A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase

Journal of Biological Chemistry

Volumn 281, Issue 11, 2006, Pages 7357-7363

  Bachmann, Rebecca A ^a   Kim, Jeong Ho ^a   Wu, Ai Luen ^a   Park, In Hyun ^a   Chen, Jie ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ENZYME KINETICS; MUTAGENESIS; PROTEINS;

ALANINES; CYTOPLASM; NUCLEUS; PEPTIDES;

CYTOLOGY;

ALANINE; LEPTOMYCIN B; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MUTANT PROTEIN; S6 KINASE; S6K1 ENZYME; UNCLASSIFIED DRUG; PEPTIDE; PROTEIN KINASE; RAPAMYCIN;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR IMPORT; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; ACTIVE TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CELL PROLIFERATION; CHEMISTRY; FLUORESCENCE MICROSCOPY; HAPLORHINI; METABOLISM; MOLECULAR GENETICS; MUTATION; REPORTER GENE; SIGNAL TRANSDUCTION;

MAMMALIA;

ACTIVE TRANSPORT, CELL NUCLEUS; ALANINE; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CYTOPLASM; GENES, REPORTER; HAPLORHINI; HUMANS; LEUCINE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PROTEIN KINASES; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 33646341231     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512218200     Document Type: Article

References (47)

1. Hay, N., and Sonenberg, N. (2004) Genes Dev. 18, 1926-1945
2. Erbay, E., Kim, J. E., and Chen, J. (2005) in Nutrient and Cell Signaling (Zempleni, J., and Dakshinamurti, K., eds), pp. 353-380, CRC Press, Inc., Boca Raton, FL
3. Gingras, A. C., Raught, B., and Sonenberg, N. (2001) Genes Dev. 15, 807-826
4. Fumagalli, S., and Thomas, G. (2000) in Translational Control of Gene Expression (Mathews, M. B., ed), pp. 695-718, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
5. Gingras, A. C., Raught, B., and Sonenberg, N. (1999) Annu. Rev. Biochem. 68, 913-963
6. Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., Jr., and Abraham, R. T. (1997) Science 277, 99-101
7. Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., and Sabatini, D. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 1432-1437
8. Gingras, A. C., Gygi, S. P., Raught, B., Polakiewicz, R. D., Abraham, R. T., Hoekstra, M. F., Aebersold, R., and Sonenberg, N. (1999) Genes Dev. 13, 1422-1437
9. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., and Yonezawa, K. (2002) Cell 110, 177-189
10. Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) Cell 110, 163-175
11. Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2004) Curr. Biol. 14, 1296-1302
12. Choi, K. M., McMahon, L. P., and Lawrence, J. C., Jr. (2003) J. Biol. Chem. 278, 19667-19673
13. Nojima, H., Tokunaga, C., Eguchi, S., Oshiro, N., Hidayat, S., Yoshino, K., Hara, K., Tanaka, N., Avruch, J., and Yonezawa, K. (2003) J. Biol. Chem. 278, 15461-15464
14. Schalm, S. S., Fingar, D. C., Sabatini, D. M., and Blenis, J. (2003) Curr. Biol. 13, 797-806
15. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
16. Sabatini, D. M., Barrow, R. K., Blackshaw, S., Burnett, P. E., Lai, M. M., Field, M. E., Bahr, B. A., Kirsch, J., Betz, H., and Snyder, S. H. (1999) Science 284, 1161-1164
17. Withers, D. J., Ouwens, D. M., Nave, B. T., van der Zon, G. C., Alarcon, C. M., Cardenas, M. E., Heitman, J., Maassen, J. A., and Shepherd, P. R. (1997) Biochem. Biophys. Res. Commun. 241, 704-709
18. Tirado, O. M., Mateo-Lozano, S., Sanders, S., Dettin, L. E., and Notario, V. (2003) Cancer Res. 63, 6290-6298
19. Desai, B. N., Myers, B. R., and Schreiber, S. L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 4319-4324
20. Drenan, R. M., Liu, X., Bertram, P. G., and Zheng, X. F. (2003) J. Biol. Chem. 24, 24
21. Kim, J. E., and Chen, J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 14340-14345
22. Drenan, R. M., Liu, X., Bertram, P. G., and Zheng, X. F. (2004) J. Biol. Chem. 279, 772-778
23. Park, I. H., Bachmann, R., Shirazi, H., and Chen, J. (2002) J. Biol. Chem. 277, 31423-31429
24. Mahanty, S. K., Wang, Y., Farley, F. W., and Elion, E. A. (1999) Cell 98, 501-512
25. Xu, L., and Massague, J. (2004) Nat. Rev. Mol. Cell. Biol. 5, 209-219
26. Klemm, J. D., Beals, C. R., and Crabtree, G. R. (1997) Curr. Biol. 7, 638-644
27. Vilella-Bach, M., Nuzzi, P., Fang, Y., and Chen, J. (1999) J. Biol. Chem. 274, 4266-4272
28. Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., and Chen, J. (2001) Science 294, 1942-1945
29. Fischer, U., Huber, J., Boelens, W. C., Mattaj, I. W., and Luhrmann, R. (1995) Cell 82, 475-483
30. Wen, W., Meinkoth, J. L., Tsien, R. Y., and Taylor, S. S. (1995) Cell 82, 463-473
31. Bogerd, H. P., Fridell, R. A., Benson, R. E., Hua, J., and Cullen, B. R. (1996) Mol. Cell. Biol. 16, 4207-4214
32. Dupont, S., Sharova, N., DeHoratius, C., Virbasius, C. M., Zhu, X., Bukrinskaya, A. G., Stevenson, M., and Green, M. R. (1999) Nature 402, 681-685
33. Macara, I. G. (2001) Microbiol. Mol. Biol. Rev. 65, 570-594
34. Combet, C., Blanchet, C., Geourjon, C., and Deleage, G. (2000) Trends Biochem. Sci. 25, 147-150
35. Chen, J., Zheng, X. F., Brown, E. J., and Schreiber, S. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 4947-4951
36. Michael, W. M. (2000) Trends Cell Biol. 10, 46-50
37. Peterson, R. T., Beal, P. A., Comb, M. J., and Schreiber, S. L. (2000) J. Biol. Chem. 275, 7416-7423
38. Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B., and Schreiber, S. L. (1995) Nature 377, 441-446
39. Kalderon, D., Richardson, W. D., Markham, A. F., and Smith, A. E. (1984) Nature 311, 33-38
40. Gorlich, D., and Kutay, U. (1999) Annu. Rev. Cell Dev. Biol. 15, 607-660
41. Bogerd, H. P., Benson, R. E., Truant, R., Herold, A., Phingbodhipakkiya, M., and Cullen, B. R. (1999) J. Biol. Chem. 274, 9771-9777
42. Andrade, M. A., and Bork, P. (1995) Nat. Genet. 11, 115-116
43. Funayama, N., Fagotto, F., McCrea, P., and Gumbiner, B. M. (1995) J. Cell Biol. 128, 959-968
44. Fagotto, F., Gluck, U., and Gumbiner, B. M. (1998) Curr. Biol. 8, 181-190
45. Xu, L., Kang, Y., Col, S., and Massague, J. (2002) Mol. Cell 10, 271-282
46. Xu, L., Alarcon, C., Col, S., and Massague, J. (2003) J. Biol. Chem. 278, 42569-42577
47. Perry, J., and Kleckner, N. (2003) Cell 112, 151-155