The time-course for up- and down-regulation of the cortical 5-hydroxytryptamine (5-HT)2A receptor density predicts 5-HT 2A receptor-mediated behavior in the rabbit

Journal of Pharmacology and Experimental Therapeutics

Volumn 323, Issue 1, 2007, Pages 327-335

  Dave, Kuldip D ^a   Harvey, John A ^a   Aloyo, Vincent J ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; BROMOLYSERGIDE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; GLEMANSERIN; KETANSERIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHRONIC DRUG ADMINISTRATION; CONTINUOUS INFUSION; CONTROLLED STUDY; FRONTAL CORTEX; HEAD MOVEMENT; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; STEREOTYPY;

AMPHETAMINES; ANIMALS; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; DOWN-REGULATION; INJECTIONS, INTRAVENTRICULAR; MALE; PIPERIDINES; RABBITS; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN AGONISTS; UP-REGULATION;

EID: 34548831411     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.121707     Document Type: Article

References (41)

1. 2A receptors in the rabbit. J Pharmacol Exp Ther 299:1066-1072.
2. 2C receptors in the rabbit: high correlation with the profile for the human receptors. Eur J Pharmacol 406:163-169.
3. 2C receptors. Trends Pharmacol Sci 26:625-630.
4. Blackshear MA and Sanders-Bush E (1982) Serotonin receptor sensitivity after acute and chronic treatment with mianserin. J Pharmacol Exp Ther 221:303-308.
5. Bland BH, Seto MG, Sinclair BR, and Fraser SM (1984) The pharmacology of hippocampal theta cells: evidence that the sensory processing correlate is cholinergic. Brain Res 299:121-131.
6. 2 receptors in rat brain. Neuropsychopharmacology 3:137-148.
7. Burnet PW, Chen CP, McGowan S, Franklin M, and Harrison PJ (1996) The effects of clozapine and haloperidol on serotonin-1A, -2A, and -2C receptor gene expression and serotonin metabolism in the rat forebrain. Neuroscience 73:531-540.
8. 2 receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rats. Brain Res 638:311-324.
9. 2A binding sites in the brain of Sardinian alcohol-preferring and nonpreferring rats. Eur J Pharmacol 373:13-19.
10. Colpaert FC, Niemegeers CJE, and Janssen PAJ (1982) A drug discrimination analysis of LSD: in vivo agonist and antagonist effects of purported serotonin antagonists and of pirenperone, an LSD-antagonist. J Pharmacol Exp Ther 221:206-214.
11. Creese I and Sibley DR (1981) Receptor adaptations to centrally acting drugs. Annu Rev Pharmacol Toxicol 21:357-391.
12. 2A receptor up-regulation in the rabbit hippocampus results in an increase in head bobs induced by intra-hippocampal DOI. Soc Neurosci Abstr 28:636.1.
13. 1 field of the hippocampus mediate head movements in the rabbit. Psychopharmacology 176:287-295.
14. 2C receptor activation. Pharmacol Biochem Behav 72:371-378.
15. 2 receptors in mediating head bobs and body shakes in the rabbit. Pharmacol Biochem Behav 77:623-629.
16. 2 and beta-adrenergic receptors following nonadrenergic and serotonergic denervation. Life Sci 44:1419-1427.
17. Fontani G, Farabollini F, and Carli G (1984) Hippocampal electrical activity and behavior in the presence of novel environmental stimuli in rabbits. Behav Brain Res 13:231-240.
18. 1 dopamine receptors in various forebrain regions of the rat. Neurosci Lett 81:183-187.
19. 2A receptors by agonists and antagonists. Brain Res Bull 56:441-451.
20. 2A receptor density and associative learning. Psychopharmacology 172:435-442.
21. Hays WL (1981) Statistics, 3rd ed., pp. 464-465, Holt, Reinhart & Winston, New York.
22. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
23. 2A receptor binding sites and function in rat frontal cortex. Neuropharmacology 38:1421-1430.
24. Kuhn DM, White FJ, and Appel JB (1978) The discriminative stimulus properties of LSD: mechanism of action. Neuropharmacology 17:257-263.
25. 2 receptors by DOM treatment. Eur J Pharmacol 163:145-149.
26. 2 receptors: role in physiological and pathological conditions, in Serotonin: From Cell Biology to Pharmacology Therapeutics (Paoletti R ed) pp 323-329, Kluwer Academic Press, Dordrecht, The Netherlands.
27. 2 antagonists: ritanserin and setoperone. Psychopharmacology 88:434-444.
28. Munson PJ and Rodbard D (198) Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239.
29. Nichols DE (2004) Hallucinogens. Pharmacol Ther 101:131-181.
30. 1A receptor mRNA after irreversible inactivation with EEDQ. Mol Brain Res 38:233-242.
31. 2 antagonist. Eur J Pharmacol 246:73-80.
32. 2 receptors in mouse brain. Mol Pharmacol 43:84-89.
33. 2A receptors: molecular biology and mechanisms of regulation. Crit Rev Neurobiol 12:319-338.
34. 2 receptor mRNA levels. Eur J Pharmacol 207:169-172.
35. 1A agonists. J Pharmacol Exp Ther 273:101-112.
36. Sloviter RS, Drust EG, Damiano BP, and Connor JD (1980) A common mechanism for lysergic acid, indolealkylamine, and phenethylamine hallucinogens: serotonergic mediation of behavioral effects in rats. J Pharmacol Exp Ther 214:231-238.
37. 2 receptors after mianserin treatment: receptor sensitivity, not receptor binding, more accurately correlates with behavior. J Pharmacol Exp Ther 254:484-488.
38. Tsao P and von Zastrow M (2000) Downregulation of G protein-coupled receptors. Curr Opin Neurobiol 10:365-369.
39. Wettstein JG, Host M, and Hitchcock JM (1999) Selectivity of action of typical and atypical anti-psychotic drugs as antagonists of the behavioral effects of 1-[2,5-demethoxy-4-iodophenyl]-2-aminopropane (DOI). Prog Neuropsychopharmacol Biol Psychiatry 23:533-544.
40. 2A receptors in vitro and in vivo. Neuroscience 91:599-606.
41. 2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats. J Pharmacol Exp Ther 282:699-706.