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Volumn 660, Issue 1, 2011, Pages 213-219

Hypothalamic proopiomelanocortin processing and the regulation of energy balance

Author keywords

MSH; Carboxypeptidase E; Obesity; POMC; Prohormone convertase; Proopiomelanocortin

Indexed keywords

ACYLTRANSFERASE; ALPHA INTERMEDIN; ALPHA INTERMEDIN 1-12; ALPHA INTERMEDIN 1-13; ARGONAUTE PROTEIN; CARBOXYPEPTIDASE H; CORTICOTROPIN; HELIX LOOP HELIX PROTEIN; INTERMEDIN; INTERMEDIN INHIBITING FACTOR; LEPTIN; PROLINE CARBOXYPEPTIDASE; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 1; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

EID: 79955938111     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.107     Document Type: Review
Times cited : (117)

References (88)
  • 1
    • 0038222630 scopus 로고    scopus 로고
    • A role for the endogenous opioid beta-endorphin in energy homeostasis
    • DOI 10.1210/en.2002-221096
    • Appleyard, S.M., Hayward, M., Young, J.I., Butler, A.A., Cone, R.D., Rubinstein, M., Low, M.J., 2003. A role for the endogenous opioid beta-endorphin in energy homeostasis. Endocrinology 144, 1753-1760. (Pubitemid 36543312)
    • (2003) Endocrinology , vol.144 , Issue.5 , pp. 1753-1760
    • Appleyard, S.M.1    Hayward, M.2    Young, J.I.3    Butler, A.A.4    Cone, R.D.5    Rubinstein, M.6    Low, M.J.7
  • 3
    • 0025762119 scopus 로고
    • PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues
    • Benjannet, S., Rondeau, N., Day, R., Chretien, M., Seidah, N.G., 1991. PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc. Natl Acad. Sci. USA 88, 3564-3568.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 3564-3568
    • Benjannet, S.1    Rondeau, N.2    Day, R.3    Chretien, M.4    Seidah, N.G.5
  • 5
    • 0035847020 scopus 로고    scopus 로고
    • Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice
    • Berman, Y., Mzhavia, N., Polonskaia, A., Devi, L.A., 2001. Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice. J. Biol. Chem. 276, 1466-1473.
    • (2001) J. Biol. Chem. , vol.276 , pp. 1466-1473
    • Berman, Y.1    Mzhavia, N.2    Polonskaia, A.3    Devi, L.A.4
  • 7
    • 67649962153 scopus 로고    scopus 로고
    • Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit
    • Blouet, C., Jo, Y.H., Li, X., Schwartz, G.J., 2009. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. J. Neurosci. 29, 8302-8311.
    • (2009) J. Neurosci. , vol.29 , pp. 8302-8311
    • Blouet, C.1    Jo, Y.H.2    Li, X.3    Schwartz, G.J.4
  • 8
    • 2542460126 scopus 로고    scopus 로고
    • Endogenous opioids and feeding behavior: A 30-year historical perspective
    • DOI 10.1016/j.peptides.2004.01.006, PII S0196978104000397
    • Bodnar, R.J., 2004. Endogenous opioids and feeding behavior: a 30-year historical perspective. Peptides 25, 697-725. (Pubitemid 38681072)
    • (2004) Peptides , vol.25 , Issue.4 , pp. 697-725
    • Bodnar, R.J.1
  • 9
    • 1842536210 scopus 로고    scopus 로고
    • Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding
    • DOI 10.1126/science.1095004
    • Bouret, S.G., Draper, S.J., Simerly, R.B., 2004. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304, 108-110. (Pubitemid 38451467)
    • (2004) Science , vol.304 , Issue.5667 , pp. 108-110
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 10
    • 12844278828 scopus 로고    scopus 로고
    • Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus
    • DOI 10.1016/j.brainres.2004.11.008, PII S0006899304017925
    • Breen, T.L., Conwell, I.M., Wardlaw, S.L., 2005. Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Brain Res. 1032, 141-148. (Pubitemid 40170319)
    • (2005) Brain Research , vol.1032 , Issue.1-2 , pp. 141-148
    • Breen, T.L.1    Conwell, I.M.2    Wardlaw, S.L.3
  • 12
    • 0030947997 scopus 로고    scopus 로고
    • Post-translational processing of proopiomelanocortin in the pituitary and in the brain
    • Castro, M.G., Morrison, E., 1997. Post-translational processing of proopiomelanocortin in the pituitary and in the brain. Crit. Rev. Neurobiol. 11, 35-57.
    • (1997) Crit. Rev. Neurobiol. , vol.11 , pp. 35-57
    • Castro, M.G.1    Morrison, E.2
  • 19
    • 23644453797 scopus 로고    scopus 로고
    • Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids
    • DOI 10.2337/diabetes.54.8.2269
    • Coll, A.P., Challis, B.G., Lopez, M., Piper, S., Yeo, G.S., O'Rahilly, S., 2005. Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. Diabetes 54, 2269-2276. (Pubitemid 41134252)
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2269-2276
    • Coll, A.P.1    Challis, B.G.2    Lopez, M.3    Piper, S.4    Yeo, G.S.H.5    O'Rahilly, S.6
  • 21
    • 0021256237 scopus 로고
    • Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone
    • Contreras, P.C., Takemori, A.E., 1984. Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone. J. Pharmacol. Exp. Ther. 229, 21-26.
    • (1984) J. Pharmacol. Exp. Ther. , vol.229 , pp. 21-26
    • Contreras, P.C.1    Takemori, A.E.2
  • 22
    • 0030976604 scopus 로고    scopus 로고
    • Carboxypeptidase e is a regulated secretory pathway sorting receptor: Genetic obliteration leads to endocrine disorders in Cpe(fat) mice
    • Cool, D.R., Normant, E., Shen, F., Chen, H.C., Pannell, L., Zhang, Y., Loh, Y.P., 1997. Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell 88, 73-83. (Pubitemid 27180332)
    • (1997) Cell , vol.88 , Issue.1 , pp. 73-83
    • Cool, D.R.1    Normant, E.2    Shen, F.-S.3    Chen, H.-C.4    Pannell, L.5    Zhang, Y.6    Loh, Y.P.7
  • 23
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • DOI 10.1126/science.1124147
    • Cota, D., Proulx, K., Smith, K.A., Kozma, S.C., Thomas, G., Woods, S.C., Seeley, R.J., 2006. Hypothalamic mTOR signaling regulates food intake. Science 312, 927-930. (Pubitemid 43727328)
    • (2006) Science , vol.312 , Issue.5775 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Blake, S.K.A.3    Kozma, S.C.4    Thomas, G.5    Woods, S.C.6    Seeley, R.J.7
  • 24
    • 0033200153 scopus 로고    scopus 로고
    • Integration of npy, agrp, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
    • DOI 10.1016/S0896-6273(00)80829-6
    • Cowley, M.A., Pronchuk, N., Fan, W., Dinulescu, D.M., Colmers, W.F., Cone, R.D., 1999. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24, 155-163. (Pubitemid 29466155)
    • (1999) Neuron , vol.24 , Issue.1 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 25
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • DOI 10.1038/35078085
    • Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Cone, R.D., Low, M.J., 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480-484. (Pubitemid 32494394)
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdan, M.G.4    Diano, S.5    Horvath, T.L.6    Cone, R.D.7    Low, M.J.8
  • 28
    • 38349151344 scopus 로고    scopus 로고
    • Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain
    • Dubern, B., Lubrano-Berthelier, C., Mencarelli, M., Ersoy, B., Frelut, M.L., Bougle, D., Costes, B., Simon, C., Tounian, P., Vaisse, C., Clement, K., 2008. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatr. Res. 63, 211-216.
    • (2008) Pediatr. Res. , vol.63 , pp. 211-216
    • Dubern, B.1    Lubrano-Berthelier, C.2    Mencarelli, M.3    Ersoy, B.4    Frelut, M.L.5    Bougle, D.6    Costes, B.7    Simon, C.8    Tounian, P.9    Vaisse, C.10    Clement, K.11
  • 29
    • 0033180532 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
    • DOI 10.1016/S0896-6273(01)80035-0
    • Elias, C.F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R.S., Bjorbaek, C., Flier, J.S., Saper, C.B., Elmquist, J.K., 1999. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23, 775-786. (Pubitemid 29411566)
    • (1999) Neuron , vol.23 , Issue.4 , pp. 775-786
    • Elias, C.F.1    Aschkenasi, C.2    Lee, C.3    Kelly, J.4    Ahima, R.S.5    Bjorbaek, C.6    Flier, J.S.7    Saper, C.B.8    Elmquist, J.K.9
  • 30
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist, J.K., Elias, C.F., Saper, C.B., 1999. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22, 221-232. (Pubitemid 29109657)
    • (1999) Neuron , vol.22 , Issue.2 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3
  • 31
    • 0022653301 scopus 로고
    • Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus
    • Emeson, R.B., Eipper, B.A., 1986. Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus. J. Neurosci. 6, 837-849. (Pubitemid 16134922)
    • (1986) Journal of Neuroscience , vol.6 , Issue.3 , pp. 837-849
    • Emeson, R.B.1    Eipper, B.A.2
  • 33
    • 34347214441 scopus 로고    scopus 로고
    • Energy balance pathways converging on the Nhlh2 transcription factor
    • Fox, D.L., Vella, K.R., Good, D.J., 2007. Energy balance pathways converging on the Nhlh2 transcription factor. Front. Biosci. 12, 3983-3993.
    • (2007) Front. Biosci. , vol.12 , pp. 3983-3993
    • Fox, D.L.1    Vella, K.R.2    Good, D.J.3
  • 37
    • 0142122392 scopus 로고    scopus 로고
    • Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats
    • DOI 10.1016/S0006-8993(03)03442-5
    • Grossman, H.C., Hadjimarkou, M.M., Silva, R.M., Giraudo, S.Q., Bodnar, R.J., 2003. Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats. Brain Res. 991, 240-244. (Pubitemid 37297953)
    • (2003) Brain Research , vol.991 , Issue.1-2 , pp. 240-244
    • Grossman, H.C.1    Hadjimarkou, M.M.2    Silva, R.M.3    Giraudo, S.Q.4    Bodnar, R.J.5
  • 38
    • 4143090543 scopus 로고    scopus 로고
    • N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin
    • Guo, L., Munzberg, H., Stuart, R.C., Nillni, E.A., Bjorbaek, C., 2004. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proc. Natl Acad. Sci. USA 101, 11797-11802.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 11797-11802
    • Guo, L.1    Munzberg, H.2    Stuart, R.C.3    Nillni, E.A.4    Bjorbaek, C.5
  • 45
    • 1642464993 scopus 로고    scopus 로고
    • Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity
    • DOI 10.1210/en.2003-0834
    • Jing, E., Nillni, E.A., Sanchez, V.C., Stuart, R.C., Good, D.J., 2004. Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity. Endocrinology 145, 1503-1513. (Pubitemid 38402353)
    • (2004) Endocrinology , vol.145 , Issue.4 , pp. 1503-1513
    • Jing, E.1    Nillni, E.A.2    Sanchez, V.C.3    Stuart, R.C.4    Good, D.J.5
  • 46
    • 8444249951 scopus 로고    scopus 로고
    • The electrophysiology of feeding circuits. Trends Endocrinol
    • Jobst, E.E., Enriori, P.J., Cowley, M.A., 2004. The electrophysiology of feeding circuits. Trends Endocrinol. Metab. TEM 15, 488-499.
    • (2004) Metab. TEM , vol.15 , pp. 488-499
    • Jobst, E.E.1    Enriori, P.J.2    Cowley, M.A.3
  • 47
    • 0035020279 scopus 로고    scopus 로고
    • Central melanocortin receptors mediate changes in food intake in the rhesus macaque
    • DOI 10.1210/en.142.6.2586
    • Koegler, F.H., Grove, K.L., Schiffmacher, A., Smith, M.S., Cameron, J.L., 2001. Central melanocortin receptors mediate changes in food intake in the rhesus macaque. Endocrinology 142, 2586-2592. (Pubitemid 32473114)
    • (2001) Endocrinology , vol.142 , Issue.6 , pp. 2586-2592
    • Koegler, F.H.1    Grove, K.L.2    Schiffmacher, A.3    Smith, M.S.4    Cameron, J.L.5
  • 48
    • 0033405582 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats
    • Korner, J., Chua Jr., S.C., Williams, J.A., Leibel, R.L., Wardlaw, S.L., 1999. Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology 70, 377-383. (Pubitemid 30009026)
    • (1999) Neuroendocrinology , vol.70 , Issue.6 , pp. 377-383
    • Korner, J.1    Chua Jr., S.C.2    Williams, J.A.3    Leibel, R.L.4    Wardlaw, S.L.5
  • 49
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G., Gruters, A., 1998. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19, 155-157.
    • (1998) Nat. Genet. , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 51
    • 34347267613 scopus 로고    scopus 로고
    • The central melanocortin system and the regulation of energy balance
    • Lee, M., Wardlaw, S.L., 2007. The central melanocortin system and the regulation of energy balance. Front. Biosci. 12, 3994-4010.
    • (2007) Front. Biosci. , vol.12 , pp. 3994-4010
    • Lee, M.1    Wardlaw, S.L.2
  • 53
    • 34547122875 scopus 로고    scopus 로고
    • Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet
    • Lee, M., Kim, A., Chua Jr., S.C., Obici, S., Wardlaw, S.L., 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am. J. Physiol. 293, E121-E131.
    • (2007) Am. J. Physiol. , vol.293
    • Lee, M.1    Kim, A.2    Chua Jr., S.C.3    Obici, S.4    Wardlaw, S.L.5
  • 54
    • 0034456997 scopus 로고    scopus 로고
    • Agouti-related protein-like immunoreactivity: Characterization of release from hypothalamic tissue and presence in serum
    • DOI 10.1210/en.141.6.1942
    • Li, J.Y., Finniss, S., Yang, Y.K., Zeng, Q., Qu, S.Y., Barsh, G., Dickinson, C., Gantz, I., 2000. Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum. Endocrinology 141, 1942-1950. (Pubitemid 32274341)
    • (2000) Endocrinology , vol.141 , Issue.6 , pp. 1942-1950
    • Li, J.-Y.1    Finniss, S.2    Yang, Y.-K.3    Zeng, Q.4    Qu, S.-Y.5    Barsh, G.6    Dickinson, C.7    Gantz, I.8
  • 55
    • 0042767613 scopus 로고    scopus 로고
    • Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats
    • DOI 10.2337/diabetes.52.8.1951
    • Li, G., Mobbs, C.V., Scarpace, P.J., 2003. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes 52, 1951-1957. (Pubitemid 36919786)
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 1951-1957
    • Li, G.1    Mobbs, C.V.2    Scarpace, P.J.3
  • 56
    • 33744763342 scopus 로고    scopus 로고
    • Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
    • Lloyd, D.J., Bohan, S., Gekakis, N., 2006. Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice. Hum. Mol. Genet. 15, 1884-1893.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1884-1893
    • Lloyd, D.J.1    Bohan, S.2    Gekakis, N.3
  • 57
    • 0038051127 scopus 로고    scopus 로고
    • State-dependent modulation of feeding behavior by proopiomelanocortin- derived beta-endorphin
    • Low, M.J., Hayward, M.D., Appleyard, S.M., Rubinstein, M., 2003. State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin. Ann. NY Acad. Sci. 994, 192-201.
    • (2003) Ann. NY Acad. Sci. , vol.994 , pp. 192-201
    • Low, M.J.1    Hayward, M.D.2    Appleyard, S.M.3    Rubinstein, M.4
  • 59
    • 0242300570 scopus 로고    scopus 로고
    • Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice
    • DOI 10.2337/diabetes.52.11.2675
    • Mizuno, T.M., Kelley, K.A., Pasinetti, G.M., Roberts, J.L., Mobbs, C.V., 2003. Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 52, 2675-2683. (Pubitemid 37339696)
    • (2003) Diabetes , vol.52 , Issue.11 , pp. 2675-2683
    • Mizuno, T.M.1    Kelley, K.A.2    Pasinetti, G.M.3    Roberts, J.L.4    Mobbs, C.V.5
  • 60
    • 0038747134 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic Proopiomelanocortin gene expression by leptin
    • DOI 10.1210/en.2002-221037
    • Munzberg, H., Huo, L., Nillni, E.A., Hollenberg, A.N., Bjorbaek, C., 2003. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144, 2121-2131. (Pubitemid 36543352)
    • (2003) Endocrinology , vol.144 , Issue.5 , pp. 2121-2131
    • Munzberg, H.1    Huo, L.2    Nillni, E.A.3    Hollenberg, A.N.4    Bjorbaek, C.5
  • 62
    • 0021802558 scopus 로고
    • Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia
    • Nicolas, P., Li, C.H., 1985. Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia. Proc. Natl Acad. Sci. USA 82, 3178-3181.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 3178-3181
    • Nicolas, P.1    Li, C.H.2
  • 63
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of Central Melanocortin receptors in vitro and in vivo by agouti-related protein
    • DOI 10.1126/science.278.5335.135
    • Ollmann, M.M., Wilson, B.D., Yang, Y.K., Kerns, J.A., Chen, Y., Gantz, I., Barsh, G.S., 1997. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-138. (Pubitemid 27446294)
    • (1997) Science , vol.278 , Issue.5335 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.-K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 64
    • 0035854112 scopus 로고    scopus 로고
    • Evidence of interactions between melanocortin and opioid systems in regulation of feeding
    • Olszewski, P.K., Wirth, M.M., Grace, M.K., Levine, A.S., Giraudo, S.Q., 2001. Evidence of interactions between melanocortin and opioid systems in regulation of feeding. NeuroReport 12, 1727-1730. (Pubitemid 32521495)
    • (2001) NeuroReport , vol.12 , Issue.8 , pp. 1727-1730
    • Olszewski, P.K.1    Wirth, M.M.2    Grace, M.K.3    Levine, A.S.4    Giraudo, S.Q.5
  • 65
    • 34247570950 scopus 로고    scopus 로고
    • Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tarct
    • Perello, M., Stuart, R.C., Nillni, E.A., 2007. Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tarct. Am. J. Physiol. 292, E1348-E1357.
    • (2007) Am. J. Physiol. , vol.292
    • Perello, M.1    Stuart, R.C.2    Nillni, E.A.3
  • 68
    • 34548061243 scopus 로고    scopus 로고
    • Minireview: Neuropeptide processing and its impact on melanocortin pathways
    • DOI 10.1210/en.2006-1686
    • Pritchard, L.E., White, A., 2007. Neuropeptide processing and its impact on melanocortin pathways. Endocrinology 148, 4201-4207. (Pubitemid 47295669)
    • (2007) Endocrinology , vol.148 , Issue.9 , pp. 4201-4207
    • Pritchard, L.E.1    White, A.2
  • 69
    • 0037373325 scopus 로고    scopus 로고
    • Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: Evidence that secretion is regulated with respect to energy balance
    • DOI 10.1210/en.2002-220866
    • Pritchard, L.E., Oliver, R.L., McLoughlin, J.D., Birtles, S., Lawrence, C.B., Turnbull, A.V., White, A., 2003. Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: evidence that secretion is regulated with respect to energy balance. Endocrinology 144, 760-766. (Pubitemid 36262843)
    • (2003) Endocrinology , vol.144 , Issue.3 , pp. 760-766
    • Pritchard, L.E.1    Oliver, R.L.2    McLoughlin, J.D.3    Birtles, S.4    Lawrence, C.B.5    Turnbull, A.V.6    White, A.7
  • 71
    • 0032972276 scopus 로고    scopus 로고
    • The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans
    • Rotimi, C.N., Comuzzie, A.G., Lowe, W.L., Luke, A., Blangero, J., Cooper, R.S., 1999. The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans. Diabetes 48, 643-644. (Pubitemid 29106883)
    • (1999) Diabetes , vol.48 , Issue.3 , pp. 643-644
    • Rotimi, C.N.1    Comuzzie, A.G.2    Lowe, W.L.3    Luke, A.4    Blangero, J.5    Cooper, R.S.6
  • 73
    • 0019407503 scopus 로고
    • Intraventricular administration of MSH induces hyperalgesia in rats
    • DOI 10.1016/S0196-9781(81)80040-X
    • Sandman, C.A., Kastin, A.J., 1981. Intraventricular administration of MSH induces hyperalgesia in rats. Peptides 2, 231-233. (Pubitemid 11030849)
    • (1981) Peptides , vol.2 , Issue.2 , pp. 231-233
    • Sandman, C.A.1    Kastin, A.J.2
  • 74
    • 3843114437 scopus 로고    scopus 로고
    • Metabolic effects of transJrgenic melanocyte-stimulating hormone overexpression in lean and obese mice
    • DOI 10.1210/en.2004-0263
    • Savontaus, E., Breen, T.L., Kim, A., Yang, L.M., Chua, S.C.J., Wardlaw, S.L., 2004. Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology 145, 3881-3891. (Pubitemid 39037577)
    • (2004) Endocrinology , vol.145 , Issue.8 , pp. 3881-3891
    • Savontaus, E.1    Breen, T.L.2    Kim, A.3    Yang, L.M.4    Chua Jr., S.C.5    Wardlaw, S.L.6
  • 75
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz, M.W., Seeley, R.J., Woods, S.C., Weigle, D.S., Campfield, L.A., Burn, P., Baskin, D.G., 1997. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119-2123. (Pubitemid 27512108)
    • (1997) Diabetes , vol.46 , Issue.12 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6    Baskin, D.G.7
  • 76
    • 0026736321 scopus 로고
    • Alpha-melanocyte-stimulating hormone antagonizes the neuroendocrine effects of corticotropin-releasing factor and interleukin-1 alpha in the primate
    • Shalts, E., Feng, Y.J., Ferin, M., Wardlaw, S.L., 1992. Alpha-melanocyte-stimulating hormone antagonizes the neuroendocrine effects of corticotropin-releasing factor and interleukin-1 alpha in the primate. Endocrinology 131, 132-138.
    • (1992) Endocrinology , vol.131 , pp. 132-138
    • Shalts, E.1    Feng, Y.J.2    Ferin, M.3    Wardlaw, S.L.4
  • 77
    • 32444449631 scopus 로고    scopus 로고
    • Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
    • Smart, J.L., Tolle, V., Low, M.J., 2006. Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. J. Clin. Investig. 116, 495-505.
    • (2006) J. Clin. Investig. , vol.116 , pp. 495-505
    • Smart, J.L.1    Tolle, V.2    Low, M.J.3
  • 78
    • 0023959725 scopus 로고
    • Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues
    • Smith, A.I., Funder, J.W., 1988. Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev 9, 159-179.
    • (1988) Endocr Rev , vol.9 , pp. 159-179
    • Smith, A.I.1    Funder, J.W.2
  • 80
    • 0025318842 scopus 로고
    • Interaction between beta-endorphin and alpha-melanocyte-stimulating hormone in the control of prolactin and luteinizing hormone secretion in the primate
    • Wardlaw, S.L., Ferin, M., 1990. Interaction between beta-endorphin and alpha-melanocyte-stimulating hormone in the control of prolactin and luteinizing hormone secretion in the primate. Endocrinology 126, 2035-2040. (Pubitemid 20139751)
    • (1990) Endocrinology , vol.126 , Issue.4 , pp. 2035-2040
    • Wardlaw, S.L.1    Ferin, M.2
  • 81
    • 0022588203 scopus 로고
    • Antagonism of beta-endorphin-induced prolactin release by alpha-melanocyte-stimulating hormone and corticotropin-like intermediate lobe peptide
    • Wardlaw, S.L., Smeal, M.M., Markowitz, C.E., 1986. Antagonism of beta-endorphin-induced prolactin release by alpha-melanocyte-stimulating hormone and corticotropin-like intermediate lobe peptide. Endocrinology 119, 112-118. (Pubitemid 16100715)
    • (1986) Endocrinology , vol.119 , Issue.1 , pp. 112-118
    • Wardlaw, S.L.1    Smeal, M.M.2    Markowitz, C.E.3
  • 82
    • 31544479789 scopus 로고    scopus 로고
    • Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins
    • DOI 10.1016/j.peptides.2005.05.029, PII S0196978105004596, The Melanocortin Pathway 2005 Part II
    • Wilkinson, C.W., 2006. Roles of acetylation and other post-translational modifications in melanocortin function and interactions with endorphins. Peptides 27, 453-471. (Pubitemid 43162918)
    • (2006) Peptides , vol.27 , Issue.2 , pp. 453-471
    • Wilkinson, C.W.1
  • 83
    • 77249146406 scopus 로고    scopus 로고
    • Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    • Williams, K.W., Margatho, L.O., Lee, C.E., Choi, M., Lee, S., Scott, M.M., Elias, C.F., Elmquist, J.K., 2010. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J. Neurosci. 30, 2472-2479.
    • (2010) J. Neurosci. , vol.30 , pp. 2472-2479
    • Williams, K.W.1    Margatho, L.O.2    Lee, C.E.3    Choi, M.4    Lee, S.5    Scott, M.M.6    Elias, C.F.7    Elmquist, J.K.8
  • 84
    • 77149176244 scopus 로고    scopus 로고
    • Effects of estradiol on cerebrospinal fluid levels of agouti-related protein in ovariectomized rhesus monkeys
    • Xiao, E., Kim, A.J., Dutia, R., Conwell, I., Ferin, M., Wardlaw, S.L., 2010. Effects of estradiol on cerebrospinal fluid levels of agouti-related protein in ovariectomized rhesus monkeys. Endocrinology 151, 1002-1009.
    • (2010) Endocrinology , vol.151 , pp. 1002-1009
    • Xiao, E.1    Kim, A.J.2    Dutia, R.3    Conwell, I.4    Ferin, M.5    Wardlaw, S.L.6
  • 87
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen, L., Diehl, N., Brennan, M.B., Hochgeschwender, U., 1999. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat. Med. 5, 1066-1070.
    • (1999) Nat. Med. , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.