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Volumn 43, Issue 6, 1997, Pages 659-660

Association between CYP2C19 genotype and proguanil oxidative polymorphism

Author keywords

CYP2C19; Intrinsic clearance; Metabolic ratio; Mutant alleles; Proguanil

Indexed keywords

PROGUANIL;

EID: 0030738072     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1997.00596.x     Document Type: Article
Times cited : (21)

References (10)
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    • The pharmacokinetics and activation of proguanil in man: Consequences of variability in drug metabolism
    • Helsby NA, Ward SA, Edwards CJ, Howells RE, Breckenridge AM. The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism. Br J Clin Pharmacol 1990; 30: 593-598.
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 593-598
    • Helsby, N.A.1    Ward, S.A.2    Edwards, C.J.3    Howells, R.E.4    Breckenridge, A.M.5
  • 3
    • 0024371975 scopus 로고
    • Intersubject variability in the metabolism of proguanil to the active metabolite cycloguanil in man
    • Ward SA, Watkins WM, Mberu E, et al. Intersubject variability in the metabolism of proguanil to the active metabolite cycloguanil in man. Br J Clin Pharmacol 1989; 27: 781-787.
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 781-787
    • Ward, S.A.1    Watkins, W.M.2    Mberu, E.3
  • 4
    • 0028228630 scopus 로고
    • In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase
    • Birkett DJ, Rees D, Andersson T, Gonzalez FJ, Miners JO, Veronese ME. In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase. BrJ Clin Pharmacol 1994; 37: 413-420.
    • (1994) BrJ Clin Pharmacol , vol.37 , pp. 413-420
    • Birkett, D.J.1    Rees, D.2    Andersson, T.3    Gonzalez, F.J.4    Miners, J.O.5    Veronese, M.E.6
  • 5
    • 0029877643 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of proguanil: A probe phenotyping drug for the mephenytoin hydroxylase polymorphism
    • Somogyi AA, Reinhard HA, Bochner F. Pharmacokinetic evaluation of proguanil: a probe phenotyping drug for the mephenytoin hydroxylase polymorphism. Br J Clin Pharmacol 1996; 41: 175-179.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 175-179
    • Somogyi, A.A.1    Reinhard, H.A.2    Bochner, F.3
  • 6
    • 0028860954 scopus 로고
    • Genetic analysis of the S-mephenytoin polymorphism in a Chinese population
    • de Morais SMF, Goldstein JA, Xie H-G, et al. Genetic analysis of the S-mephenytoin polymorphism in a Chinese population. Clin Pharmacol Ther 1995; 58: 404-411.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 404-411
    • De Morais, S.M.F.1    Goldstein, J.A.2    Xie, H.-G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.