Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors

ChemMedChem

Volumn 6, Issue 6, 2011, Pages 1011-1016

  Patel, Dipam ^a,b   Jain, Mukul ^a   Shah, Shailesh R ^b   Bahekar, Rajesh ^a   Jadav, Pradip ^a   Darji, Brijesh ^a   Siriki, Yernaidu ^a   Bandyopadhyay, Debdutta ^a   Joharapurkar, Amit ^a   Kshirsagar, Samadhan ^a   Patel, Harilal ^a   Shaikh, Mubeen ^a   Sairam, Kalapatapu V V M ^a   Patel, Pankaj ^a  

^a ZYDUS RESEARCH CENTRE   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

Benzotriazoles; Inhibitors; Metabolic disorders; PTP1B; TCPTP

Indexed keywords

ANTIDIABETIC AGENT; BENZOTRIAZOLE DERIVATIVE; KETONE DERIVATIVE; NAPHTHALENE DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INHIBITION; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ANIMALS; DIABETES MELLITUS; ENZYME INHIBITORS; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79957607076     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100077     Document Type: Article

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