Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex

Neuroscience

Volumn 116, Issue 1, 2003, Pages 107-117

  Miner, L A H ^a   Backstrom, J R ^b   Sanders Bush, E ^b   Sesack, S R ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Hallucinogens; Immunocytochemistry; Neuroleptics; Schizophrenia; Ultrastructure

Indexed keywords

MONOAMINE; PEROXIDASE; POLYCLONAL ANTIBODY; SEROTONIN 2A RECEPTOR; DOPAMINE; GLUTAMIC ACID; SEROTONIN RECEPTOR;

ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BRAIN LEVEL; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DENDRITE; DENDRITIC SPINE; GLIA CELL; IMMUNOREACTIVITY; LIMBIC CORTEX; MALE; MYELINATED NERVE; MYELINATION; NERVE FIBER; NONHUMAN; PREFRONTAL CORTEX; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PYRAMIDAL NERVE CELL; RAT; SYNAPSE; TISSUE DISTRIBUTION; ANIMAL; CHEMISTRY; ELECTRON MICROSCOPY; ENZYME IMMUNOASSAY; SPRAGUE DAWLEY RAT; SYNAPTOSOME; ULTRASTRUCTURE;

ANIMALS; DENDRITES; DOPAMINE; GLUTAMIC ACID; IMMUNOENZYME TECHNIQUES; MALE; MICROSCOPY, ELECTRON; PREFRONTAL CORTEX; PRESYNAPTIC TERMINALS; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN;

EID: 0037439245     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00580-8     Document Type: Article

References (55)

1. Aghajanian G.K., Marek G.J. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 36:1997;589-599.
2. Aghajanian G.K., Marek G.J. Serotonin model of schizophrenia emerging role of glutamate mechanisms . Brain Res Rev. 31:2000;302-312.
3. Aghajanian G.K., Marek G.J. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain Res. 825:1999;161-171.
4. 2) receptor binding in the frontal cortex of schizophrenic patients. J Neural Transm. 85:1991;19-29.
5. Backstrom J.R., Sanders-Bush E. Generation of anti-peptide antibodies against serotonin 5-HT2A and 5-HT2C receptors. J Neurosci Methods. 77:1997;109-117.
6. Beaudet A., Descarries L. Fine structure of monoamine axon terminals in cerebral cortex. Descarries L., Reader T.R., Jasper H.H. Monoamine Innervation of the Cerebral Cortex. 1984;77-93 Liss, New York.
7. Berger B., Thierry A.-M., Tassin J.P., Moyne M.A. Dopaminergic innervation of the rat prefrontal cortex a fluorescence histochemical study . Brain Res. 106:1976;133-145.
8. Berry S.A., Shah M.C., Kahn N., Roth B.L. Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptors occurs via the endosome pathway in vivo. Mol Pharmacol. 50:1996;306-313.
9. Bhatnagar A., Willins D.L., Gray J.A., Woods J., Benovic J.L., Roth B.L. The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem. 276:2001;8269-8277.
10. 2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology. 15:1996;442-455.
11. Chan J., Aoki C., Pickel V.M. Optimization of differential immunogold-silver and peroxidase labeling with maintenance of ultrastructure in brain sections before plastic embedding. J Neurosci Methods. 33:1990;113-127.
12. Cornea-Hebert V., Riad M., Wu C., Singh S.K., Descarries L. Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat. J Comp Neurol. 409:1999;187-209.
13. Courtoy P.J., Picton D.H., Farquhar M.G. Resolution and limitations of the immunoperoxidase procedure in the localization of extracellular matrix antigens. J Histochem Cytochem. 31:1983;945-951.
14. Cyr M., Landry M., DiPaolo T. Modulation by estrogen-receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain. Neuropsychopharmacology. 23:2000;69-78.
15. Dean B., Hussain T., Hayes W., Scarr E., Kitsoulis S., Hill C., Opeskin K., Copolov D.L. Changes in serotonin2A and GABA(A) receptors in schizophrenia studies on the human dorsolateral prefrontal cortex . J Neurochem. 72:1999;1593-1599.
16. Descarries L., Umbriaco D. Ultrastructural basis of monoamine and acetylcholine function in CNS. Semin Neurosci. 7:1995;309-318.
17. Doherty M.D., Pickel V.M. Ultrastructural localization of the 5-HT2A receptor in dopaminergic neurons in the ventral tegmental area. Brain Res. 864:2000;176-185.
18. Glennon R.A. Do classical hallucinogens act as 5-HT2 agonists or antagonists? Neuropsychopharmacology. 3:1990;509-517.
19. Gobert A., Millan M.J. Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats. Neuropharmacology. 38:1999;315-317.
20. Gurevich E.V., Joyce J.N. Alterations in the cortical serotonergic system in schizophrenia a postmortem study . Biol Psychiatry. 42:1997;529-545.
21. Hamada S., Senzaki K., Hamaguchi-Hamada K., Tabuchi K., Yamamoto H., Yamamoto T., Yoshikawa S., Okano H., Okado N. Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken. Mol Brain Res. 54:1998;199-211.
22. 2 receptor binding in patients with chronic schizophrenia. Psychopharmacology. 112:1993;S35-S39.
23. Iyer R.N., Bradberry C.W. Serotonin-mediated increase in prefrontal cortex dopamine release pharmacological characterization . J Pharmacol Exp Ther. 277:1996;40-47.
24. 2A serotonin receptors in the primate cerebral cortex possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites . Proc Natl Acad Sci USA. 95:1998;735-740.
25. Jansson A., Tinner B., Bancila M., Verge D., Steinbusch H.W.M., Agnati L.F., Fuxe K. Relationship of 5-hydroxytryptamine immunoreactive terminal-like varicosities to 5-hydroxytryptamine-2A receptor-immunoreactive neuronal processes in the rat brain. J Chem Neuroanat. 22:2001;185-203.
26. Kahn R.S., Davidson M. Serotonin, dopamine and their interactions in schizophrenia. Psychopharmacology. 112:1993;S1-S4.
27. Krettek J.E., Price J.L. The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat. J Comp Neurol. 171:1977;157-192.
28. Kroeze W.K., Roth B.L. The molecular biology of serotonin receptors therapeutic implications for the interface of mood and psychosis . Biol Psychiatry. 44:1998;1128-1142.
29. Kuroda M., Murakami K., Shinkai M., Ojima H., Kishi K. Electron microscopic evidence that axon terminals from the mediodorsal thalamic nucleus make direct synaptic contacts with callosal cells in the prelimbic cortex of the rat. Brain Res. 677:1995;348-353.
30. Kuroda M., Ojima H., Igarashi H., Murakami K., Okada A., Shinkai M. Synaptic relationships between axon terminals from the mediodorsal thalamic nucleus and layer III pyramidal cells in the prelimbic cortex of the rat. Brain Res. 708:1996;185-190.
31. Laruelle M., Abi-Dargham A., Casanova M.F., Toti R., Weinberger D.R., Kleinman J.E. Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. Arch Gen Psychiatry. 50:1993;810-818.
32. Leranth C., Pickel V.M. Electron microscopic preembedding double-immunostaining methods. Heimer L., Záborszky L. Neuroanatomical Tract Tracing Methods 2 Recent Progress . 1989;129-172 Plenum, New York.
33. Lindvall O., Björklund A. General organization of cortical monoamine systems. Descarries L., Reader T.R., Jasper H.H. Monoamine Innervation of the Cerebral Cortex. 1984;9-40 Liss, New York.
34. Lopez-Gimenez J.F., Vilaro M.T., Palacios J.M., Mengod G. Mapping of the 5-HT2A receptors and their mRNA in monkey brain [3H]MDL100, 907 autoradiography and in situ hybridization studies . J Comp Neurol. 429:2001;571-589.
35. Marek G.J., Aghajanian G.K. LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on neurons in the rat piriform cortex. J Pharmacol Exp Ther. 278:1996;1373-1382.
36. Marek G.J., Aghajanian G.K. 5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells suppression by μ-opiate receptor activation . Neuroscience. 86:1998;485-497.
37. Martin-Ruiz R., Puig M.V., Celada P., Shapiro D.A., Roth B.L., Mengod G., Artigas F. Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. J Neurosci. 21:2001;9856-9866.
38. Matsumoto M., Togashi H., Mori K., Ueno K.-I., Miyamoto A., Yoshioka M. Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex. Eur J Pharmacol. 383:1999;39-48.
39. Matsumoto M., Yoshioka M., Togashi H., Mori K., Ueno K.-I., Saito H. Effects of idazoxan on dopamine release in the prefrontal cortex of freely moving rats. Eur J Pharmacol. 343:1998;165-170.
40. Meltzer H.Y. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology. 21:1999;106S-115S.
41. Miner L.A.H., Schroeter S., Blakely R.D., Sesack S.R. Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. J Comp Neurol. 427:2000;220-234.
42. Moore R.Y., Halaris A.E., Jones B.E. Serotonin neurons of the midbrain raphe ascending projections . J Comp Neurol. 180:1978;417-438.
43. Nocjar C., Roth B.L., Pehek E.A. Colocalization of serotonin-2A receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. 111:2002;163-176.
44. Novikoff A., Novikoff P., Quintana N., Davis C. Diffusion artifacts in 3, 3′-diaminobenzidine cytochemistry. J Histochem Cytochem. 20:1972;745-749.
45. Pehek E.A. Local infusion of the serotonin antagonists ritanserin or ICS 205, 930 increases in vivo dopamine release in the rat medial prefrontal cortex. Synapse. 24:1996;12-18.
46. Pehek E.A., McFarlane H.G., Maguschak K., Price B., Pluto C.P. M100, 907, a selective 5-HT2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex. Brain Res. 888:2001;51-59.
47. Peters A., Jones E.G. Classification of cortical neurons. Jones E.G., Peters A. Cerebral Cortex. 1984;107-121 Plenum, New York.
48. Peters A., Palay S.L., Webster H. The fine structure of the nervous system Neurons and their supporting cells . 1991;Oxford, New York.
49. Pompeiano M., Palacios J.M., Mengod G. Distribution of the serotonin 5-HT2 receptor family mRNAs comparison between 5-HT2A and 5-HT2C receptors . Mol Brain Res. 23:1994;163-178.
50. Sanders-Bush E., Burris K.D., Knoth K. Lysergic acid diethylamide and 2, 5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. J Pharmacol Exp Ther. 246:1988;924-928.
51. Schmidt C.J., Fadayel G.M. The selective 5-HT2A receptor antagonist, MDL 100, 907, increases dopamine efflux in the prefrontal cortex of the rat. Eur J Pharmacol. 273:1995;273-279.
52. Svensson T.H., Mathe J.M., Andersson J.L., Nomikos G.G., Hildebrand B.E., Marcus M. Mode of action of atypical neuroleptics in relation to the phencyclidine model of schizophrenia role of 5-HT2 receptor and alpha 1-adrenoreceptor antagonism . J Clin Pharmacol. 15:1995;11S-18S.
53. Willins D.L., Berry S.A., Alsayegh L., Backstrom J.R., Sanders-Bush E., Friedman L., Roth B.L. Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo. Neuroscience. 91:1999;599-606.
54. 2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse. 27:1997;79-82.
55. Xu T., Pandey S.C. Cellular localization of serotonin2A (5HT2A) receptors in the rat brain. Brain Res Bull. 51:2000;499-505.