Novel complexation hydrogels for oral peptide delivery: In vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers

Journal of Biomedical Materials Research - Part A

Volumn 67, Issue 2, 2003, Pages 609-617

  Ichikawa, Hideki ^a,b   Peppas, Nicholas A ^a  

^a The University of Texas at Austin   (United States)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Caco 2 cells; Cytotoxicity; Insulin transport; Oral peptide delivery; pH sensitive hydrogels; Transepithelial electrical resistance

Indexed keywords

COMPLEXATION; ELECTRIC RESISTANCE; INSULIN; MONOLAYERS; POLYMERIZATION;

CYTOTOXICITY;

HYDROGELS;

CALCIUM; CARRIER PROTEIN; FREE RADICAL; INSULIN; MACROGOL; PEPTIDE; POLYMER; POLYMETHACRYLIC ACID;

AQUEOUS SOLUTION; ARTICLE; CALORIMETRY; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CELL SWELLING; CELL VIABILITY; CHEMICAL COMPOSITION; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ELECTRIC RESISTANCE; EVALUATION; HORMONE TRANSPORT; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; INSULIN TRANSPORT; INTESTINE EPITHELIUM CELL; MONOLAYER CULTURE; NONHUMAN; PARTICLE SIZE; POLYMERIZATION;

EID: 0348014780     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.10128     Document Type: Article

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