Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics

Journal of Biological Chemistry

Volumn 281, Issue 43, 2006, Pages 32784-32795

  Ala, Paul J ^a   Gonneville, Lucie ^a   Hillman, Milton C ^a   Becker Pasha, Mary ^a   Wei, Min ^a   Reid, Brian G ^a   Klabe, Ronald ^a   Yue, Eddy W ^a   Wayland, Brian ^a   Douty, Brent ^a   Polam, Padmaja ^a   Wasserman, Zelda ^a   Bower, Michael ^a   Combs, Andrew P ^a   Burn, Timothy C ^a   Hollis, Gregory F ^a   Wynn, Richard ^a  

^a Experimental Station   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONPEPTIDIC INHIBITORS; PEPTIDES; PROTEIN-TYROSINE PHOSPHATASE 1B;

AMINES; CONFORMATIONS; CRYSTAL STRUCTURE; ENZYMES; HYDROGEN BONDS; PHOSPHORUS COMPOUNDS;

ENZYME INHIBITION;

ARGININE; BENZENE DERIVATIVE; HETEROCYCLIC COMPOUND; ISOTHIAZOLE DERIVATIVE; ISOTHIAZOLIDINONE; PHENOL; PHENYLALANINE; PHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG; WATER;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HUMANS; HYDROGEN BONDING; HYDROLYSIS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIAZOLES; WATER;

EID: 33845921519     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606873200     Document Type: Article

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