Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3216-3221

  Mincione, Francesco ^a   Benedini, Francesca ^b   Biondi, Stefano ^b   Cecchi, Alessandro ^c   Temperini, Claudia ^c   Formicola, Giuseppe ^c   Pacileo, Ilaria ^c   Scozzafava, Andrea ^c   Masini, Emanuela ^c   Supuran, Claudiu T ^c  

^a Ospedale di Pescia   (Italy)

^b NicOx Research Institute   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Antiglaucoma drug; Carbonic anhydrase; Nitrate ester; NO; Sulfonamide; X ray crystallography

Indexed keywords

ACETAZOLAMIDE; BRINZOLAMIDE; CARBONATE DEHYDRATASE; DICLOFENAMIDE; DORZOLAMIDE; ETHOXZOLAMIDE; METHAZOLAMIDE; NITRIC OXIDE; SULFONAMIDE;

ARTICLE; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG SYNTHESIS; GLAUCOMA; HUMAN; IN VITRO STUDY; INTRAOCULAR HYPERTENSION; NONHUMAN; X RAY CRYSTALLOGRAPHY;

ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; GLAUCOMA; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE; OCULAR HYPERTENSION; PROTEIN ISOFORMS; RABBITS; SULFONAMIDES; THIOPHENES;

ANIMALIA;

EID: 79956062824     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.046     Document Type: Article

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