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Volumn 3, Issue 4, 2011, Pages 347-378

Clinical management of HIV drug resistance

Author keywords

Clinical management; Drug resistance testing; HIV

Indexed keywords

ANTIRETROVIRUS AGENT; ENFUVIRTIDE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; INTEGRASE INHIBITOR; MARAVIROC; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

EID: 79955654096     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v3040347     Document Type: Review
Times cited : (68)

References (179)
  • 1
    • 73549103358 scopus 로고    scopus 로고
    • The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic
    • Broder, S. The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic. Antivir. Res. 2010, 85, 1-18.
    • (2010) Antivir. Res. , vol.85 , pp. 1-18
    • Broder, S.1
  • 2
    • 77952008414 scopus 로고    scopus 로고
    • Antiretroviral therapy in the clinic
    • Tsibris, A.M.; Hirsch, M.S. Antiretroviral therapy in the clinic. J. Virol. 2010, 84, 5458-5464.
    • (2010) J. Virol. , vol.84 , pp. 5458-5464
    • Tsibris, A.M.1    Hirsch, M.S.2
  • 3
    • 77954734865 scopus 로고    scopus 로고
    • Antiretroviral therapy and management of HIV infection
    • Volberding, P.A.; Deeks, S.G. Antiretroviral therapy and management of HIV infection. Lancet 2010, 376, 49-62.
    • (2010) Lancet , vol.376 , pp. 49-62
    • Volberding, P.A.1    Deeks, S.G.2
  • 4
    • 73549084507 scopus 로고    scopus 로고
    • Clinical management of HIV-1 resistance
    • Paredes, R.; Clotet, B. Clinical management of HIV-1 resistance. Antivir. Res. 2010, 85, 245-265.
    • (2010) Antivir. Res. , vol.85 , pp. 245-265
    • Paredes, R.1    Clotet, B.2
  • 8
    • 42049091085 scopus 로고    scopus 로고
    • The prevalence of transmitted antiretroviral drug resistance in treatment-naive patients and factors influencing first-line treatment regimen selection
    • Huang, H.Y.; Daar, E.S.; Sax, P.E.; Young, B.; Cook, P.; Benson, P.; Cohen, C.; Scribner, A.; Hu, H. The prevalence of transmitted antiretroviral drug resistance in treatment-naive patients and factors influencing first-line treatment regimen selection. HIV Med. 2008, 9, 285-293.
    • (2008) HIV Med. , vol.9 , pp. 285-293
    • Huang, H.Y.1    Daar, E.S.2    Sax, P.E.3    Young, B.4    Cook, P.5    Benson, P.6    Cohen, C.7    Scribner, A.8    Hu, H.9
  • 9
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson, A.S.; Neumann, A.U.; Markowitz, M.; Leonard, J.M.; Ho, D.D. HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science 1996, 271, 1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 10
    • 0031000756 scopus 로고    scopus 로고
    • Human immunodeficiency virus drug therapy and virus load
    • Bonhoeffer, S.; Coffin, J.M.; Nowak, M.A. Human immunodeficiency virus drug therapy and virus load. J. Virol. 1997, 71, 3275-3278.
    • (1997) J. Virol. , vol.71 , pp. 3275-3278
    • Bonhoeffer, S.1    Coffin, J.M.2    Nowak, M.A.3
  • 11
    • 0029803480 scopus 로고    scopus 로고
    • HIV viral dynamics
    • Coffin, J.M. HIV viral dynamics. AIDS 1996, 10, S75-S84.
    • (1996) AIDS , vol.10
    • Coffin, J.M.1
  • 12
    • 0033946764 scopus 로고    scopus 로고
    • Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: The relative roles of drift and selection
    • Frost, S.D.; Nijhuis, M.; Schuurman, R.; Boucher, C.A.; Brown, A.J. Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: The relative roles of drift and selection. J. Virol. 2000, 74, 6262-6268.
    • (2000) J. Virol. , vol.74 , pp. 6262-6268
    • Frost, S.D.1    Nijhuis, M.2    Schuurman, R.3    Boucher, C.A.4    Brown, A.J.5
  • 13
    • 20844451906 scopus 로고    scopus 로고
    • Emergence of drug-resistant HIV-1 after intrapartum administration of single-dose nevirapine is substantially underestimated
    • Johnson, J.A.; Li, J.F.; Morris, L.; Martinson, N.; Gray, G.; McIntyre, J.; Heneine, W. Emergence of drug-resistant HIV-1 after intrapartum administration of single-dose nevirapine is substantially underestimated. J. Infect. Dis. 2005, 192, 16-23.
    • (2005) J. Infect. Dis. , vol.192 , pp. 16-23
    • Johnson, J.A.1    Li, J.F.2    Morris, L.3    Martinson, N.4    Gray, G.5    McIntyre, J.6    Heneine, W.7
  • 15
    • 4043095592 scopus 로고    scopus 로고
    • Retroviral recombination: Review of genetic analyses
    • Hu, W.S.; Rhodes, T.; Dang, Q.; Pathak, V. Retroviral recombination: Review of genetic analyses. Front. Biosci. 2003, 8, d143-d155.
    • (2003) Front. Biosci. , vol.8
    • Hu, W.S.1    Rhodes, T.2    Dang, Q.3    Pathak, V.4
  • 16
    • 0030895312 scopus 로고    scopus 로고
    • Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations
    • Barry, M.; Gibbons, S.; Back, D.; Mulcahy, F. Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin. Pharmacokinet. 1997, 32, 194-209.
    • (1997) Clin. Pharmacokinet. , vol.32 , pp. 194-209
    • Barry, M.1    Gibbons, S.2    Back, D.3    Mulcahy, F.4
  • 20
    • 63249107185 scopus 로고    scopus 로고
    • Strategies for promoting adherence to antiretroviral therapy: A review of the literature
    • Simoni, J.M.; Amico, K.R.; Pearson, C.R.; Malow, R. Strategies for promoting adherence to antiretroviral therapy: a review of the literature. Curr. Infect. Dis. Rep. 2008, 10, 515-521.
    • (2008) Curr. Infect. Dis. Rep. , vol.10 , pp. 515-521
    • Simoni, J.M.1    Amico, K.R.2    Pearson, C.R.3    Malow, R.4
  • 21
    • 77249154010 scopus 로고    scopus 로고
    • Antiretroviral adherence interventions: Translating research findings to the real world clinic
    • Simoni, J.M.; Amico, K.R.; Smith, L.; Nelson, K. Antiretroviral adherence interventions: Translating research findings to the real world clinic. Curr. HIV/AIDS Rep. 2010, 7, 44-51.
    • (2010) Curr. HIV/AIDS Rep. , vol.7 , pp. 44-51
    • Simoni, J.M.1    Amico, K.R.2    Smith, L.3    Nelson, K.4
  • 22
    • 77953083248 scopus 로고    scopus 로고
    • Effect of directly observed therapy for highly active antiretroviral therapy on virologic, immunologic, and adherence outcomes: A meta-analysis and systematic review
    • Hart, J.E.; Jeon, C.Y.; Ivers, L.C.; Behforouz, H.L.; Caldas, A.; Drobac, P.C.; Shin, S.S. Effect of directly observed therapy for highly active antiretroviral therapy on virologic, immunologic, and adherence outcomes: a meta-analysis and systematic review. J. Acquir. Immune Defic. Syndr. 2010, 54, 167-179.
    • (2010) J. Acquir. Immune Defic. Syndr. , vol.54 , pp. 167-179
    • Hart, J.E.1    Jeon, C.Y.2    Ivers, L.C.3    Behforouz, H.L.4    Caldas, A.5    Drobac, P.C.6    Shin, S.S.7
  • 23
    • 76249093081 scopus 로고    scopus 로고
    • Standard care impact on effects of highly active antiretroviral therapy adherence interventions: A meta-analysis of randomized controlled trials
    • de Bruin, M.; Viechtbauer, W.; Schaalma, H.P.; Kok, G.; Abraham, C.; Hospers, H.J. Standard care impact on effects of highly active antiretroviral therapy adherence interventions: A meta-analysis of randomized controlled trials. Arch. Intern. Med. 2010, 170, 240-250.
    • (2010) Arch. Intern. Med. , vol.170 , pp. 240-250
    • de Bruin, M.1    Viechtbauer, W.2    Schaalma, H.P.3    Kok, G.4    Abraham, C.5    Hospers, H.J.6
  • 24
    • 70349645396 scopus 로고    scopus 로고
    • The risk of virologic failure decreases with duration of HIV suppression, at greater than 50% adherence to antiretroviral therapy
    • Rosenblum, M.; Deeks, S.G.; van der Laan, M.; Bangsberg, D.R. The risk of virologic failure decreases with duration of HIV suppression, at greater than 50% adherence to antiretroviral therapy. PLoS ONE 2009, 4, e7196.
    • (2009) PLoS ONE , vol.4
    • Rosenblum, M.1    Deeks, S.G.2    van der Laan, M.3    Bangsberg, D.R.4
  • 28
    • 46049096099 scopus 로고    scopus 로고
    • Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection
    • Shen, L.; Siliciano, R.F. Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection. J. Allergy Clin. Immunol. 2008, 122, 22-28.
    • (2008) J. Allergy Clin. Immunol. , vol.122 , pp. 22-28
    • Shen, L.1    Siliciano, R.F.2
  • 29
    • 79952989124 scopus 로고    scopus 로고
    • Targeting viral reservoirs: Ability of antiretroviral therapy to stop viral replication
    • Maldarelli, F. Targeting viral reservoirs: Ability of antiretroviral therapy to stop viral replication. Curr. Opin. HIV AIDS 2011, 6, 49-56.
    • (2011) Curr. Opin. HIV AIDS , vol.6 , pp. 49-56
    • Maldarelli, F.1
  • 31
    • 70649093023 scopus 로고    scopus 로고
    • Pharmacogenomics of CYP3A: Considerations for HIV treatment
    • Lakhman, S.S.; Ma, Q.; Morse, G.D. Pharmacogenomics of CYP3A: Considerations for HIV treatment. Pharmacogenomics 2009, 10, 1323-1339.
    • (2009) Pharmacogenomics , vol.10 , pp. 1323-1339
    • Lakhman, S.S.1    Ma, Q.2    Morse, G.D.3
  • 32
    • 79952010199 scopus 로고    scopus 로고
    • Pharmacogenetics of cutaneous adverse drug reactions
    • Aihara, M. Pharmacogenetics of cutaneous adverse drug reactions. J. Dermatol. 2011, 38, 246-254.
    • (2011) J. Dermatol. , vol.38 , pp. 246-254
    • Aihara, M.1
  • 34
    • 55849107771 scopus 로고    scopus 로고
    • HIV-1 drug resistance genotyping quality assessment: Results of the ENVA7 Genotyping Proficiency Programme
    • Pandit, A.; Mackay, W.G.; Steel, C.; van Loon, A.M.; Schuurman, R. HIV-1 drug resistance genotyping quality assessment: results of the ENVA7 Genotyping Proficiency Programme. J. Clin. Virol. 2008, 43, 401-406.
    • (2008) J. Clin. Virol. , vol.43 , pp. 401-406
    • Pandit, A.1    Mackay, W.G.2    Steel, C.3    van Loon, A.M.4    Schuurman, R.5
  • 36
    • 15244345879 scopus 로고    scopus 로고
    • RNA extraction prior to HIV-1 resistance detection using Line Probe Assay (LiPA): Comparison of three methods
    • Labayru, C.; Eiros, J.M.; Hernandez, B.; de Lejarazu, R.O.; Torres, A.R. RNA extraction prior to HIV-1 resistance detection using Line Probe Assay (LiPA): comparison of three methods. J. Clin. Virol. 2005, 32, 265-271.
    • (2005) J. Clin. Virol. , vol.32 , pp. 265-271
    • Labayru, C.1    Eiros, J.M.2    Hernandez, B.3    de Lejarazu, R.O.4    Torres, A.R.5
  • 37
    • 34548076341 scopus 로고    scopus 로고
    • Sensitive oligonucleotide ligation assay for low-level detection of nevirapine resistance mutations in human immunodeficiency virus type 1 quasispecies
    • Lalonde, M.S.; Troyer, R.M.; Syed, A.R.; Bulime, S.; Demers, K.; Bajunirwe, F.; Arts, E.J. Sensitive oligonucleotide ligation assay for low-level detection of nevirapine resistance mutations in human immunodeficiency virus type 1 quasispecies. J. Clin. Microbiol. 2007, 45, 2604-2615.
    • (2007) J. Clin. Microbiol. , vol.45 , pp. 2604-2615
    • Lalonde, M.S.1    Troyer, R.M.2    Syed, A.R.3    Bulime, S.4    Demers, K.5    Bajunirwe, F.6    Arts, E.J.7
  • 38
    • 19044364264 scopus 로고    scopus 로고
    • Analysis of HIV-1 drug resistant mutations by line probe assay and direct sequencing in a cohort of therapy naive HIV-1 infected Italian patients
    • Re, M.C.; Monari, P.; Bon, I.; Gibellini, D.; Vitone, F.; Borderi, M.; La Placa, M. Analysis of HIV-1 drug resistant mutations by line probe assay and direct sequencing in a cohort of therapy naive HIV-1 infected Italian patients. BMC Microbiol. 2001, 1, 30.
    • (2001) BMC Microbiol. , vol.1 , pp. 30
    • Re, M.C.1    Monari, P.2    Bon, I.3    Gibellini, D.4    Vitone, F.5    Borderi, M.6    la Placa, M.7
  • 39
    • 0022495870 scopus 로고
    • Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
    • Adachi, A.; Gendelman, H.E.; Koenig, S.; Folks, T.; Willey, R.; Rabson, A.; Martin, M.A. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 1986, 59, 284-291.
    • (1986) J. Virol. , vol.59 , pp. 284-291
    • Adachi, A.1    Gendelman, H.E.2    Koenig, S.3    Folks, T.4    Willey, R.5    Rabson, A.6    Martin, M.A.7
  • 42
    • 33747150776 scopus 로고    scopus 로고
    • Algorithms for the interpretation of HIV-1 genotypic drug resistance information
    • Vercauteren, J.; Vandamme, A.M. Algorithms for the interpretation of HIV-1 genotypic drug resistance information. Antivir. Res. 2006, 71, 335-342.
    • (2006) Antivir. Res. , vol.71 , pp. 335-342
    • Vercauteren, J.1    Vandamme, A.M.2
  • 43
    • 84857896238 scopus 로고    scopus 로고
    • Available online, (accessed on 21 February)
    • HIV Drug Resistance Website. Available online: http://hivdb.stanford.edu (accessed on 21 February 2011).
    • (2011) HIV Drug Resistance Website
  • 44
    • 0035923671 scopus 로고    scopus 로고
    • Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons
    • Garcia-Lerma, J.G.; Nidtha, S.; Blumoff, K.; Weinstock, H.; Heneine, W. Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons. Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 13907-13912.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 13907-13912
    • Garcia-Lerma, J.G.1    Nidtha, S.2    Blumoff, K.3    Weinstock, H.4    Heneine, W.5
  • 45
    • 77956649470 scopus 로고    scopus 로고
    • Intensification of a failing regimen with zidovudine may cause sustained virologic suppression in the presence of resensitising mutations including K65R
    • Stephan, C.; Dauer, B.; Bickel, M.; Haberl, A.; Locher, L.; Muller, A.; Klauke, S.; Berger, A.; Doerr, H.W.; Sturmer, M.; Staszewski, S. Intensification of a failing regimen with zidovudine may cause sustained virologic suppression in the presence of resensitising mutations including K65R. J. Infect. 2010, 61, 346-350.
    • (2010) J. Infect. , vol.61 , pp. 346-350
    • Stephan, C.1    Dauer, B.2    Bickel, M.3    Haberl, A.4    Locher, L.5    Muller, A.6    Klauke, S.7    Berger, A.8    Doerr, H.W.9    Sturmer, M.10    Staszewski, S.11
  • 46
    • 0030816830 scopus 로고    scopus 로고
    • A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors
    • Shi, C.; Mellors, J.W. A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors. Antimicrob. Agents Chemother. 1997, 41, 2781-2785.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2781-2785
    • Shi, C.1    Mellors, J.W.2
  • 47
    • 0344474694 scopus 로고    scopus 로고
    • A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs
    • Hertogs, K.; de Bethune, M.P.; Miller, V.; Ivens, T.; Schel, P.; Van Cauwenberge, A.; Van Den Eynde, C.; Van Gerwen, V.; Azijn, H.; et al. A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs. Antimicrob. Agents Chemother. 1998, 42, 269-276.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 269-276
    • Hertogs, K.1    de Bethune, M.P.2    Miller, V.3    Ivens, T.4    Schel, P.5    van Cauwenberge, A.6    van den Eynde, C.7    van Gerwen, V.8    Azijn, H.9
  • 49
    • 0028085161 scopus 로고
    • Recombinant virus assay: A rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates
    • Kellam, P.; Larder, B.A. Recombinant virus assay: A rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates. Antimicrob. Agents Chemother. 1994, 38, 23-30.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 23-30
    • Kellam, P.1    Larder, B.A.2
  • 50
    • 0036218617 scopus 로고    scopus 로고
    • Distinct mutational drug resistance profiles of HIV-1 RNA in plasma and culture isolates of patients receiving antiretroviral therapy
    • Debiaggi, M.; Bruno, R.; Sacchi, P.; Achilli, G.; Romero, E.; Filice, G. Distinct mutational drug resistance profiles of HIV-1 RNA in plasma and culture isolates of patients receiving antiretroviral therapy. Intervirology 2002, 45, 52-55.
    • (2002) Intervirology , vol.45 , pp. 52-55
    • Debiaggi, M.1    Bruno, R.2    Sacchi, P.3    Achilli, G.4    Romero, E.5    Filice, G.6
  • 52
    • 0034632745 scopus 로고    scopus 로고
    • HIV type 1 protease cleavage site mutations and viral fitness: Implications for drug susceptibility phenotyping assays
    • Robinson, L.H.; Myers, R.E.; Snowden, B.W.; Tisdale, M.; Blair, E.D. HIV type 1 protease cleavage site mutations and viral fitness: implications for drug susceptibility phenotyping assays. AIDS Res. Hum. Retroviruses 2000, 16, 1149-1156.
    • (2000) AIDS Res. Hum. Retroviruses , vol.16 , pp. 1149-1156
    • Robinson, L.H.1    Myers, R.E.2    Snowden, B.W.3    Tisdale, M.4    Blair, E.D.5
  • 53
    • 7644230388 scopus 로고    scopus 로고
    • Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease
    • Prabu-Jeyabalan, M.; Nalivaika, E.A.; King, N.M.; Schiffer, C.A. Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease. J. Virol. 2004, 78, 12446-12454.
    • (2004) J. Virol. , vol.78 , pp. 12446-12454
    • Prabu-Jeyabalan, M.1    Nalivaika, E.A.2    King, N.M.3    Schiffer, C.A.4
  • 54
    • 70350317566 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance
    • Kolli, M.; Stawiski, E.; Chappey, C.; Schiffer, C.A. Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance. J. Virol. 2009, 83, 11027-11042.
    • (2009) J. Virol. , vol.83 , pp. 11027-11042
    • Kolli, M.1    Stawiski, E.2    Chappey, C.3    Schiffer, C.A.4
  • 56
    • 0035822981 scopus 로고    scopus 로고
    • World-wide variation in HIV-1 phenotypic susceptibility in untreated individuals: Biologically relevant values for resistance testing
    • Harrigan, P.R.; Montaner, J.S.; Wegner, S.A.; Verbiest, W.; Miller, V.; Wood, R.; Larder, B.A. World-wide variation in HIV-1 phenotypic susceptibility in untreated individuals: biologically relevant values for resistance testing. AIDS 2001, 15, 1671-1677.
    • (2001) AIDS , vol.15 , pp. 1671-1677
    • Harrigan, P.R.1    Montaner, J.S.2    Wegner, S.A.3    Verbiest, W.4    Miller, V.5    Wood, R.6    Larder, B.A.7
  • 62
    • 84857897436 scopus 로고    scopus 로고
    • Available online, (accessed on 21 February)
    • Geno2pheno 3.2. Available online: www.geno2pheno.org (accessed on 21 February, 2011).
    • (2011) Geno2pheno 3.2
  • 63
    • 84857907307 scopus 로고    scopus 로고
    • Available online, (accessed on 21 February)
    • HIV French Resistance Website. Available online: http://www.hivfrenchresistance.org (accessed on 21 February, 2011).
    • (2011) HIV French Resistance Website
  • 64
    • 84857909201 scopus 로고    scopus 로고
    • REGA, Available online, (accessed on 21 February)
    • REGA. Available online: http://regaweb.med.kuleuven.be/software/rega_algorithm/ (accessed on 21 February 2011).
    • (2011)
  • 66
    • 33646744181 scopus 로고    scopus 로고
    • Web resources for HIV type 1 genotypic-resistance test interpretation
    • Liu, T.F.; Shafer, R.W. Web resources for HIV type 1 genotypic-resistance test interpretation. Clin. Infect. Dis. 2006, 42, 1608-1618.
    • (2006) Clin. Infect. Dis. , vol.42 , pp. 1608-1618
    • Liu, T.F.1    Shafer, R.W.2
  • 67
    • 84857898668 scopus 로고    scopus 로고
    • IASUSA, Available online, (accessed on 21 February)
    • IASUSA. Available online: http://www.iasusa.org/resistance_mutations/index.html (accessed on 21 February, 2011).
    • (2011)
  • 68
    • 79955675136 scopus 로고    scopus 로고
    • HIV drug resistance
    • In, Zeichner, S., Read, J., Eds.; Cambridge University Press: Cambridge, UK
    • Maldarelli, F. HIV drug resistance. In Handbook of Pediatric HIV Care; Zeichner, S., Read, J., Eds.; Cambridge University Press: Cambridge, UK, 2006.
    • (2006) Handbook of Pediatric HIV Care
    • Maldarelli, F.1
  • 70
    • 12244262297 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic analysis of lopinavir-ritonavir in combination with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively pretreated human immunodeficiency virus-infected patients
    • Hsu, A.; Isaacson, J.; Brun, S.; Bernstein, B.; Lam, W.; Bertz, R.; Foit, C.; Rynkiewicz, K.; Richards, B.; King, M.; Rode, R.; Kempf, D.J.; Granneman, G.R.; Sun, E. Pharmacokinetic-pharmacodynamic analysis of lopinavir-ritonavir in combination with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively pretreated human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 2003, 47, 350-359.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 350-359
    • Hsu, A.1    Isaacson, J.2    Brun, S.3    Bernstein, B.4    Lam, W.5    Bertz, R.6    Foit, C.7    Rynkiewicz, K.8    Richards, B.9    King, M.10    Rode, R.11    Kempf, D.J.12    Granneman, G.R.13    Sun, E.14
  • 73
    • 77953792513 scopus 로고    scopus 로고
    • Instantaneous inhibitory potential is similar to inhibitory quotient at predicting HIV-1 response to antiretroviral therapy
    • Henrich, T.J.; Ribaudo, H.J.; Kuritzkes, D.R. Instantaneous inhibitory potential is similar to inhibitory quotient at predicting HIV-1 response to antiretroviral therapy. Clin. Infect. Dis. 2010, 51, 93-98.
    • (2010) Clin. Infect. Dis. , vol.51 , pp. 93-98
    • Henrich, T.J.1    Ribaudo, H.J.2    Kuritzkes, D.R.3
  • 76
    • 0037083803 scopus 로고    scopus 로고
    • Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: A randomized study (ARGENTA)
    • Cingolani, A.; Antinori, A.; Rizzo, M.G.; Murri, R.; Ammassari, A.; Baldini, F.; Di Giambenedetto, S.; Cauda, R.; De Luca, A. Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: A randomized study (ARGENTA). AIDS 2002, 16, 369-379.
    • (2002) AIDS , vol.16 , pp. 369-379
    • Cingolani, A.1    Antinori, A.2    Rizzo, M.G.3    Murri, R.4    Ammassari, A.5    Baldini, F.6    Di Giambenedetto, S.7    Cauda, R.8    de Luca, A.9
  • 79
    • 0033942065 scopus 로고    scopus 로고
    • Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: Pharmacological data from the Viradapt Study
    • Durant, J.; Clevenbergh, P.; Garraffo, R.; Halfon, P.; Icard, S.; Del Giudice, P.; Montagne, N.; Schapiro, J.M.; Dellamonica, P. Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: Pharmacological data from the Viradapt Study. AIDS 2000, 14, 1333-1339.
    • (2000) AIDS , vol.14 , pp. 1333-1339
    • Durant, J.1    Clevenbergh, P.2    Garraffo, R.3    Halfon, P.4    Icard, S.5    Del Giudice, P.6    Montagne, N.7    Schapiro, J.M.8    Dellamonica, P.9
  • 80
    • 0033920318 scopus 로고    scopus 로고
    • A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS
    • Baxter, J.D.; Mayers, D.L.; Wentworth, D.N.; Neaton, J.D.; Hoover, M.L.; Winters, M.A.; Mannheimer, S.B.; Thompson, M.A.; Abrams, D.I.; Brizz, B.J.; Ioannidis, J.P.; Merigan, T.C. A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS. AIDS 2000, 14, F83-F93.
    • (2000) AIDS , vol.14
    • Baxter, J.D.1    Mayers, D.L.2    Wentworth, D.N.3    Neaton, J.D.4    Hoover, M.L.5    Winters, M.A.6    Mannheimer, S.B.7    Thompson, M.A.8    Abrams, D.I.9    Brizz, B.J.10    Ioannidis, J.P.11    Merigan, T.C.12
  • 83
    • 7744231500 scopus 로고    scopus 로고
    • Limited benefit of antiretroviral resistance testing in treatment-experienced patients: A meta-analysis
    • Panidou, E.T.; Trikalinos, T.A.; Ioannidis, J.P. Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysis. AIDS 2004, 18, 2153-2161.
    • (2004) AIDS , vol.18 , pp. 2153-2161
    • Panidou, E.T.1    Trikalinos, T.A.2    Ioannidis, J.P.3
  • 84
    • 67651089497 scopus 로고    scopus 로고
    • The association of HIV susceptibility testing with survival among HIV-infected patients receiving antiretroviral therapy: A cohort study
    • Palella, F.J. Jr.; Armon, C.; Buchacz, K.; Cole, S.R.; Chmiel, J.S.; Novak, R.M.; Wood, K.; Moorman, A.C.; Brooks, J.T. The association of HIV susceptibility testing with survival among HIV-infected patients receiving antiretroviral therapy: A cohort study. Ann. Intern. Med. 2009, 151, 73-84.
    • (2009) Ann. Intern. Med. , vol.151 , pp. 73-84
    • Palella Jr., F.J.1    Armon, C.2    Buchacz, K.3    Cole, S.R.4    Chmiel, J.S.5    Novak, R.M.6    Wood, K.7    Moorman, A.C.8    Brooks, J.T.9
  • 85
    • 85037057763 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adults and Adolescents
    • Department of Health and Human Services, 1 December
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Department of Health and Human Services. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. 1 December 2009; pp. 1-161.
    • (2009) Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents , pp. 1-161
  • 87
    • 58149133507 scopus 로고    scopus 로고
    • Structure and function of HIV-1 reverse transcriptase: Molecular mechanisms of polymerization and inhibition
    • Sarafianos, S.G.; Marchand, B.; Das, K.; Himmel, D.M.; Parniak, M.A.; Hughes, S.H.; Arnold, E. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. J. Mol. Biol. 2009, 385, 693-713.
    • (2009) J. Mol. Biol. , vol.385 , pp. 693-713
    • Sarafianos, S.G.1    Marchand, B.2    Das, K.3    Himmel, D.M.4    Parniak, M.A.5    Hughes, S.H.6    Arnold, E.7
  • 89
    • 34250633201 scopus 로고    scopus 로고
    • Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase
    • Gotte, M. Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase. Curr. Opin. HIV AIDS 2007, 2, 103-107.
    • (2007) Curr. Opin. HIV AIDS , vol.2 , pp. 103-107
    • Gotte, M.1
  • 90
    • 77955298676 scopus 로고    scopus 로고
    • Resistance pathways of human immunodeficiency virus type 1 against the combination of zidovudine and lamivudine
    • Theys, K.; Deforche, K.; Libin, P.; Camacho, R.J.; Van Laethem, K.; Vandamme, A.M. Resistance pathways of human immunodeficiency virus type 1 against the combination of zidovudine and lamivudine. J. Gen. Virol. 2010, 91, 1898-1908.
    • (2010) J. Gen. Virol. , vol.91 , pp. 1898-1908
    • Theys, K.1    Deforche, K.2    Libin, P.3    Camacho, R.J.4    van Laethem, K.5    Vandamme, A.M.6
  • 91
    • 0037310042 scopus 로고    scopus 로고
    • Lamivudine can exert a modest antiviral effect against human immunodeficiency virus type 1 containing the M184V mutation
    • Quan, Y.; Brenner, B.G.; Oliveira, M.; Wainberg, M.A. Lamivudine can exert a modest antiviral effect against human immunodeficiency virus type 1 containing the M184V mutation. Antimicrob. Agents Chemother. 2003, 47, 747-754.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 747-754
    • Quan, Y.1    Brenner, B.G.2    Oliveira, M.3    Wainberg, M.A.4
  • 92
    • 43049105858 scopus 로고    scopus 로고
    • Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase
    • Menendez-Arias, L. Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase. Virus Res. 2008, 134, 124-146.
    • (2008) Virus Res. , vol.134 , pp. 124-146
    • Menendez-Arias, L.1
  • 93
    • 33646528913 scopus 로고    scopus 로고
    • Insertions and deletions in HIV-1 reverse transcriptase: Consequences for drug resistance and viral fitness
    • Menendez-Arias, L.; Matamoros, T.; Cases-Gonzalez, C.E. Insertions and deletions in HIV-1 reverse transcriptase: consequences for drug resistance and viral fitness. Curr. Pharm. Des. 2006, 12, 1811-1825.
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 1811-1825
    • Menendez-Arias, L.1    Matamoros, T.2    Cases-Gonzalez, C.E.3
  • 94
  • 96
    • 34547105526 scopus 로고    scopus 로고
    • Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine
    • Brehm, J.H.; Koontz, D.; Meteer, J.D.; Pathak, V.; Sluis-Cremer, N.; Mellors, J.W. Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine. J. Virol. 2007, 81, 7852-7859.
    • (2007) J. Virol. , vol.81 , pp. 7852-7859
    • Brehm, J.H.1    Koontz, D.2    Meteer, J.D.3    Pathak, V.4    Sluis-Cremer, N.5    Mellors, J.W.6
  • 97
    • 34250811908 scopus 로고    scopus 로고
    • Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance
    • Delviks-Frankenberry, K.A.; Nikolenko, G.N.; Barr, R.; Pathak, V.K. Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance. J. Virol. 2007, 81, 6837-6845.
    • (2007) J. Virol. , vol.81 , pp. 6837-6845
    • Delviks-Frankenberry, K.A.1    Nikolenko, G.N.2    Barr, R.3    Pathak, V.K.4
  • 98
    • 43049144549 scopus 로고    scopus 로고
    • Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase
    • Ren, J.; Stammers, D.K. Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase. Virus Res. 2008, 134, 157-170.
    • (2008) Virus Res. , vol.134 , pp. 157-170
    • Ren, J.1    Stammers, D.K.2
  • 99
    • 0032509101 scopus 로고    scopus 로고
    • Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution
    • Ding, J.; Das, K.; Hsiou, Y.; Sarafianos, S.G.; Clark, A.D., Jr.; Jacobo-Molina, A.; Tantillo, C.; Hughes, S.H.; Arnold, E. Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution. J. Mol. Biol. 1998, 284, 1095-1111.
    • (1998) J. Mol. Biol. , vol.284 , pp. 1095-1111
    • Ding, J.1    Das, K.2    Hsiou, Y.3    Sarafianos, S.G.4    Clark Jr., A.D.5    Jacobo-Molina, A.6    Tantillo, C.7    Hughes, S.H.8    Arnold, E.9
  • 100
    • 0034284122 scopus 로고    scopus 로고
    • Recent changes to RasMol, recombining the variants
    • Bernstein, H.J. Recent changes to RasMol, recombining the variants. Trends Biochem. Sci. 2000, 25, 453-455.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 453-455
    • Bernstein, H.J.1
  • 102
    • 17444385950 scopus 로고    scopus 로고
    • NNRTI hypersusceptibility
    • Delgado, J.; Shulman, N. NNRTI hypersusceptibility. AIDS Read. 2005, 15, 28-30, 32-24.
    • (2005) AIDS Read. , vol.15
    • Delgado, J.1    Shulman, N.2
  • 105
    • 64049111226 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs
    • Ambrose, Z.; Herman, B.D.; Sheen, C.W.; Zelina, S.; Moore, K.L.; Tachedjian, G.; Nissley, D.V.; Sluis-Cremer, N. The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs. J. Virol. 2009, 83, 3826-3833.
    • (2009) J. Virol. , vol.83 , pp. 3826-3833
    • Ambrose, Z.1    Herman, B.D.2    Sheen, C.W.3    Zelina, S.4    Moore, K.L.5    Tachedjian, G.6    Nissley, D.V.7    Sluis-Cremer, N.8
  • 106
    • 33646376232 scopus 로고    scopus 로고
    • Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors
    • Clark, S.A.; Shulman, N.S.; Bosch, R.J.; Mellors, J.W. Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors. AIDS 2006, 20, 981-984.
    • (2006) AIDS , vol.20 , pp. 981-984
    • Clark, S.A.1    Shulman, N.S.2    Bosch, R.J.3    Mellors, J.W.4
  • 107
    • 38949183670 scopus 로고    scopus 로고
    • Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience
    • Demeter, L.M.; DeGruttola, V.; Lustgarten, S.; Bettendorf, D.; Fischl, M.; Eshleman, S.; Spreen, W.; Nguyen, B.Y.; Koval, C.E.; Eron, J.J.; Hammer, S.; Squires, K. Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience. HIV Clin. Trials 2008, 9, 11-25.
    • (2008) HIV Clin. Trials , vol.9 , pp. 11-25
    • Demeter, L.M.1    de Gruttola, V.2    Lustgarten, S.3    Bettendorf, D.4    Fischl, M.5    Eshleman, S.6    Spreen, W.7    Nguyen, B.Y.8    Koval, C.E.9    Eron, J.J.10    Hammer, S.11    Squires, K.12
  • 109
    • 55049134097 scopus 로고    scopus 로고
    • Resilience to resistance of HIV-1 protease inhibitors: Profile of darunavir
    • Lefebvre, E.; Schiffer, C.A. Resilience to resistance of HIV-1 protease inhibitors: Profile of darunavir. AIDS Rev. 2008, 10, 131-142.
    • (2008) AIDS Rev. , vol.10 , pp. 131-142
    • Lefebvre, E.1    Schiffer, C.A.2
  • 110
    • 67649628164 scopus 로고    scopus 로고
    • New approaches to HIV protease inhibitor drug design II: Testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors
    • Nalam, M.N.; Schiffer, C.A. New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors. Curr. Opin. HIV AIDS 2008, 3, 642-646.
    • (2008) Curr. Opin. HIV AIDS , vol.3 , pp. 642-646
    • Nalam, M.N.1    Schiffer, C.A.2
  • 111
    • 48449083017 scopus 로고    scopus 로고
    • HIV-1 drug resistance mutations: An updated framework for the second decade of HAART
    • Shafer, R.W.; Schapiro, J.M. HIV-1 drug resistance mutations: an updated framework for the second decade of HAART. AIDS Rev. 2008, 10, 67-84.
    • (2008) AIDS Rev. , vol.10 , pp. 67-84
    • Shafer, R.W.1    Schapiro, J.M.2
  • 112
    • 3042855671 scopus 로고    scopus 로고
    • The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients
    • Turner, D.; Schapiro, J.M.; Brenner, B.G.; Wainberg, M.A. The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients. Antivir. Ther. 2004, 9, 301-314.
    • (2004) Antivir. Ther. , vol.9 , pp. 301-314
    • Turner, D.1    Schapiro, J.M.2    Brenner, B.G.3    Wainberg, M.A.4
  • 114
    • 0036121219 scopus 로고    scopus 로고
    • Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes
    • Prabu-Jeyabalan, M.; Nalivaika, E.; Schiffer, C.A. Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes. Structure 2002, 10, 369-381.
    • (2002) Structure , vol.10 , pp. 369-381
    • Prabu-Jeyabalan, M.1    Nalivaika, E.2    Schiffer, C.A.3
  • 118
    • 33646868062 scopus 로고    scopus 로고
    • Characterization of envelope glycoprotein gp41 genotype and phenotypic susceptibility to enfuvirtide at baseline and on treatment in the phase III clinical trials TORO-1 and TORO-2
    • Melby, T.; Sista, P.; DeMasi, R.; Kirkland, T.; Roberts, N.; Salgo, M.; Heilek-Snyder, G.; Cammack, N.; Matthews, T.J.; Greenberg, M.L. Characterization of envelope glycoprotein gp41 genotype and phenotypic susceptibility to enfuvirtide at baseline and on treatment in the phase III clinical trials TORO-1 and TORO-2. AIDS Res. Hum. Retroviruses 2006, 22, 375-385.
    • (2006) AIDS Res. Hum. Retroviruses , vol.22 , pp. 375-385
    • Melby, T.1    Sista, P.2    de Masi, R.3    Kirkland, T.4    Roberts, N.5    Salgo, M.6    Heilek-Snyder, G.7    Cammack, N.8    Matthews, T.J.9    Greenberg, M.L.10
  • 123
    • 50949119501 scopus 로고    scopus 로고
    • Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance
    • Zahm, J.A.; Bera, S.; Pandey, K.K.; Vora, A.; Stillmock, K.; Hazuda, D.; Grandgenett, D.P. Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance. Antimicrob. Agents Chemother. 2008, 52, 3358-3368.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 3358-3368
    • Zahm, J.A.1    Bera, S.2    Pandey, K.K.3    Vora, A.4    Stillmock, K.5    Hazuda, D.6    Grandgenett, D.P.7
  • 124
    • 52149105352 scopus 로고    scopus 로고
    • Integrase inhibitors: A clinical review of raltegravir and elvitegravir
    • Grant, P.; Zolopa, A. Integrase inhibitors: A clinical review of raltegravir and elvitegravir. J. HIV Ther. 2008, 13, 36-39.
    • (2008) J. HIV Ther. , vol.13 , pp. 36-39
    • Grant, P.1    Zolopa, A.2
  • 126
    • 74549114178 scopus 로고    scopus 로고
    • Integrase inhibitors: A novel class of antiretroviral agents
    • Schafer, J.J.; Squires, K.E. Integrase inhibitors: A novel class of antiretroviral agents. Ann. Pharmacother. 2010, 44, 145-156.
    • (2010) Ann. Pharmacother. , vol.44 , pp. 145-156
    • Schafer, J.J.1    Squires, K.E.2
  • 127
    • 79953177586 scopus 로고    scopus 로고
    • HIV integrase resistance profiles and S/GSK1349572 baseline phenotypic susceptibility for individuals experiencing virological failure on raltegravir and enrolling in the VIKING phase IIb Pilot study (ING112961)
    • Clotet, B.; C.K.; Lalezari, J.; Young, B.; Huang, J.; Underwood, M.R.; Ait-Khaled, M.; Nichols, W.G. HIV integrase resistance profiles and S/GSK1349572 baseline phenotypic susceptibility for individuals experiencing virological failure on raltegravir and enrolling in the VIKING phase IIb Pilot study (ING112961). Antivir. Ther. 2010, 15, A:61.
    • (2010) Antivir. Ther. , vol.15
    • Clotet, B.C.K.1    Lalezari, J.2    Young, B.3    Huang, J.4    Underwood, M.R.5    Ait-Khaled, M.6    Nichols, W.G.7
  • 128
    • 77949365510 scopus 로고    scopus 로고
    • Retroviral intasome assembly and inhibition of DNA strand transfer
    • Hare, S.; Gupta, S.S.; Valkov, E.; Engelman, A.; Cherepanov, P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature 2010, 464, 232-236.
    • (2010) Nature , vol.464 , pp. 232-236
    • Hare, S.1    Gupta, S.S.2    Valkov, E.3    Engelman, A.4    Cherepanov, P.5
  • 129
    • 34250667082 scopus 로고    scopus 로고
    • Resistance and viral subtypes: How important are the differences and why do they occur?
    • Brenner, B.G. Resistance and viral subtypes: How important are the differences and why do they occur? Curr. Opin. HIV AIDS 2007, 2, 94-102.
    • (2007) Curr. Opin. HIV AIDS , vol.2 , pp. 94-102
    • Brenner, B.G.1
  • 130
    • 59549100674 scopus 로고    scopus 로고
    • Role of genetic diversity amongst HIV-1 non-B subtypes in drug resistance: A systematic review of virologic and biochemical evidence
    • Martinez-Cajas, J.L.; Pant-Pai, N.; Klein, M.B.; Wainberg, M.A. Role of genetic diversity amongst HIV-1 non-B subtypes in drug resistance: A systematic review of virologic and biochemical evidence. AIDS Rev. 2008, 10, 212-223.
    • (2008) AIDS Rev. , vol.10 , pp. 212-223
    • Martinez-Cajas, J.L.1    Pant-Pai, N.2    Klein, M.B.3    Wainberg, M.A.4
  • 131
  • 132
    • 0037415062 scopus 로고    scopus 로고
    • A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors
    • Brenner, B.; Turner, D.; Oliveira, M.; Moisi, D.; Detorio, M.; Carobene, M.; Marlink, R.G.; Schapiro, J.; Roger, M.; Wainberg, M.A. A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors. AIDS 2003, 17, F1-F5.
    • (2003) AIDS , vol.17
    • Brenner, B.1    Turner, D.2    Oliveira, M.3    Moisi, D.4    Detorio, M.5    Carobene, M.6    Marlink, R.G.7    Schapiro, J.8    Roger, M.9    Wainberg, M.A.10
  • 133
    • 0035984778 scopus 로고    scopus 로고
    • Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT
    • Loemba, H.; Brenner, B.; Parniak, M.A.; Ma'ayan, S.; Spira, B.; Moisi, D.; Oliveira, M.; Detorio, M.; Wainberg, M.A. Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT. Antimicrob. Agents Chemother. 2002, 46, 2087-2094.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2087-2094
    • Loemba, H.1    Brenner, B.2    Parniak, M.A.3    Ma'ayan, S.4    Spira, B.5    Moisi, D.6    Oliveira, M.7    Detorio, M.8    Wainberg, M.A.9
  • 134
    • 44449104622 scopus 로고    scopus 로고
    • Expected response to protease inhibitors of HIV-1 non-B subtype viruses according to resistance algorithms
    • Champenois, K.; Bocket, L.; Deuffic-Burban, S.; Cotte, L.; Andre, P.; Choisy, P.; Yazdanpanah, Y. Expected response to protease inhibitors of HIV-1 non-B subtype viruses according to resistance algorithms. AIDS 2008, 22, 1087-1089.
    • (2008) AIDS , vol.22 , pp. 1087-1089
    • Champenois, K.1    Bocket, L.2    Deuffic-Burban, S.3    Cotte, L.4    Andre, P.5    Choisy, P.6    Yazdanpanah, Y.7
  • 136
    • 65549129096 scopus 로고    scopus 로고
    • Effect of HIV-1 subtype on virologic and immunologic response to starting highly active antiretroviral therapy
    • Geretti, A.M.; Harrison, L.; Green, H.; Sabin, C.; Hill, T.; Fearnhill, E.; Pillay, D.; Dunn, D. Effect of HIV-1 subtype on virologic and immunologic response to starting highly active antiretroviral therapy. Clin. Infect. Dis. 2009, 48, 1296-1305.
    • (2009) Clin. Infect. Dis. , vol.48 , pp. 1296-1305
    • Geretti, A.M.1    Harrison, L.2    Green, H.3    Sabin, C.4    Hill, T.5    Fearnhill, E.6    Pillay, D.7    Dunn, D.8
  • 137
    • 33846081762 scopus 로고    scopus 로고
    • Susceptibility of HIV-1 non-B subtypes and recombinant variants to Enfuvirtide
    • Holguin, A.; Faudon, J.L.; Labernardiere, J.L.; Soriano, V. Susceptibility of HIV-1 non-B subtypes and recombinant variants to Enfuvirtide. J. Clin. Virol. 2007, 38, 176-180.
    • (2007) J. Clin. Virol. , vol.38 , pp. 176-180
    • Holguin, A.1    Faudon, J.L.2    Labernardiere, J.L.3    Soriano, V.4
  • 138
    • 71049159978 scopus 로고    scopus 로고
    • Differences in resistance mutations among HIV-1 non-subtype B infections: A systematic review of evidence (1996-2008)
    • Martinez-Cajas, J.L.; Pai, N.P.; Klein, M.B.; Wainberg, M.A. Differences in resistance mutations among HIV-1 non-subtype B infections: a systematic review of evidence (1996-2008). J. Int. AIDS Soc. 2009, 12, 11.
    • (2009) J. Int. AIDS Soc. , vol.12 , pp. 11
    • Martinez-Cajas, J.L.1    Pai, N.P.2    Klein, M.B.3    Wainberg, M.A.4
  • 140
    • 77950264042 scopus 로고    scopus 로고
    • Integrase variability and susceptibility to HIV integrase inhibitors: Impact of subtypes, antiretroviral experience and duration of HIV infection
    • Garrido, C.; Geretti, A.M.; Zahonero, N.; Booth, C.; Strang, A.; Soriano, V.; De Mendoza, C. Integrase variability and susceptibility to HIV integrase inhibitors: impact of subtypes, antiretroviral experience and duration of HIV infection. J. Antimicrob. Chemother. 2010, 65, 320-326.
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 320-326
    • Garrido, C.1    Geretti, A.M.2    Zahonero, N.3    Booth, C.4    Strang, A.5    Soriano, V.6    de Mendoza, C.7
  • 141
    • 58749087228 scopus 로고    scopus 로고
    • Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: Implications for HIV-2 treatment in resouce-limited West Africa
    • Gottlieb, G.S.; Badiane, N.M.; Hawes, S.E.; Fortes, L.; Toure, M.; Ndour, C.T.; Starling, A.K.; Traore, F.; Sall, F.; Wong, K.G.; et al. Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: Implications for HIV-2 treatment in resouce-limited West Africa. Clin. Infect. Dis. 2009, 48, 476-483.
    • (2009) Clin. Infect. Dis. , vol.48 , pp. 476-483
    • Gottlieb, G.S.1    Badiane, N.M.2    Hawes, S.E.3    Fortes, L.4    Toure, M.5    Ndour, C.T.6    Starling, A.K.7    Traore, F.8    Sall, F.9    Wong, K.G.10
  • 144
    • 67651146871 scopus 로고    scopus 로고
    • Increased reporting of detectable plasma HIV-1 RNA levels at the critical threshold of 50 copies per milliliter with the Taqman assay in comparison to the Amplicor assay
    • Lima, V.; Harrigan, R.; Montaner, J.S. Increased reporting of detectable plasma HIV-1 RNA levels at the critical threshold of 50 copies per milliliter with the Taqman assay in comparison to the Amplicor assay. J. Acquir. Immune Defic. Syndr. 2009, 51, 3-6.
    • (2009) J. Acquir. Immune Defic. Syndr. , vol.51 , pp. 3-6
    • Lima, V.1    Harrigan, R.2    Montaner, J.S.3
  • 145
    • 67651062415 scopus 로고    scopus 로고
    • Increased frequency of HIV-1 viral load blip rate observed after switching from Roche Cobas Amplicor to Cobas Taqman assay
    • Smit, E.; Bhattacharya, S.; Osman, H.; Taylor, S. Increased frequency of HIV-1 viral load blip rate observed after switching from Roche Cobas Amplicor to Cobas Taqman assay. J. Acquir. Immune Defic. Syndr. 2009, 51, 364-365.
    • (2009) J. Acquir. Immune Defic. Syndr. , vol.51 , pp. 364-365
    • Smit, E.1    Bhattacharya, S.2    Osman, H.3    Taylor, S.4
  • 146
    • 38949215106 scopus 로고    scopus 로고
    • Plasma load discrepancies between the Roche Cobas Amplicor human immunodeficiency virus type 1 (HIV-1) Monitor version 1.5 and Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 assays
    • author reply 834
    • Yao, J.D.; Germer, J.J.; Damond, F.; Roquebert, B.; Descamps, D. Plasma load discrepancies between the Roche Cobas Amplicor human immunodeficiency virus type 1 (HIV-1) Monitor version 1.5 and Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 assays. J. Clin. Microbiol. 2008, 46, 834; author reply 834.
    • (2008) J. Clin. Microbiol. , vol.46 , pp. 834
    • Yao, J.D.1    Germer, J.J.2    Damond, F.3    Roquebert, B.4    Descamps, D.5
  • 147
    • 51749121954 scopus 로고    scopus 로고
    • The significance of low-level plasma HIV viral load on COBAS TaqMan HIV-1 assays for patients with undetectable plasma viral load on COBAS Amplicor monitor version 1.5
    • Manavi, K. The significance of low-level plasma HIV viral load on COBAS TaqMan HIV-1 assays for patients with undetectable plasma viral load on COBAS Amplicor monitor version 1.5. HIV Clin. Trials 2008, 9, 283-286.
    • (2008) HIV Clin. Trials , vol.9 , pp. 283-286
    • Manavi, K.1
  • 148
    • 34250847144 scopus 로고    scopus 로고
    • Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase
    • Parikh, U.M.; Zelina, S.; Sluis-Cremer, N.; Mellors, J.W. Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase. AIDS 2007, 21, 1405-1414.
    • (2007) AIDS , vol.21 , pp. 1405-1414
    • Parikh, U.M.1    Zelina, S.2    Sluis-Cremer, N.3    Mellors, J.W.4
  • 149
    • 84857907134 scopus 로고    scopus 로고
    • AIDSINFO, Available online, (accessed on 21 February)
    • AIDSINFO. Available online: http://www.aidsinfo.nih.gov/ (accessed on 21 February 2011).
    • (2011)
  • 150
    • 1642277960 scopus 로고    scopus 로고
    • Detection of drug-resistant minority variants of HIV-1 during virologic failure of indinavir, lamivudine, and zidovudine
    • Dykes, C.; Najjar, J.; Bosch, R.J.; Wantman, M.; Furtado, M.; Hart, S.; Hammer, S.M.; Demeter, L.M. Detection of drug-resistant minority variants of HIV-1 during virologic failure of indinavir, lamivudine, and zidovudine. J. Infect. Dis. 2004, 189, 1091-1096.
    • (2004) J. Infect. Dis. , vol.189 , pp. 1091-1096
    • Dykes, C.1    Najjar, J.2    Bosch, R.J.3    Wantman, M.4    Furtado, M.5    Hart, S.6    Hammer, S.M.7    Demeter, L.M.8
  • 151
  • 152
  • 154
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
    • Coffin, J.M. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 1995, 267, 483-489.
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 155
    • 77954192930 scopus 로고    scopus 로고
    • Low-frequency HIV-1 drug resistance mutations can be clinically significant but must be interpreted with caution
    • Johnson, J.A.; Geretti, A.M. Low-frequency HIV-1 drug resistance mutations can be clinically significant but must be interpreted with caution. J. Antimicrob. Chemother. 2010, 65, 1322-1326.
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 1322-1326
    • Johnson, J.A.1    Geretti, A.M.2
  • 156
    • 73349116621 scopus 로고    scopus 로고
    • Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy
    • Geretti, A.M.; Fox, Z.V.; Booth, C.L.; Smith, C.J.; Phillips, A.N.; Johnson, M.; Li, J.F.; Heneine, W.; Johnson, J.A. Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 2009, 52, 569-573.
    • (2009) J. Acquir. Immune Defic. Syndr. , vol.52 , pp. 569-573
    • Geretti, A.M.1    Fox, Z.V.2    Booth, C.L.3    Smith, C.J.4    Phillips, A.N.5    Johnson, M.6    Li, J.F.7    Heneine, W.8    Johnson, J.A.9
  • 160
    • 79955665073 scopus 로고    scopus 로고
    • A5208 OCTANE Study Team. NNRTI-resistant Variants Detected by Allele-specific PCR Predict Outcome of NVP-containing ART in Women with Prior Exposure to sdNVP: Results from the OCTANE/A5208 Study
    • In, San Francisco, CA, USA, 16-19 February
    • Boltz, V.; Lockman, Y.Z. S; Hong, F.; Halvas, E.; McIntyre, J.; Currier, J.; Hughes, M.; Coffin, J.; Mellors, J.; A5208 OCTANE Study Team. NNRTI-resistant Variants Detected by Allele-specific PCR Predict Outcome of NVP-containing ART in Women with Prior Exposure to sdNVP: Results from the OCTANE/A5208 Study. In Proceedings of the Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, USA, 16-19 February 2010.
    • (2010) Proceedings of the Conference on Retroviruses and Opportunistic Infections
    • Boltz, V.1    Lockman, Y.Z.S.2    Hong, F.3    Halvas, E.4    McIntyre, J.5    Currier, J.6    Hughes, M.7    Coffin, J.8    Mellors, J.9
  • 163
    • 67650682133 scopus 로고    scopus 로고
    • Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use
    • Le, T.; Chiarella, J.; Simen, B.B.; Hanczaruk, B.; Egholm, M.; Landry, M.L.; Dieckhaus, K.; Rosen, M.I.; Kozal, M.J. Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use. PLoS ONE 2009, 4, e6079.
    • (2009) PLoS ONE , vol.4
    • le, T.1    Chiarella, J.2    Simen, B.B.3    Hanczaruk, B.4    Egholm, M.5    Landry, M.L.6    Dieckhaus, K.7    Rosen, M.I.8    Kozal, M.J.9
  • 165
    • 67651055421 scopus 로고    scopus 로고
    • Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing
    • Archer, J.; Braverman, M.S.; Taillon, B.E.; Desany, B.; James, I.; Harrigan, P.R.; Lewis, M.; Robertson, D.L. Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing. AIDS 2009, 23, 1209-1218.
    • (2009) AIDS , vol.23 , pp. 1209-1218
    • Archer, J.1    Braverman, M.S.2    Taillon, B.E.3    Desany, B.4    James, I.5    Harrigan, P.R.6    Lewis, M.7    Robertson, D.L.8
  • 166
    • 43049095987 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: A view from the clinic and ex vivo
    • Martinez-Picado, J.; Martinez, M.A. HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: A view from the clinic and ex vivo. Virus Res 2008, 134, 104-123.
    • (2008) Virus Res , vol.134 , pp. 104-123
    • Martinez-Picado, J.1    Martinez, M.A.2
  • 167
    • 33745778007 scopus 로고    scopus 로고
    • Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1
    • Hu, Z.; Giguel, F.; Hatano, H.; Reid, P.; Lu, J.; Kuritzkes, D.R. Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1. J. Virol. 2006, 80, 7020-7027.
    • (2006) J. Virol. , vol.80 , pp. 7020-7027
    • Hu, Z.1    Giguel, F.2    Hatano, H.3    Reid, P.4    Lu, J.5    Kuritzkes, D.R.6
  • 169
    • 77957310350 scopus 로고    scopus 로고
    • Effect of Raltegravir Resistance Mutations in HIV-1 Integrase on Viral Fitness
    • Hu, Z.; Kuritzkes, D.R. Effect of Raltegravir Resistance Mutations in HIV-1 Integrase on Viral Fitness. J. Acquir. Immune Defic. Syndr. 2010, 55, 148-155.
    • (2010) J. Acquir. Immune Defic. Syndr. , vol.55 , pp. 148-155
    • Hu, Z.1    Kuritzkes, D.R.2
  • 170
    • 3042799046 scopus 로고    scopus 로고
    • Relative replicative fitness of human immunodeficiency virus type 1 mutants resistant to enfuvirtide (T-20)
    • Lu, J.; Sista, P.; Giguel, F.; Greenberg, M.; Kuritzkes, D.R. Relative replicative fitness of human immunodeficiency virus type 1 mutants resistant to enfuvirtide (T-20). J. Virol. 2004, 78, 4628-4637.
    • (2004) J. Virol. , vol.78 , pp. 4628-4637
    • Lu, J.1    Sista, P.2    Giguel, F.3    Greenberg, M.4    Kuritzkes, D.R.5
  • 171
    • 59649126954 scopus 로고    scopus 로고
    • In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine
    • Paredes, R.; Sagar, M.; Marconi, V.C.; Hoh, R.; Martin, J.N.; Parkin, N.T.; Petropoulos, C.J.; Deeks, S.G.; Kuritzkes, D.R. In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine. J. Virol. 2009, 83, 2038-2043.
    • (2009) J. Virol. , vol.83 , pp. 2038-2043
    • Paredes, R.1    Sagar, M.2    Marconi, V.C.3    Hoh, R.4    Martin, J.N.5    Parkin, N.T.6    Petropoulos, C.J.7    Deeks, S.G.8    Kuritzkes, D.R.9
  • 173
    • 70349337790 scopus 로고    scopus 로고
    • Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure
    • Fransen, S.; Karmochkine, M.; Huang, W.; Weiss, L.; Petropoulos, C.J.; Charpentier, C. Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure. Antimicrob. Agents Chemother. 2009, 53, 4522-4524.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4522-4524
    • Fransen, S.1    Karmochkine, M.2    Huang, W.3    Weiss, L.4    Petropoulos, C.J.5    Charpentier, C.6
  • 175
    • 77956289669 scopus 로고    scopus 로고
    • Hierarchical Bayesian inference for HIV dynamic differential equation models incorporating multiple treatment factors
    • Huang, Y.; Wu, H.; Acosta, E.P. Hierarchical Bayesian inference for HIV dynamic differential equation models incorporating multiple treatment factors. Biom J. 2010, 52, 470-486.
    • (2010) Biom J. , vol.52 , pp. 470-486
    • Huang, Y.1    Wu, H.2    Acosta, E.P.3


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