-
1
-
-
0038222630
-
A role for the endogenous opioid beta-endorphin in energy homeostasis
-
DOI 10.1210/en.2002-221096
-
Appleyard, S.M., Hayward, M., Young, J.I., Butler, A.A., Cone, R.D., Rubinstein, M., Low, M.J., 2003. A role for the endogenous opioid beta-endorphin in energy homeostasis. Endocrinology 144, 1753-1760. (Pubitemid 36543312)
-
(2003)
Endocrinology
, vol.144
, Issue.5
, pp. 1753-1760
-
-
Appleyard, S.M.1
Hayward, M.2
Young, J.I.3
Butler, A.A.4
Cone, R.D.5
Rubinstein, M.6
Low, M.J.7
-
2
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
DOI 10.1016/j.neuron.2004.06.004, PII S089662730400354X
-
Balthasar, N., Coppari, R., McMinn, J., Liu, S.M., Lee, C.E., Tang, V., Kenny, C.D., McGovern, R.A., Chua, S.C.J., Elmquist, J.K., Lowell, B.B., 2004. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42, 983-991. (Pubitemid 38798236)
-
(2004)
Neuron
, vol.42
, Issue.6
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr., S.C.9
Elmquist, J.K.10
Lowell, B.B.11
-
3
-
-
0025762119
-
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues
-
Benjannet, S., Rondeau, N., Day, R., Chretien, M., Seidah, N.G., 1991. PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc. Natl Acad. Sci. USA 88, 3564-3568.
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 3564-3568
-
-
Benjannet, S.1
Rondeau, N.2
Day, R.3
Chretien, M.4
Seidah, N.G.5
-
4
-
-
0037109670
-
The catabolic action of insulin in the brain is mediated by melanocortins
-
Benoit, S.C., Air, E.L., Coolen, L.M., Strauss, R., Jackman, A., Clegg, D.J., Seeley, R.J., Woods, S.C., 2002. The catabolic action of insulin in the brain is mediated by melanocortins. J. Neurosci. 22, 9048-9052. (Pubitemid 35379074)
-
(2002)
Journal of Neuroscience
, vol.22
, Issue.20
, pp. 9048-9052
-
-
Benoit, S.C.1
Air, E.L.2
Coolen, L.M.3
Strauss, R.4
Jackman, A.5
Clegg, D.J.6
Seeley, R.J.7
Woods, S.C.8
-
5
-
-
0035847020
-
Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice
-
Berman, Y., Mzhavia, N., Polonskaia, A., Devi, L.A., 2001. Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice. J. Biol. Chem. 276, 1466-1473.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 1466-1473
-
-
Berman, Y.1
Mzhavia, N.2
Polonskaia, A.3
Devi, L.A.4
-
6
-
-
33645089926
-
A role for beta-melanocyte-stimulating hormone in human body-weight regulation
-
Biebermann, H., Castaneda, T.R., van Landeghem, F., von Deimling, A., Escher, F., Brabant, G., Hebebrand, J., Hinney, A., Tschop, M.H., Gruters, A., Krude, H., 2006. A role for beta-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab. 3, 141-146.
-
(2006)
Cell Metab.
, vol.3
, pp. 141-146
-
-
Biebermann, H.1
Castaneda, T.R.2
Van Landeghem, F.3
Von Deimling, A.4
Escher, F.5
Brabant, G.6
Hebebrand, J.7
Hinney, A.8
Tschop, M.H.9
Gruters, A.10
Krude, H.11
-
7
-
-
67649962153
-
Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit
-
Blouet, C., Jo, Y.H., Li, X., Schwartz, G.J., 2009. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. J. Neurosci. 29, 8302-8311.
-
(2009)
J. Neurosci.
, vol.29
, pp. 8302-8311
-
-
Blouet, C.1
Jo, Y.H.2
Li, X.3
Schwartz, G.J.4
-
8
-
-
2542460126
-
Endogenous opioids and feeding behavior: A 30-year historical perspective
-
DOI 10.1016/j.peptides.2004.01.006, PII S0196978104000397
-
Bodnar, R.J., 2004. Endogenous opioids and feeding behavior: a 30-year historical perspective. Peptides 25, 697-725. (Pubitemid 38681072)
-
(2004)
Peptides
, vol.25
, Issue.4
, pp. 697-725
-
-
Bodnar, R.J.1
-
9
-
-
1842536210
-
Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding
-
DOI 10.1126/science.1095004
-
Bouret, S.G., Draper, S.J., Simerly, R.B., 2004. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304, 108-110. (Pubitemid 38451467)
-
(2004)
Science
, vol.304
, Issue.5667
, pp. 108-110
-
-
Bouret, S.G.1
Draper, S.J.2
Simerly, R.B.3
-
10
-
-
12844278828
-
Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus
-
DOI 10.1016/j.brainres.2004.11.008, PII S0006899304017925
-
Breen, T.L., Conwell, I.M., Wardlaw, S.L., 2005. Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Brain Res. 1032, 141-148. (Pubitemid 40170319)
-
(2005)
Brain Research
, vol.1032
, Issue.1-2
, pp. 141-148
-
-
Breen, T.L.1
Conwell, I.M.2
Wardlaw, S.L.3
-
11
-
-
0034456398
-
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
-
DOI 10.1210/en.141.9.3518
-
Butler, A.A., Kesterson, R.A., Khong, K., Cullen, M.J., Pelleymounter, M.A., Dekoning, J., Baetscher, M., Cone, R.D., 2000. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141, 3518-3521. (Pubitemid 32269044)
-
(2000)
Endocrinology
, vol.141
, Issue.9
, pp. 3518-3521
-
-
Butler, A.A.1
Kesterson, R.A.2
Khong, K.3
Cullen, M.J.4
Pelleymounter, M.A.5
Dekoning, J.6
Baetscher, M.7
Cone, R.D.8
-
12
-
-
0030947997
-
Post-translational processing of proopiomelanocortin in the pituitary and in the brain
-
Castro, M.G., Morrison, E., 1997. Post-translational processing of proopiomelanocortin in the pituitary and in the brain. Crit. Rev. Neurobiol. 11, 35-57.
-
(1997)
Crit. Rev. Neurobiol.
, vol.11
, pp. 35-57
-
-
Castro, M.G.1
Morrison, E.2
-
13
-
-
0037101841
-
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
-
Challis, B.G., Pritchard, L.E., Creemers, J.W., Delplanque, J., Keogh, J.M., Luan, J., Wareham, N.J., Yeo, G.S., Bhattacharyya, S., Froguel, P., White, A., Farooqi, I.S., O'Rahilly, S., 2002. A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum. Mol. Genet. 11, 1997-2004.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 1997-2004
-
-
Challis, B.G.1
Pritchard, L.E.2
Creemers, J.W.3
Delplanque, J.4
Keogh, J.M.5
Luan, J.6
Wareham, N.J.7
Yeo, G.S.8
Bhattacharyya, S.9
Froguel, P.10
White, A.11
Farooqi, I.S.12
O'Rahilly, S.13
-
14
-
-
12144291698
-
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)
-
Challis, B.G., Coll, A.P., Yeo, G.S., Pinnock, S.B., Dickson, S.L., Thresher, R.R., Dixon, J., Zahn, D., Rochford, J.J., White, A., Oliver, R.L., Millington, G., Aparicio, S.A., Colledge, W.H., Russ, A.P., Carlton, M.B., O'Rahilly, S., 2004. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc. Natl Acad. Sci. USA 101, 4695-4700.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 4695-4700
-
-
Challis, B.G.1
Coll, A.P.2
Yeo, G.S.3
Pinnock, S.B.4
Dickson, S.L.5
Thresher, R.R.6
Dixon, J.7
Zahn, D.8
Rochford, J.J.9
White, A.10
Oliver, R.L.11
Millington, G.12
Aparicio, S.A.13
Colledge, W.H.14
Russ, A.P.15
Carlton, M.B.16
O'Rahilly, S.17
-
15
-
-
0033818103
-
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
-
Chen, A.S., Marsh, D.J., Trumbauer, M.E., Frazier, E.G., Guan, X.M., Yu, H., Rosenblum, C.I., Vongs, A., Feng, Y., Cao, L., Metzger, J.M., Strack, A.M., Camacho, R.E., Mellin, T.N., Nunes, C.N., Min, W., Fisher, J., Gopal-Truter, S., MacIntyre, D.E., Chen, H.Y., Van Der Ploeg, L.H., 2000. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet. 26, 97-102.
-
(2000)
Nat. Genet.
, vol.26
, pp. 97-102
-
-
Chen, A.S.1
Marsh, D.J.2
Trumbauer, M.E.3
Frazier, E.G.4
Guan, X.M.5
Yu, H.6
Rosenblum, C.I.7
Vongs, A.8
Feng, Y.9
Cao, L.10
Metzger, J.M.11
Strack, A.M.12
Camacho, R.E.13
Mellin, T.N.14
Nunes, C.N.15
Min, W.16
Fisher, J.17
Gopal-Truter, S.18
MacIntyre, D.E.19
Chen, H.Y.20
Van Der Ploeg, L.H.21
more..
-
16
-
-
0034897806
-
Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity
-
Chen, H., Jawahar, S., Qian, Y., Duong, Q., Chan, G., Parker, A., Meyer, J.M., Moore, K.J., Chayen, S., Gross, D.J., Glaser, B., Permutt, M.A., Fricker, L.D., 2001. Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity. Hum. Mutat. 18, 120-131.
-
(2001)
Hum. Mutat.
, vol.18
, pp. 120-131
-
-
Chen, H.1
Jawahar, S.2
Qian, Y.3
Duong, Q.4
Chan, G.5
Parker, A.6
Meyer, J.M.7
Moore, K.J.8
Chayen, S.9
Gross, D.J.10
Glaser, B.11
Permutt, M.A.12
Fricker, L.D.13
-
17
-
-
57349175699
-
Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygousmutation in the POMC gene
-
Clement, K., Dubern, B., Mencarelli, M., Czernichow, P., Ito, S., Wakamatsu, K., Barsh, G.S., Vaisse, C., Leger, J., 2008.Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygousmutation in the POMC gene. J. Clin. Endocrinol. Metab. 93, 4955-4962.
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 4955-4962
-
-
Clement, K.1
Dubern, B.2
Mencarelli, M.3
Czernichow, P.4
Ito, S.5
Wakamatsu, K.6
Barsh, G.S.7
Vaisse, C.8
Leger, J.9
-
18
-
-
2942631413
-
Proopiomelanocortin and energy balance: Insights from human and murine genetics
-
Coll, A.P., Farooqi, I.S., Challis, B.G., Yeo, G.S., O'Rahilly, S., 2004. Proopiomelanocortin and energy balance: insights from human and murine genetics. J. Clin. Endocrinol. Metab. 89, 2557-2562.
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 2557-2562
-
-
Coll, A.P.1
Farooqi, I.S.2
Challis, B.G.3
Yeo, G.S.4
O'Rahilly, S.5
-
19
-
-
23644453797
-
Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids
-
DOI 10.2337/diabetes.54.8.2269
-
Coll, A.P., Challis, B.G., Lopez, M., Piper, S., Yeo, G.S., O'Rahilly, S., 2005. Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. Diabetes 54, 2269-2276. (Pubitemid 41134252)
-
(2005)
Diabetes
, vol.54
, Issue.8
, pp. 2269-2276
-
-
Coll, A.P.1
Challis, B.G.2
Lopez, M.3
Piper, S.4
Yeo, G.S.H.5
O'Rahilly, S.6
-
20
-
-
0031017322
-
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
-
Comuzzie, A.G., Hixson, J.E., Almasy, L., Mitchell, B.D., Mahaney, M.C., Dyer, T.D., Stern, M.P., MacCluer, J.W., Blangero, J., 1997. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat. Genet. 15, 273-276.
-
(1997)
Nat. Genet.
, vol.15
, pp. 273-276
-
-
Comuzzie, A.G.1
Hixson, J.E.2
Almasy, L.3
Mitchell, B.D.4
Mahaney, M.C.5
Dyer, T.D.6
Stern, M.P.7
MacCluer, J.W.8
Blangero, J.9
-
21
-
-
0021256237
-
Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone
-
Contreras, P.C., Takemori, A.E., 1984. Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone. J. Pharmacol. Exp. Ther. 229, 21-26.
-
(1984)
J. Pharmacol. Exp. Ther.
, vol.229
, pp. 21-26
-
-
Contreras, P.C.1
Takemori, A.E.2
-
22
-
-
0030976604
-
Carboxypeptidase e is a regulated secretory pathway sorting receptor: Genetic obliteration leads to endocrine disorders in Cpe(fat) mice
-
Cool, D.R., Normant, E., Shen, F., Chen, H.C., Pannell, L., Zhang, Y., Loh, Y.P., 1997. Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell 88, 73-83. (Pubitemid 27180332)
-
(1997)
Cell
, vol.88
, Issue.1
, pp. 73-83
-
-
Cool, D.R.1
Normant, E.2
Shen, F.-S.3
Chen, H.-C.4
Pannell, L.5
Zhang, Y.6
Loh, Y.P.7
-
23
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
DOI 10.1126/science.1124147
-
Cota, D., Proulx, K., Smith, K.A., Kozma, S.C., Thomas, G., Woods, S.C., Seeley, R.J., 2006. Hypothalamic mTOR signaling regulates food intake. Science 312, 927-930. (Pubitemid 43727328)
-
(2006)
Science
, vol.312
, Issue.5775
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Blake, S.K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
24
-
-
0033200153
-
Integration of npy, agrp, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
-
DOI 10.1016/S0896-6273(00)80829-6
-
Cowley, M.A., Pronchuk, N., Fan, W., Dinulescu, D.M., Colmers, W.F., Cone, R.D., 1999. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24, 155-163. (Pubitemid 29466155)
-
(1999)
Neuron
, vol.24
, Issue.1
, pp. 155-163
-
-
Cowley, M.A.1
Pronchuk, N.2
Fan, W.3
Dinulescu, D.M.4
Colmers, W.F.5
Cone, R.D.6
-
25
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
DOI 10.1038/35078085
-
Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Cone, R.D., Low, M.J., 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480-484. (Pubitemid 32494394)
-
(2001)
Nature
, vol.411
, Issue.6836
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdan, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
26
-
-
33645508923
-
Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: Interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3
-
Creemers, J.W., Pritchard, L.E., Gyte, A., Le Rouzic, P., Meulemans, S., Wardlaw, S.L., Zhu, X., Steiner, D.F., Davies, N., Armstrong, D., Lawrence, C.B., Luckman, S.M., Schmitz, C.A., Davies, R.A., Brennand, J.C., White, A., 2006. Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3. Endocrinology 147, 1621-1631.
-
(2006)
Endocrinology
, vol.147
, pp. 1621-1631
-
-
Creemers, J.W.1
Pritchard, L.E.2
Gyte, A.3
Le Rouzic, P.4
Meulemans, S.5
Wardlaw, S.L.6
Zhu, X.7
Steiner, D.F.8
Davies, N.9
Armstrong, D.10
Lawrence, C.B.11
Luckman, S.M.12
Schmitz, C.A.13
Davies, R.A.14
Brennand, J.C.15
White, A.16
-
27
-
-
84992268836
-
Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway
-
Creemers, J.W., Lee, Y.S., Oliver, R.L., Bahceci, M., Tuzcu, A., Gokalp, D., Keogh, J., Herber, S., White, A., O'Rahilly, S., Farooqi, I.S., 2008. Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway. J. Clin. Endocrinol. Metab. 93, 4494-4499.
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 4494-4499
-
-
Creemers, J.W.1
Lee, Y.S.2
Oliver, R.L.3
Bahceci, M.4
Tuzcu, A.5
Gokalp, D.6
Keogh, J.7
Herber, S.8
White, A.9
O'Rahilly, S.10
Farooqi, I.S.11
-
28
-
-
38349151344
-
Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain
-
Dubern, B., Lubrano-Berthelier, C., Mencarelli, M., Ersoy, B., Frelut, M.L., Bougle, D., Costes, B., Simon, C., Tounian, P., Vaisse, C., Clement, K., 2008. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatr. Res. 63, 211-216.
-
(2008)
Pediatr. Res.
, vol.63
, pp. 211-216
-
-
Dubern, B.1
Lubrano-Berthelier, C.2
Mencarelli, M.3
Ersoy, B.4
Frelut, M.L.5
Bougle, D.6
Costes, B.7
Simon, C.8
Tounian, P.9
Vaisse, C.10
Clement, K.11
-
29
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
DOI 10.1016/S0896-6273(01)80035-0
-
Elias, C.F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R.S., Bjorbaek, C., Flier, J.S., Saper, C.B., Elmquist, J.K., 1999. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23, 775-786. (Pubitemid 29411566)
-
(1999)
Neuron
, vol.23
, Issue.4
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
Kelly, J.4
Ahima, R.S.5
Bjorbaek, C.6
Flier, J.S.7
Saper, C.B.8
Elmquist, J.K.9
-
30
-
-
0033082380
-
From lesions to leptin: Hypothalamic control of food intake and body weight
-
Elmquist, J.K., Elias, C.F., Saper, C.B., 1999. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22, 221-232. (Pubitemid 29109657)
-
(1999)
Neuron
, vol.22
, Issue.2
, pp. 221-232
-
-
Elmquist, J.K.1
Elias, C.F.2
Saper, C.B.3
-
31
-
-
0022653301
-
Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus
-
Emeson, R.B., Eipper, B.A., 1986. Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus. J. Neurosci. 6, 837-849. (Pubitemid 16134922)
-
(1986)
Journal of Neuroscience
, vol.6
, Issue.3
, pp. 837-849
-
-
Emeson, R.B.1
Eipper, B.A.2
-
32
-
-
33750592655
-
Heterozygosity for a POMC-null mutation and increased obesity risk in humans
-
DOI 10.2337/db06-0214
-
Farooqi, I.S., Drop, S., Clements, A., Keogh, J.M., Biernacka, J., Lowenbein, S., Challis, B.G., O'Rahilly, S., 2006. Heterozygosity for a POMC-null mutation and increased obesity risk in humans. Diabetes 55, 2549-2553. (Pubitemid 44871155)
-
(2006)
Diabetes
, vol.55
, Issue.9
, pp. 2549-2553
-
-
Farooqi, I.S.1
Drop, S.2
Clements, A.3
Keogh, J.M.4
Biernacka, J.5
Lowenbein, S.6
Challis, B.G.7
O'Rahilly, S.8
-
33
-
-
34347214441
-
Energy balance pathways converging on the Nhlh2 transcription factor
-
Fox, D.L., Vella, K.R., Good, D.J., 2007. Energy balance pathways converging on the Nhlh2 transcription factor. Front. Biosci. 12, 3983-3993.
-
(2007)
Front. Biosci.
, vol.12
, pp. 3983-3993
-
-
Fox, D.L.1
Vella, K.R.2
Good, D.J.3
-
34
-
-
58149391976
-
Monitoring FoxO1 localization in chemically identified neurons
-
Fukuda, M., Jones, J.E., Olson, D., Hill, J., Lee, C.E., Gautron, L., Choi, M., Zigman, J.M., Lowell, B.B., Elmquist, J.K., 2008. Monitoring FoxO1 localization in chemically identified neurons. J. Neurosci. 28, 13640-13648.
-
(2008)
J. Neurosci.
, vol.28
, pp. 13640-13648
-
-
Fukuda, M.1
Jones, J.E.2
Olson, D.3
Hill, J.4
Lee, C.E.5
Gautron, L.6
Choi, M.7
Zigman, J.M.8
Lowell, B.B.9
Elmquist, J.K.10
-
35
-
-
12644253798
-
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
-
Furuta, M., Yano, H., Zhou, A., Rouille, Y., Holst, J.J., Carroll, R., Ravazzola, M., Orci, L., Furuta, H., Steiner, D.F., 1997. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc. Natl Acad. Sci. USA 94, 6646-6651.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 6646-6651
-
-
Furuta, M.1
Yano, H.2
Zhou, A.3
Rouille, Y.4
Holst, J.J.5
Carroll, R.6
Ravazzola, M.7
Orci, L.8
Furuta, H.9
Steiner, D.F.10
-
36
-
-
0031280002
-
Overexpression of Agrt leads to obesity in transgenic mice
-
Graham, M., Shutter, J.R., Sarmiento, U., Sarosi, I., Stark, K.L., 1997. Overexpression of Agrt leads to obesity in transgenic mice. Nat. Genet. 17, 273-274.
-
(1997)
Nat. Genet.
, vol.17
, pp. 273-274
-
-
Graham, M.1
Shutter, J.R.2
Sarmiento, U.3
Sarosi, I.4
Stark, K.L.5
-
37
-
-
0142122392
-
Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats
-
DOI 10.1016/S0006-8993(03)03442-5
-
Grossman, H.C., Hadjimarkou, M.M., Silva, R.M., Giraudo, S.Q., Bodnar, R.J., 2003. Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats. Brain Res. 991, 240-244. (Pubitemid 37297953)
-
(2003)
Brain Research
, vol.991
, Issue.1-2
, pp. 240-244
-
-
Grossman, H.C.1
Hadjimarkou, M.M.2
Silva, R.M.3
Giraudo, S.Q.4
Bodnar, R.J.5
-
38
-
-
4143090543
-
N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin
-
Guo, L., Munzberg, H., Stuart, R.C., Nillni, E.A., Bjorbaek, C., 2004. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proc. Natl Acad. Sci. USA 101, 11797-11802.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 11797-11802
-
-
Guo, L.1
Munzberg, H.2
Stuart, R.C.3
Nillni, E.A.4
Bjorbaek, C.5
-
39
-
-
17344371519
-
A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10
-
Hager, J., Dina, C., Francke, S., Dubois, S., Houari, M., Vatin, V., Vaillant, E., Lorentz, N., Basdevant, A., Clement, K., Guy-Grand, B., Froguel, P., 1998. A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat. Genet. 20, 304-308.
-
(1998)
Nat. Genet.
, vol.20
, pp. 304-308
-
-
Hager, J.1
Dina, C.2
Francke, S.3
Dubois, S.4
Houari, M.5
Vatin, V.6
Vaillant, E.7
Lorentz, N.8
Basdevant, A.9
Clement, K.10
Guy-Grand, B.11
Froguel, P.12
-
40
-
-
77950264425
-
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
-
Hill, J.W., Elias, C.F., Fukuda, M., Williams, K.W., Berglund, E.D., Holland, W.L., Cho, Y.R., Chuang, J.C., Xu, Y., Choi, M., Lauzon, D., Lee, C.E., Coppari, R., Richardson, J.A., Zigman, J.M., Chua, S., Scherer, P.E., Lowell, B.B., Bruning, J.C., Elmquist, J.K., 2010. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 11, 286-297.
-
(2010)
Cell Metab.
, vol.11
, pp. 286-297
-
-
Hill, J.W.1
Elias, C.F.2
Fukuda, M.3
Williams, K.W.4
Berglund, E.D.5
Holland, W.L.6
Cho, Y.R.7
Chuang, J.C.8
Xu, Y.9
Choi, M.10
Lauzon, D.11
Lee, C.E.12
Coppari, R.13
Richardson, J.A.14
Zigman, J.M.15
Chua, S.16
Scherer, P.E.17
Lowell, B.B.18
Bruning, J.C.19
Elmquist, J.K.20
more..
-
41
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Berkemeier, L.R., Gu, W., Kesterson, R.A., Boston, B.A., Cone, R.D., Smith, F.J., Campfield, L.A., Burn, P., Lee, F., 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141. (Pubitemid 27180337)
-
(1997)
Cell
, vol.88
, Issue.1
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
Smith, F.J.11
Campfield, L.A.12
Burn, P.13
Frank, L.14
-
42
-
-
0037387207
-
ATP channels
-
DOI 10.1210/en.2002-221033
-
Ibrahim, N., Bosch, M.A., Smart, J.L., Qiu, J., Rubinstein, M., Ronnekleiv, O.K., Low, M.J., Kelly, M.J., 2003. Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. Endocrinology 144, 1331-1340. (Pubitemid 36428475)
-
(2003)
Endocrinology
, vol.144
, Issue.4
, pp. 1331-1340
-
-
Ibrahim, N.1
Bosch, M.A.2
Smart, J.L.3
Qiu, J.4
Rubinstein, M.5
Ronnekleiv, O.K.6
Low, M.J.7
Kelly, M.J.8
-
43
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
Jackson, R.S., Creemers, J.W., Ohagi, S., Raffin-Sanson, M.L., Sanders, L., Montague, C.T., Hutton, J.C., O'Rahilly, S., 1997. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat. Genet. 16, 303-306.
-
(1997)
Nat. Genet.
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
Creemers, J.W.2
Ohagi, S.3
Raffin-Sanson, M.L.4
Sanders, L.5
Montague, C.T.6
Hutton, J.C.7
O'Rahilly, S.8
-
44
-
-
0346096721
-
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
-
Jackson, R.S., Creemers, J.W., Farooqi, I.S., Raffin-Sanson, M.L., Varro, A., Dockray, G.J., Holst, J.J., Brubaker, P.L., Corvol, P., Polonsky, K.S., Ostrega, D., Becker, K.L., Bertagna, X., Hutton, J.C., White, A., Dattani, M.T., Hussain, K., Middleton, S.J., Nicole, T.M., Milla, P.J., Lindley, K.J., O'Rahilly, S., 2003. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J. Clin. Investig. 112, 1550-1560.
-
(2003)
J. Clin. Investig.
, vol.112
, pp. 1550-1560
-
-
Jackson, R.S.1
Creemers, J.W.2
Farooqi, I.S.3
Raffin-Sanson, M.L.4
Varro, A.5
Dockray, G.J.6
Holst, J.J.7
Brubaker, P.L.8
Corvol, P.9
Polonsky, K.S.10
Ostrega, D.11
Becker, K.L.12
Bertagna, X.13
Hutton, J.C.14
White, A.15
Dattani, M.T.16
Hussain, K.17
Middleton, S.J.18
Nicole, T.M.19
Milla, P.J.20
Lindley, K.J.21
O'Rahilly, S.22
more..
-
45
-
-
1642464993
-
Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity
-
DOI 10.1210/en.2003-0834
-
Jing, E., Nillni, E.A., Sanchez, V.C., Stuart, R.C., Good, D.J., 2004. Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity. Endocrinology 145, 1503-1513. (Pubitemid 38402353)
-
(2004)
Endocrinology
, vol.145
, Issue.4
, pp. 1503-1513
-
-
Jing, E.1
Nillni, E.A.2
Sanchez, V.C.3
Stuart, R.C.4
Good, D.J.5
-
46
-
-
8444249951
-
The electrophysiology of feeding circuits. Trends Endocrinol
-
Jobst, E.E., Enriori, P.J., Cowley, M.A., 2004. The electrophysiology of feeding circuits. Trends Endocrinol. Metab. TEM 15, 488-499.
-
(2004)
Metab. TEM
, vol.15
, pp. 488-499
-
-
Jobst, E.E.1
Enriori, P.J.2
Cowley, M.A.3
-
47
-
-
0035020279
-
Central melanocortin receptors mediate changes in food intake in the rhesus macaque
-
DOI 10.1210/en.142.6.2586
-
Koegler, F.H., Grove, K.L., Schiffmacher, A., Smith, M.S., Cameron, J.L., 2001. Central melanocortin receptors mediate changes in food intake in the rhesus macaque. Endocrinology 142, 2586-2592. (Pubitemid 32473114)
-
(2001)
Endocrinology
, vol.142
, Issue.6
, pp. 2586-2592
-
-
Koegler, F.H.1
Grove, K.L.2
Schiffmacher, A.3
Smith, M.S.4
Cameron, J.L.5
-
48
-
-
0033405582
-
Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats
-
Korner, J., Chua Jr., S.C., Williams, J.A., Leibel, R.L., Wardlaw, S.L., 1999. Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology 70, 377-383. (Pubitemid 30009026)
-
(1999)
Neuroendocrinology
, vol.70
, Issue.6
, pp. 377-383
-
-
Korner, J.1
Chua Jr., S.C.2
Williams, J.A.3
Leibel, R.L.4
Wardlaw, S.L.5
-
49
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G., Gruters, A., 1998. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19, 155-157.
-
(1998)
Nat. Genet.
, vol.19
, pp. 155-157
-
-
Krude, H.1
Biebermann, H.2
Luck, W.3
Horn, R.4
Brabant, G.5
Gruters, A.6
-
50
-
-
0242320429
-
Obesity due to proopiomelanocortin deficiency: Three new cases and treatment trials with thyroid hormone and ACTH4-10
-
Krude, H., Biebermann, H., Schnabel, D., Tansek, M.Z., Theunissen, P., Mullis, P.E., Gruters, A., 2003. Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J. Clin. Endocrinol. Metab. 88, 4633-4640.
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 4633-4640
-
-
Krude, H.1
Biebermann, H.2
Schnabel, D.3
Tansek, M.Z.4
Theunissen, P.5
Mullis, P.E.6
Gruters, A.7
-
51
-
-
34347267613
-
The central melanocortin system and the regulation of energy balance
-
Lee, M., Wardlaw, S.L., 2007. The central melanocortin system and the regulation of energy balance. Front. Biosci. 12, 3994-4010.
-
(2007)
Front. Biosci.
, vol.12
, pp. 3994-4010
-
-
Lee, M.1
Wardlaw, S.L.2
-
52
-
-
33645048441
-
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance
-
Lee, Y.S., Challis, B.G., Thompson, D.A., Yeo, G.S., Keogh, J.M., Madonna, M.E., Wraight, V., Sims, M., Vatin, V., Meyre, D., Shield, J., Burren, C., Ibrahim, Z., Cheetham, T., Swift, P., Blackwood, A., Hung, C.C., Wareham, N.J., Froguel, P., Millhauser, G.L., O'Rahilly, S., Farooqi, I.S., 2006. A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab. 3, 135-140.
-
(2006)
Cell Metab.
, vol.3
, pp. 135-140
-
-
Lee, Y.S.1
Challis, B.G.2
Thompson, D.A.3
Yeo, G.S.4
Keogh, J.M.5
Madonna, M.E.6
Wraight, V.7
Sims, M.8
Vatin, V.9
Meyre, D.10
Shield, J.11
Burren, C.12
Ibrahim, Z.13
Cheetham, T.14
Swift, P.15
Blackwood, A.16
Hung, C.C.17
Wareham, N.J.18
Froguel, P.19
Millhauser, G.L.20
O'Rahilly, S.21
Farooqi, I.S.22
more..
-
53
-
-
34547122875
-
Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet
-
Lee, M., Kim, A., Chua Jr., S.C., Obici, S., Wardlaw, S.L., 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am. J. Physiol. 293, E121-E131.
-
(2007)
Am. J. Physiol.
, vol.293
-
-
Lee, M.1
Kim, A.2
Chua Jr., S.C.3
Obici, S.4
Wardlaw, S.L.5
-
54
-
-
0034456997
-
Agouti-related protein-like immunoreactivity: Characterization of release from hypothalamic tissue and presence in serum
-
DOI 10.1210/en.141.6.1942
-
Li, J.Y., Finniss, S., Yang, Y.K., Zeng, Q., Qu, S.Y., Barsh, G., Dickinson, C., Gantz, I., 2000. Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum. Endocrinology 141, 1942-1950. (Pubitemid 32274341)
-
(2000)
Endocrinology
, vol.141
, Issue.6
, pp. 1942-1950
-
-
Li, J.-Y.1
Finniss, S.2
Yang, Y.-K.3
Zeng, Q.4
Qu, S.-Y.5
Barsh, G.6
Dickinson, C.7
Gantz, I.8
-
55
-
-
0042767613
-
Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats
-
DOI 10.2337/diabetes.52.8.1951
-
Li, G., Mobbs, C.V., Scarpace, P.J., 2003. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes 52, 1951-1957. (Pubitemid 36919786)
-
(2003)
Diabetes
, vol.52
, Issue.8
, pp. 1951-1957
-
-
Li, G.1
Mobbs, C.V.2
Scarpace, P.J.3
-
56
-
-
33744763342
-
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
-
Lloyd, D.J., Bohan, S., Gekakis, N., 2006. Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice. Hum. Mol. Genet. 15, 1884-1893.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1884-1893
-
-
Lloyd, D.J.1
Bohan, S.2
Gekakis, N.3
-
57
-
-
0038051127
-
State-dependent modulation of feeding behavior by proopiomelanocortin- derived beta-endorphin
-
Low, M.J., Hayward, M.D., Appleyard, S.M., Rubinstein, M., 2003. State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin. Ann. NY Acad. Sci. 994, 192-201.
-
(2003)
Ann. NY Acad. Sci.
, vol.994
, pp. 192-201
-
-
Low, M.J.1
Hayward, M.D.2
Appleyard, S.M.3
Rubinstein, M.4
-
58
-
-
0033867056
-
Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression
-
McMinn, J.E., Wilkinson, C.W., Havel, P.J., Woods, S.C., Schwartz, M.W., 2000. Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279, R695-R703.
-
(2000)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.279
-
-
McMinn, J.E.1
Wilkinson, C.W.2
Havel, P.J.3
Woods, S.C.4
Schwartz, M.W.5
-
59
-
-
0242300570
-
Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice
-
DOI 10.2337/diabetes.52.11.2675
-
Mizuno, T.M., Kelley, K.A., Pasinetti, G.M., Roberts, J.L., Mobbs, C.V., 2003. Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 52, 2675-2683. (Pubitemid 37339696)
-
(2003)
Diabetes
, vol.52
, Issue.11
, pp. 2675-2683
-
-
Mizuno, T.M.1
Kelley, K.A.2
Pasinetti, G.M.3
Roberts, J.L.4
Mobbs, C.V.5
-
60
-
-
0038747134
-
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic Proopiomelanocortin gene expression by leptin
-
DOI 10.1210/en.2002-221037
-
Munzberg, H., Huo, L., Nillni, E.A., Hollenberg, A.N., Bjorbaek, C., 2003. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144, 2121-2131. (Pubitemid 36543352)
-
(2003)
Endocrinology
, vol.144
, Issue.5
, pp. 2121-2131
-
-
Munzberg, H.1
Huo, L.2
Nillni, E.A.3
Hollenberg, A.N.4
Bjorbaek, C.5
-
61
-
-
0029040210
-
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
-
Naggert, J.K., Fricker, L.D., Varlamov, O., Nishina, P.M., Rouille, Y., Steiner, D.F., Carroll, R.J., Paigen, B.J., Leiter, E.H., 1995. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat. Genet. 10, 135-142.
-
(1995)
Nat. Genet.
, vol.10
, pp. 135-142
-
-
Naggert, J.K.1
Fricker, L.D.2
Varlamov, O.3
Nishina, P.M.4
Rouille, Y.5
Steiner, D.F.6
Carroll, R.J.7
Paigen, B.J.8
Leiter, E.H.9
-
62
-
-
0021802558
-
Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia
-
Nicolas, P., Li, C.H., 1985. Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia. Proc. Natl Acad. Sci. USA 82, 3178-3181.
-
(1985)
Proc. Natl Acad. Sci. USA
, vol.82
, pp. 3178-3181
-
-
Nicolas, P.1
Li, C.H.2
-
63
-
-
0030764741
-
Antagonism of Central Melanocortin receptors in vitro and in vivo by agouti-related protein
-
DOI 10.1126/science.278.5335.135
-
Ollmann, M.M., Wilson, B.D., Yang, Y.K., Kerns, J.A., Chen, Y., Gantz, I., Barsh, G.S., 1997. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-138. (Pubitemid 27446294)
-
(1997)
Science
, vol.278
, Issue.5335
, pp. 135-138
-
-
Ollmann, M.M.1
Wilson, B.D.2
Yang, Y.-K.3
Kerns, J.A.4
Chen, Y.5
Gantz, I.6
Barsh, G.S.7
-
64
-
-
0035854112
-
Evidence of interactions between melanocortin and opioid systems in regulation of feeding
-
Olszewski, P.K., Wirth, M.M., Grace, M.K., Levine, A.S., Giraudo, S.Q., 2001. Evidence of interactions between melanocortin and opioid systems in regulation of feeding. NeuroReport 12, 1727-1730. (Pubitemid 32521495)
-
(2001)
NeuroReport
, vol.12
, Issue.8
, pp. 1727-1730
-
-
Olszewski, P.K.1
Wirth, M.M.2
Grace, M.K.3
Levine, A.S.4
Giraudo, S.Q.5
-
65
-
-
34247570950
-
Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tarct
-
Perello, M., Stuart, R.C., Nillni, E.A., 2007. Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tarct. Am. J. Physiol. 292, E1348-E1357.
-
(2007)
Am. J. Physiol.
, vol.292
-
-
Perello, M.1
Stuart, R.C.2
Nillni, E.A.3
-
66
-
-
1842529267
-
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
-
DOI 10.1126/science.1089459
-
Pinto, S., Roseberry, A.G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J.M., Horvath, T.L., 2004. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304, 110-115. (Pubitemid 38451468)
-
(2004)
Science
, vol.304
, Issue.5667
, pp. 110-115
-
-
Pinto, S.1
Roseberry, A.G.2
Liu, H.3
Diano, S.4
Shanabrough, M.5
Cai, X.6
Friedman, J.M.7
Horvath, T.L.8
-
67
-
-
70350369729
-
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
-
Plum, L., Lin, H.V., Dutia, R., Tanaka, J., Aizawa, K.S., Matsumoto, M., Kim, A.J., Cawley, N.X., Paik, J.H., Loh, Y.P., Depinho, R.A., Wardlaw, S.L., Accili, D., 2009. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat. Med. 15, 1195-1201.
-
(2009)
Nat. Med.
, vol.15
, pp. 1195-1201
-
-
Plum, L.1
Lin, H.V.2
Dutia, R.3
Tanaka, J.4
Aizawa, K.S.5
Matsumoto, M.6
Kim, A.J.7
Cawley, N.X.8
Paik, J.H.9
Loh, Y.P.10
Depinho, R.A.11
Wardlaw, S.L.12
Accili, D.13
-
68
-
-
34548061243
-
Minireview: Neuropeptide processing and its impact on melanocortin pathways
-
DOI 10.1210/en.2006-1686
-
Pritchard, L.E., White, A., 2007. Neuropeptide processing and its impact on melanocortin pathways. Endocrinology 148, 4201-4207. (Pubitemid 47295669)
-
(2007)
Endocrinology
, vol.148
, Issue.9
, pp. 4201-4207
-
-
Pritchard, L.E.1
White, A.2
-
69
-
-
0037373325
-
Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: Evidence that secretion is regulated with respect to energy balance
-
DOI 10.1210/en.2002-220866
-
Pritchard, L.E., Oliver, R.L., McLoughlin, J.D., Birtles, S., Lawrence, C.B., Turnbull, A.V., White, A., 2003. Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: evidence that secretion is regulated with respect to energy balance. Endocrinology 144, 760-766. (Pubitemid 36262843)
-
(2003)
Endocrinology
, vol.144
, Issue.3
, pp. 760-766
-
-
Pritchard, L.E.1
Oliver, R.L.2
McLoughlin, J.D.3
Birtles, S.4
Lawrence, C.B.5
Turnbull, A.V.6
White, A.7
-
70
-
-
15144357684
-
A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
-
Rossi, M., Kim, M.S., Morgan, D.G., Small, C.J., Edwards, C.M., Sunter, D., Abusnana, S., Goldstone, A.P., Russell, S.H., Stanley, S.A., Smith, D.M., Yagaloff, K., Ghatei, M.A., Bloom, S.R., 1998. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139, 4428-4431. (Pubitemid 28513735)
-
(1998)
Endocrinology
, vol.139
, Issue.10
, pp. 4428-4431
-
-
Rossi, M.1
Kim, M.S.2
Morgan, D.G.A.3
Small, C.J.4
Edwards, C.M.B.5
Sunter, D.6
Abusnana, S.7
Goldstone, A.P.8
Russell, S.H.9
Stanley, S.A.10
Smith, D.M.11
Yagaloff, K.12
Ghatei, M.A.13
Bloom, S.R.14
-
71
-
-
0032972276
-
The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans
-
Rotimi, C.N., Comuzzie, A.G., Lowe, W.L., Luke, A., Blangero, J., Cooper, R.S., 1999. The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans. Diabetes 48, 643-644. (Pubitemid 29106883)
-
(1999)
Diabetes
, vol.48
, Issue.3
, pp. 643-644
-
-
Rotimi, C.N.1
Comuzzie, A.G.2
Lowe, W.L.3
Luke, A.4
Blangero, J.5
Cooper, R.S.6
-
72
-
-
4043060941
-
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone
-
Sanchez, V.C., Goldstein, J., Stuart, R.C., Hovanesian, V., Huo, L., Munzberg, H., Friedman, T.C., Bjorbaek, C., Nillni, E.A., 2004. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J. Clin. Investig. 114, 357-369.
-
(2004)
J. Clin. Investig.
, vol.114
, pp. 357-369
-
-
Sanchez, V.C.1
Goldstein, J.2
Stuart, R.C.3
Hovanesian, V.4
Huo, L.5
Munzberg, H.6
Friedman, T.C.7
Bjorbaek, C.8
Nillni, E.A.9
-
73
-
-
0019407503
-
Intraventricular administration of MSH induces hyperalgesia in rats
-
DOI 10.1016/S0196-9781(81)80040-X
-
Sandman, C.A., Kastin, A.J., 1981. Intraventricular administration of MSH induces hyperalgesia in rats. Peptides 2, 231-233. (Pubitemid 11030849)
-
(1981)
Peptides
, vol.2
, Issue.2
, pp. 231-233
-
-
Sandman, C.A.1
Kastin, A.J.2
-
74
-
-
3843114437
-
Metabolic effects of transJrgenic melanocyte-stimulating hormone overexpression in lean and obese mice
-
DOI 10.1210/en.2004-0263
-
Savontaus, E., Breen, T.L., Kim, A., Yang, L.M., Chua, S.C.J., Wardlaw, S.L., 2004. Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology 145, 3881-3891. (Pubitemid 39037577)
-
(2004)
Endocrinology
, vol.145
, Issue.8
, pp. 3881-3891
-
-
Savontaus, E.1
Breen, T.L.2
Kim, A.3
Yang, L.M.4
Chua Jr., S.C.5
Wardlaw, S.L.6
-
75
-
-
0030775971
-
Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
-
Schwartz, M.W., Seeley, R.J., Woods, S.C., Weigle, D.S., Campfield, L.A., Burn, P., Baskin, D.G., 1997. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119-2123. (Pubitemid 27512108)
-
(1997)
Diabetes
, vol.46
, Issue.12
, pp. 2119-2123
-
-
Schwartz, M.W.1
Seeley, R.J.2
Woods, S.C.3
Weigle, D.S.4
Campfield, L.A.5
Burn, P.6
Baskin, D.G.7
-
76
-
-
0026736321
-
Alpha-melanocyte-stimulating hormone antagonizes the neuroendocrine effects of corticotropin-releasing factor and interleukin-1 alpha in the primate
-
Shalts, E., Feng, Y.J., Ferin, M., Wardlaw, S.L., 1992. Alpha-melanocyte-stimulating hormone antagonizes the neuroendocrine effects of corticotropin-releasing factor and interleukin-1 alpha in the primate. Endocrinology 131, 132-138.
-
(1992)
Endocrinology
, vol.131
, pp. 132-138
-
-
Shalts, E.1
Feng, Y.J.2
Ferin, M.3
Wardlaw, S.L.4
-
77
-
-
32444449631
-
Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
-
Smart, J.L., Tolle, V., Low, M.J., 2006. Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. J. Clin. Investig. 116, 495-505.
-
(2006)
J. Clin. Investig.
, vol.116
, pp. 495-505
-
-
Smart, J.L.1
Tolle, V.2
Low, M.J.3
-
78
-
-
0023959725
-
Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues
-
Smith, A.I., Funder, J.W., 1988. Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev 9, 159-179.
-
(1988)
Endocr Rev
, vol.9
, pp. 159-179
-
-
Smith, A.I.1
Funder, J.W.2
-
79
-
-
68849092560
-
Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents
-
Wallingford, N., Perroud, B., Gao, Q., Coppola, A., Gyengesi, E., Liu, Z.W., Gao, X.B., Diament, A., Haus, K.A., Shariat-Madar, Z., Mahdi, F., Wardlaw, S.L., Schmaier, A.H., Warden, C.H., Diano, S., 2009. Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents. J. Clin. Investig. 119, 2291-2303.
-
(2009)
J. Clin. Investig.
, vol.119
, pp. 2291-2303
-
-
Wallingford, N.1
Perroud, B.2
Gao, Q.3
Coppola, A.4
Gyengesi, E.5
Liu, Z.W.6
Gao, X.B.7
Diament, A.8
Haus, K.A.9
Shariat-Madar, Z.10
Mahdi, F.11
Wardlaw, S.L.12
Schmaier, A.H.13
Warden, C.H.14
Diano, S.15
-
80
-
-
0025318842
-
Interaction between beta-endorphin and alpha-melanocyte-stimulating hormone in the control of prolactin and luteinizing hormone secretion in the primate
-
Wardlaw, S.L., Ferin, M., 1990. Interaction between beta-endorphin and alpha-melanocyte-stimulating hormone in the control of prolactin and luteinizing hormone secretion in the primate. Endocrinology 126, 2035-2040. (Pubitemid 20139751)
-
(1990)
Endocrinology
, vol.126
, Issue.4
, pp. 2035-2040
-
-
Wardlaw, S.L.1
Ferin, M.2
-
81
-
-
0022588203
-
Antagonism of beta-endorphin-induced prolactin release by alpha-melanocyte-stimulating hormone and corticotropin-like intermediate lobe peptide
-
Wardlaw, S.L., Smeal, M.M., Markowitz, C.E., 1986. Antagonism of beta-endorphin-induced prolactin release by alpha-melanocyte-stimulating hormone and corticotropin-like intermediate lobe peptide. Endocrinology 119, 112-118. (Pubitemid 16100715)
-
(1986)
Endocrinology
, vol.119
, Issue.1
, pp. 112-118
-
-
Wardlaw, S.L.1
Smeal, M.M.2
Markowitz, C.E.3
-
82
-
-
31544479789
-
Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins
-
DOI 10.1016/j.peptides.2005.05.029, PII S0196978105004596, The Melanocortin Pathway 2005 Part II
-
Wilkinson, C.W., 2006. Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins. Peptides 27, 453-471. (Pubitemid 43162918)
-
(2006)
Peptides
, vol.27
, Issue.2
, pp. 453-471
-
-
Wilkinson, C.W.1
-
83
-
-
77249146406
-
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
-
Williams, K.W., Margatho, L.O., Lee, C.E., Choi, M., Lee, S., Scott, M.M., Elias, C.F., Elmquist, J.K., 2010. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J. Neurosci. 30, 2472-2479.
-
(2010)
J. Neurosci.
, vol.30
, pp. 2472-2479
-
-
Williams, K.W.1
Margatho, L.O.2
Lee, C.E.3
Choi, M.4
Lee, S.5
Scott, M.M.6
Elias, C.F.7
Elmquist, J.K.8
-
84
-
-
77149176244
-
Effects of estradiol on cerebrospinal fluid levels of agouti-related protein in ovariectomized rhesus monkeys
-
Xiao, E., Kim, A.J., Dutia, R., Conwell, I., Ferin, M., Wardlaw, S.L., 2010. Effects of estradiol on cerebrospinal fluid levels of agouti-related protein in ovariectomized rhesus monkeys. Endocrinology 151, 1002-1009.
-
(2010)
Endocrinology
, vol.151
, pp. 1002-1009
-
-
Xiao, E.1
Kim, A.J.2
Dutia, R.3
Conwell, I.4
Ferin, M.5
Wardlaw, S.L.6
-
85
-
-
29144519352
-
Effects of hypothalamic neurodegeneration on energy balance
-
Xu, A.W., Kaelin, C.B., Morton, G.J., Ogimoto, K., Stanhope, K., Graham, J., Baskin, D.G., Havel, P., Schwartz, M.W., Barsh, G.S., 2005a. Effects of hypothalamic neurodegeneration on energy balance. PLoS Biol. 3, e415.
-
(2005)
PLoS Biol.
, vol.3
-
-
Xu, A.W.1
Kaelin, C.B.2
Morton, G.J.3
Ogimoto, K.4
Stanhope, K.5
Graham, J.6
Baskin, D.G.7
Havel, P.8
Schwartz, M.W.9
Barsh, G.S.10
-
86
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
Xu, A.W., Kaelin, C.B., Takeda, K., Akira, S., Schwartz, M.W., Barsh, G.S., 2005b. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J. Clin. Investig. 115, 951-958.
-
(2005)
J. Clin. Investig.
, vol.115
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
87
-
-
0032863468
-
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
-
Yaswen, L., Diehl, N., Brennan, M.B., Hochgeschwender, U., 1999. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5, 1066-1070.
-
(1999)
Nat. Med.
, vol.5
, pp. 1066-1070
-
-
Yaswen, L.1
Diehl, N.2
Brennan, M.B.3
Hochgeschwender, U.4
-
88
-
-
0036679173
-
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
-
Zhu, X., Zhou, A., Dey, A., Norrbom, C., Carroll, R., Zhang, C., Laurent, V., Lindberg, I., Ugleholdt, R., Holst, J.J., Steiner, D.F., 2002. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc. Natl Acad. Sci. USA 99, 10293-10298.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 10293-10298
-
-
Zhu, X.1
Zhou, A.2
Dey, A.3
Norrbom, C.4
Carroll, R.5
Zhang, C.6
Laurent, V.7
Lindberg, I.8
Ugleholdt, R.9
Holst, J.J.10
Steiner, D.F.11
|