Age and CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in man

Therapie

Volumn 51, Issue 4, 1996, Pages 363-366

  Sotaniemi, E A ^a   Lumme, P ^a   Arvela, P ^a   Rautio, A ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Age; Coumarin; Cytochrome P450 isoforms; Gender; MEGX

Indexed keywords

COUMARIN; CYTOCHROME P450 ISOENZYME; DEETHYLLIDOCAINE; LIDOCAINE; MELILOTUS EXTRACT;

ADULT; AGE; CLINICAL TRIAL; CONFERENCE PAPER; DRUG BLOOD LEVEL; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; GENDER; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; LIVER MICROSOME METABOLISM; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADULT; AGE FACTORS; AGED; ARYL HYDROCARBON HYDROXYLASES; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; ISOENZYMES; LIDOCAINE; LIVER; MALE; MIXED FUNCTION OXYGENASES; UMBELLIFERONES;

EID: 0029740082     PISSN: 00405957     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. Kato R, Vassanelli P, Frontino G, Chesara E. Variation in the activity of liver microsomal drug-metabolizing enzymes in rats in relation to age. Biochem Pharmacol 1964; 13: 1037-1051.
2. Kamataki T, Maeda K, Shimada M et al. Age-related alteration in the activities of drug-metabolizing enzymes and contents of sex-specific forms cytochrome P450 in liver microsomes from male and female rats. J Pharmacol Exp Ther 1985;233:222-228.
3. Loi C-M, Vestal RE. Drug metabolism in the elderly. Pharmacol Ther 1988; 36: 131-149.
4. Durnas C, Loi C-M, Cusak BJ. Hepatic drug metabolism and aging. Clin Pharmacokinet 1990; 19: 359-389.
5. O'Malley K, Crooks J, Duke E, Stevenson IH. Effect of age and sex on human drug metabolism. BMJ 1971; iii : 607-609.
6. Abernethy DR, Greenblatt DJ. Impairment of lidocaine clearance in elderly male subjects. J Cardiovasc Pharmacol 1983; 5: 1093-1096.
7. Hust LK, Fleishaker JC, Peters GR et al. Effect of age and gender on trilazad pharmacokinetics in humans. Clin Pharmacol Ther 1994; 55: 378-384.
8. James OFW, Rawlins MD, Woodhouse K. Lack of ageing effects on human microsomal monooxygenase enzyme activitis and on inactivation pathways for reactive metabolic intermediates. In: Kitani K, ed., Liver and aging. Amsterdam: Elsevier Biomedical Press, 1982: 395-406.
9. Woodhouse KW, Mutch E, Williams FW et al. The effect of age on pathways of drug metabolism in human liver. Age Ageing 1984; 13: 328-334.
10. Schmucker DL, Woodhouse KW, Wang RK et al. Effects of age and gender on in vitro properties of human liver microsomal monooxygenases. Clin Pharmacol Ther 1990; 48: 365-374.
11. O'Mahony MS, Woodhouse KW. Age, environmental factors and drug metabolism. Pharmacol Ther 1994; 61: 279-287.
12. Woodhouse K. Modifications of drug metabolism in relation to age in humans. Therapie (Suppl) 1995; 50: 25. (Abstr.)
13. Schaffner F, Popper H. Cholestasis is the result of hypoactive hypertrophic smooth endoplasmic reticulum in the hepatocyte. Lancet 1969; ii: 355-359.
14. Sotaniemi EA, Ahlquist J, Pelkonen RO et al. Liver parenchymal changes and indices of drug metabolism in alcoholics. Eur J Clin Pharmacol 1977; 11: 295-303.
15. Sotaniemi EA, Sutinen S, Sutinen S et al. Liver injury in subjects occupationally exposed to chemicals in low doses. Acta Med Scand 1982; 212: 207-215.
16. Oellerlich M, Raude E, Brudelski M et al. Monoethylglycinexylide formation kinetics: a novel approach to assessment of liver function. J Clin Chem Clin Biochem 1987; 24: 845-853.
17. Bargetzi MJ, Aoyama T, Gonzales FJ et al. Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4. Clin Pharmacol Ther 1989; 46: 521-527.
18. Rautio A, Kraul H, Kojo A et al. Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics 1992; 2: 227-233.
19. Sotaniemi EA, Rautio A, Bäckström M et al. CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients. Br J Clin Pharmacol 1995; 39: 71-76.
20. Risteli J, Niemi S, Trivedi P et al. Rapid equilibrium radioimmunoassay for the aminoterminal propeptide for human type III procollagen. Clin Chem 1988; 34: 715-718.
21. Wrighton SA, Ring BJ, Watkins PB et al. Identification of polymorphically expressed member of human cytochrome P450 III family. Mol Pharmacol 1989; 36: 97-105.
22. Shaw PM, Barnes TS, Cameron D et al. Purification and characterization of an anticonvulsant-induced human cytochrome P-450 catalysing cyclosporine metabolism. Biochem J 1989; 263: 653-663.
23. Waxman DJ, Azarnoff L. Phenobarbital induction of cytochrome gene expression. Biochem J 1992; 281: 577-592.
24. Ged C, Rouillon JM, Pichard L et al. The increase in urinary excretion of 6β-hydrocortisol as a marker of human hepatic cytochrome P450IIIA induction. Br J Clin Pharmacol 1989; 28: 373-387.
25. Pelkonen O, Raunio H, Rautio A et al. Coumarin 7-hydroxylase: Characteristics and regulation in mouse and man. J Irish Cell Phys Surg 1993; 32 (Suppl. 1): 24-28.
26. Fernandez-Salguero P, Hoffman SMG, Cholerton S et al. A genetic polymorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Genet 1995; 57: 651-660.
27. Mäenpää J, Juvonen R, Raunio H et al. Metabolic interactions of methoxsalen and coumarin in humans and mice. Biochem Pharmacol 1994; 48: 1363-1369.
28. Sherlock S, Beam AG, Billing BH et al. Splanchnic blood flow in man by the bromsulfalein method: the relation of peripherial plasma bromsulfalein level to the calculated flow. J Lab Clin Med 1950; 35: 923-932.
29. Adir J, Miller AK, Vestal RE. Effects of total plasma concentration and age on tolbutamide plasma protein binding. Clin Pharmacol Ther 1982; 31: 488-493.