Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways

International Journal of Oncology

Volumn 39, Issue 1, 2011, Pages 217-224

  Lin, Chin Chung ^a,b   Kuo, Chao Lin ^c   Lee, Mau Hwa ^a   Lai, Kuang Chi ^d,e   Lin, Jing Pin ^c   Yang, Jai Sing ^c   Yu, Chun Shu ^c   Lu, Chi Cheng ^f   Chiang, Jo Hua ^f   Chueh, Fu Shin ^g   Chung, Jing Gung ^c,g  

^a FENG YUAN HOSPITAL   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

^f NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^g ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase activation; U2 OS human osteosarcoma cells; Unfolded protein response; Wogonin

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ACTIVATING TRANSCRIPTION FACTOR 6; ACTIVATING TRANSCRIPTION FACTOR 6 ALPHA; APOPTOSIS INDUCING FACTOR; CALCIUM; CALPAIN 1; CALPAIN 2; CASPASE 3; CASPASE 4; CASPASE 8; CASPASE 9; CYTOCHROME C; ENDONUCLEASE G; FAS ANTIGEN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BAD; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; WOGONIN;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE G1 PHASE; CELL STRAIN; CELL VIABILITY; DOSE TIME EFFECT RELATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRION; MITOCHONDRION DYSFUNCTION; MITOCHONDRION SWELLING; OSTEOSARCOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STAINING; WESTERN BLOTTING;

APOPTOSIS; CALCIUM; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DRUGS, CHINESE HERBAL; ENDOPLASMIC RETICULUM; FLAVANONES; HUMANS; INTRACELLULAR SPACE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MODELS, BIOLOGICAL; OSTEOSARCOMA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 79955989711     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1027     Document Type: Article

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