The Effect of Various in Vitro Conditions on the Permeability Characteristics of the Buccal Mucosa

Journal of Pharmaceutical Sciences

Volumn 92, Issue 12, 2003, Pages 2399-2410

  Nicolazzo, Joseph A ^a   Reed, Barry L ^a   Finnin, Barrie C ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Buccal mucosa; Caffeine; Estradiol; Paracellular; Permeability; Tissue integrity; Tissue viability; Transcellular

Indexed keywords

CAFFEINE; ESTRADIOL;

ANIMAL TISSUE; ARTICLE; CADAVER; CELL DEATH; CELL VIABILITY; CHEEK MUCOSA; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG TRANSPORT; EPITHELIUM; FROZEN SECTION; HISTOLOGY; HYDROPHILICITY; LIPOPHILICITY; MOUTH MUCOSA; NONHUMAN; PERMEABILITY; SWINE; TEMPERATURE; TISSUE INJURY;

EID: 0344443713     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10505     Document Type: Article

References (36)

1. Rathbone MJ, Hadgraft J. 1991. Absorption of drugs from the human oral cavity. Int J Pharm 74:9-24.
2. de Vries ME, Boddé HE, Verhoef JC, Junginger HE. 1991. Developments in buccal drug delivery. Crit Rev Ther Drug Carrier Syst 8:271-303.
3. Shojaei AH, Chang RK, Guo X, Burnside BA, Couch RA. 2001. Systemic drug delivery via the buccal mucosal route. Pharm Tech 25:70-81.
4. Squier CA. 1977. Membrane coating granules in nonkeratinizing oral epithelium. J Ultrastruct Res 60:212-220.
5. Zhang H, Robinson JR. 1996. Routes of drug transport across oral mucosa. In: Rathbone MJ, editor. Oral mucosal drug delivery. New York: Marcel Dekker Inc., pp 51-63.
6. Deneer VHM, Drese GB, Roemelé PEH, Verhoef JC, Lie-A-Huen L, Kingma JH, Brouwers JRBJ, Junginger HE. 2002. Buccal transport of flecainide and sotalol: Effect of a bile salt and ionization state. Int J Pharm 241:127-134.
7. Gandhi RB, Robinson JR. 1994. Oral cavity as a site for bioadhesive drug delivery. Adv Drug Del Rev 13:43-74.
8. Lesch CA, Squier CA, Cruchley A, Williams DM, Speight P. 1989. The permeability of human oral mucosa and skin to water. J Dent Res 68:1345-1349.
9. Hoogstraate AJ, Cullander C, Nagelkerke JF, Senel S, Verhoef JC, Junginger HE, Boddé HE. 1994. Diffusion rates and transport pathways of fluorescein isothiocyanate (FITC)-labeled model compounds through buccal epithelium. Pharm Res 11:83-89.
10. Squier CA. 1973. The permeability of keratinized and nonkeratinized oral epithelium to horseradish peroxidase. J Ultrastruct Res 43:160-177.
11. Squier CA, Rooney L. 1976. The permeability of keratinized and nonkeratinized oral epithelium to lanthanum in vivo. J Ultrastruct Res 54:286-295.
12. Wertz PW, Squier CA. 1991. Cellular and molecular basis of barrier function in oral epithelium. Crit Rev Ther Drug Carrier Syst 8:237-269.
13. Imbert D, Cullander C. 1999. Buccal mucosa in vitro experiments I. Confocal imaging of vital staining and MTT assays for the determination of tissue viability. J Controlled Release 58:39-50.
14. Imbert D, Cullander C. 1997. Assessment of cornea viability by confocal laser scanning microscopy and MTT assay. Cornea 16:666-674.
15. Gandhi R, Robinson J. 1992. Mechanisms of penetration enhancement for transbuccal delivery of salicylic acid. Int J Pharm 85:129-140.
16. Healy CM, Cruchley AT, Thornhill MH, Williams DM. 2000. The effect of sodium lauryl sulphate, triclosan and zinc on the permeability of normal oral mucosa. Oral Dis 6:118-123.
17. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
18. Hoogstraate AJ, Boddé HE. 1993. Methods for assessing the buccal mucosa as a route of drug delivery. Adv Drug Del Rev 12:99-125.
19. de Vries ME, Boddé HE, Verhoef JC, Ponec M, Crane WIHM, Junginger HE. 1991. Localization of the permeability barrier inside porcine buccal mucosa: A combined in vitro study of drug permeability, electrical resistance and tissue morphology. Int J Pharm 76:25-35.
20. Bronaugh RL, Stewart RF. 1984. Methods for in vitro percutaneous absorption studies III: Hydrophobic compounds. J Pharm Sci 73:1255-1258.
21. Bronaugh RL, Stewart RF. 1986. Methods for in vitro percutaneous absorption studies VI: Preparation of the barrier layer. J Pharm Sci 75:487-491.
22. Squier CA, Cox P, Wertz PW. 1991. Lipid content and water permeability of skin and oral mucosa. J Invest Dermatol 96:123-126.
23. Squier CA, Cox PS, Wertz PW, Downing DT. 1986. The lipid composition of porcine epidermis and oral epithelium. Arch Oral Biol 31:741-747.
24. Law S, Wertz PW, Swartzendruber DC, Squier CA. 1995. Regional variation in content, composition and organization of porcine epithelial barrier lipids revealed by thin-layer chromatography and transmission electron microscopy. Arch Oral Biol 40:1085-1091.
25. Squier CA, Wertz PW. 1996. Structure and function of the oral mucosa and implications for drug delivery. In: Rathbone MJ, editor. Oral mucosal drug delivery. New York: Marcel Dekker Inc., pp 1-26.
26. Su L, Lane EB, Morgan PR. 1996. Keratin 14 and 19 expression in normal, dysplastic and malignant oral epithelia-A study using in situ hybridization and immunohistochemistry. J Oral Pathol Med 25:293-301.
27. van der Bijl P, van Eyk AD, Thompson IO, Stander IA. 1998. Diffusion rates of vasopressin through human vaginal and buccal mucosa. Eur J Oral Sci 106:958-962.
28. van der Bijl P, van Eyk AD, Thompson IOC. 1998. Effect of freezing on the permeability of human buccal and vaginal mucosa. S Afr J Sci 94:499-502.
29. Agu RU, Dang HV, Jorissen M, Willems T, Kinget R, Verbeke N. 2002. Nasal absorption enhancement strategies for therapeutic peptides: An in vitro study using cultured human nasal epithelium. Int J Pharm 237:179-191.
30. Aungst BJ, Nguyen NH, Bulgarelli JP, Oates-Lenz K. 2000. The influence of donor and reservoir additives on Caco-2 permeability and secretory transport of HIV protease inhibitors and other lipophilic compounds. Pharm Res 17:1175-1180.
31. Hoogstraate AJ, Senel S, Cullander C, Verhoef J, Junginger HE, Boddé HE. 1996. Effects of bile salts on transport rates and routes of FITC-labelled compounds across porcine buccal epithelium in vitro. J Controlled Release 40:211-221.
32. Junginger HE, Hoogstraate JA, Verhoef JC. 1999. Recent advances in buccal drug delivery and absorption - In vitro and in vivo studies. J Controlled Release 62:149-159.
33. Schürmann W, Turner P. 1978. Membrane model of the human oral mucosa as derived from buccal absorption performance and physicochemical properties of the beta-blocking drugs atenolol and propranolol. J Pharm Pharmacol 30:137-147.
34. Zhang H, Robinson JR. 1996. In vitro methods for measuring permeability of the oral mucosa. In: Rathbone MJ, editor. Oral mucosal drug delivery. New York: Marcel Dekker Inc., pp 85-100.
35. Shojaei AH. 1998. Buccal mucosa as a route for systemic drug delivery: A review. J Pharm Pharmaceut Sci 1:15-30.
36. Mazur P. 1984. Freezing of living cells: mechanisms and implications. Am J Physiol 247:C125-C142.