Lack of pharmacokinetic interaction between dextromethorphan, coumarin and mephenytoin in man after simultaneous administration

Pharmazie

Volumn 51, Issue 1, 1996, Pages 46-51

  Endres, H G E ^a   Henschel, L ^a   Merkel, Ute ^a   Hippius, Marion ^a   Hoffmann, Annemarie ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN; CYTOCHROME P450; DEXTROMETHORPHAN; MEPHENYTOIN;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYDROXYLATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADULT; ANTICOAGULANTS; ANTICONVULSANTS; ANTITUSSIVE AGENTS; COUMARINS; DEXTROMETHORPHAN; DRUG INTERACTIONS; HUMANS; LIVER FUNCTION TESTS; MALE; MEPHENYTOIN; PHENOTYPE;

EID: 0030041966     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. deMorais, S. M. F.; Wilkinson, G. R.; Blaisdell, J., Nakamura, K., Meyer, U. A.; Goldstein, J. A.: J. Biol Chem. 269, 15419 (1994)
2. Ralling, M. V.: Clin. Pharm. 8, 852 (1989)
3. Alván, G.; Bechtel, P ; Iselius, L.; Gundert-Remy, U.: Eur J. Clin. Pharmacol. 39, 533 (1990)
4. Evans, D. A. P ; Mahgoub, A.; Sloan, T. P.; Idle, J. R.; Smith, R. L.: J. Med Genet. 17, 102 (1980)
5. Eichelbaum, M.; Reetz, K. P ; Schmidt, E. K.; Zekorn, C.: Xenobiotika 16, 465 (1986)
6. Raunio, H., Syngelma, T.; Pasanen, M.; Juvonen, R.; Honkakoski, P.; Kairaluoma, M. A.; Sotaniemi, E.; Lang, M A ; Pelkonen, O.: Biochem. Pharmacol. 37, 3889 (1988)
7. Nebert, D. W ; Nelson, D. R.; Coon, M. J.; Estabrook, R. W.; Feyereisen, R.; Fujii-Kuriyama, Y.; Gonzalez, F. J.; Guengerich, F. P.; Gunsalus, I. C.; Johnson, E. F., Loper, J. C.; Sato, R.; Waterman, M. R.; Waxman, D. J.: DNA Cell. Biol. 10, 1 (1991)
8. Phillips, I. R , Shephard, E A.; Povey, S.; Davis, M. B.; Kelsey, G.; Monteiro, M., West, L. F.; Cowell, J.: Ann. Hum. Genet 49, 207 (1985)
9. Miles, J. S.; Bickmore, W., Brook, J. D.; McLaren, A. W.; Meehan, R.; Wolf, C. R.: Nucleis Acids Res. 17, 2907 (1989)
10. Aoyama, T.; Yamano, S , Guzelian, P S.; Gelboin, H. V.; Gonzalez, F. J.. Proc. Natl Acad. Sci. USA 87, 4790 (1990)
11. Hathcock, J. N.: Fed. Proc. 44, 124 (1985)
12. Conney, A. H.: Pharmacol Rev. 19, 317 (1967)
13. Van Der Graaff, M.; Vermeulen, N. P. E.; Joeres, R P ; Vliestra, J.; Breimer, D. D.: J. Pharmacol. Exp. Therap. 227, 459 (1983)
14. Teunissen, M. W. E.; DeLeede, L. G. J.; Boeijinga, J. K.; Breimer, D. D.: J. Pharmacol. Exp. Therap. 233, 770 (1985)
15. Pelkonen, O.; Breimer, D. D. in. Welling, P. G.; Balant, L. P. (eds.). Handbook of Experimental Pharmacology, Vol. 110, Pharmacokinetics of Drugs, p. 291, Springer Verlag, Berlin/Heidelberg 1994
16. Henschel, L.; Hoffmann, A.: Z. Gastroenterol. 29, 645 (1991)
17. Truckenbrodt, J.; Kraul, H.; Huster, A.; Topfer, R.; Henschel, L.; Hoffmann, A.; Reinhardt, M.; Jorke, D.: Gastroenterol. J. 50, 179 (1990)
18. Evans, W. E.; Relling, M. V.; Petros, W P ; Meyer, W. H ; Mirro, J.; Crom, W. R.: Clin. Pharm. Therap. 45, 568 (1989)
19. Walters, D. G.; Lake, B. G.; Cottrell, R. C.: J. Chromatogr. 196, 501 (1980)
20. Küpfer, A.; Brilis, G. M.; Watson, J. T., Harris, T. M.: Drug Metabol. Disp. 8, 1 (1980)
21. Küpfer, A.; Roberts, R. K.; Schenker, S.; Branch, R. A.: J. Pharmacol. Exp. Therap. 218, 193 (1981)
22. McClashland, T. M.; Donovan, J. P., Amelsberg, A.; Rossi, S. S.: Hofmann, A. F., Shaw, B. W.; Quigley, E. M. M : Hepatology 19, 1381 (1994)
23. Raaflaub, J.: Schweiz. Med. Wschr 111, 1406 (1981)
24. Meier, P. J.. Schweiz. Med. Wschr. 112, 258 (1982)