The structural basis for the selectivity of benzotriazole inhibitors of PTP1B

Biochemistry

Volumn 42, Issue 39, 2003, Pages 11451-11459

  Scapin, Giovanna ^a   Patel, Sangita B ^a   Becker, Joseph W ^a   Wang, Qingping ^b   Desponts, Caroline ^b   Waddleton, Deena ^b   Skorey, Kathryn ^b   Cromlish, Wanda ^b   Bayly, Christopher ^b   Therien, Michel ^b   Gauthier, Jacques Yves ^b   Li, Chun Sing ^b   Lau, Cheuk K ^b   Ramachandran, Chidambaram ^b   Kennedy, Brian P ^b   Asante Appiah, Ernest ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; CRYSTAL STRUCTURE; ENZYMES; INSULIN;

BINDING SITES;

BIOCHEMISTRY;

BENZOTRIAZOLE DERIVATIVE; DIFLUOROMETHYLPHOSPHONIC ACID INHIBITOR; INSULIN; PHENYLALANINE; PHOSPHATASE; PHOSPHATE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE IB; PROTEIN TYROSINE PHOSPHATASE IB INHIBITOR; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; T LYMPHOCYTE;

AMINO ACIDS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PHOSPHINIC ACIDS; POINT MUTATION; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRIAZOLES;

EID: 0141706651     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035098j     Document Type: Article

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