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Volumn , Issue , 2019, Pages 581-642

In Vivo Probes for Studying Induction and Inhibition of Cytochrome P450 Enzymes in Humans

(1)  Wilkinson, Grant R a  

a NONE

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EID: 79956158224     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780429131967-14     Document Type: Chapter
Times cited : (1)

References (330)
  • 1
    • 0029003827 scopus 로고
    • Keynote address: Man, mice, microsomes, metabolites, and mathematics— 40 years after the revolution
    • Gillette JR. Keynote address: man, mice, microsomes, metabolites, and mathematics— 40 years after the revolution. Drug Metab Rev 1995; 27:1-44.
    • (1995) Drug Metab Rev , vol.27 , pp. 1-44
    • Gillette, J.R.1
  • 2
    • 0031884233 scopus 로고    scopus 로고
    • Assessment of the predictive power of genotypes for the in vivo catalytic function of CYP2D6 in a German population
    • Griese EU, Zanger UM, Bradermanns U, et al. Assessment of the predictive power of genotypes for the in vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics 1998; 8:15-26.
    • (1998) Pharmacogenetics , vol.8 , pp. 15-26
    • Griese, E.U.1    Zanger, U.M.2    Bradermanns, U.3
  • 3
    • 0029782373 scopus 로고    scopus 로고
    • Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism
    • Johnson EF, Waterman MR, eds, San Diego, CA: Academic Press
    • Goldstein JA, Blaisdell J. Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism. In: Johnson EF, Waterman MR, eds. Cytochrome P450, Part B: Methods in Enzymology. San Diego, CA: Academic Press, 1996; 272:210-218.
    • (1996) Cytochrome P450, Part B: Methods in Enzymology , vol.272 , pp. 210-218
    • Goldstein, J.A.1    Blaisdell, J.2
  • 4
    • 0014403645 scopus 로고
    • Genetic control of drug levels in man: Antipyrine
    • Vesell ES, Page JG. Genetic control of drug levels in man: antipyrine. Science 1968; 161:72-73.
    • (1968) Science , vol.161 , pp. 72-73
    • Vesell, E.S.1    Page, J.G.2
  • 5
    • 0019493382 scopus 로고
    • Assessment of urinary 63-hydroxycortisol as an in vivo index of mixedfunction oxygenase activity
    • Park BK. Assessment of urinary 63-hydroxycortisol as an in vivo index of mixedfunction oxygenase activity. Br J Clin Pharmacol 1981; 12:97-102.
    • (1981) Br J Clin Pharmacol , vol.12 , pp. 97-102
    • Park, B.K.1
  • 6
    • 3643081997 scopus 로고
    • Prediction of interpatient variability of drug metabolizing ability
    • Wilkinson GR, Rawlins MD, eds., Lancaster, PA: MTP Press
    • Wilkinson GR. Prediction of interpatient variability of drug metabolizing ability. In: Wilkinson GR, Rawlins MD, eds. Drug Metabolism and Disposition: Considerations in Clinical Pharmacology. Lancaster, PA: MTP Press, 1985, 183-209.
    • (1985) Drug Metabolism and Disposition: Considerations in Clinical Pharmacology , pp. 183-209
    • Wilkinson, G.R.1
  • 7
    • 0023929834 scopus 로고
    • Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6P-hydroxylase cytochrome P-450 enzyme
    • Waxman DJ, Attisano C, Guengerich FP, et al. Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6P-hydroxylase cytochrome P-450 enzyme. Arch Biochem Biophys 1988; 263:424-436.
    • (1988) Arch Biochem Biophys , vol.263 , pp. 424-436
    • Waxman, D.J.1    Attisano, C.2    Guengerich, F.P.3
  • 8
    • 0024427759 scopus 로고
    • The increase in urinary excretion of 6P-hydroxyCortisol as a marker of human hepatic cytochrome P450IIIA induction
    • Ged C, Rouillon JM, Pichard L, et al. The increase in urinary excretion of 6P-hydroxyCortisol as a marker of human hepatic cytochrome P450IIIA induction. Br J Clin Pharmacol 1989; 28:373-387.
    • (1989) Br J Clin Pharmacol , vol.28 , pp. 373-387
    • Ged, C.1    Rouillon, J.M.2    Pichard, L.3
  • 9
    • 0026732029 scopus 로고
    • Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IHA (CYP3A) activity
    • Watkins PB, Turgeon DK, Saenger P, et al. Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IHA (CYP3A) activity. Clin Pharmacol Ther 1992; 52:265-273.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 265-273
    • Watkins, P.B.1    Turgeon, D.K.2    Saenger, P.3
  • 10
    • 0026601064 scopus 로고
    • Heterogeneity of CYP3A isoforms metabolizing erythromycin and Cortisol
    • Hunt CM, Watkins PB, Saenger P, et al. Heterogeneity of CYP3A isoforms metabolizing erythromycin and Cortisol. Clin Pharmacol Ther 1992; 51:18-23.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 18-23
    • Hunt, C.M.1    Watkins, P.B.2    Saenger, P.3
  • 11
    • 0027770062 scopus 로고
    • Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men
    • Kinirons MT, O'Shea D, Downing TE, et al. Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men. Clin Pharmacol Ther 1993; 54:621-629.
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 621-629
    • Kinirons, M.T.1    O'shea, D.2    Downing, T.E.3
  • 12
    • 0000569935 scopus 로고
    • Route of administration does not explain the lack of correlation between putative in vivo probes of cytochrome P4503A
    • Kinirons MT, O'Shea D, Groopman JD, et al. Route of administration does not explain the lack of correlation between putative in vivo probes of cytochrome P4503A. Br J Clin Pharmacol 1994; 37:501P-502P.
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 501P-502P
    • Kinirons, M.T.1    O'shea, D.2    Groopman, J.D.3
  • 13
    • 0031922629 scopus 로고    scopus 로고
    • Effect of grapefruit juice on urinary 6p-hydroxycortisol/cortisoi excretion
    • Seidegard J, Dahlstrom K, Kullberg A. Effect of grapefruit juice on urinary 6p-hydroxycortisol/cortisoi excretion. Clin Exp Pharmacol Physiol 1998; 25:379-381.
    • (1998) Clin Exp Pharmacol Physiol , vol.25 , pp. 379-381
    • Seidegard, J.1    Dahlstrom, K.2    Kullberg, A.3
  • 14
    • 0031868142 scopus 로고    scopus 로고
    • Urinary excretion of 6-beta-hydroxycortisol as an in vivo marker for CYP3A induction: Applications and recommendations
    • Kovacs SJ, Martin DE, Everitt DE, et al. Urinary excretion of 6-beta-hydroxycortisol as an in vivo marker for CYP3A induction: applications and recommendations. Clin Pharmacol Ther 1998; 63:617-622.
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 617-622
    • Kovacs, S.J.1    Martin, D.E.2    Everitt, D.E.3
  • 16
    • 0031892907 scopus 로고    scopus 로고
    • Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4
    • Monsarrat B, Chatelut E, Royer I, et al. Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4. Drug Metab Dispos 1998; 26:229-233.
    • (1998) Drug Metab Dispos , vol.26 , pp. 229-233
    • Monsarrat, B.1    Chatelut, E.2    Royer, I.3
  • 17
    • 0023132476 scopus 로고
    • Clearance approaches in pharmacology
    • Wilkinson GR. Clearance approaches in pharmacology. Pharmacol Rev 1987; 39: 1-47.
    • (1987) Pharmacol Rev , vol.39 , pp. 1-47
    • Wilkinson, G.R.1
  • 18
    • 0023035844 scopus 로고
    • Polymorphic drug oxidation: Pharmacokinetic basis and comparison of experimental indices
    • Jackson PR, Tucker GT, Lennard MS, et al. Polymorphic drug oxidation: pharmacokinetic basis and comparison of experimental indices. Br J Clin Pharmacol 1986; 22:541-550.
    • (1986) Br J Clin Pharmacol , vol.22 , pp. 541-550
    • Jackson, P.R.1    Tucker, G.T.2    Lennard, M.S.3
  • 19
    • 0033406050 scopus 로고    scopus 로고
    • Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes
    • Dalen P, Dahl ML, Eichelbaum M, et al. Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes. Pharmacogenetics 1999; 9:697-706.
    • (1999) Pharmacogenetics , vol.9 , pp. 697-706
    • Dalen, P.1    Dahl, M.L.2    Eichelbaum, M.3
  • 20
    • 0019515321 scopus 로고
    • Debrisoquine hydroxylation capacity: Problems of assessment in two populations
    • Inaba T, Otton SV, Kalow W. Debrisoquine hydroxylation capacity: problems of assessment in two populations. Clin Pharmacol Ther 1981; 29:218-223.
    • (1981) Clin Pharmacol Ther , vol.29 , pp. 218-223
    • Inaba, T.1    Otton, S.V.2    Kalow, W.3
  • 21
    • 0023193252 scopus 로고
    • Genetic predisposition to bladder cancer: Ability to hydroxylate debrisoquine and mephenytoin as risk factors
    • Kaisary A, Smith P, Jacqz E, et al. Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors. Cancer Res 1987; 47:5488-5493.
    • (1987) Cancer Res , vol.47 , pp. 5488-5493
    • Kaisary, A.1    Smith, P.2    Jacqz, E.3
  • 22
    • 0021237993 scopus 로고
    • Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
    • Kiipfer A, Preisig R. Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man. Eur J Clin Pharmacol 1984; 26:753-759.
    • (1984) Eur J Clin Pharmacol , vol.26 , pp. 753-759
    • Kiipfer, A.1    Preisig, R.2
  • 23
    • 0021684926 scopus 로고
    • Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
    • Wedlund PJ, Aslanian WS, McAllister CB, et al. Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clin Pharmacol Ther 1984; 36:773-780.
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 773-780
    • Wedlund, P.J.1    Aslanian, W.S.2    McAllister, C.B.3
  • 24
    • 0029978651 scopus 로고    scopus 로고
    • Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: Comparison of sparteine and dextromethorphan
    • Kevorkian JP, Michel C, Hofmann U, et al. Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: comparison of sparteine and dextromethorphan. Clin Pharmacol Ther 1996; 59:583-592.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 583-592
    • Kevorkian, J.P.1    Michel, C.2    Hofmann, U.3
  • 25
    • 0028304678 scopus 로고
    • Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics
    • Girre C, Lucas D, Hispand E, et al. Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics. Biochem Pharmacol 1994; 47:1503-1508.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1503-1508
    • Girre, C.1    Lucas, D.2    Hispand, E.3
  • 26
    • 0031909513 scopus 로고    scopus 로고
    • Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: Choice of dose and phenotypic trait measure
    • Frye RF, Adedoyin A, Mauro K, et al. Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: choice of dose and phenotypic trait measure. J Clin Pharmacol 1998; 38:82-89.
    • (1998) J Clin Pharmacol , vol.38 , pp. 82-89
    • Frye, R.F.1    Adedoyin, A.2    Mauro, K.3
  • 27
    • 0019723001 scopus 로고
    • Drug metabolite kinetics
    • Houston JB. Drug metabolite kinetics. Pharmacol Ther 1982; 15:521-552.
    • (1982) Pharmacol Ther , vol.15 , pp. 521-552
    • Houston, J.B.1
  • 28
    • 0029035739 scopus 로고
    • Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms
    • Kim RB, O'Shea D, Wilkinson GR. Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms. Clin Pharmacol Ther 1995; 57:645-655.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 645-655
    • Kim, R.B.1    O'shea, D.2    Wilkinson, G.R.3
  • 29
    • 0020989281 scopus 로고
    • The C02 breath tests as monitors of the cytochrome P450 dependent mixed function monooxygenase system
    • Lambert GH, Kotake AN, Schoeller D. The C02 breath tests as monitors of the cytochrome P450 dependent mixed function monooxygenase system. Prog Clin Biol Res 1983; 135:119-145.
    • (1983) Prog Clin Biol Res , vol.135 , pp. 119-145
    • Lambert, G.H.1    Kotake, A.N.2    Schoeller, D.3
  • 30
    • 0022649901 scopus 로고
    • Drug pharmacokinetics and the carbon dioxide breath test
    • Lane EA, Parashos I. Drug pharmacokinetics and the carbon dioxide breath test. J Pharmacokinet Biopharm 1986; 14:29-49.
    • (1986) J Pharmacokinet Biopharm , vol.14 , pp. 29-49
    • Lane, E.A.1    Parashos, I.2
  • 31
    • 0028847788 scopus 로고
    • The erythromycin breath test predicts the clearance of midazolam
    • Lown KS, Thummel KE, Benedict PE, et al. The erythromycin breath test predicts the clearance of midazolam. Clin Pharmacol Ther 1995; 57:16-24.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 16-24
    • Lown, K.S.1    Thummel, K.E.2    Benedict, P.E.3
  • 32
    • 0025285552 scopus 로고
    • A "cocktail" strategy to assess in vivo oxidative drug metabolism in humans
    • Breimer DD, Schellens JHM. A "cocktail" strategy to assess in vivo oxidative drug metabolism in humans. Trends Pharmacol Sei 1990; 11:223-225.
    • (1990) Trends Pharmacol Sei , vol.11 , pp. 223-225
    • Breimer, D.D.1    Schellens, J.H.M.2
  • 33
    • 0024336503 scopus 로고
    • S-Mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin
    • Sanz EJ, Villen T, Alm C, et al. S-Mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin. Clin Pharmacol Ther 1989; 45:495-499.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 495-499
    • Sanz, E.J.1    Villen, T.2    Alm, C.3
  • 34
    • 0025955418 scopus 로고
    • Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans
    • Schellens JHM, Ghabrial H, van der Wart HHF, et al. Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans. Clin Pharmacol Ther 1991; 50:520-528.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 520-528
    • Schellens, J.H.M.1    Ghabrial, H.2    van der Wart, H.H.F.3
  • 35
    • 0030712276 scopus 로고    scopus 로고
    • Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes
    • Frye RF, Matzke GR, Adedoyin A, et al. Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes. Clin Pharmacol Ther 1997; 62:365-376.
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 365-376
    • Frye, R.F.1    Matzke, G.R.2    Adedoyin, A.3
  • 36
    • 0030041966 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between dextromethorphan, coumarin and mephenytoin in man after simultaneous administration
    • Endres HGE, Henschel L, Merkel U, et al. Lack of pharmacokinetic interaction between dextromethorphan, coumarin and mephenytoin in man after simultaneous administration. Pharmazie 1996; 51:46-51.
    • (1996) Pharmazie , vol.51 , pp. 46-51
    • Endres, H.G.E.1    Henschel, L.2    Merkel, U.3
  • 37
    • 0031688229 scopus 로고    scopus 로고
    • Chloroquine modulation of specific metabolizing enzymes activities: Investigation with selective five drug cocktail
    • Adedoyin A, Frye RF, Mauro K, et al. Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail. Br J Clin Pharmacol 1998; 46:215-219.
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 215-219
    • Adedoyin, A.1    Frye, R.F.2    Mauro, K.3
  • 38
    • 0027265750 scopus 로고
    • CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans
    • Jacqz-Aigrain E, Funck-Brentano C, Cresteil T. CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans. Pharmacogenetics 1993; 3:197-204.
    • (1993) Pharmacogenetics , vol.3 , pp. 197-204
    • Jacqz-Aigrain, E.1    Funck-Brentano, C.2    Cresteil, T.3
  • 39
    • 0029917318 scopus 로고    scopus 로고
    • Quantification of dextromethorphan and metabolites: A dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity
    • Jones DR, Gorski JC, Hamman MA, et al. Quantification of dextromethorphan and metabolites: a dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity. J Chromatogr B Biomed Appl 1996; 678:105-111.
    • (1996) J Chromatogr B Biomed Appl , vol.678 , pp. 105-111
    • Jones, D.R.1    Gorski, J.C.2    Hamman, M.A.3
  • 40
    • 0029965231 scopus 로고    scopus 로고
    • Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity
    • Ducharme J, Abdullah S, Wainer IW. Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity. J Chromatogr B Biomed Appl 1996; 678:113-128.
    • (1996) J Chromatogr B Biomed Appl , vol.678 , pp. 113-128
    • Ducharme, J.1    Abdullah, S.2    Wainer, I.W.3
  • 41
    • 0030889604 scopus 로고    scopus 로고
    • Metabolism of dextromethorphan in vitro: Involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1
    • Schmider J, Greenblatt DJ, Fogelman SM, et al. Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1. Biopharm Drug Dispos 1997; 18:227-240.
    • (1997) Biopharm Drug Dispos , vol.18 , pp. 227-240
    • Schmider, J.1    Greenblatt, D.J.2    Fogelman, S.M.3
  • 42
    • 0031015345 scopus 로고    scopus 로고
    • Human P450 metabolism of warfarin
    • Kaminsky LS, Zhang ZY. Human P450 metabolism of warfarin. Pharmacol Ther 1997; 73:67-74.
    • (1997) Pharmacol Ther , vol.73 , pp. 67-74
    • Kaminsky, L.S.1    Zhang, Z.Y.2
  • 43
    • 0029867317 scopus 로고    scopus 로고
    • Formation of (R)-8-hydroxywarfarin in human liver microsomes—a new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19
    • Wienkers LC, Wurden CJ, Storch E, et al. Formation of (R)-8-hydroxywarfarin in human liver microsomes—a new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19. Drug Metab Dispos 1996; 24:610-614.
    • (1996) Drug Metab Dispos , vol.24 , pp. 610-614
    • Wienkers, L.C.1    Wurden, C.J.2    Storch, E.3
  • 45
    • 0027197152 scopus 로고
    • The use of caffeine for enzyme assays: A critical appraisal
    • Kalow W, Tang BK. The use of caffeine for enzyme assays: a critical appraisal. Clin Pharmacol Ther 1993; 53:503-514.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 503-514
    • Kalow, W.1    Tang, B.K.2
  • 46
    • 0029981725 scopus 로고    scopus 로고
    • The use of caffeine as a metabolic probe for human drug metabolizing enzymes
    • Miners JO, Birkett DJ. The use of caffeine as a metabolic probe for human drug metabolizing enzymes. Gen Pharmacol 1996; 27:245-249.
    • (1996) Gen Pharmacol , vol.27 , pp. 245-249
    • Miners, J.O.1    Birkett, D.J.2
  • 47
    • 0344840980 scopus 로고    scopus 로고
    • Evaluation of caffeine as a test drug for CYPTA2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations
    • Fuhr U, Rost KL, Engelhardt R, et al. Evaluation of caffeine as a test drug for CYPTA2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations. Pharmacogenetics 1996; 6:159-176.
    • (1996) Pharmacogenetics , vol.6 , pp. 159-176
    • Fuhr, U.1    Rost, K.L.2    Engelhardt, R.3
  • 48
    • 0025341935 scopus 로고
    • Use of quantitative liver function tests— caffeine clearance and galactose elimination capacity—after orthotopic liver transplantation
    • Nagel RA, Dirix LY, Hay liar KM, et al. Use of quantitative liver function tests— caffeine clearance and galactose elimination capacity—after orthotopic liver transplantation. J Hepatol 1990; 10:149-157.
    • (1990) J Hepatol , vol.10 , pp. 149-157
    • Nagel, R.A.1    Dirix, L.Y.2    Hay Liar, K.M.3
  • 49
    • 0031935574 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic methods used to estimate caffeine clearance and comparison with a Bayesian forecasting method
    • Denaro CP, Jacob P III, Benowitz NL. Evaluation of pharmacokinetic methods used to estimate caffeine clearance and comparison with a Bayesian forecasting method. Ther Drug Monit 1998; 20:78-87.
    • (1998) Ther Drug Monit , vol.20 , pp. 78-87
    • Denaro, C.P.1    Jacob, P.2    Benowitz, N.L.3
  • 50
    • 0026799377 scopus 로고
    • Intra-individual variability of caffeine elimination in healthy subjects
    • Balogh A, Harder S, Vollandt R, et al. Intra-individual variability of caffeine elimination in healthy subjects. Int J Clin Pharmacol Ther Toxicol 1992; 30: 383-387.
    • (1992) Int J Clin Pharmacol Ther Toxicol , vol.30 , pp. 383-387
    • Balogh, A.1    Harder, S.2    Vollandt, R.3
  • 51
    • 0029974530 scopus 로고    scopus 로고
    • Caffeine urinary metabolite ratios as markers of enzyme activity: A theoretical assessment
    • Rostami-Hodjegan A, Nurminen S, Jackson PR, et al. Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment. Pharmacogenetics 1996; 6:121-149.
    • (1996) Pharmacogenetics , vol.6 , pp. 121-149
    • Rostami-Hodjegan, A.1    Nurminen, S.2    Jackson, P.R.3
  • 52
    • 0023254252 scopus 로고
    • Overnight salivary caffeine clearance: a liver function test suitable for routine use
    • Jost G, Wahllander A, von Mandach U, et al. Overnight salivary caffeine clearance: a liver function test suitable for routine use. Hepatology 1987; 7:338-344.
    • (1987) Hepatology , vol.7 , pp. 338-344
    • Jost, G.1    Wahllander, A.2    von Mandach, U.3
  • 53
    • 0027510377 scopus 로고
    • Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man
    • Fuhr U, Klittich K, Staib AH. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin Pharmacol 1993; 35:431-436.
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 431-436
    • Fuhr, U.1    Klittich, K.2    Staib, A.H.3
  • 54
    • 0023227456 scopus 로고
    • A urinary metabolite ratio that reflects systemic caffeine clearance
    • Campbell ME, Spielberg SP, Kalow W. A urinary metabolite ratio that reflects systemic caffeine clearance. Clin Pharmacol Ther 1987; 42:157-165.
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 157-165
    • Campbell, M.E.1    Spielberg, S.P.2    Kalow, W.3
  • 55
    • 0025342609 scopus 로고
    • Assessment of hepatic function— comparison of caffeine clearance in serum and saliva during the day and at night
    • Wahllander A, Mohr S, Paumgartner G. Assessment of hepatic function— comparison of caffeine clearance in serum and saliva during the day and at night. J Hepatol 1990; 10:129-137.
    • (1990) J Hepatol , vol.10 , pp. 129-137
    • Wahllander, A.1    Mohr, S.2    Paumgartner, G.3
  • 56
    • 0028336745 scopus 로고
    • Simple and reliable CYP1A2 phenotyping by the paraxanthine/ caffeine ratio in plasma and in saliva
    • Fuhr U, Rost KL. Simple and reliable CYP1A2 phenotyping by the paraxanthine/ caffeine ratio in plasma and in saliva. Pharmacogenetics 1994; 4:109-116.
    • (1994) Pharmacogenetics , vol.4 , pp. 109-116
    • Fuhr, U.1    Rost, K.L.2
  • 57
    • 0019845496 scopus 로고
    • Assessment of the cytochrome P-448 dependent liver enzyme system by a caffeine breath test
    • Wietholtz H, Voegelin M, Arnaud MJ, et al. Assessment of the cytochrome P-448 dependent liver enzyme system by a caffeine breath test. Eur J Clin Pharmacol 1981; 21:53-59.
    • (1981) Eur J Clin Pharmacol , vol.21 , pp. 53-59
    • Wietholtz, H.1    Voegelin, M.2    Arnaud, M.J.3
  • 58
    • 0020331435 scopus 로고
    • The caffeine C02 breath test: Dose response and route of N-demethylation in smokers and nonsmokers
    • Kotake AN, Schoeller DA, Lambert GH, et al. The caffeine C02 breath test: dose response and route of N-demethylation in smokers and nonsmokers. Clin Pharmacol Ther 1982; 32:261-269.
    • (1982) Clin Pharmacol Ther , vol.32 , pp. 261-269
    • Kotake, A.N.1    Schoeller, D.A.2    Lambert, G.H.3
  • 59
    • 0028818391 scopus 로고
    • Microsomal function in hepatitis B surface antigen healthy carriers: Assessment of cytochrome P450 1A2 activity by the 14C-caffeine breath test
    • Horsmans Y, De Köninck X, Geubel AP, et al. Microsomal function in hepatitis B surface antigen healthy carriers: assessment of cytochrome P450 1A2 activity by the 14C-caffeine breath test. Pharmacol Toxicol 1995; 77:247-249.
    • (1995) Pharmacol Toxicol , vol.77 , pp. 247-249
    • Horsmans, Y.1    de Köninck, X.2    Geubel, A.P.3
  • 60
    • 0026699994 scopus 로고
    • Increase of cytochrome P450IA2 activity by omeprazole: Evidence by the 13C-(N-3-methyl)-caffeine breath test in poor and extensive metabolizers of S-mephenytoin
    • Rost KL, Brosicke H, Brockmoller J, et al. Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-(N-3-methyl)-caffeine breath test in poor and extensive metabolizers of S-mephenytoin. Clin Pharmacol Ther 1992; 52:170-180.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 170-180
    • Rost, K.L.1    Brosicke, H.2    Brockmoller, J.3
  • 61
    • 0028240671 scopus 로고
    • Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: Coincidence with plasma clearance and breath test
    • Rost KL, Roots I. Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test. Clin Pharmacol Ther 1994; 55:402-411.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 402-411
    • Rost, K.L.1    Roots, I.2
  • 62
    • 0021369535 scopus 로고
    • Caffeine: A model compound for measuring liver function
    • Renner E, Wietholtz H, Huguenin P, et al. Caffeine: a model compound for measuring liver function. Hepatology 1984; 4:38-46.
    • (1984) Hepatology , vol.4 , pp. 38-46
    • Renner, E.1    Wietholtz, H.2    Huguenin, P.3
  • 63
    • 0023924937 scopus 로고
    • Maturation of caffeine N-demethylation in infancy: A study using the 13C02 breath test
    • Pons G, Blais JC, Rey E, et al. Maturation of caffeine N-demethylation in infancy: a study using the 13C02 breath test. Pediatr Res 1988; 23:632-636.
    • (1988) Pediatr Res , vol.23 , pp. 632-636
    • Pons, G.1    Blais, J.C.2    Rey, E.3
  • 64
    • 0029898260 scopus 로고    scopus 로고
    • The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity
    • Fontana RJ, Turgeon DK, Woolf TF, et al. The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity. Hepatology 1996; 23:1429-1435.
    • (1996) Hepatology , vol.23 , pp. 1429-1435
    • Fontana, R.J.1    Turgeon, D.K.2    Woolf, T.F.3
  • 65
    • 0021289071 scopus 로고
    • A (14C) phenacetin breath test to measure hepatic function in man
    • Breen KJ, Bury RW, Calder IV, et al. A (14C) phenacetin breath test to measure hepatic function in man. Hepatology 1984; 4:47-52.
    • (1984) Hepatology , vol.4 , pp. 47-52
    • Breen, K.J.1    Bury, R.W.2    Calder, I.V.3
  • 66
    • 0021946431 scopus 로고
    • Comparison of the phenacetin and aminopyrine breath tests: Effect of liver disease, inducers and cobaltous chloride
    • Schoeller DA, Kotake AN, Lambert GH, et al. Comparison of the phenacetin and aminopyrine breath tests: effect of liver disease, inducers and cobaltous chloride. Hepatology 1985; 5:276-281.
    • (1985) Hepatology , vol.5 , pp. 276-281
    • Schoeller, D.A.1    Kotake, A.N.2    Lambert, G.H.3
  • 67
    • 0025892853 scopus 로고
    • Caffeine as a metabolic probe: Validation of its use for acetylator phenotyping
    • Tang BK, Kadar D, Quian L, et al. Caffeine as a metabolic probe: validation of its use for acetylator phenotyping. Clin Pharmacol Ther 1991; 49:648-657.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 648-657
    • Tang, B.K.1    Kadar, D.2    Quian, L.3
  • 68
    • 0028934923 scopus 로고
    • Caffeine as a metabolic probe: A comparison of the metabolic ratios used to assess CYP1A2 activity
    • Notarianni LJ, Oliver SE, Dobrocky P, et al. Caffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activity. Br J Clin Pharmacol 1995; 39:65-69.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 65-69
    • Notarianni, L.J.1    Oliver, S.E.2    Dobrocky, P.3
  • 69
    • 0029971627 scopus 로고    scopus 로고
    • Validation of urine caffeine metabolite ratios with use of stable isotope-labeled caffeine clearance
    • Denaro CP, Wilson M, Jacob P III, et al. Validation of urine caffeine metabolite ratios with use of stable isotope-labeled caffeine clearance. Clin Pharmacol Ther 1996; 59:284-296.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 284-296
    • Denaro, C.P.1    Wilson, M.2    Jacob, P.3
  • 70
    • 0028333956 scopus 로고
    • Caffeine as a probe for CYP1A2 activity: Potential influence of renal factors on urinary phenotypic trait measurements
    • Tang BK, Zhou Y, Kadar D, et al. Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements. Pharmacogenetics 1994; 4:117-124.
    • (1994) Pharmacogenetics , vol.4 , pp. 117-124
    • Tang, B.K.1    Zhou, Y.2    Kadar, D.3
  • 71
    • 0026879487 scopus 로고
    • Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites
    • Butler MA, Lange NP, Young JF, et al. Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics 1992; 2:116-127.
    • (1992) Pharmacogenetics , vol.2 , pp. 116-127
    • Butler, M.A.1    Lange, N.P.2    Young, J.F.3
  • 72
    • 0028336794 scopus 로고
    • Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: Absence of mutation prescribing the phenotype in the CYP1A2 gene
    • Nakajima M, Yokoi T, Mizutani M, et al. Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene. Cancer Epidemiol Biomarkers Prev 1994; 3:413-421.
    • (1994) Cancer Epidemiol Biomarkers Prev , vol.3 , pp. 413-421
    • Nakajima, M.1    Yokoi, T.2    Mizutani, M.3
  • 73
    • 0029039042 scopus 로고
    • Polymorphic drug metabolism: Studies with recombinant Chinese hamster cells and analyses in human populations
    • Yokoi T, Sawada M, Kamataki T. Polymorphic drug metabolism: studies with recombinant Chinese hamster cells and analyses in human populations. Pharmacogenetics 1995; 5:S65-S69.
    • (1995) Pharmacogenetics , vol.5 , pp. S65-S69
    • Yokoi, T.1    Sawada, M.2    Kamataki, T.3
  • 74
    • 0026621673 scopus 로고
    • Racial and gender differences in Af-acetyltransferase, xanthine oxidase, and CYP1A2 activities
    • Relling MV, Lin JS, Ayers GD, et al. Racial and gender differences in Af-acetyltransferase, xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther 1992; 52:643-658.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 643-658
    • Relling, M.V.1    Lin, J.S.2    Ayers, G.D.3
  • 75
    • 0025969276 scopus 로고
    • Caffeine as a metabolic probe: Exploration of the enzymeinducing effect of cigarette smoking
    • Kalow W, BK Tang. Caffeine as a metabolic probe: exploration of the enzymeinducing effect of cigarette smoking. Clin Pharmacol Ther 1991; 49:44-48.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 44-48
    • Kalow, W.1    Tang, B.K.2
  • 76
    • 0026094528 scopus 로고
    • Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities
    • Kalow W, Tang BK. Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities. Clin Pharmacol Ther 1991; 50:508-519.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 508-519
    • Kalow, W.1    Tang, B.K.2
  • 77
    • 0026756018 scopus 로고
    • Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine
    • Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 1992; 13: 1561-1568.
    • (1992) Carcinogenesis , vol.13 , pp. 1561-1568
    • Vistisen, K.1    Poulsen, H.E.2    Loft, S.3
  • 79
    • 0028605469 scopus 로고
    • A population and family study of CYP1A2 using caffeine urinary metabolites
    • Catteau A, Bechtel YC, Poisson N, et al. A population and family study of CYP1A2 using caffeine urinary metabolites. Eur J Clin Pharmacol 1995; 47:423-430.
    • (1995) Eur J Clin Pharmacol , vol.47 , pp. 423-430
    • Catteau, A.1    Bechtel, Y.C.2    Poisson, N.3
  • 80
    • 0029891271 scopus 로고    scopus 로고
    • Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans
    • Rasmussen BB, Brosen K. Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans. Ther Drug Monit 1996; 18:254-262.
    • (1996) Ther Drug Monit , vol.18 , pp. 254-262
    • Rasmussen, B.B.1    Brosen, K.2
  • 81
    • 0027999623 scopus 로고
    • Rapid metabolic phenotypes of acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps
    • Lang NP, Butler MA, Massengill J, et al. Rapid metabolic phenotypes of acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol Biomarkers Prev 1994; 3:675-682.
    • (1994) Cancer Epidemiol Biomarkers Prev , vol.3 , pp. 675-682
    • Lang, N.P.1    Butler, M.A.2    Massengill, J.3
  • 82
    • 0025278485 scopus 로고
    • Human N-acetylation genotype determination with urinary caffeine metabolites
    • Kilbane AJ, Silbart LK, Manis M, et al. Human N-acetylation genotype determination with urinary caffeine metabolites. Clin Pharmacol Ther 1990; 47:470-477.
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 470-477
    • Kilbane, A.J.1    Silbart, L.K.2    Manis, M.3
  • 83
    • 0028942638 scopus 로고
    • Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities
    • McQuilkin SH, Nierenberg DW, Bresnick E. Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities. Cancer Epidemiol Biomarkers Prev 1995; 4:139-146.
    • (1995) Cancer Epidemiol Biomarkers Prev , vol.4 , pp. 139-146
    • McQuilkin, S.H.1    Nierenberg, D.W.2    Bresnick, E.3
  • 84
    • 0023740895 scopus 로고
    • Interindividual and intraindividualvariability in acetylation: Characterization with caffeine
    • Hardy BG, Lemieux C, Walker SE, et al. Interindividual and intraindividualvariability in acetylation: characterization with caffeine. Clin Pharmacol Ther 1988; 44:152-157.
    • (1988) Clin Pharmacol Ther , vol.44 , pp. 152-157
    • Hardy, B.G.1    Lemieux, C.2    Walker, S.E.3
  • 85
    • 0023472855 scopus 로고
    • An alternative test for acetylator phenotyping with caffeine
    • Tang BK, Kadar D, Kalow W. An alternative test for acetylator phenotyping with caffeine. Clin Pharmacol Ther 1987; 42:509-513.
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 509-513
    • Tang, B.K.1    Kadar, D.2    Kalow, W.3
  • 86
    • 8044244218 scopus 로고    scopus 로고
    • Theophylline has no advantages over caffeine as a putative model drug for assessing CYP1A2 activity in humans
    • Rasmussen BB, Brosen K. Theophylline has no advantages over caffeine as a putative model drug for assessing CYP1A2 activity in humans. Br J Clin Pharmacol 1997; 43:253-258.
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 253-258
    • Rasmussen, B.B.1    Brosen, K.2
  • 87
    • 0023733220 scopus 로고
    • Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse
    • Raunio H, Syngelma T, Pasanen M, et al. Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse. Biochem Pharmacol 1988; 37:3889-3895.
    • (1988) Biochem Pharmacol , vol.37 , pp. 3889-3895
    • Raunio, H.1    Syngelma, T.2    Pasanen, M.3
  • 88
    • 0025214234 scopus 로고
    • Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxy-lase activity
    • Miles JS, McLaren AW, Forrester LM, et al. Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxy-lase activity. Biochem J 1990; 267:365-371.
    • (1990) Biochem J , vol.267 , pp. 365-371
    • Miles, J.S.1    McLaren, A.W.2    Forrester, L.M.3
  • 89
    • 0028925110 scopus 로고
    • Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity
    • Kharasch ED, Hankins DC, Thummel KE. Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology 1995; 82:689-699.
    • (1995) Anesthesiology , vol.82 , pp. 689-699
    • Kharasch, E.D.1    Hankins, D.C.2    Thummel, K.E.3
  • 90
    • 0030924897 scopus 로고    scopus 로고
    • Cytochrome P4502E1 is the principal catalyst of human oxidative halothane metabolism in vitro
    • Spracklin DK, Hankins DC, Fisher JM, et al. Cytochrome P4502E1 is the principal catalyst of human oxidative halothane metabolism in vitro. J Pharmacol Exp Ther 1997; 281:400-411.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 400-411
    • Spracklin, D.K.1    Hankins, D.C.2    Fisher, J.M.3
  • 91
    • 0030831766 scopus 로고    scopus 로고
    • Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid
    • Sadeque AJM, Fisher MB, Korzekwa KR, et al. Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid. J Pharmacol Exp Ther 1997; 283:698-703.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 698-703
    • Sadeque, A.J.M.1    Fisher, M.B.2    Korzekwa, K.R.3
  • 92
    • 0028832603 scopus 로고
    • Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N,N-diethylthiolcarbamate (DETC-ME). The terminal step in the bioactivation of disulfiram
    • Madan A, Parkinson A, Faiman MD. Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N,N-diethylthiolcarbamate (DETC-ME). The terminal step in the bioactivation of disulfiram. Drug Metab Dispos 1995; 23:1153-1163.
    • (1995) Drug Metab Dispos , vol.23 , pp. 1153-1163
    • Madan, A.1    Parkinson, A.2    Faiman, M.D.3
  • 93
    • 0029813840 scopus 로고    scopus 로고
    • Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes
    • Torchin CD, McNeilly PJ, Kapetanovic IM, et al. Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes. Drug Metab Dispos 1996; 24:1002-1008.
    • (1996) Drug Metab Dispos , vol.24 , pp. 1002-1008
    • Torchin, C.D.1    McNeilly, P.J.2    Kapetanovic, I.M.3
  • 94
    • 0000169111 scopus 로고    scopus 로고
    • CYP3A4 and CYP2A6 are involved in the biotransformation of letrozole
    • Wirz B, Valles B, Parkinson A, et al. CYP3A4 and CYP2A6 are involved in the biotransformation of letrozole. ISSX Proc 1996; 10:359.
    • (1996) ISSX Proc , vol.10 , pp. 359
    • Wirz, B.1    Valles, B.2    Parkinson, A.3
  • 95
    • 0030435329 scopus 로고    scopus 로고
    • (+)-Cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes
    • Nunoya KI, Yokoi T, Kimura K, et al. (+)-Cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes. J Pharmacol Exp Ther 1996; 277:768-774.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 768-774
    • Nunoya, K.I.1    Yokoi, T.2    Kimura, K.3
  • 96
    • 0025022689 scopus 로고
    • The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
    • Yamano S, Tatsuno J, Gonzalez FJ. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry 1990; 29: 1322-1329.
    • (1990) Biochemistry , vol.29 , pp. 1322-1329
    • Yamano, S.1    Tatsuno, J.2    Gonzalez, F.J.3
  • 97
    • 0030697098 scopus 로고    scopus 로고
    • A single amino acid substitution (Leul60His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin
    • Hadidi H, Zahlsen K, Idle JR, et al. A single amino acid substitution (Leul60His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin. Food Chem Toxicol 1997; 35:903-907.
    • (1997) Food Chem Toxicol , vol.35 , pp. 903-907
    • Hadidi, H.1    Zahlsen, K.2    Idle, J.R.3
  • 98
    • 0035154274 scopus 로고    scopus 로고
    • Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: Implications for interindividual differences in nicotine metabolism
    • Oscarson M. Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism. Drug Metab Dispos 2001; 29:91-95.
    • (2001) Drug Metab Dispos , vol.29 , pp. 91-95
    • Oscarson, M.1
  • 99
    • 0029099107 scopus 로고
    • A genetic polymorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
    • Fernandez-Salguero P, Hoffman SM, Cholerton S, et al. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Genet 1995; 57:651-660.
    • (1995) Am J Hum Genet , vol.57 , pp. 651-660
    • Fernandez-Salguero, P.1    Hoffman, S.M.2    Cholerton, S.3
  • 100
    • 7144257874 scopus 로고    scopus 로고
    • A new deleted allele in the human cytochrome P4502A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (-i-)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502)
    • Nunoya K, Yokoi T, Kimura K, et al. A new deleted allele in the human cytochrome P4502A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (-i-)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502). Pharmacogenetics 1998; 8:239-249.
    • (1998) Pharmacogenetics , vol.8 , pp. 239-249
    • Nunoya, K.1    Yokoi, T.2    Kimura, K.3
  • 101
    • 0033807421 scopus 로고    scopus 로고
    • Duplications and defects in the CYP2A6 gene: Identification, genotyping and in vivo effectson smoking
    • Rao Y, Hoffmann E, Zia M, et al. Duplications and defects in the CYP2A6 gene: identification, genotyping and in vivo effectson smoking. Mol Pharmacol 2000; 58:747-755.
    • (2000) Mol Pharmacol , vol.58 , pp. 747-755
    • Rao, Y.1    Hoffmann, E.2    Zia, M.3
  • 102
    • 0026934672 scopus 로고
    • Interindividual variability of coumarin 7-hydroxylation in healthy volunteers
    • Rautio A, Kraul H, Kojo A, et al. Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics 1992; 2:227-233.
    • (1992) Pharmacogenetics , vol.2 , pp. 227-233
    • Rautio, A.1    Kraul, H.2    Kojo, A.3
  • 103
    • 0026582870 scopus 로고
    • Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine
    • Cholerton S, Idle ME, Vas A, et al. Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine. J Chromatogr 1992; 575: 325-330.
    • (1992) J Chromatogr , vol.575 , pp. 325-330
    • Cholerton, S.1    Idle, M.E.2    Vas, A.3
  • 104
    • 0027984350 scopus 로고
    • Interindividual variability of coumarin 7-hydroxylation in a Turkish population
    • Iscan M, Rostami H, Iscan M, et al. Interindividual variability of coumarin 7-hydroxylation in a Turkish population. Eur J Clin Pharmacol 1994; 47:315-318.
    • (1994) Eur J Clin Pharmacol , vol.47 , pp. 315-318
    • Iscan, M.1    Rostami, H.2    Iscan, M.3
  • 105
    • 0031737551 scopus 로고    scopus 로고
    • Genotyping of human cytochrome P4502A6 (CYP2A6), a nicotine C-oxidase
    • Oscarson M, Gullsten H, Rautio A, et al. Genotyping of human cytochrome P4502A6 (CYP2A6), a nicotine C-oxidase. FEBS Letters 1998; 438:201-205.
    • (1998) FEBS Letters , vol.438 , pp. 201-205
    • Oscarson, M.1    Gullsten, H.2    Rautio, A.3
  • 106
    • 0029740082 scopus 로고    scopus 로고
    • Age and CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in man
    • Sotaniemi EA, Lumme P, Arvela P, et al. Age and CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in man. Therapie 1996; 51:363-366.
    • (1996) Therapie , vol.51 , pp. 363-366
    • Sotaniemi, E.A.1    Lumme, P.2    Arvela, P.3
  • 107
    • 0028218139 scopus 로고
    • Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers
    • Merkel U, Sigusch H, Hoffmann A. Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers. Eur J Clin Pharmacol 1994; 46:175-177.
    • (1994) Eur J Clin Pharmacol , vol.46 , pp. 175-177
    • Merkel, U.1    Sigusch, H.2    Hoffmann, A.3
  • 108
  • 109
    • 0028900559 scopus 로고
    • CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients
    • Sotaniemi EA, Rautio A, Backstrom M, et al. CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients. Br J Clin Pharmacol 1995; 39:71-76.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 71-76
    • Sotaniemi, E.A.1    Rautio, A.2    Backstrom, M.3
  • 110
    • 0031875570 scopus 로고    scopus 로고
    • Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6
    • Hadidi H, Irshaid Y, Vagbo CB, et al. Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6. Eur J Clin Pharmacol 1998; 54:437-441.
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 437-441
    • Hadidi, H.1    Irshaid, Y.2    Vagbo, C.B.3
  • 111
    • 0025663358 scopus 로고
    • The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds
    • Egan D, O'Kennedy R, Moran E, et al. The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds. Drug Metab Rev 1990; 22:503-529.
    • (1990) Drug Metab Rev , vol.22 , pp. 503-529
    • Egan, D.1    O'kennedy, R.2    Moran, E.3
  • 112
    • 0028205208 scopus 로고
    • An updated review of the clinical development of coumarin (1,2-benzopyrene) and 7-hydroxycoumarin
    • Marshall ME, Mohler JL, Edmonds K, et al. An updated review of the clinical development of coumarin (1,2-benzopyrene) and 7-hydroxycoumarin. J Cancer Res Clin Oncol 1994; 120:S39-S42.
    • (1994) J Cancer Res Clin Oncol , vol.120 , pp. S39-S42
    • Marshall, M.E.1    Mohler, J.L.2    Edmonds, K.3
  • 114
    • 0030885491 scopus 로고    scopus 로고
    • A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
    • Messina ES, Tyndale RF, Sellers EM. A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. J Pharmacol Exp Ther 1997; 282: 1608-1614.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 1608-1614
    • Messina, E.S.1    Tyndale, R.F.2    Sellers, E.M.3
  • 115
    • 5544281923 scopus 로고    scopus 로고
    • Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes
    • Nakajima M, Yamamoto T, Nunoya KI, et al. Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes. J Pharmacol Exp Ther 1996; 277:1010-1015.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1010-1015
    • Nakajima, M.1    Yamamoto, T.2    Nunoya, K.I.3
  • 116
    • 0027987497 scopus 로고
    • Metabolism of nicotine to cotinine studied by a dual stable isotope method
    • Benowitz NL, Jacob P III. Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clin Pharmacol Ther 1994; 56:483-493.
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 483-493
    • Benowitz, N.L.1    Jacob, P.2
  • 117
    • 0032496880 scopus 로고    scopus 로고
    • Nicotine metabolism and intake in Black and White smokers
    • Perez-Stable EJ, Herrera B, Jacob P III, et al. Nicotine metabolism and intake in Black and White smokers. JAMA 1998; 280:152-156.
    • (1998) JAMA , vol.280 , pp. 152-156
    • Perez-Stable, E.J.1    Herrera, B.2    Jacob, P.3
  • 119
    • 0031841377 scopus 로고    scopus 로고
    • Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
    • Miners JO, Birkett DJ. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol 1998; 45:525-538.
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 525-538
    • Miners, J.O.1    Birkett, D.J.2
  • 120
    • 0030868485 scopus 로고    scopus 로고
    • Genetic association between sensitivity to warfarin and expression of CYP2C9*3
    • Steward DJ, Haining RL, Henne KR, et al. Genetic association between sensitivity to warfarin and expression of CYP2C9*3. Pharmacogenetics 1997; 7:361-376.
    • (1997) Pharmacogenetics , vol.7 , pp. 361-376
    • Steward, D.J.1    Haining, R.L.2    Henne, K.R.3
  • 121
    • 0032511212 scopus 로고    scopus 로고
    • Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype
    • Henne KR, Gaedigk A, Gupta G, et al. Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype. J Chromatogr B Biomed Sci Appl 1998; 710:143-148.
    • (1998) J Chromatogr B Biomed Sci Appl , vol.710 , pp. 143-148
    • Henne, K.R.1    Gaedigk, A.2    Gupta, G.3
  • 122
    • 0031807762 scopus 로고    scopus 로고
    • Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes
    • Takahashi H, Kashima T, Nomizo Y, et al. Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes. Clin Pharmacol Ther 1998; 63:519-528.
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 519-528
    • Takahashi, H.1    Kashima, T.2    Nomizo, Y.3
  • 123
    • 0030947801 scopus 로고    scopus 로고
    • Allelic and functional variability of cytochrome P4502C9
    • Bhasker CR, Miners JO, Coulter S, et al. Allelic and functional variability of cytochrome P4502C9. Pharmacogenetics 1997; 7:51-58.
    • (1997) Pharmacogenetics , vol.7 , pp. 51-58
    • Bhasker, C.R.1    Miners, J.O.2    Coulter, S.3
  • 124
    • 0033040522 scopus 로고    scopus 로고
    • Phenotypic and genotypic investigations of a healthy volunteer deficiency in the conversion of losartan to its active metabolite E-3174
    • McCrea JB, Cribb A, Rushmore T, et al. Phenotypic and genotypic investigations of a healthy volunteer deficiency in the conversion of losartan to its active metabolite E-3174. Clin Pharmacol Ther 1999; 65:348-352.
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 348-352
    • McCrea, J.B.1    Cribb, A.2    Rushmore, T.3
  • 125
    • 0029564238 scopus 로고
    • Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy
    • Furuya H, Fernandez-Salguero P, Gregory W, et al. Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy. Pharmacogenetics 1995; 5:389-392.
    • (1995) Pharmacogenetics , vol.5 , pp. 389-392
    • Furuya, H.1    Fernandez-Salguero, P.2    Gregory, W.3
  • 126
    • 0029951216 scopus 로고    scopus 로고
    • Limited value of the urinary phenytoin metabolic ratio for the assessment of cytochrome P4502C9 activity in vivo
    • Tassaneeyakul W, Birkett DJ, Pass MC, et al. Limited value of the urinary phenytoin metabolic ratio for the assessment of cytochrome P4502C9 activity in vivo. Br J Clin Pharmacol 1996; 42:774-778.
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 774-778
    • Tassaneeyakul, W.1    Birkett, D.J.2    Pass, M.C.3
  • 127
    • 0023355128 scopus 로고
    • Hepatic metabolism of tolbutamide: Characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship in vivo disposition
    • Knodell RG, Hall SD, Wilkinson GR, et al. Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship in vivo disposition. J Pharmacol Exp Ther 1987; 241:1112-1119.
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 1112-1119
    • Knodell, R.G.1    Hall, S.D.2    Wilkinson, G.R.3
  • 128
    • 0025264682 scopus 로고
    • Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers
    • Veronese ME, Miners JO, Randies D, et al. Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers. Clin Pharmacol Ther 1990; 47:403-411.
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 403-411
    • Veronese, M.E.1    Miners, J.O.2    Randies, D.3
  • 129
    • 0027529381 scopus 로고
    • Tolbutamide hydroxylation in humans: Lack of bimodality in 106 healthy subjects
    • Veronese ME, Miners JO, Rees DLP, et al. Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjects. Pharmacogenetics 1993; 3:86-93.
    • (1993) Pharmacogenetics , vol.3 , pp. 86-93
    • Veronese, M.E.1    Miners, J.O.2    Rees, D.L.P.3
  • 131
    • 0028846142 scopus 로고
    • In vivo inhibition profile of cytochrome P450TB (CYP2C9) by (±)-fluvastatin
    • Transon C, Leemann T, Vogt N, et al. In vivo inhibition profile of cytochrome P450TB (CYP2C9) by (±)-fluvastatin. Clin Pharmacol Ther 1995; 58:412-417.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 412-417
    • Transon, C.1    Leemann, T.2    Vogt, N.3
  • 132
    • 0001391255 scopus 로고    scopus 로고
    • Flurbiprofen as a selective in vivo probe of CYP2C9 activity
    • Frye RF, Tracy TS, Hutzler JM, et al. Flurbiprofen as a selective in vivo probe of CYP2C9 activity. Clin Pharmacol Ther 2000; 67:109.
    • (2000) Clin Pharmacol Ther , vol.67 , pp. 109
    • Frye, R.F.1    Tracy, T.S.2    Hutzler, J.M.3
  • 133
    • 0027445449 scopus 로고
    • Isolation and characterization of human liver cytochrome P4502C19: Correlation between 2C19 and S-mephenytoin S-hydroxylation
    • Wrighton SA, Stevens JC, Becker GW, et al. Isolation and characterization of human liver cytochrome P4502C19: correlation between 2C19 and S-mephenytoin S-hydroxylation. Arch Biochem Biophys 1993; 306:240-245.
    • (1993) Arch Biochem Biophys , vol.306 , pp. 240-245
    • Wrighton, S.A.1    Stevens, J.C.2    Becker, G.W.3
  • 134
    • 0028279041 scopus 로고
    • Evidence that CYP2C19 is the major (S')-mephenytoin 4'-hydroxylase in humans
    • Goldstein JA, Faletto MB, Romkes-Sparks M, et al. Evidence that CYP2C19 is the major (S')-mephenytoin 4'-hydroxylase in humans. Biochemistry 1994; 33:1743-1752.
    • (1994) Biochemistry , vol.33 , pp. 1743-1752
    • Goldstein, J.A.1    Faletto, M.B.2    Romkes-Sparks, M.3
  • 135
    • 0022212549 scopus 로고
    • Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
    • Kiipfer A, Branch RA. Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation. Clin Pharmacol Ther 1985; 38:414-418.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 414-418
    • Kiipfer, A.1    Branch, R.A.2
  • 136
    • 0028207548 scopus 로고
    • Stereoselective disposition of hexobarbital and its metabolites: Relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects
    • Adedoyin A, Prakash C, O'Shea D, et al. Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects. Pharmacogenetics 1994; 4:27-38.
    • (1994) Pharmacogenetics , vol.4 , pp. 27-38
    • Adedoyin, A.1    Prakash, C.2    O'shea, D.3
  • 137
    • 0025735576 scopus 로고
    • The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism—a panel study
    • Ward SA, Helsby NA, Skjelbo E, et al. The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism—a panel study. Br J Clin Pharmacol 1991; 31:689-692.
    • (1991) Br J Clin Pharmacol , vol.31 , pp. 689-692
    • Ward, S.A.1    Helsby, N.A.2    Skjelbo, E.3
  • 138
    • 0026816971 scopus 로고
    • Polymorphic hydroxylation of S'-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects
    • Andersson T, Regardh CG, Lou YC, et al. Polymorphic hydroxylation of S'-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects. Pharmacogenetics 1992; 2:25-31.
    • (1992) Pharmacogenetics , vol.2 , pp. 25-31
    • Andersson, T.1    Regardh, C.G.2    Lou, Y.C.3
  • 139
    • 0030938161 scopus 로고    scopus 로고
    • Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4'-hydroxylation phenotype status
    • Sohn DR, Kwon JT, Kim HK, et al. Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4'-hydroxylation phenotype status. Clin Pharmacol Ther 1997; 61:574-582.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 574-582
    • Sohn, D.R.1    Kwon, J.T.2    Kim, H.K.3
  • 140
    • 13144282661 scopus 로고    scopus 로고
    • Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4'-hydroxylation phenotype and genotype
    • Tanaka M, Ohkubo T, Otani K, et al. Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4'-hydroxylation phenotype and genotype. Clin Pharmacol Ther 1997; 62:619-628.
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 619-628
    • Tanaka, M.1    Ohkubo, T.2    Otani, K.3
  • 141
    • 0024580554 scopus 로고
    • Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquin hydroxylation phenotype
    • Bertilsson L, Henthorn TK, Sanz E, et al. Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin hydroxylation phenotype. Clin Pharmacol Ther 1989; 45:348-355.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 348-355
    • Bertilsson, L.1    Henthorn, T.K.2    Sanz, E.3
  • 142
    • 0025964524 scopus 로고
    • The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine
    • Skjelbo E, Brosen K, Hallas J, et al. The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine. Clin Pharmacol Ther 1991; 49:18-23.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 18-23
    • Skjelbo, E.1    Brosen, K.2    Hallas, J.3
  • 143
    • 0028303496 scopus 로고
    • Single-dose kinetics of clomipramine: Relationship to the sparteine and 5-mephenytoin oxidation polymorphisms
    • Nielsen KK, Brosen K, Hansen MGJ, et al. Single-dose kinetics of clomipramine: relationship to the sparteine and 5-mephenytoin oxidation polymorphisms. Clin Pharmacol Ther 1994; 55:518-527.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 518-527
    • Nielsen, K.K.1    Brosen, K.2    Hansen, M.G.J.3
  • 144
    • 0026469799 scopus 로고
    • Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes
    • Breyer-Pfaff U, Pfandl B, Nill K, et al. Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes. Clin Pharmacol Ther 1992; 52:350-358.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 350-358
    • Breyer-Pfaff, U.1    Pfandl, B.2    Nill, K.3
  • 145
    • 0029819847 scopus 로고    scopus 로고
    • Formation of meprobamate from carisoprodol is catalyzed by CYP2C19
    • Dalen P, Alvan G, Wakelkamp M, et al. Formation of meprobamate from carisoprodol is catalyzed by CYP2C19. Pharmacogenetics 1996; 6:387-394.
    • (1996) Pharmacogenetics , vol.6 , pp. 387-394
    • Dalen, P.1    Alvan, G.2    Wakelkamp, M.3
  • 146
    • 0027472058 scopus 로고
    • Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms
    • Sindrup SH, Brosen K, Hansen MGJ, et al. Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms. Ther Drug Monit 1993; 15:11-17.
    • (1993) Ther Drug Monit , vol.15 , pp. 11-17
    • Sindrup, S.H.1    Brosen, K.2    Hansen, M.G.J.3
  • 147
    • 0029016328 scopus 로고
    • Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study
    • Gram LF, Guentert TW, Grange S, et al. Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: a panel study. Clin Pharmacol Ther 1995; 57:670-677.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 670-677
    • Gram, L.F.1    Guentert, T.W.2    Grange, S.3
  • 148
    • 0024534047 scopus 로고
    • Propranolol's metabolism is determined by both mephenytoin and debrisoquine hydroxylase activities
    • Ward SA, Walle T, Walle UK, et al. Propranolol's metabolism is determined by both mephenytoin and debrisoquine hydroxylase activities. Clin Pharmacol Ther 1989; 45:72-79.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 72-79
    • Ward, S.A.1    Walle, T.2    Walle, U.K.3
  • 149
    • 0002161215 scopus 로고    scopus 로고
    • The role of CYP2C19 in the formation of nelfmavir hydroxy-f-butylamide (M8): In vitro/in vivo correlation
    • Lillibridge JH, Lee CA, Pithavala YK, et al. The role of CYP2C19 in the formation of nelfmavir hydroxy-f-butylamide (M8): in vitro/in vivo correlation. ISSX Proc 1998; 13:55.
    • (1998) ISSX Proc , vol.13 , pp. 55
    • Lillibridge, J.H.1    Lee, C.A.2    Pithavala, Y.K.3
  • 151
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin in humans
    • de Morais SMF, Wilkinson GR, Blaisdell J, et al. The major genetic defect responsible for the polymorphism of S-mephenytoin in humans. J Biol Chem 1994; 269:15419-15422.
    • (1994) J Biol Chem , vol.269 , pp. 15419-15422
    • de Morais, S.M.F.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 152
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of S-mephenytoin metabolism in Japanese
    • de Morais SMF, Wilkinson GR, Blaisdell J, et al. Identification of a new genetic defect responsible for the polymorphism of S-mephenytoin metabolism in Japanese. Mol Pharmacol 1994; 46:594-598.
    • (1994) Mol Pharmacol , vol.46 , pp. 594-598
    • de Morais, S.M.F.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 153
    • 0028865992 scopus 로고
    • A multifamily study on the relationship between CYP2C19 genotype and S-mephenytom oxidation phenotype
    • Brosen K, de Morais SMF, Meyer UA, et al. A multifamily study on the relationship between CYP2C19 genotype and S-mephenytom oxidation phenotype. Pharmacogenetics 1995; 5:312-317.
    • (1995) Pharmacogenetics , vol.5 , pp. 312-317
    • Brosen, K.1    de Morais, S.M.F.2    Meyer, U.A.3
  • 154
    • 15444340367 scopus 로고    scopus 로고
    • A novel defect in human CYP2C19: Mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin
    • Ferguson RJ, deMorais SMF, Benhamou S, et al. A novel defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin. J Pharmacol Exp Ther 1998; 284:356-361.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 356-361
    • Ferguson, R.J.1    Demorais, S.M.F.2    Benhamou, S.3
  • 155
    • 15644372745 scopus 로고    scopus 로고
    • An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians
    • Ibeanu GC, Blaisdell J, Ghanayem BI, et al. An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians. Pharmacogenetics 1998; 8:129-135.
    • (1998) Pharmacogenetics , vol.8 , pp. 129-135
    • Ibeanu, G.C.1    Blaisdell, J.2    Ghanayem, B.I.3
  • 156
    • 8244249473 scopus 로고    scopus 로고
    • Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele
    • Xiao ZS, Goldstein JA, Xie HG, et al. Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. J Pharmacol Exp Ther 1997; 281:604-609.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 604-609
    • Xiao, Z.S.1    Goldstein, J.A.2    Xie, H.G.3
  • 157
    • 0032159423 scopus 로고    scopus 로고
    • Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin
    • Ibeanu GC, Goldstein JA, Meyer U, et al. Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. J Pharmacol Exp Ther 1998; 286:1490-1495.
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 1490-1495
    • Ibeanu, G.C.1    Goldstein, J.A.2    Meyer, U.3
  • 158
    • 0032797302 scopus 로고    scopus 로고
    • A novel transversion in intron5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolism of the anticonvulsant drug S-mephenytoin
    • Ibeanu GC, Blaisdell J, Ferguson RJ, et al. A novel transversion in intron5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolism of the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther 1999; 290:635-640.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 635-640
    • Ibeanu, G.C.1    Blaisdell, J.2    Ferguson, R.J.3
  • 159
    • 0030904031 scopus 로고    scopus 로고
    • Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations
    • Goldstein JA, Ishizaki T, Chiba K, et al. Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics 1997; 7:59-64.
    • (1997) Pharmacogenetics , vol.7 , pp. 59-64
    • Goldstein, J.A.1    Ishizaki, T.2    Chiba, K.3
  • 160
    • 0025572192 scopus 로고
    • Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
    • Alvan G, Bechtel P, Iselius L, et al. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur J Clin Pharmacol 1990; 39:533-537.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 533-537
    • Alvan, G.1    Bechtel, P.2    Iselius, L.3
  • 161
    • 0029055448 scopus 로고
    • Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe
    • Masimirembwa C, Bertilsson L, Johnansson I, et al. Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe. Clin Pharmacol Ther 1995; 57:656-661.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 656-661
    • Masimirembwa, C.1    Bertilsson, L.2    Johnansson, I.3
  • 162
    • 0029775045 scopus 로고    scopus 로고
    • Genetic polymorphism of S-mephenytoin 4'-hydroxylation in African-Americans
    • Edeki TI, Goldstein JA, de Morais SMF, et al. Genetic polymorphism of S-mephenytoin 4'-hydroxylation in African-Americans. Pharmacogenetics 1996; 6: 357-360.
    • (1996) Pharmacogenetics , vol.6 , pp. 357-360
    • Edeki, T.I.1    Goldstein, J.A.2    de Morais, S.M.F.3
  • 163
    • 0029912595 scopus 로고    scopus 로고
    • Determination of CYP2C19 in phenotype in black Americans with omeprazole: Correlation with genotype
    • Marinac JS, Balian JD, Foxworth JW, et al. Determination of CYP2C19 in phenotype in black Americans with omeprazole: correlation with genotype. Clin Pharmacol Ther 1996; 60:138-144.
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 138-144
    • Marinac, J.S.1    Balian, J.D.2    Foxworth, J.W.3
  • 164
    • 0022220338 scopus 로고
    • Genetic polymorphism of mephenytoin p(4')-hydroxylation: Difference between Orientals and Caucasians
    • Jurima M, Inaba T, Kadar D, et al. Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians. Br J Clin Pharmacol 1985; 19:483-487.
    • (1985) Br J Clin Pharmacol , vol.19 , pp. 483-487
    • Jurima, M.1    Inaba, T.2    Kadar, D.3
  • 165
    • 0022178173 scopus 로고
    • Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations
    • Nakasaura K, Goto F, Ray WA, et al. Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther 1985; 38:402-408.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 402-408
    • Nakasaura, K.1    Goto, F.2    Ray, W.A.3
  • 166
    • 0026506140 scopus 로고
    • Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
    • Bertilsson L, Lou YQ, Du YL, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin. Clin Pharmacol Ther 1992; 51:388-397.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 388-397
    • Bertilsson, L.1    Lou, Y.Q.2    Du, Y.L.3
  • 167
    • 0029824252 scopus 로고    scopus 로고
    • Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population
    • Roh HK, Dahl ML, Johansson I, et al. Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population. Pharmacogenetics 1996; 6:441-447.
    • (1996) Pharmacogenetics , vol.6 , pp. 441-447
    • Roh, H.K.1    Dahl, M.L.2    Johansson, I.3
  • 168
    • 0026705708 scopus 로고
    • Incidence of S-mephenytom hydroxylation deficiency in a Korean population and the inter-phenotypic differences in diazepam pharmacokinetics
    • Sohn DR, Kusaka M, Ishizaki T, et al. Incidence of S-mephenytom hydroxylation deficiency in a Korean population and the inter-phenotypic differences in diazepam pharmacokinetics. Clin Pharmacol Ther 1992; 52:160-169.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 160-169
    • Sohn, D.R.1    Kusaka, M.2    Ishizaki, T.3
  • 169
    • 0022623877 scopus 로고
    • Polymorphic metabolism of mephenytoin in man: Pharmacokinetic interaction with a co-regulated substrate, mephobarbital
    • Jacqz E, Hall SD, Branch RA, et al. Polymorphic metabolism of mephenytoin in man: pharmacokinetic interaction with a co-regulated substrate, mephobarbital. Clin Pharmacol Ther 1986; 39:646-653.
    • (1986) Clin Pharmacol Ther , vol.39 , pp. 646-653
    • Jacqz, E.1    Hall, S.D.2    Branch, R.A.3
  • 170
    • 0027183673 scopus 로고
    • Reproducibility over time of mephenytoin and debrisoquine hydroxylation phenotypes
    • Lerena A, Valdivielso MJ, Benitez J, et al. Reproducibility over time of mephenytoin and debrisoquine hydroxylation phenotypes. Pharmacol Toxicol 1993; 73:46-48.
    • (1993) Pharmacol Toxicol , vol.73 , pp. 46-48
    • Lerena, A.1    Valdivielso, M.J.2    Benitez, J.3
  • 171
    • 0027471030 scopus 로고
    • Genetically determined drugmetabolizing activity and desipramine-associated cardiotoxicity: A case report
    • Bluhm RE, Wilkinson GR, Shelton R, et al. Genetically determined drugmetabolizing activity and desipramine-associated cardiotoxicity: a case report. Clin Pharmacol Ther 1993; 53:89-95.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 89-95
    • Bluhm, R.E.1    Wilkinson, G.R.2    Shelton, R.3
  • 172
    • 0030799213 scopus 로고    scopus 로고
    • An S-mephenytoin cysteine conjugate identified in urine of extensive but not of poor metabolizers of S-mephenytoin
    • Tybring G, Nordin J, Bergman T, et al. An S-mephenytoin cysteine conjugate identified in urine of extensive but not of poor metabolizers of S-mephenytoin. Pharmacogenetics 1997; 7:355-360.
    • (1997) Pharmacogenetics , vol.7 , pp. 355-360
    • Tybring, G.1    Nordin, J.2    Bergman, T.3
  • 173
    • 0023155021 scopus 로고
    • Pharmacogenetic association between the formation of 4-hydroxymephenytoin and a new metabolite of S-mephenytoin in man
    • Wedlund PJ, Sweetman BJ, Wilkinson GR, et al. Pharmacogenetic association between the formation of 4-hydroxymephenytoin and a new metabolite of S-mephenytoin in man. Drug Metab Dispos 1987; 15:277-279.
    • (1987) Drug Metab Dispos , vol.15 , pp. 277-279
    • Wedlund, P.J.1    Sweetman, B.J.2    Wilkinson, G.R.3
  • 174
    • 0025970955 scopus 로고
    • Limitation to the use of the urinary S/Rmephenytoin ratio in pharmacogenetic studies
    • Zhang Y, Blouin RA, McNamara PJ, et al. Limitation to the use of the urinary S/Rmephenytoin ratio in pharmacogenetic studies. Br J Clin Pharmacol 1991; 31: 350-352.
    • (1991) Br J Clin Pharmacol , vol.31 , pp. 350-352
    • Zhang, Y.1    Blouin, R.A.2    McNamara, P.J.3
  • 175
    • 0026934962 scopus 로고
    • A methodological investigation on the estimation of the S-mephenytoin hydroxylation phenotype using the urinary S/R ratio
    • Tybring G, Bertilsson L. A methodological investigation on the estimation of the S-mephenytoin hydroxylation phenotype using the urinary S/R ratio. Pharmacogenetics 1992; 2:241-243.
    • (1992) Pharmacogenetics , vol.2 , pp. 241-243
    • Tybring, G.1    Bertilsson, L.2
  • 176
    • 0029775811 scopus 로고    scopus 로고
    • In vivo and in vitro measurement of CYP2C19 activity
    • Johnson EF, Waterman MR, San Diego: Academic Press
    • Wedlund PJ, Wilkinson GR. In vivo and in vitro measurement of CYP2C19 activity. In: Johnson EF, Waterman MR, eds. Cytochrome P450, Part B: Methods in Enzymology. San Diego: Academic Press, 1996; 272:105-114.
    • (1996) Cytochrome P450, Part B: Methods in Enzymology , vol.272 , pp. 105-114
    • Wedlund, P.J.1    Wilkinson, G.R.2
  • 177
    • 0024336503 scopus 로고
    • S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin
    • Sanz EJ, Villen T, Aim C, et al. S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin. Clin Pharmacol Ther 1989; 45:495-499.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 495-499
    • Sanz, E.J.1    Villen, T.2    Aim, C.3
  • 178
    • 0026633279 scopus 로고
    • Caution in the use of a 100 mg dose of racemic mephenytoin for phenotyping Southeastern Oriental subjects
    • Setiabudy R, Chiba K, Kusaka M, et al. Caution in the use of a 100 mg dose of racemic mephenytoin for phenotyping Southeastern Oriental subjects. Br J Clin Pharmacol 1992; 33:665-666.
    • (1992) Br J Clin Pharmacol , vol.33 , pp. 665-666
    • Setiabudy, R.1    Chiba, K.2    Kusaka, M.3
  • 179
    • 0027366623 scopus 로고
    • Oxidative metabolism of omeprazole in human liver microsomes: Cosegregation with S-mephenytoin 4/-hydroxylation
    • Chiba K, Kobayashi K, Manabe K, et al. Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4/-hydroxylation. J Pharmacol Exp Ther 1993; 266:52-59.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 52-59
    • Chiba, K.1    Kobayashi, K.2    Manabe, K.3
  • 180
    • 0027145018 scopus 로고
    • Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism
    • Andersson T, Miners JO, Veronese ME, et al. Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. Br J Clin Pharmacol 1993; 36:521-530.
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 521-530
    • Andersson, T.1    Miners, J.O.2    Veronese, M.E.3
  • 181
    • 0029858783 scopus 로고    scopus 로고
    • Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes
    • Karam WG, Goldstein JA, Lasker JM, et al. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab Dispos 1996; 24:1081-1087.
    • (1996) Drug Metab Dispos , vol.24 , pp. 1081-1087
    • Karam, W.G.1    Goldstein, J.A.2    Lasker, J.M.3
  • 182
    • 0026806412 scopus 로고
    • Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population
    • Sohn DR, Kobayashi K, Chiba K, et al. Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population. J Pharmacol Exp Ther 1992; 262:1195-1202.
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 1195-1202
    • Sohn, D.R.1    Kobayashi, K.2    Chiba, K.3
  • 183
    • 0029043462 scopus 로고
    • Interphenotype differences in disposition and effect on gastrin levels of omeprazole—suitability of omeprazole as a probe for CYP2C19
    • Chang M, Tybring G, Dahl ML, et al. Interphenotype differences in disposition and effect on gastrin levels of omeprazole—suitability of omeprazole as a probe for CYP2C19. Br J Clin Pharmacol 1995; 39:511-518.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 511-518
    • Chang, M.1    Tybring, G.2    Dahl, M.L.3
  • 184
    • 0029587180 scopus 로고
    • Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: Comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype
    • Chang M, Dahl ML, Tybring G, et al. Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype. Pharmacogenetics 1995; 5: 358-368.
    • (1995) Pharmacogenetics , vol.5 , pp. 358-368
    • Chang, M.1    Dahl, M.L.2    Tybring, G.3
  • 185
    • 12644315063 scopus 로고    scopus 로고
    • Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, CYP2C19mi inexon 5 and CYP2C19m2 in exon 4, in Japanese subjects
    • Ieiri I, Kubota T, Urae A, et al. Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, CYP2C19mi inexon 5 and CYP2C19m2 in exon 4, in Japanese subjects. Clin Pharmacol Ther 1996; 59: 647-653.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 647-653
    • Ieiri, I.1    Kubota, T.2    Urae, A.3
  • 186
    • 0029018767 scopus 로고
    • The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: A population study
    • Balian JD, Sukhova N, Harris JW, et al. The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study. Clin Pharmacol Ther 1995; 57:662-669.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 662-669
    • Balian, J.D.1    Sukhova, N.2    Harris, J.W.3
  • 187
    • 0029088251 scopus 로고
    • Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment
    • Rost KL, Brockmoller J, Esdorn F, et al. Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment. J Hepatol 1995; 23: 268-277.
    • (1995) J Hepatol , vol.23 , pp. 268-277
    • Rost, K.L.1    Brockmoller, J.2    Esdorn, F.3
  • 188
    • 0028919941 scopus 로고
    • Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population
    • Setiabudy R, Kusaka M, Chiba K, et al. Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population. Br J Clin Pharmacol 1995; 39:297-303.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 297-303
    • Setiabudy, R.1    Kusaka, M.2    Chiba, K.3
  • 189
    • 0024371975 scopus 로고
    • Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man
    • Ward SA, Watkins WM, Mberu E, et al. Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man. Br J Clin Pharmacol 1989; 27:781-787.
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 781-787
    • Ward, S.A.1    Watkins, W.M.2    Mberu, E.3
  • 190
    • 0025038681 scopus 로고
    • The pharmaco-kinetics and activation of proguanil in man: Consequences of variability in drug metabolism
    • Helsby NA, Ward SA, Edwards G, et al. The pharmaco-kinetics and activation of proguanil in man: consequences of variability in drug metabolism. Br J Clin Pharmacol 1990; 30:593-598.
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 593-598
    • Helsby, N.A.1    Ward, S.A.2    Edwards, G.3
  • 191
    • 0027272518 scopus 로고
    • Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark
    • Brosen K, Skjelbo E, Flachs H. Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark. Br J Clin Pharmacol 1993; 36:105-108.
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 105-108
    • Brosen, K.1    Skjelbo, E.2    Flachs, H.3
  • 192
    • 0029130304 scopus 로고
    • Evidence for the polymorphic oxidation of debrisoquine and proguanil in a New Zealand Maori population
    • Wanwimolruk S, Pratt EL, Denton JR, et al. Evidence for the polymorphic oxidation of debrisoquine and proguanil in a New Zealand Maori population. Pharmacogenetics 1995; 5:193-198.
    • (1995) Pharmacogenetics , vol.5 , pp. 193-198
    • Wanwimolruk, S.1    Pratt, E.L.2    Denton, J.R.3
  • 193
    • 0029146759 scopus 로고
    • Evidence for the polymorphic oxidation of debrisoquine and proguanil in a Khmer (Cambodian) population
    • Wanwimolruk S, Thou MR, Woods DJ. Evidence for the polymorphic oxidation of debrisoquine and proguanil in a Khmer (Cambodian) population. Br J Clin Pharmacol 1995; 40:166-169.
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 166-169
    • Wanwimolruk, S.1    Thou, M.R.2    Woods, D.J.3
  • 194
    • 0029960882 scopus 로고    scopus 로고
    • Chloro-guanide metabolism in relation to the efficacy in malaria prophylaxis and the .S-mephenytoin oxidation in Tanzanians
    • Skjelbo E, Mutabingwa TK, Bygbjerg I, et al. Chloro-guanide metabolism in relation to the efficacy in malaria prophylaxis and the .S-mephenytoin oxidation in Tanzanians. Clin Pharmacol Ther 1996; 59:304-311.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 304-311
    • Skjelbo, E.1    Mutabingwa, T.K.2    Bygbjerg, I.3
  • 195
    • 0029877643 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of proguanil: A probe phenotyping drug for the mephenytoin hydroxylase polymorphism
    • Somogyi AA, Reinhard HA, Bochner F. Pharmacokinetic evaluation of proguanil: a probe phenotyping drug for the mephenytoin hydroxylase polymorphism. Br J Clin Pharmacol 1996; 41:175-179.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 175-179
    • Somogyi, A.A.1    Reinhard, H.A.2    Bochner, F.3
  • 196
    • 0029903784 scopus 로고    scopus 로고
    • Proguanil metabolism in relation to S-mephenytoin oxidation in a Turkish population
    • Basci NE, Bozkurt A, Kortunay S, et al. Proguanil metabolism in relation to S-mephenytoin oxidation in a Turkish population. Br J Clin Pharmacol 1996; 42: 771-773.
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 771-773
    • Basci, N.E.1    Bozkurt, A.2    Kortunay, S.3
  • 197
    • 0030738072 scopus 로고    scopus 로고
    • Association between CYP2C19 genotype and proguanil oxidative polymorphism
    • Coller JK, Somogyi AA, Bochner F. Association between CYP2C19 genotype and proguanil oxidative polymorphism. Br J Clin Pharmacol 1997; 43:659-660.
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 659-660
    • Coller, J.K.1    Somogyi, A.A.2    Bochner, F.3
  • 198
    • 0031787036 scopus 로고    scopus 로고
    • Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population
    • Hoskins JM, Shenfield GM, Gross AS. Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population. Br J Clin Pharmacol 1998; 46:499-504.
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 499-504
    • Hoskins, J.M.1    Shenfield, G.M.2    Gross, A.S.3
  • 199
    • 0026582038 scopus 로고
    • Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans
    • Funck-Brentano C, Bosco O, Jacqz-Aigrain E, et al. Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans. Clin Pharmacol Ther 1992; 51:507-512.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 507-512
    • Funck-Brentano, C.1    Bosco, O.2    Jacqz-Aigrain, E.3
  • 200
    • 0028864296 scopus 로고
    • Comparison of chlorguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans
    • Partovian C, Jacqz-Aigrain E, Keundjian A, et al. Comparison of chlorguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans. Clin Pharmacol Ther 1995; 58:257-263.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 257-263
    • Partovian, C.1    Jacqz-Aigrain, E.2    Keundjian, A.3
  • 201
    • 0028228630 scopus 로고
    • In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by Smephenytoin hydroxylase
    • Birkett DJ, Rees D, Andersson T, et al. In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by Smephenytoin hydroxylase. Br J Clin Pharmacol 1994; 37:413-420.
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 413-420
    • Birkett, D.J.1    Rees, D.2    Andersson, T.3
  • 202
    • 0025305464 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism-clinical aspects
    • Eichelbaum M, Gross AS. The genetic polymorphism of debrisoquine/sparteine metabolism-clinical aspects. Pharmacol Ther 1990; 46:377-394.
    • (1990) Pharmacol Ther , vol.46 , pp. 377-394
    • Eichelbaum, M.1    Gross, A.S.2
  • 203
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer UA, Zanger UM. Molecular mechanisms of genetic polymorphisms of drug metabolism. Ann Rev Pharmacol Toxicol 1997; 37:269-296.
    • (1997) Ann Rev Pharmacol Toxicol , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 204
    • 0017695082 scopus 로고
    • Polymorphic hydroxylation of debrisoquine in man
    • Mahgoub A, Idle JR, Dring LG, et al. Polymorphic hydroxylation of debrisoquine in man. Lancet 1977; 2:584-586.
    • (1977) Lancet , vol.2 , pp. 584-586
    • Mahgoub, A.1    Idle, J.R.2    Dring, L.G.3
  • 205
    • 0017667456 scopus 로고
    • Polymorphic hydroxylation of debrisoquine
    • Tucker GT, Silas JH, Iyun AO, et al. Polymorphic hydroxylation of debrisoquine. Lancet 1977; 2:718.
    • (1977) Lancet , vol.2 , pp. 718
    • Tucker, G.T.1    Silas, J.H.2    Iyun, A.O.3
  • 206
    • 0018615011 scopus 로고
    • Defective N-oxidation of sparteine in man: A new pharmacogenetic defect
    • Eichelbaum M, Spannbrucker N, Steincke B, et al. Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 1979; 16: 183-187.
    • (1979) Eur J Clin Pharmacol , vol.16 , pp. 183-187
    • Eichelbaum, M.1    Spannbrucker, N.2    Steincke, B.3
  • 207
    • 0028856846 scopus 로고
    • Molecular basis of polymorphic drug metabolism
    • Daly AK. Molecular basis of polymorphic drug metabolism. J Mol Med 1995; 73: 539-553.
    • (1995) J Mol Med , vol.73 , pp. 539-553
    • Daly, A.K.1
  • 208
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 2D-locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Lundqvist E, Bertilsson L, et al. Inherited amplification of an active gene in the cytochrome P450 2D-locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci U S A 1993; 90:11825-11829.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3
  • 209
    • 0030860004 scopus 로고    scopus 로고
    • Polymorphism of the cytochrome P450 C YP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
    • Marez D, Legrand M, Sabbagh N, et al. Polymorphism of the cytochrome P450 C YP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics 1997; 7:193-202.
    • (1997) Pharmacogenetics , vol.7 , pp. 193-202
    • Marez, D.1    Legrand, M.2    Sabbagh, N.3
  • 211
    • 0029850096 scopus 로고    scopus 로고
    • Phenotype and genotype analysis of debrisoquine hydroxylase (CYP2D6) in a black Zimbabwean population—reduced enzyme activity and evaluation of metabolic correlation of CYP2D6 probe drugs
    • Masimirembwa C, Hasler J, Bertilsson L, et al. Phenotype and genotype analysis of debrisoquine hydroxylase (CYP2D6) in a black Zimbabwean population—reduced enzyme activity and evaluation of metabolic correlation of CYP2D6 probe drugs. Eur J Clin Pharmacol 1996; 51:117-122.
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 117-122
    • Masimirembwa, C.1    Hasler, J.2    Bertilsson, L.3
  • 212
    • 0022496369 scopus 로고
    • Metoprolol and debrisoquin metabolism in Nigerians: Lack of evidence for polymorphic oxidation
    • Iyun AO, Lennard MS, Tucker GT, et al. Metoprolol and debrisoquin metabolism in Nigerians: lack of evidence for polymorphic oxidation. Clin Pharmacol Ther 1986; 40:387-394.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 387-394
    • Iyun, A.O.1    Lennard, M.S.2    Tucker, G.T.3
  • 213
    • 0026004805 scopus 로고
    • Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects
    • Relling MV, Cherrie J, Schell MJ, et al. Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects. Clin Pharmacol Ther 1991; 50:308-313.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 308-313
    • Relling, M.V.1    Cherrie, J.2    Schell, M.J.3
  • 214
    • 0029622428 scopus 로고
    • The pharmacogenetics of codeine hypoalgesia
    • Sindrup SH, Brosen K. The pharmacogenetics of codeine hypoalgesia. Pharmacogenetics 1995; 5:335-346.
    • (1995) Pharmacogenetics , vol.5 , pp. 335-346
    • Sindrup, S.H.1    Brosen, K.2
  • 215
    • 0027534276 scopus 로고
    • Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine
    • Bertilsson L, Dahl ML, Sjoqvist F, et al. Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine. Lancet 1993; 341:63.
    • (1993) Lancet , vol.341 , pp. 63
    • Bertilsson, L.1    Dahl, M.L.2    Sjoqvist, F.3
  • 216
    • 0031739606 scopus 로고    scopus 로고
    • Tjernberg A, et al. 1- and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans
    • Eiermann B, Edlund PO, Tjernberg A, et al. 1- and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans. Drug Metab Dispos 1998; 26:1096-1101.
    • (1998) Drug Metab Dispos , vol.26 , pp. 1096-1101
    • Eiermann, B.1    Edlund, P.O.2
  • 217
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmoller J, Bauer S, et al. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997; 60:284-295.
    • (1997) Am J Hum Genet , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3
  • 218
    • 0019206754 scopus 로고
    • Clinical pharmacokinetics of metoprolol
    • Regardh CG, Johnsson G. Clinical pharmacokinetics of metoprolol. Clin Pharmacokinet 1980; 5:557-569.
    • (1980) Clin Pharmacokinet , vol.5 , pp. 557-569
    • Regardh, C.G.1    Johnsson, G.2
  • 219
    • 0020409410 scopus 로고
    • Oxidation phenotype—a major determinant of metoprololol metabolism and response
    • Lennard MS, Silas JH, Freestone S, et al. Oxidation phenotype—a major determinant of metoprololol metabolism and response. New Engl J Med 1982; 307: 1558-1560.
    • (1982) New Engl J Med , vol.307 , pp. 1558-1560
    • Lennard, M.S.1    Silas, J.H.2    Freestone, S.3
  • 220
    • 0021798210 scopus 로고
    • Genetically determined variability in acetylation and oxidation. Therapeutic implications
    • Clark DWJ. Genetically determined variability in acetylation and oxidation. Therapeutic implications. Drugs 1985; 29:342-375.
    • (1985) Drugs , vol.29 , pp. 342-375
    • Clark, D.W.J.1
  • 221
    • 0022381040 scopus 로고
    • Metoprolol metabolism and debrisoquine oxidation polymorphism—population and family studies
    • McGourty JC, Silas JH, Lennard MS, et al. Metoprolol metabolism and debrisoquine oxidation polymorphism—population and family studies. Br J Clin Pharmacol 1985; 20:555-566.
    • (1985) Br J Clin Pharmacol , vol.20 , pp. 555-566
    • McGourty, J.C.1    Silas, J.H.2    Lennard, M.S.3
  • 222
    • 0026091975 scopus 로고
    • Metoprolol oxidation polymorphism in a Korean population: Comparison with native Japanese and Chinese populations
    • Sohn DR, Shin SG, Park CW, et al. Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations. Br J Clin Pharmacol 1991; 32:504-507.
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 504-507
    • Sohn, D.R.1    Shin, S.G.2    Park, C.W.3
  • 223
    • 0021082394 scopus 로고
    • Differential stereoselective of metoprolol in extensive and poor debrisoquin metabolisers
    • Lennard MS, Tucker GT, Silas JH, et al. Differential stereoselective of metoprolol in extensive and poor debrisoquin metabolisers. Clin Pharmacol Ther 1983; 34: 732-737.
    • (1983) Clin Pharmacol Ther , vol.34 , pp. 732-737
    • Lennard, M.S.1    Tucker, G.T.2    Silas, J.H.3
  • 224
    • 0026769498 scopus 로고
    • Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two East Asian populations
    • Sohn DR, Kusaka M, Shin SG, et al. Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two East Asian populations. Ther Drug Monit 1992; 14:184-189.
    • (1992) Ther Drug Monit , vol.14 , pp. 184-189
    • Sohn, D.R.1    Kusaka, M.2    Shin, S.G.3
  • 225
    • 0022338958 scopus 로고
    • Polymorphic dextromethorphan metabolism: Co-segregation of oxidative O-demethylation with debrisoquin hydroxylation
    • Schmid B, Bircher J, Preisig R, et al. Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation. Clin Pharmacol Ther 1985; 38:618-624.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 618-624
    • Schmid, B.1    Bircher, J.2    Preisig, R.3
  • 226
    • 0031971273 scopus 로고    scopus 로고
    • Omission of the deconjugation step in urine analysis and the unaltered outcome of CYP2D6 phenotyping with dextromethorphan
    • Basci NE, Bozkurt A, Kayaalp SO, et al. Omission of the deconjugation step in urine analysis and the unaltered outcome of CYP2D6 phenotyping with dextromethorphan. Eur J Drug Metab Pharmacokinet 1998; 23:1-5.
    • (1998) Eur J Drug Metab Pharmacokinet , vol.23 , pp. 1-5
    • Basci, N.E.1    Bozkurt, A.2    Kayaalp, S.O.3
  • 227
    • 0029853347 scopus 로고    scopus 로고
    • The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans
    • Capon DA, Bochner F, Kerry N, et al. The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans. Clin Pharmacol Ther 1996; 60:295-307.
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 295-307
    • Capon, D.A.1    Bochner, F.2    Kerry, N.3
  • 228
    • 0022501297 scopus 로고
    • Pharmacogenetics of dextromethorphan O-demethylation in man
    • Kiipfer A, Schmid B, Pfaff G. Pharmacogenetics of dextromethorphan O-demethylation in man. Xenobiotica 1986; 16:421-433.
    • (1986) Xenobiotica , vol.16 , pp. 421-433
    • Kiipfer, A.1    Schmid, B.2    Pfaff, G.3
  • 229
    • 0025830058 scopus 로고
    • Salivary analysis of determination of dextromethorphan metabolic phenotype
    • Hou ZY, Pickle LW, Meyer PS, et al. Salivary analysis of determination of dextromethorphan metabolic phenotype. Clin Pharmacol Ther 1991; 49:410-419.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 410-419
    • Hou, Z.Y.1    Pickle, L.W.2    Meyer, P.S.3
  • 230
    • 0031836582 scopus 로고    scopus 로고
    • Novel single-point plasma or saliva dextromethorphan method for determining CYP2D6 activity
    • Hu YP, Tang HS, Lane HY, et al. Novel single-point plasma or saliva dextromethorphan method for determining CYP2D6 activity. J Pharmacol Exp Ther 1998; 285:955-960.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 955-960
    • Hu, Y.P.1    Tang, H.S.2    Lane, H.Y.3
  • 231
    • 0024557660 scopus 로고
    • Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db 1 activity
    • Dayer P, Leemann T, Striberni R. Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db 1 activity. Clin Pharmacol Ther 1989; 45:34-40.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 34-40
    • Dayer, P.1    Leemann, T.2    Striberni, R.3
  • 232
    • 0028038065 scopus 로고
    • The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: In vitro studies using human liver microsomes
    • Kerry NL, Somogyi AA, Bochner F, et al. The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes. Br J Clin Pharmacol 1994; 38:243-248.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 243-248
    • Kerry, N.L.1    Somogyi, A.A.2    Bochner, F.3
  • 233
    • 0026361512 scopus 로고
    • Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: Inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers
    • Evans WE, Relling MV. Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers. Pharmacogenetics 1991; 1:143-148.
    • (1991) Pharmacogenetics , vol.1 , pp. 143-148
    • Evans, W.E.1    Relling, M.V.2
  • 234
    • 0026472355 scopus 로고
    • Polymorphism of dextromethorphan metabolism: Relationships between phenotype, genotype and response to the administration of encainide in humans
    • Funck-Brentano C, Thomas G, Jacqz-Algrain E, et al. Polymorphism of dextromethorphan metabolism: relationships between phenotype, genotype and response to the administration of encainide in humans. J Pharmacol Exp Ther 1992; 263:780-786.
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 780-786
    • Funck-Brentano, C.1    Thomas, G.2    Jacqz-Algrain, E.3
  • 235
    • 0029150871 scopus 로고
    • Prediction of phenotype for dextromethorphan O-demethylation by using polymerase chain reaction in healthy volunteers
    • Zimmermann T, Schlenk R, Pfaff P, et al. Prediction of phenotype for dextromethorphan O-demethylation by using polymerase chain reaction in healthy volunteers. Arzneimittelforschung 1995; 45:41-43.
    • (1995) Arzneimittelforschung , vol.45 , pp. 41-43
    • Zimmermann, T.1    Schlenk, R.2    Pfaff, P.3
  • 236
    • 0029146538 scopus 로고
    • Antidepressant drug interactions and the cytochrome P450 system—the role of cytochrome P4502D6
    • Ereshefsky L, Riesenman C, Lam YW. Antidepressant drug interactions and the cytochrome P450 system—the role of cytochrome P4502D6. Clin Pharmacokinet 1995; 29(suppl 1): 10-19.
    • (1995) Clin Pharmacokinet , vol.29 , pp. 10-19
    • Ereshefsky, L.1    Riesenman, C.2    Lam, Y.W.3
  • 237
    • 0030867948 scopus 로고    scopus 로고
    • Pharmacokinetic drug interactions of new antidepressants: A review of the effects of the metabolism of other drugs
    • Richelson E. Pharmacokinetic drug interactions of new antidepressants: a review of the effects of the metabolism of other drugs. Mayo Clin Proc 1997; 72:835-847.
    • (1997) Mayo Clin Proc , vol.72 , pp. 835-847
    • Richelson, E.1
  • 238
    • 0025342853 scopus 로고
    • Correlations among the metabolic ratios of three test probes (metoprolol, debrisoquine and sparteine) for genetically determined oxidation polymorphism in a Japanese population
    • Horai Y, Taga J, Ishizaki T, et al. Correlations among the metabolic ratios of three test probes (metoprolol, debrisoquine and sparteine) for genetically determined oxidation polymorphism in a Japanese population. Br J Clin Pharmacol 1990; 29: 111-115.
    • (1990) Br J Clin Pharmacol , vol.29 , pp. 111-115
    • Horai, Y.1    Taga, J.2    Ishizaki, T.3
  • 239
    • 0021846817 scopus 로고
    • Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians
    • Woolhouse NM, Eichelbaum M, Oates NS, et al. Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians. Clin Pharmacol Ther 1985; 37:512-521.
    • (1985) Clin Pharmacol Ther , vol.37 , pp. 512-521
    • Woolhouse, N.M.1    Eichelbaum, M.2    Oates, N.S.3
  • 240
    • 0027248189 scopus 로고
    • Debrisoquine and metoprolol oxidation in Zambians: A population study
    • Simooya O O, Njunju E, Hodjegan AR, et al. Debrisoquine and metoprolol oxidation in Zambians: a population study. Pharmacogenetics 1993; 3:205-208.
    • (1993) Pharmacogenetics , vol.3 , pp. 205-208
    • O O, S.1    Njunju, E.2    Hodjegan, A.R.3
  • 241
    • 0031828554 scopus 로고    scopus 로고
    • Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians
    • Droll K, Bruce-Mensah K, Otton SV, et al. Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians. Pharmacogenetics 1998; 8:325-333.
    • (1998) Pharmacogenetics , vol.8 , pp. 325-333
    • Droll, K.1    Bruce-Mensah, K.2    Otton, S.V.3
  • 243
    • 0026849692 scopus 로고
    • Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians
    • Lennard MS, Iyun AO, Jackson PR, et al. Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians. Pharmacogenetics 1992; 2:89-92.
    • (1992) Pharmacogenetics , vol.2 , pp. 89-92
    • Lennard, M.S.1    Iyun, A.O.2    Jackson, P.R.3
  • 244
    • 84965949194 scopus 로고
    • Non-correlation between debrisoquine and metoprolol polymorphisms in the Venda
    • Sommers DK, Moncrieff J, Avenant J. Non-correlation between debrisoquine and metoprolol polymorphisms in the Venda. Hum Toxicol 1989; 8:365-368.
    • (1989) Hum Toxicol , vol.8 , pp. 365-368
    • Sommers, D.K.1    Moncrieff, J.2    Avenant, J.3
  • 245
    • 0025848319 scopus 로고
    • Absence of polymorphism of sparteine oxidation in the South African Venda
    • Sommers DK, Moncrieff J, Avena JC. Absence of polymorphism of sparteine oxidation in the South African Venda. Hum Exp Toxicol 1991; 10:175-178.
    • (1991) Hum Exp Toxicol , vol.10 , pp. 175-178
    • Sommers, D.K.1    Moncrieff, J.2    Avena, J.C.3
  • 246
    • 84973816037 scopus 로고
    • Metoprolol alpha-hydroxylation polymorphism in the San Bushmen of Southern Africa
    • Sommers DK, Moncrieff J, Avenant J. Metoprolol alpha-hydroxylation polymorphism in the San Bushmen of Southern Africa. Hum Toxicol 1989; 8: 39-43.
    • (1989) Hum Toxicol , vol.8 , pp. 39-43
    • Sommers, D.K.1    Moncrieff, J.2    Avenant, J.3
  • 247
    • 84973847615 scopus 로고
    • Polymorphism of the 4-hydroxylation of debrisoquine in the San Bushmen of Southern Africa
    • Sommers DK, Moncrieff J, Avenant J. Polymorphism of the 4-hydroxylation of debrisoquine in the San Bushmen of Southern Africa. Human Toxicol 1988; 7:273-276.
    • (1988) Human Toxicol , vol.7 , pp. 273-276
    • Sommers, D.K.1    Moncrieff, J.2    Avenant, J.3
  • 248
    • 0029853664 scopus 로고    scopus 로고
    • A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: Association with diminished debrisoquine hydroxylase activity
    • Masimirembwa D, Persson I, Bertilsson L, et al. A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity. Br J Clin Pharmacol 1996; 42: 713-719.
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 713-719
    • Masimirembwa, D.1    Persson, I.2    Bertilsson, L.3
  • 249
    • 0031438162 scopus 로고    scopus 로고
    • A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function
    • Oscarson M, Hidestrand M, Johansson I, et al. A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function. Mol Pharmacol 1997; 52:1034-1040.
    • (1997) Mol Pharmacol , vol.52 , pp. 1034-1040
    • Oscarson, M.1    Hidestrand, M.2    Johansson, I.3
  • 250
    • 0028104234 scopus 로고
    • Metoprolol alpha-hydroxylation is a poor probe for debrisoquine oxidation (CYP2D6) polymorphism in Jordanians
    • Al-Hadidi HF, Irshaid YM, Rawashdeh NM. Metoprolol alpha-hydroxylation is a poor probe for debrisoquine oxidation (CYP2D6) polymorphism in Jordanians. Eur J Clin Pharmacol 1994; 47:311-314.
    • (1994) Eur J Clin Pharmacol , vol.47 , pp. 311-314
    • Al-Hadidi, H.F.1    Irshaid, Y.M.2    Rawashdeh, N.M.3
  • 251
    • 0030513346 scopus 로고    scopus 로고
    • Dextromethorphan metabolism in Jordanians: Dissociation of dextromethorphan O-demethylation from debrisoquine 4-hydroxylation
    • Irshaid YM, Al-Hadidi HF, Latif A, et al. Dextromethorphan metabolism in Jordanians: dissociation of dextromethorphan O-demethylation from debrisoquine 4-hydroxylation. Eur J Clin Metab Pharmacokinet 1996; 21:301-307.
    • (1996) Eur J Clin Metab Pharmacokinet , vol.21 , pp. 301-307
    • Irshaid, Y.M.1    Al-Hadidi, H.F.2    Latif, A.3
  • 254
    • 0030889322 scopus 로고    scopus 로고
    • Genetic polymorphism of human CYP2E1: Characterization of two variant alleles
    • Hu Y, Oscarson M, Johansson I, et al. Genetic polymorphism of human CYP2E1: characterization of two variant alleles. Mol Pharmacol 1997; 51:370-376.
    • (1997) Mol Pharmacol , vol.51 , pp. 370-376
    • Hu, Y.1    Oscarson, M.2    Johansson, I.3
  • 255
    • 0031737607 scopus 로고    scopus 로고
    • A genetic polymorphism in the regulatory sequence of human CYP2E1: Association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake
    • McCarver DG, Byun R, Hines RN, et al. A genetic polymorphism in the regulatory sequence of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. Toxicol Appl Pharmacol 1998; 152:276-281.
    • (1998) Toxicol Appl Pharmacol , vol.152 , pp. 276-281
    • McCarver, D.G.1    Byun, R.2    Hines, R.N.3
  • 256
    • 0032411072 scopus 로고    scopus 로고
    • Detection and characterization of novel polymorphisms in the CYP2E1 gene
    • Fairbrother KS, Grove J, de Waziers I, et al. Detection and characterization of novel polymorphisms in the CYP2E1 gene. Pharmacogenetics 1998; 8:543-552.
    • (1998) Pharmacogenetics , vol.8 , pp. 543-552
    • Fairbrother, K.S.1    Grove, J.2    de Waziers, I.3
  • 257
    • 0029878329 scopus 로고    scopus 로고
    • Human cytochrome P450 2E1 (CYP2E1): From genotype of phenotype
    • Carriere V, Berthou F, Baird S, et al. Human cytochrome P450 2E1 (CYP2E1): from genotype of phenotype. Pharmacogenetics 1996; 6:203-211.
    • (1996) Pharmacogenetics , vol.6 , pp. 203-211
    • Carriere, V.1    Berthou, F.2    Baird, S.3
  • 258
    • 0031720001 scopus 로고    scopus 로고
    • Expression of cytochrome P4502E1 (CYP2E1) in human liver: Assessment of mRNA, genotype and phenotype
    • Powell H, Kitteringham NR, Pirmohamed M, et al. Expression of cytochrome P4502E1 (CYP2E1) in human liver: assessment of mRNA, genotype and phenotype. Pharmacogenetics 1998; 8:411-421.
    • (1998) Pharmacogenetics , vol.8 , pp. 411-421
    • Powell, H.1    Kitteringham, N.R.2    Pirmohamed, M.3
  • 259
    • 0030436852 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians
    • Kim RB, Yamazaki H, Chiba K, et al. In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. J Pharmacol Exp Ther 1996; 279: 4-11.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 4-11
    • Kim, R.B.1    Yamazaki, H.2    Chiba, K.3
  • 260
    • 0028863438 scopus 로고
    • Cytochrome P450 2E1 genotype and chlorzoxazone metabolisminhealthy and alcoholic Caucasian subjects
    • Lucas D, Menez C, Girre C, et al. Cytochrome P450 2E1 genotype and chlorzoxazone metabolisminhealthy and alcoholic Caucasian subjects. Pharmacogenetics 1995; 5:298-304.
    • (1995) Pharmacogenetics , vol.5 , pp. 298-304
    • Lucas, D.1    Menez, C.2    Girre, C.3
  • 261
    • 0033048246 scopus 로고    scopus 로고
    • Genetic and dietary predictors of CYP2E1 activity: A phenotyping study in Hawaii Japanese using chlorzoxazone
    • Le Marchand L, Wilkinson GR, Wilkens LR. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol Biomarkers Prev 1999; 8:495-500.
    • (1999) Cancer Epidemiol Biomarkers Prev , vol.8 , pp. 495-500
    • Le Marchand, L.1    Wilkinson, G.R.2    Wilkens, L.R.3
  • 262
    • 0025223625 scopus 로고
    • Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450IIE1
    • Peter R, Bocker R, Beaune PH, et al. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450IIE1. Chem Res Toxicol 1990; 3:566-573.
    • (1990) Chem Res Toxicol , vol.3 , pp. 566-573
    • Peter, R.1    Bocker, R.2    Beaune, P.H.3
  • 263
    • 0027438967 scopus 로고
    • Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone
    • Carriere V, Goasduff T, Ratanasavanh D, et al. Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone. Chem Res Toxicol 1994; 6:852-857.
    • (1994) Chem Res Toxicol , vol.6 , pp. 852-857
    • Carriere, V.1    Goasduff, T.2    Ratanasavanh, D.3
  • 264
    • 0028918999 scopus 로고
    • Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation
    • Yamazaki H, Guo Z, Guengerich FP. Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation. Drug Metab Dispos 1995; 23:438-440.
    • (1995) Drug Metab Dispos , vol.23 , pp. 438-440
    • Yamazaki, H.1    Guo, Z.2    Guengerich, F.P.3
  • 265
    • 0028997743 scopus 로고
    • Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1
    • Ono S, Hatanaka T, Hotta H, et al. Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1. Pharmacogenetics 1995; 5:141-148.
    • (1995) Pharmacogenetics , vol.5 , pp. 141-148
    • Ono, S.1    Hatanaka, T.2    Hotta, H.3
  • 266
    • 0030895593 scopus 로고    scopus 로고
    • Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone
    • Gorski JC, Jones DR, Wrighton SA, SD Hall. Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone. Xenobiotica 1997; 27: 243-256.
    • (1997) Xenobiotica , vol.27 , pp. 243-256
    • Gorski, J.C.1    Jones, D.R.2    Wrighton, S.A.3    Hall, S.D.4
  • 267
    • 0028037221 scopus 로고
    • Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: A putative probe of CYP2E1 activity
    • O'Shea D, Davis SN, Kim RB, et al. Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity. Clin Pharmacol Ther 1994; 56:359-367.
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 359-367
    • O'shea, D.1    Davis, S.N.2    Kim, R.B.3
  • 268
    • 0029775813 scopus 로고    scopus 로고
    • Chlorzoxazone: An in vitro and in vivo substrate probe for liver CYP2E1
    • Johnson EF, Waterman MR, San Diego, CA: Academic Press
    • Lucas D, Menez JF, Berthou F. Chlorzoxazone: an in vitro and in vivo substrate probe for liver CYP2E1. In: Johnson EF, Waterman MR, eds. Cytochrome P450, Part B: Methods in Enzymology. San Diego, CA: Academic Press, 1996; 272: 115-123.
    • (1996) Cytochrome P450, Part B: Methods in Enzymology , vol.272 , pp. 115-123
    • Lucas, D.1    Menez, J.F.2    Berthou, F.3
  • 269
    • 0027159323 scopus 로고
    • Single-dose disulfiram inhibition of chlorzoxazone metabolism: A clinical probe for P4502E1
    • Kharasch ED, Thummel KE, Mhyre J, et al. Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P4502E1. Clin Pharmacol Ther 1993; 53:643-650.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 643-650
    • Kharasch, E.D.1    Thummel, K.E.2    Mhyre, J.3
  • 270
    • 0031868634 scopus 로고    scopus 로고
    • Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers
    • Eap CB, Schnyder C, Besson J, et al. Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers. Clin Pharmacol Ther 1998; 64:52-57.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 52-57
    • Eap, C.B.1    Schnyder, C.2    Besson, J.3
  • 271
    • 0031696057 scopus 로고    scopus 로고
    • Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress
    • Leclercq I, Desager JP, Horsmans Y. Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress. Clin Pharmacol Ther 1998; 64:144-149.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 144-149
    • Leclercq, I.1    Desager, J.P.2    Horsmans, Y.3
  • 272
    • 0027163604 scopus 로고
    • Inhibition and induction of cytochrome P4502El-catalyzed oxidation by isoniazid in humans
    • Zand R, Nelson SD, Slattery JT, et al. Inhibition and induction of cytochrome P4502El-catalyzed oxidation by isoniazid in humans. Clin Pharmacol Ther 1993; 54:142-149.
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 142-149
    • Zand, R.1    Nelson, S.D.2    Slattery, J.T.3
  • 273
    • 0031026584 scopus 로고    scopus 로고
    • Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators
    • O'Shea D, Kim RB, Wilkinson GR. Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators. Br J Clin Pharmacol 1997; 43:99-103.
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 99-103
    • O'shea, D.1    Kim, R.B.2    Wilkinson, G.R.3
  • 274
    • 0030815178 scopus 로고    scopus 로고
    • Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans
    • Gebhardt AC, Lucas D, Menez JF, et al. Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. Hepatology 1997; 26:957-961.
    • (1997) Hepatology , vol.26 , pp. 957-961
    • Gebhardt, A.C.1    Lucas, D.2    Menez, J.F.3
  • 275
    • 0030832859 scopus 로고    scopus 로고
    • CYP2E1 activity in patients with alcoholic liver disease
    • Dilger K, Metzler J, Bode JC, et al. CYP2E1 activity in patients with alcoholic liver disease. J Hepatol 1997; 27:1009-1014.
    • (1997) J Hepatol , vol.27 , pp. 1009-1014
    • Dilger, K.1    Metzler, J.2    Bode, J.C.3
  • 276
    • 0031961095 scopus 로고    scopus 로고
    • Cytochrome P4052E1 inducibility and hydroxyethyl radical formation among alcoholics
    • Dupont I, Lucas D, Clot P, et al. Cytochrome P4052E1 inducibility and hydroxyethyl radical formation among alcoholics. J Hepatol 1998; 28:564-572.
    • (1998) J Hepatol , vol.28 , pp. 564-572
    • Dupont, I.1    Lucas, D.2    Clot, P.3
  • 277
    • 0028915241 scopus 로고
    • Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase
    • Lucas D, Menez C, Girre C, et al. Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase. Alcohol Clin Exp Res 1995; 19:362-366.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 362-366
    • Lucas, D.1    Menez, C.2    Girre, C.3
  • 278
    • 0028355767 scopus 로고
    • Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone—a putative measure of CYP2E1 activity
    • Kim RB, O'Shea D, Wilkinson GR. Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone—a putative measure of CYP2E1 activity. Pharmacogenetics 1994; 4:162-165.
    • (1994) Pharmacogenetics , vol.4 , pp. 162-165
    • Kim, R.B.1    O'shea, D.2    Wilkinson, G.R.3
  • 279
    • 0028826430 scopus 로고
    • Urinary excretion of 6-hydroxychlorzoxazone as an index of CYP2E1 activity
    • Dreisbach AW, Ferencz N, Hopkins NE, et al. Urinary excretion of 6-hydroxychlorzoxazone as an index of CYP2E1 activity. Clin Pharmacol Ther 1995; 58: 498-505.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 498-505
    • Dreisbach, A.W.1    Ferencz, N.2    Hopkins, N.E.3
  • 280
    • 0028876741 scopus 로고
    • Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe
    • Vesell ES, DeAngelo Seaton T, A-Rahim YI. Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe. Pharmacogenetics 1995; 5: 53-57.
    • (1995) Pharmacogenetics , vol.5 , pp. 53-57
    • Vesell, E.S.1    Deangelo Seaton, T.2    A-Rahim, Y.I.3
  • 281
    • 0031748173 scopus 로고    scopus 로고
    • In vitro and in vivo drug interactions involving human CYP3A
    • Thummel KE, Wilkinson GR. In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol 1998; 38:389-430.
    • (1998) Annu Rev Pharmacol Toxicol , vol.38 , pp. 389-430
    • Thummel, K.E.1    Wilkinson, G.R.2
  • 282
    • 0342437515 scopus 로고    scopus 로고
    • Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction
    • Thummel KE, Kunze KL, Shen DD. Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction. Adv Drug Deliv Rev 1997; 27:99-127.
    • (1997) Adv Drug Deliv Rev , vol.27 , pp. 99-127
    • Thummel, K.E.1    Kunze, K.L.2    Shen, D.D.3
  • 283
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P4503A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P4503A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995; 13:129-134.
    • (1995) Mol Carcinog , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 284
    • 0032907322 scopus 로고    scopus 로고
    • Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
    • Kim RB, Wandel C, Leake B, et al. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharmacol Res 1999; 16:408-414.
    • (1999) Pharmacol Res , vol.16 , pp. 408-414
    • Kim, R.B.1    Wandel, C.2    Leake, B.3
  • 285
    • 0028071759 scopus 로고
    • Noninvasive tests of CYP3A enzymes
    • Watkins PB. Noninvasive tests of CYP3A enzymes. Pharmacogenetics 1994; 4: 171-184.
    • (1994) Pharmacogenetics , vol.4 , pp. 171-184
    • Watkins, P.B.1
  • 286
    • 0027077439 scopus 로고
    • Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4
    • Fleming CM, Branch RA, Wilkinson GR, et al. Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4. Mol Pharmacol 1992; 41: 975-980.
    • (1992) Mol Pharmacol , vol.41 , pp. 975-980
    • Fleming, C.M.1    Branch, R.A.2    Wilkinson, G.R.3
  • 287
    • 0028237981 scopus 로고
    • Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population
    • May DG, Porter J, Wilkinson GR, et al. Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population. Clin Pharmacol Ther 1994; 55:492-500.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 492-500
    • May, D.G.1    Porter, J.2    Wilkinson, G.R.3
  • 289
    • 0026878890 scopus 로고
    • The ability to 4-hydroxylate debrisoquine is related to recurrence of bladder cancer
    • Fleming CM, Kaisary A, Wilkinson GR, et al. The ability to 4-hydroxylate debrisoquine is related to recurrence of bladder cancer. Pharmacogenetics 1992; 2: 128-134.
    • (1992) Pharmacogenetics , vol.2 , pp. 128-134
    • Fleming, C.M.1    Kaisary, A.2    Wilkinson, G.R.3
  • 290
    • 0027984941 scopus 로고
    • Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer
    • Fleming CM, Persad R, Kaisary A, et al. Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer. Pharmacogenetics 1994; 4:199-207.
    • (1994) Pharmacogenetics , vol.4 , pp. 199-207
    • Fleming, C.M.1    Persad, R.2    Kaisary, A.3
  • 291
    • 0028998002 scopus 로고
    • The procarcinogen hypothesis for bladder cancer: Activities of individual drug metabolizing enzymes as risk factors
    • Branch RA, Chern HD, Adedoyin A, et al. The procarcinogen hypothesis for bladder cancer: activities of individual drug metabolizing enzymes as risk factors. Pharmacogenetics 1995; 5:S97-S102.
    • (1995) Pharmacogenetics , vol.5 , pp. S97-S102
    • Branch, R.A.1    Chern, H.D.2    Adedoyin, A.3
  • 292
    • 0025162357 scopus 로고
    • Scleroderma is associated with differences in individual routes of metabolism: A study with dapsone, debrisoquin, and mephenytoin
    • May DG, Black CM, Olsen NJ, et al. Scleroderma is associated with differences in individual routes of metabolism: a study with dapsone, debrisoquin, and mephenytoin. Clin Pharmacol Ther 1990; 48:286-295.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 286-295
    • May, D.G.1    Black, C.M.2    Olsen, N.J.3
  • 293
    • 0026715612 scopus 로고
    • Activity of oxidative routes of metabolism of debrisoquine, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease
    • Black C, May G, Csuka ME, et al. Activity of oxidative routes of metabolism of debrisoquine, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease. Clin Pharmacol Ther 1992; 52:659-667.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 659-667
    • Black, C.1    May, G.2    Csuka, M.E.3
  • 294
    • 0030060304 scopus 로고    scopus 로고
    • Comparison of the dapsone recovery ratio and the erythromycin breath test as in vivo probes of CYP3A activity in patients with rheumatoid arthritis receiving cyclosporine
    • Stein CM, Kinirons MT, Pincus T, et al. Comparison of the dapsone recovery ratio and the erythromycin breath test as in vivo probes of CYP3A activity in patients with rheumatoid arthritis receiving cyclosporine. Clin Pharmacol Ther 1996; 59: 47-51.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 47-51
    • Stein, C.M.1    Kinirons, M.T.2    Pincus, T.3
  • 295
    • 0028839899 scopus 로고
    • Metabolism of dapsone to its hydroxylamine by cytochrome P-450 2E1 in vitro and in vivo
    • Mitra AK, Thummel KE, Kalhorn TF, et al. Metabolism of dapsone to its hydroxylamine by cytochrome P-450 2E1 in vitro and in vivo. Clin Pharmacol Ther 1995; 58:556-566.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 556-566
    • Mitra, A.K.1    Thummel, K.E.2    Kalhorn, T.F.3
  • 296
    • 0029416939 scopus 로고
    • N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: Implications for inhibition of haemotoxicity
    • Gill HJ, Tingle MD, Park BK. N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity. Br J Clin Pharmacol 1995; 40:531-538.
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 531-538
    • Gill, H.J.1    Tingle, M.D.2    Park, B.K.3
  • 297
    • 0032987001 scopus 로고    scopus 로고
    • Effects of ketoconazole on the erythromycin breath test and the dapsone recovery ratio
    • Kinirons MT, Krivoruk Y, Wilkinson GR, et al. Effects of ketoconazole on the erythromycin breath test and the dapsone recovery ratio. Br J Clin Pharmacol 1999; 47:223-224.
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 223-224
    • Kinirons, M.T.1    Krivoruk, Y.2    Wilkinson, G.R.3
  • 298
    • 0025063782 scopus 로고
    • The erythromycin breath test as a predictor of cyclosporine blood levels
    • Watkins PG, Hamilton TA, Annesley TM, et al. The erythromycin breath test as a predictor of cyclosporine blood levels. Clin Pharmacol Ther 1990; 48:120-129.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 120-129
    • Watkins, P.G.1    Hamilton, T.A.2    Annesley, T.M.3
  • 299
    • 0026496411 scopus 로고
    • Erythromycin breath test predicts oral clearance of cyclosporine in kidney transplant recipients
    • Turgeon DK, Normolle DP, Leichtman AB, et al. Erythromycin breath test predicts oral clearance of cyclosporine in kidney transplant recipients. Clin Pharmacol Ther 1992; 52:471-478.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 471-478
    • Turgeon, D.K.1    Normolle, D.P.2    Leichtman, A.B.3
  • 300
    • 0028149595 scopus 로고
    • P4503A activity and cyclosporine dosing in kidney and heart transplant recipients
    • Turgeon DK, Leichtman AB, Lown KS, et al. P4503A activity and cyclosporine dosing in kidney and heart transplant recipients. Clin Pharmacol Ther 1994; 56: 253-260.
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 253-260
    • Turgeon, D.K.1    Leichtman, A.B.2    Lown, K.S.3
  • 301
    • 0028277839 scopus 로고
    • Prediction of interpatient and intrapatient variation in OG 37-325 dosing requirements by the erythromycin breath test: A prospective study in renal transplant recipients
    • Turgeon DK, Leichtman AB, Blake DS, et al. Prediction of interpatient and intrapatient variation in OG 37-325 dosing requirements by the erythromycin breath test: a prospective study in renal transplant recipients. Transplantation 1994; 57: 1736-1741.
    • (1994) Transplantation , vol.57 , pp. 1736-1741
    • Turgeon, D.K.1    Leichtman, A.B.2    Blake, D.S.3
  • 302
    • 12644270207 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test
    • Cheng CL, Smith DE, Carver PL, et al. Steady-state pharmacokinetics of delavirdine in HIV-positive patients: effect on erythromycin breath test. Clin Pharmacol Ther 1997; 61:531-543.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 531-543
    • Cheng, C.L.1    Smith, D.E.2    Carver, P.L.3
  • 303
    • 0003389581 scopus 로고    scopus 로고
    • CYP3A4 and the erythromycin breath test
    • Wagner D. CYP3A4 and the erythromycin breath test. Clin Pharmacol Ther 1998; 64:129-130.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 129-130
    • Wagner, D.1
  • 304
    • 0024556650 scopus 로고
    • Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients
    • Watkins PB, Murray SA, Winkelman LG, et al. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. J Clin Invest 1989; 83:688-697.
    • (1989) J Clin Invest , vol.83 , pp. 688-697
    • Watkins, P.B.1    Murray, S.A.2    Winkelman, L.G.3
  • 305
    • 0028608020 scopus 로고
    • Metabolism of cytochrome P4503A substrates in vivo administered by the same route: Lack of correlation between alfentanil clearance and erythromycin breath test
    • Krivoruk Y, Kinirons MT, Wood AJJ, et al. Metabolism of cytochrome P4503A substrates in vivo administered by the same route: lack of correlation between alfentanil clearance and erythromycin breath test. Clin Pharmacol Ther 1994; 56: 608-614.
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 608-614
    • Krivoruk, Y.1    Kinirons, M.T.2    Wood, A.J.J.3
  • 306
    • 0031850954 scopus 로고    scopus 로고
    • Human MDR1 and mouse mdrla P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene
    • Schuetz EG, Yasuda K, Arimori K, et al. Human MDR1 and mouse mdrla P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. Arch Biochem Biophys 1998; 350:340-347.
    • (1998) Arch Biochem Biophys , vol.350 , pp. 340-347
    • Schuetz, E.G.1    Yasuda, K.2    Arimori, K.3
  • 308
    • 0030696112 scopus 로고    scopus 로고
    • Predicting drug interactions in vivo from experiments in vitro: Human studies with paclitaxel and ketoconazole
    • Jamis-Dow CA, Pearl ML, Watkins PB, et al. Predicting drug interactions in vivo from experiments in vitro: human studies with paclitaxel and ketoconazole. Am J Clin Oncol 1997; 20:592-599.
    • (1997) Am J Clin Oncol , vol.20 , pp. 592-599
    • Jamis-Dow, C.A.1    Pearl, M.L.2    Watkins, P.B.3
  • 309
    • 0028828640 scopus 로고
    • Omeprazole does not affect measured CYP3A4 activity using the erythromycin breath test
    • Tateishi T, Graham SG, Krivoruk Y, et al. Omeprazole does not affect measured CYP3A4 activity using the erythromycin breath test. Br J Clin Pharmacol 1995; 40: 411-412.
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 411-412
    • Tateishi, T.1    Graham, S.G.2    Krivoruk, Y.3
  • 310
    • 0027405132 scopus 로고
    • Interferon suppresses erythromycin metabolism in rats and human subjects
    • Craig PI, Tapner M, Farrell GC. Interferon suppresses erythromycin metabolism in rats and human subjects. Hepatology 1993; 17:230-235.
    • (1993) Hepatology , vol.17 , pp. 230-235
    • Craig, P.I.1    Tapner, M.2    Farrell, G.C.3
  • 311
    • 0024373348 scopus 로고
    • Oxidation of midazolam and triazolam by human liver cytochrome P450DIA4
    • Kronbach T, Mathys D, Umeno M, et al. Oxidation of midazolam and triazolam by human liver cytochrome P450DIA4. Mol Pharmacol 1989; 36:89-96.
    • (1989) Mol Pharmacol , vol.36 , pp. 89-96
    • Kronbach, T.1    Mathys, D.2    Umeno, M.3
  • 312
    • 0028234586 scopus 로고
    • Regioselective biotransformation of midazolam by members of the human cytochrome P4503A (CYP3A) subfamily
    • Gorski JC, Hall SD, Jones DR, et al. Regioselective biotransformation of midazolam by members of the human cytochrome P4503A (CYP3A) subfamily. Biochem Pharmacol 1994; 47:1643-1653.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1643-1653
    • Gorski, J.C.1    Hall, S.D.2    Jones, D.R.3
  • 313
    • 0028114619 scopus 로고
    • Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients
    • Thummel KE, Shen DD, Podoll TD, et al. Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients. J Pharmacol Exp Ther 1994; 271:549-556.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 549-556
    • Thummel, K.E.1    Shen, D.D.2    Podoll, T.D.3
  • 314
    • 0030015297 scopus 로고    scopus 로고
    • Oral first-pass elimination of midazolam involves both gastro-intestinal and hepatic CYP3A-mediated metabolism
    • Thummel KE, O'Shea D, Paine MF, et al. Oral first-pass elimination of midazolam involves both gastro-intestinal and hepatic CYP3A-mediated metabolism. Clin Pharmacol Ther 1996; 59:491-502.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 491-502
    • Thummel, K.E.1    O'shea, D.2    Paine, M.F.3
  • 315
    • 0022642077 scopus 로고
    • Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis
    • MacGiichrist AJ, Birnie GG, Cook A, et al. Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis. Gut 1986; 27:190-195.
    • (1986) Gut , vol.27 , pp. 190-195
    • Macgiichrist, A.J.1    Birnie, G.G.2    Cook, A.3
  • 316
    • 0024509738 scopus 로고
    • Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects
    • Pentikainen PJ, Valisalmi L, Himberg JJ, et al. Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects. J Clin Pharmacol 1989; 29:272-277.
    • (1989) J Clin Pharmacol , vol.29 , pp. 272-277
    • Pentikainen, P.J.1    Valisalmi, L.2    Himberg, J.J.3
  • 317
    • 0029738490 scopus 로고    scopus 로고
    • First-pass metabolism of midazolam by the human intestine
    • Paine MF, Shen DD, Kunze KL, et al. First-pass metabolism of midazolam by the human intestine. Clin Pharmacol Ther 1996; 60:14-24.
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 14-24
    • Paine, M.F.1    Shen, D.D.2    Kunze, K.L.3
  • 318
    • 0027985506 scopus 로고
    • Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intra-individual hepatic P4503A variability after liver transplantation
    • Thummel KE, Shen DD, Podoll TD, et al. Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intra-individual hepatic P4503A variability after liver transplantation. J Pharmacol Exp Ther 1994; 271: 557-566.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 557-566
    • Thummel, K.E.1    Shen, D.D.2    Podoll, T.D.3
  • 319
    • 0030068752 scopus 로고    scopus 로고
    • Rifampin drastically reduces plasma concentrations and effects of oral midazolam
    • Backman JT, Olkkola KT, Neuvonen PJ. Rifampin drastically reduces plasma concentrations and effects of oral midazolam. Clin Pharmacol Ther 1996; 59:7-13.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 7-13
    • Backman, J.T.1    Olkkola, K.T.2    Neuvonen, P.J.3
  • 320
    • 0028357256 scopus 로고
    • Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole
    • Olkkola KT, Backman JT, Neuvonen PJ. Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole. Clin Pharmacol Ther 1994; 55:481-485.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 481-485
    • Olkkola, K.T.1    Backman, J.T.2    Neuvonen, P.J.3
  • 321
    • 0029043387 scopus 로고
    • Azithromycin does not increase plasma concentrations of oral midazolam
    • Backman JT, Olkkola KT, Neuvonen PJ. Azithromycin does not increase plasma concentrations of oral midazolam. Int J Clin Pharmacol Ther 1995; 33:356-359.
    • (1995) Int J Clin Pharmacol Ther , vol.33 , pp. 356-359
    • Backman, J.T.1    Olkkola, K.T.2    Neuvonen, P.J.3
  • 322
    • 0028083315 scopus 로고
    • Azithromycin does not alter the effects of oral midazolam on human performance
    • Mattila MJ, Vanakoski J, Idanpaan-Heikkla JJ. Azithromycin does not alter the effects of oral midazolam on human performance. Eur J Clin Pharmacol 1994; 47:49-52.
    • (1994) Eur J Clin Pharmacol , vol.47 , pp. 49-52
    • Mattila, M.J.1    Vanakoski, J.2    Idanpaan-Heikkla, J.J.3
  • 323
    • 0029112998 scopus 로고
    • Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers
    • Ahonen J, Olkkola KT, Neuvonen PJ. Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers. Br J Clin Pharmacol 1995; 40:270-272.
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 270-272
    • Ahonen, J.1    Olkkola, K.T.2    Neuvonen, P.J.3
  • 324
    • 0031696409 scopus 로고    scopus 로고
    • The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin
    • Gorski JC, Jones DR, Haehner-Daniels BD, et al. The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin. Clin Pharmacol Ther 1998; 64:133-143.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 133-143
    • Gorski, J.C.1    Jones, D.R.2    Haehner-Daniels, B.D.3
  • 325
    • 0033309227 scopus 로고    scopus 로고
    • Concurrent administration of the erythromycin breath test (EBT) and oral midazolam (MDZ) as in vivo probes for CYP3A activity
    • McCrea J, Prueksaritanont T, Gertz BJ, et al. Concurrent administration of the erythromycin breath test (EBT) and oral midazolam (MDZ) as in vivo probes for CYP3A activity. J Clin Pharmacol Ther 1999; 39:1212-1220.
    • (1999) J Clin Pharmacol Ther , vol.39 , pp. 1212-1220
    • McCrea, J.1    Prueksaritanont, T.2    Gertz, B.J.3
  • 326
    • 0030822760 scopus 로고    scopus 로고
    • Examination of purported probes of human CYP2B6
    • Ekins S, VandenBraden M, Ring BJ, et al. Examination of purported probes of human CYP2B6. Pharmacogenetics 1997; 7:165-179.
    • (1997) Pharmacogenetics , vol.7 , pp. 165-179
    • Ekins, S.1    Vandenbraden, M.2    Ring, B.J.3
  • 327
    • 0030739223 scopus 로고    scopus 로고
    • Human cytochrome P4502B6: Interindividual hepatic expression, substrate specificity, and role in procarcinogen activation
    • Code EL, Crespi CL, Penman BW, et al. Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. Drug Metab Dispos 1997; 25:985-993.
    • (1997) Drug Metab Dispos , vol.25 , pp. 985-993
    • Code, E.L.1    Crespi, C.L.2    Penman, B.W.3
  • 328
    • 0032160463 scopus 로고    scopus 로고
    • Further characterization of the expression in liver and catalytic activity of CYP2B6
    • Ekins S, VandenBraden M, Ring BJ, et al. Further characterization of the expression in liver and catalytic activity of CYP2B6. J Pharmacol Exp Ther 1998; 286: 1253-1259.
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 1253-1259
    • Ekins, S.1    Vandenbraden, M.2    Ring, B.J.3
  • 329
    • 0031845066 scopus 로고    scopus 로고
    • Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6
    • Ko JW, Desta Z, Flockhart DA. Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6. Drug Metab Dispos 1998; 26:775-778.
    • (1998) Drug Metab Dispos , vol.26 , pp. 775-778
    • Ko, J.W.1    Desta, Z.2    Flockhart, D.A.3
  • 330
    • 0030988863 scopus 로고    scopus 로고
    • Human liver CYP2B6-catalyzed hydroxylation of RP 73401
    • Stevens JC, White RB, Hsu SH, et al. Human liver CYP2B6-catalyzed hydroxylation of RP 73401. J Pharmacol Exp Ther 1997; 282:1389-1395.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 1389-1395
    • Stevens, J.C.1    White, R.B.2    Hsu, S.H.3


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