.2    Shenk, T.3
  • 102
    • 0027996410 scopus 로고
    • Molecular biology of serotonin (5-HT) receptors
    • Peroutka S.J. Molecular biology of serotonin (5-HT) receptors. Synapse. 18:1994;241-260.
    • (1994) Synapse , vol.18 , pp. 241-260
    • Peroutka, S.J.1
  • 103
    • 0028365650 scopus 로고
    • The molecular evolution of G protein-coupled receptors: Focus on 5-hydroxytryptamine receptors
    • Peroutka S.J., Howell T.A. The molecular evolution of G protein-coupled receptors Focus on 5-hydroxytryptamine receptors . Neuropharmacology. 33:1994;319-324.
    • (1994) Neuropharmacology , vol.33 , pp. 319-324
    • Peroutka, S.J.1    Howell, T.A.2
  • 104
    • 0027186438 scopus 로고
    • Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase
    • Plassat J.L., Amlaiky N., Hen R. Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 44:1993;229-236.
    • (1993) Mol Pharmacol , vol.44 , pp. 229-236
    • Plassat, J.L.1    Amlaiky, N.2    Hen, R.3
  • 106
    • 0028842093 scopus 로고
    • Multiple mechanisms of receptor-G protein signaling specificity
    • Raymond J.R. Multiple mechanisms of receptor-G protein signaling specificity. Am J Physiol. 269:1995;F141-F158.
    • (1995) Am J Physiol , vol.269
    • Raymond, J.R.1
  • 107
    • 0026701825 scopus 로고
    • Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells
    • Raymond J.R., Albers F.J., Middleton J.P. Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 346:1992;127-137.
    • (1992) Naunyn Schmiedebergs Arch Pharmacol , vol.346 , pp. 127-137
    • Raymond, J.R.1    Albers, F.J.2    Middleton, J.P.3
  • 108
    • 0027522086 scopus 로고
    • Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha
    • Raymond J.R., Olsen C.L., Gettys T.W. Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha. Biochemistry. 32:1993;11064-11073.
    • (1993) Biochemistry , vol.32 , pp. 11064-11073
    • Raymond, J.R.1    Olsen, C.L.2    Gettys, T.W.3
  • 110
    • 0028061499 scopus 로고
    • Multiple serotonin receptors: Clinical and experimental aspects
    • Roth B.L. Multiple serotonin receptors Clinical and experimental aspects . Ann Clin Psychiatry. 6:1994;67-78.
    • (1994) Ann Clin Psychiatry , vol.6 , pp. 67-78
    • Roth, B.L.1
  • 111
    • 0023227107 scopus 로고
    • Multiple mechanisms of serotonergic signal transduction
    • Roth B.L., Chuang D.M. Multiple mechanisms of serotonergic signal transduction. Life Sci. 41:1987;1051-1064.
    • (1987) Life Sci , vol.41 , pp. 1051-1064
    • Roth, B.L.1    Chuang, D.M.2
  • 113
    • 0001792366 scopus 로고
    • The role of serotonin in schizophrenia
    • F.E. Bloom, & D.G. Kupfer. New York: Raven Press
    • Roth B.L., Meltzer H.Y. The role of serotonin in schizophrenia. Bloom F.E., Kupfer D.G. Psychopharmacology A Fourth Generation of Progress . 1995;1215-1227 Raven Press, New York.
    • (1995) Psychopharmacology: A Fourth Generation of Progress , pp. 1215-1227
    • Roth, B.L.1    Meltzer, H.Y.2
  • 114
    • 0021683773 scopus 로고
    • Aortic recognition sites for serotonin (5-HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover
    • Roth B.L., Nakaki T., Chuang D.M., Costa E. Aortic recognition sites for serotonin (5-HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover. Neuropharmacology. 23:1984;1223-1225.
    • (1984) Neuropharmacology , vol.23 , pp. 1223-1225
    • Roth, B.L.1    Nakaki, T.2    Chuang, D.M.3    Costa, E.4
  • 118
    • 0000102525 scopus 로고
    • Mutagenesis of 5-HT2 serotonin receptors: What does an analysis of many mutant receptors tell us?
    • Roth B.L., Choudhary M.S., Craigo S. Mutagenesis of 5-HT2 serotonin receptors What does an analysis of many mutant receptors tell us? Med Chem Res. 3:1993;297-305.
    • (1993) Med Chem Res , vol.3 , pp. 297-305
    • Roth, B.L.1    Choudhary, M.S.2    Craigo, S.3
  • 119
    • 0028261434 scopus 로고
    • Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
    • Roth B.L., Craigo S.C., Choudhary S., Uluer A., Monsma F.J., Shen Y., et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 268:1994;1403-1410.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1403-1410
    • Roth, B.L.1    Craigo, S.C.2    Choudhary, S.3    Uluer, A.4    Monsma, F.J.5    Shen, Y.6
  • 122
    • 77956741415 scopus 로고    scopus 로고
    • Binding of typical and atypical antipsychotic drugs to multiple neurotransmitter receptors
    • Roth B.L., Meltzer H.Y., Khan N. Binding of typical and atypical antipsychotic drugs to multiple neurotransmitter receptors. Adv Pharmacol. 42:1998;482-485.
    • (1998) Adv Pharmacol , vol.42 , pp. 482-485
    • Roth, B.L.1    Meltzer, H.Y.2    Khan, N.3
  • 124
    • 85058247683 scopus 로고    scopus 로고
    • G-protein coupled receptor (GPCR) trafficking in the central nervous system: Relevance for drugs of abuse
    • (in press b)
    • Roth BL, Willins DL, Kroeze WK (in press b): G-protein coupled receptor (GPCR) trafficking in the central nervous system: Relevance for drugs of abuse. Drug Alcohol Depend.
    • Drug Alcohol Depend.
    • Roth, B.L.1    Willins, D.L.2    Kroeze, W.K.3
  • 127
    • 0030837058 scopus 로고    scopus 로고
    • Molecular identification of a G protein-coupled receptor family which is expressed in planarians
    • Saitoh O., Yuruzume E., Watanabe K., Nakata H. Molecular identification of a G protein-coupled receptor family which is expressed in planarians. Gene. 195:1997;55-61.
    • (1997) Gene , vol.195 , pp. 55-61
    • Saitoh, O.1    Yuruzume, E.2    Watanabe, K.3    Nakata, H.4
  • 128
    • 0026542571 scopus 로고
    • A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns
    • Saudou F., Boschert U., Amlaiky N., Plassat J.L., Hen R. A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns. EMBO J. 11:1992;1-7.
    • (1992) EMBO J , vol.11 , pp. 1-7
    • Saudou, F.1    Boschert, U.2    Amlaiky, N.3    Plassat, J.L.4    Hen, R.5
  • 129
    • 0029556994 scopus 로고
    • Projection structure of frog rhodopsin in two crystal forms
    • Schertler G., Hargrave P. Projection structure of frog rhodopsin in two crystal forms. Proc Natl Acad Sci USA. 92:1995;11578-11582.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11578-11582
    • Schertler, G.1    Hargrave, P.2
  • 131
    • 0021781594 scopus 로고
    • Treatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine
    • Scholz E., Dichgans J. Treatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine. Eur Arch Psychiatry Neurol Sci. 235:1985;60-64.
    • (1985) Eur Arch Psychiatry Neurol Sci , vol.235 , pp. 60-64
    • Scholz, E.1    Dichgans, J.2
  • 136
    • 84921126724 scopus 로고
    • Chimeric mice with targeted disruptions of the 5-HT1c receptor gene
    • Tecott L.H., Sun L., Julius D. Chimeric mice with targeted disruptions of the 5-HT1c receptor gene. Soc Neurosci Abs. 19:1993;632.
    • (1993) Soc Neurosci Abs , vol.19 , pp. 632
    • Tecott, L.H.1    Sun, L.2    Julius, D.3
  • 137
    • 0027957050 scopus 로고
    • Multiple serotonin receptor subtypes: Molecular cloning and functional expression
    • Teitler M., Herrick-Davis K. Multiple serotonin receptor subtypes Molecular cloning and functional expression . Crit Rev Neurobiol. 8:1994;175-188.
    • (1994) Crit Rev Neurobiol , vol.8 , pp. 175-188
    • Teitler, M.1    Herrick-Davis, K.2
  • 138
    • 0028235547 scopus 로고
    • Antagonist-mediated down-regulation of 5-hydroxytryptamine type 2 receptor gene expression: Modulation of transcription
    • Toth M., Shenk T. Antagonist-mediated down-regulation of 5-hydroxytryptamine type 2 receptor gene expression Modulation of transcription . Mol Pharmacol. 45:1994;1095-1100.
    • (1994) Mol Pharmacol , vol.45 , pp. 1095-1100
    • Toth, M.1    Shenk, T.2
  • 139
    • 0028053758 scopus 로고
    • The 5′ flanking region of the serotonin 2 receptor gene directs brain specific expression in transgenic animals
    • Toth M., Ding D., Shenk T. The 5′ flanking region of the serotonin 2 receptor gene directs brain specific expression in transgenic animals. Mol Brain Res. 27:1994;315-319.
    • (1994) Mol Brain Res , vol.27 , pp. 315-319
    • Toth, M.1    Ding, D.2    Shenk, T.3
  • 142
    • 0027175853 scopus 로고
    • Site-directed mutagenesis of the serotonin 5-hydroxytryptamine receptor: Identification of amino acids necessary for ligand binding and receptor activation
    • Wang C.D., Gallaher T.K., Shih J.C. Site-directed mutagenesis of the serotonin 5-hydroxytryptamine receptor Identification of amino acids necessary for ligand binding and receptor activation . Mol Pharmacol. 43:1993;931-940.
    • (1993) Mol Pharmacol , vol.43 , pp. 931-940
    • Wang, C.D.1    Gallaher, T.K.2    Shih, J.C.3
  • 143
    • 0344250903 scopus 로고
    • Receptor models and ligand-induced responses: New insights for structure-activity relations
    • In: Sanz F, Giraldo J, Manaut F, editors. Prous Science Publishers
    • Weinstein H, Zhang D (1995): Receptor models and ligand-induced responses: New insights for structure-activity relations. In: Sanz F, Giraldo J, Manaut F, editors. QSAR and Molecular Modelling: Concepts, Prous Science Publishers, pp 497-507.
    • (1995) QSAR and Molecular Modelling: Concepts , pp. 497-507
    • Weinstein, H.1    Zhang, D.2
  • 144
    • 0000531055 scopus 로고
    • Molecular graphics models of members of 5-HT2 subfamily: 5-HT2A, 5-HT2B, and 5-HT2C receptors
    • Westkaemper R., Glennon R. Molecular graphics models of members of 5-HT2 subfamily 5-HT2A, 5-HT2B, and 5-HT2C receptors . Med Chem Res. 3:1993;317-334.
    • (1993) Med Chem Res , vol.3 , pp. 317-334
    • Westkaemper, R.1    Glennon, R.2
  • 146
    • 0344250902 scopus 로고    scopus 로고
    • The atypical antipsychotic drug clozapine alters the subcellular distribution of 5-HT2A receptors
    • Willins D.L., Alsayegh L., Berry S., Khan N., Roth B.L. The atypical antipsychotic drug clozapine alters the subcellular distribution of 5-HT2A receptors. Soc Neurosci Abs. 23:1997;972.
    • (1997) Soc Neurosci Abs , vol.23 , pp. 972
    • Willins, D.L.1    Alsayegh, L.2    Berry, S.3    Khan, N.4    Roth, B.L.5
  • 147
    • 0030612257 scopus 로고    scopus 로고
    • Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
    • Willins D.L., Deutch A.Y., Roth B.L. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse. 27:1997;79-82.
    • (1997) Synapse , vol.27 , pp. 79-82
    • Willins, D.L.1    Deutch, A.Y.2    Roth, B.L.3
  • 150
    • 0030218836 scopus 로고    scopus 로고
    • 2C receptor: Complete cDNA, genomic structure, and alternatively spliced variant
    • 2C receptor Complete cDNA, genomic structure, and alternatively spliced variant . Genomics. 35:1996;551-561.
    • (1996) Genomics , vol.35 , pp. 551-561
    • Xie, E.1    Zhu, L.2    Zhao, L.3    Chang, L.S.4
  • 151
    • 0030916968 scopus 로고    scopus 로고
    • Molecular cloning of 5-hydroxytryptamine (5-HT) type 1 receptor genes from the Japanese puffer fish, Fugu rubripes
    • Yamaguchi F., Brenner S. Molecular cloning of 5-hydroxytryptamine (5-HT) type 1 receptor genes from the Japanese puffer fish, Fugu rubripes. Gene. 191:1997;219-223.
    • (1997) Gene , vol.191 , pp. 219-223
    • Yamaguchi, F.1    Brenner, S.2
  • 153
    • 0031128218 scopus 로고    scopus 로고
    • Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus
    • Yau J.L., Noble J., Widdowson J., Seckl J.R. Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus. Brain Res Mol Brain Res. 45:1997;182-186.
    • (1997) Brain Res Mol Brain Res , vol.45 , pp. 182-186
    • Yau, J.L.1    Noble, J.2    Widdowson, J.3    Seckl, J.R.4
  • 154
    • 0031043685 scopus 로고    scopus 로고
    • Muscarinic m4 receptor activation by some atypical antipsychotic drugs
    • Zeng X.P., Le F., Richelson E. Muscarinic m4 receptor activation by some atypical antipsychotic drugs. Eur J Pharmacol. 321:1997;349-354.
    • (1997) Eur J Pharmacol , vol.321 , pp. 349-354
    • Zeng, X.P.1    Le, F.2    Richelson, E.3
  • 155
    • 0028987198 scopus 로고
    • Transcriptional regulation of hippocampal 5-HT1a receptors by corticosteroid hormones
    • Zhong P., Ciaranello R.D. Transcriptional regulation of hippocampal 5-HT1a receptors by corticosteroid hormones. Brain Res Mol Brain Res. 29:1995;23-34.
    • (1995) Brain Res Mol Brain Res , vol.29 , pp. 23-34
    • Zhong, P.1    Ciaranello, R.D.2
  • 157
    • 0026761109 scopus 로고
    • 5-Hydroxytryptamine receptors
    • Zifa E., Fillion G. 5-Hydroxytryptamine receptors. Pharmacol Rev. 44:1992;401-458.
    • (1992) Pharmacol Rev , vol.44 , pp. 401-458
    • Zifa, E.1    Fillion, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.