메뉴 건너뛰기




Volumn 70, Issue 6, 1999, Pages 377-383

Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats

Author keywords

Leptin; Melanocortin stimulating hormone; Obesity; Proopiomelanocortin

Indexed keywords

HETEROGENEOUS NUCLEAR RNA; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PROOPIOMELANOCORTIN; SODIUM CHLORIDE;

EID: 0033405582     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054499     Document Type: Article
Times cited : (83)

References (45)
  • 2
    • 0032177037 scopus 로고    scopus 로고
    • Unraveling the central nervous system pathways underlying responses to leptin
    • Elmquist JK, Maratos-Flier E, Saper CB, Flier JS: Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci 1998;1:445-450.
    • (1998) Nat Neurosci , vol.1 , pp. 445-450
    • Elmquist, J.K.1    Maratos-Flier, E.2    Saper, C.B.3    Flier, J.S.4
  • 3
    • 0023959725 scopus 로고
    • Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues
    • Smith Al, Funder JW: Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev 1988; 9:159-179.
    • (1988) Endocr Rev , vol.9 , pp. 159-179
    • Smith, A.1    Funder, J.W.2
  • 4
    • 0030001086 scopus 로고    scopus 로고
    • Chronic food restriction and acute food deprivation decrease mRNA levels of opioid peptides in arcuate nucleus
    • Kim EM, Welch CC, Grace MK, Billington CJ, Levine AS: Chronic food restriction and acute food deprivation decrease mRNA levels of opioid peptides in arcuate nucleus. Am J Physiol 1996;270:R1019-R1024.
    • (1996) Am J Physiol , vol.270
    • Kim, E.M.1    Welch, C.C.2    Grace, M.K.3    Billington, C.J.4    Levine, A.S.5
  • 5
    • 0025038674 scopus 로고
    • Altered expression of hypothalamic neuro-peptide mRNAs in food-restriction and food-deprived rats
    • Brady LS, Smith MA, Gold PW, Herkenham M: Altered expression of hypothalamic neuro-peptide mRNAs in food-restriction and food-deprived rats. Neuroendocrinology 1990;52: 441-447.
    • (1990) Neuroendocrinology , vol.52 , pp. 441-447
    • Brady, L.S.1    Smith, M.A.2    Gold, P.W.3    Herkenham, M.4
  • 6
    • 0027058673 scopus 로고
    • Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats
    • Bergendahl M, Wiemann JN, Clifton DK, Huhtaniemi I, Steiner RA: Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats. Neuroendocrinology 1992;56:913-920.
    • (1992) Neuroendocrinology , vol.56 , pp. 913-920
    • Bergendahl, M.1    Wiemann, J.N.2    Clifton, D.K.3    Huhtaniemi, I.4    Steiner, R.A.5
  • 7
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD: Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997;185:165-168.
    • (1997) Nature , vol.185 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 10
    • 0032547042 scopus 로고    scopus 로고
    • Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
    • Satoh N, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Yoshimasa Y, Nakao K: Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett 1998;249:107-110.
    • (1998) Neurosci Lett , vol.249 , pp. 107-110
    • Satoh, N.1    Ogawa, Y.2    Katsuura, G.3    Numata, Y.4    Masuzaki, H.5    Yoshimasa, Y.6    Nakao, K.7
  • 12
    • 0031838353 scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A: Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1948;19:155-157.
    • (1948) Nat Genet , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Grüters, A.6
  • 14
    • 0031436635 scopus 로고    scopus 로고
    • The molecular genetics of rodent single gene obesities
    • Leibel RL, Chung WK, Chua SC Jr: The molecular genetics of rodent single gene obesities. J Biol Chem 1997;272:31937-31940.
    • (1997) J Biol Chem , vol.272 , pp. 31937-31940
    • Leibel, R.L.1    Chung, W.K.2    Chua S.C., Jr.3
  • 17
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y. Gantz I, Barsh GS: Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997; 278:135-138.
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 18
    • 0030893647 scopus 로고    scopus 로고
    • Hypothalamic expression of ART. A novel gene related to agouti, is upregulated in obese and diabetic mutant mice
    • Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R, Stark KL: Hypothalamic expression of ART. a novel gene related to agouti, is upregulated in obese and diabetic mutant mice. Genes Dev 1997;11:593-602.
    • (1997) Genes Dev , vol.11 , pp. 593-602
    • Shutter, J.R.1    Graham, M.2    Kinsey, A.C.3    Scully, S.4    Lüthy, R.5    Stark, K.L.6
  • 21
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • Thornton JF, Cheung CC, Clifton DK, Steiner RA: Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 1997;138:5063-5066.
    • (1997) Endocrinology , vol.138 , pp. 5063-5066
    • Thornton, J.F.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 23
    • 0031888157 scopus 로고
    • Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
    • Mizuno TM, Kleopoulos SP, Bergen HT, Roberts JL, Priest CA, Mobbs CV: Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 1988;47:294-297.
    • (1988) Diabetes , vol.47 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 24
    • 0030928715 scopus 로고    scopus 로고
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
    • Cheung CC, Clifton DK, Steiner RA: Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997;138:4489-4492.
    • (1997) Endocrinology , vol.138 , pp. 4489-4492
    • Cheung, C.C.1    Clifton, D.K.2    Steiner, R.A.3
  • 25
    • 0031963436 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity in chemically defined targed neurons of the hypothalamus
    • Hakansson ML, Brown H, Ghilardi N, Skoda RC, Meister B: Leptin receptor immunoreactivity in chemically defined targed neurons of the hypothalamus. J Neurosci 1998;18:559-572.
    • (1998) J Neurosci , vol.18 , pp. 559-572
    • Hakansson, M.L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 26
    • 0015891045 scopus 로고
    • Obese spontaneous hypertensive rats: A model for the study of atherosclerosis
    • Koletsky S: Obese spontaneous hypertensive rats: A model for the study of atherosclerosis. Exp Mol Pathol 1973;19:53-60.
    • (1973) Exp Mol Pathol , vol.19 , pp. 53-60
    • Koletsky, S.1
  • 27
    • 0030267744 scopus 로고    scopus 로고
    • Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat
    • Takaya K, Ogawa Y, Hiraoka J, Hosoda K, Yamori Y, Nakao K, Koletsky RJ: Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat Genet 1996;14:130-131.
    • (1996) Nat Genet , vol.14 , pp. 130-131
    • Takaya, K.1    Ogawa, Y.2    Hiraoka, J.3    Hosoda, K.4    Yamori, Y.5    Nakao, K.6    Koletsky, R.J.7
  • 28
    • 0031046730 scopus 로고    scopus 로고
    • Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr)
    • Wu-Peng XS, Chua SC Jr, Okada N, Liu SM, Nicolson M, Leibel RL: Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr). Diabetes 1997;46:513-518.
    • (1997) Diabetes , vol.46 , pp. 513-518
    • Wu-Peng, X.S.1    Chua S.C., Jr.2    Okada, N.3    Liu, S.M.4    Nicolson, M.5    Leibel, R.L.6
  • 29
    • 0013936989 scopus 로고
    • Construction and implantation of a permanent cannula for making injections into the lateral ventricle of the rat brain
    • Hayden JF, Johnson LR, Maickel RP: Construction and implantation of a permanent cannula for making injections into the lateral ventricle of the rat brain. Life Sci 1966;5:1509-1515.
    • (1966) Life Sci , vol.5 , pp. 1509-1515
    • Hayden, J.F.1    Johnson, L.R.2    Maickel, R.P.3
  • 30
    • 0022588203 scopus 로고
    • Antagonism of β-endorphin-induced prolactin release by α-melanocyte-stimulating hormone and corticotropin-like intermediate lobe peptide
    • Wardlaw SL, Smeal MM, Markowitz CE: Antagonism of β-endorphin-induced prolactin release by α-melanocyte-stimulating hormone and corticotropin-like intermediate lobe peptide. Endocrinology 1986;119:112-118.
    • (1986) Endocrinology , vol.119 , pp. 112-118
    • Wardlaw, S.L.1    Smeal, M.M.2    Markowitz, C.E.3
  • 31
    • 0031964236 scopus 로고    scopus 로고
    • Glucocorticoid regulation of hypothalamic proopiomelanocortin
    • Wardlaw SL, McCarthy KC, Conwell IM: Glucocorticoid regulation of hypothalamic proopiomelanocortin. Neuroendocrinology 1998; 67:51-57.
    • (1998) Neuroendocrinology , vol.67 , pp. 51-57
    • Wardlaw, S.L.1    McCarthy, K.C.2    Conwell, I.M.3
  • 32
    • 0017184389 scopus 로고
    • A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M: A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248.
    • (1976) Anal Biochem , vol.72 , pp. 248
    • Bradford, M.1
  • 33
    • 0025156990 scopus 로고
    • Corticotropin-releasing factor differentially regulates anterior and intermediate pituitary lobe proopiomelanocortin gene transcription, nuclear precursor RNA and mature mRNA in vivo
    • Autelitano DJ, Blum M, Lopingco M, Allen RG, Roberts JL: Corticotropin-releasing factor differentially regulates anterior and intermediate pituitary lobe proopiomelanocortin gene transcription, nuclear precursor RNA and mature mRNA in vivo. Neuroendocrinology 1990;51:123-130.
    • (1990) Neuroendocrinology , vol.51 , pp. 123-130
    • Autelitano, D.J.1    Blum, M.2    Lopingco, M.3    Allen, R.G.4    Roberts, J.L.5
  • 34
    • 0024594999 scopus 로고
    • Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus
    • Blum M, Roberts JL, Wardlaw SL: Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus. Endocrinology 1989;124:2283-2288.
    • (1989) Endocrinology , vol.124 , pp. 2283-2288
    • Blum, M.1    Roberts, J.L.2    Wardlaw, S.L.3
  • 35
    • 0028118639 scopus 로고
    • The effect of time of day on levels of hypothalamic proopiomelanocortin primary transcript, processing intermediate and messenger ribonucleic acid in proestrous and estrous rats
    • Scarbrough K, Jakubowski M, Levin N, Wise PM, Roberts JL: The effect of time of day on levels of hypothalamic proopiomelanocortin primary transcript, processing intermediate and messenger ribonucleic acid in proestrous and estrous rats. Endocrinology 1994;134:555-565.
    • (1994) Endocrinology , vol.134 , pp. 555-565
    • Scarbrough, K.1    Jakubowski, M.2    Levin, N.3    Wise, P.M.4    Roberts, J.L.5
  • 36
    • 0022612249 scopus 로고
    • Regulation of β-endorphin, corticotropin-like intermediate lobe peptide, and α-melanotropin-stimulating hormone in the hypothalamus by testosterone
    • Wardlaw SL: Regulation of β-endorphin, corticotropin-like intermediate lobe peptide, and α-melanotropin-stimulating hormone in the hypothalamus by testosterone. Endocrinology 1986;119:19-24.
    • (1986) Endocrinology , vol.119 , pp. 19-24
    • Wardlaw, S.L.1
  • 37
    • 0025014547 scopus 로고
    • Differential effects of haloperidol on the rat pituitary: Decreased biosynthesis, processing and release of anterior lobe pro-opiomelanocortin
    • Meador-Woodruff JH, Pellerito B, Bronstein D, Lin HL, Ling N, Akil H: Differential effects of haloperidol on the rat pituitary: Decreased biosynthesis, processing and release of anterior lobe pro-opiomelanocortin. Neuroendocrinology 1990;51:294-303.
    • (1990) Neuroendocrinology , vol.51 , pp. 294-303
    • Meador-Woodruff, J.H.1    Pellerito, B.2    Bronstein, D.3    Lin, H.L.4    Ling, N.5    Akil, H.6
  • 38
    • 0031764893 scopus 로고    scopus 로고
    • Evidence suggesting that galanin (GAL). Melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus
    • Sahu A: Evidence suggesting that galanin (GAL). melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 1998;139:795-798.
    • (1998) Endocrinology , vol.139 , pp. 795-798
    • Sahu, A.1
  • 39
    • 0023779936 scopus 로고
    • Glucocorticoid regulation of proopiomelanocortin messenger ribonucleic acid content of rat hypothalamus
    • Beaulieu S, Gagne B, Barden N: Glucocorticoid regulation of proopiomelanocortin messenger ribonucleic acid content of rat hypothalamus. Mol Endocrinol 1988;2:727-731.
    • (1988) Mol Endocrinol , vol.2 , pp. 727-731
    • Beaulieu, S.1    Gagne, B.2    Barden, N.3
  • 40
    • 0002044343 scopus 로고
    • Glucocorticoid regulation of proopiomelanocortin mRNA levels in rat arcuate nucleus
    • Long Y, Couet J, Simard J, Pelletier G: Glucocorticoid regulation of proopiomelanocortin mRNA levels in rat arcuate nucleus. Mol Cel Neurosci 1990;1:78-83.
    • (1990) Mol Cel Neurosci , vol.1 , pp. 78-83
    • Long, Y.1    Couet, J.2    Simard, J.3    Pelletier, G.4
  • 41
  • 42
    • 0024597033 scopus 로고
    • Characterization of α-MSH-related peptides released from rat hypothalamic neurons in vitro
    • Jégou S, Tranchand-Bunel D, Delbende C, Blasquez C. Vaudry H: Characterization of α-MSH-related peptides released from rat hypothalamic neurons in vitro. Mol Brain Res 1989; 5:219-226.
    • (1989) Mol Brain Res , vol.5 , pp. 219-226
    • Jégou, S.1    Tranchand-Bunel, D.2    Delbende, C.3    Blasquez, C.4    Vaudry, H.5
  • 43
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD: Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 1994;8:1298-1308.
    • (1994) Mol Endocrinol , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 45
    • 0020032007 scopus 로고
    • A-acetylation regulates the behavioral activity of α-melanotropin in a multineurotransmitter neuron
    • O'Donohue TL, Handelmann GE, Miller RL, Jacobowitz DM: A-Acetylation regulates the behavioral activity of α-melanotropin in a multineurotransmitter neuron. Science 1982;215: 1125-1127.
    • (1982) Science , vol.215 , pp. 1125-1127
    • O'Donohue, T.L.1    Handelmann, G.E.2    Miller, R.L.3    Jacobowitz, D.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.