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Volumn 13, Issue 2, 2008, Pages 36-39

Integrase inhibitors: A clinical review of raltegravir and elvitegravir

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ATAZANAVIR; DARUNAVIR; EFAVIRENZ; ELVITEGRAVIR; ENFUVIRTIDE; GS 1830105; INTEGRASE; LAMIVUDINE; NEVIRAPINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; PROTEINASE INHIBITOR; RALTEGRAVIR; RIFABUTIN; RIFAMPICIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR; TIPRANAVIR; UNCLASSIFIED DRUG;

EID: 52149105352     PISSN: 14620308     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (19)

References (16)
  • 1
    • 0025133394 scopus 로고
    • Retroviral DNA integration directed by HIV integration protein in vitro
    • Bushman FD, Fujiwara T, Craigie R. Retroviral DNA integration directed by HIV integration protein in vitro. Science, 1990, 249, 1555-1558.
    • (1990) Science , vol.249 , pp. 1555-1558
    • Bushman, F.D.1    Fujiwara, T.2    Craigie, R.3
  • 2
    • 34147136222 scopus 로고    scopus 로고
    • Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
    • Grinsztejn B, Nguyen BY, Katlama C et al. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet, 2007, 369, 1261-1269.
    • (2007) Lancet , vol.369 , pp. 1261-1269
    • Grinsztejn, B.1    Nguyen, B.Y.2    Katlama, C.3
  • 3
    • 43749098454 scopus 로고    scopus 로고
    • 48-week results from BENCHMRK-1, a phase III study or raltegravir in patients with failing antiretroviral therapy with triple-class resistant HIV-1
    • Boston, February, Abstract 788
    • Cooper DA, Gatell J, Rockstroh J et al. 48-week results from BENCHMRK-1, a phase III study or raltegravir in patients with failing antiretroviral therapy with triple-class resistant HIV-1. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 788.
    • (2008) 15th Conference on Retroviruses and Opportunistic Infections
    • Cooper, D.A.1    Gatell, J.2    Rockstroh, J.3
  • 4
    • 43749084994 scopus 로고    scopus 로고
    • 48-week results from BENCHMRK-2, a phase III study or raltegravir in patients with failing antiretroviral therapy with triple-class resistant HIV-1
    • Boston, February, Abstract 789
    • Steigbigel R, Kumar P, Eron J et al. 48-week results from BENCHMRK-2, a phase III study or raltegravir in patients with failing antiretroviral therapy with triple-class resistant HIV-1. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 789.
    • (2008) 15th Conference on Retroviruses and Opportunistic Infections
    • Steigbigel, R.1    Kumar, P.2    Eron, J.3
  • 5
    • 48949088324 scopus 로고    scopus 로고
    • Outcomes of patients switched from enfuvirtide to raltegravir within a virologically suppressive regimen
    • Boston, February, Abstract 799
    • Harris M, Larsen G, Montaner J. Outcomes of patients switched from enfuvirtide to raltegravir within a virologically suppressive regimen. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 799.
    • (2008) 15th Conference on Retroviruses and Opportunistic Infections
    • Harris, M.1    Larsen, G.2    Montaner, J.3
  • 6
    • 52149092106 scopus 로고    scopus 로고
    • Retrospective analysis of a switch from enfuvirtide to raltegravir in patients with undetectable viral load: Efficacy at 12 weeks in a Montreal cohort
    • Montreal, April
    • Talbot A, Marcotte S, Thomas R et al. Retrospective analysis of a switch from enfuvirtide to raltegravir in patients with undetectable viral load: efficacy at 12 weeks in a Montreal cohort. 17th Annual Canadian Conference on HIV/AIDS Research, Montreal, April 2008.
    • (2008) 17th Annual Canadian Conference on HIV/AIDS Research
    • Talbot, A.1    Marcotte, S.2    Thomas, R.3
  • 7
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
    • Markowitz M, Nguyen BY, Gotuzzo E et al. Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr 2007, 46, 125-133.
    • (2007) J Acquir Immune Defic Syndr , vol.46 , pp. 125-133
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3
  • 8
    • 52149099604 scopus 로고    scopus 로고
    • accessed 24th June 2008
    • www.fda.gov/cder/foi/nda/2007/022145_ClinPharmR_P1.pdf accessed 24th June 2008.
  • 9
    • 34248199833 scopus 로고    scopus 로고
    • The HIV integrase inhibitor GS-9137 demonstrates potent ARV activity in treatment-experienced patients
    • Los Angeles, February, Abstract 143LB
    • Zolopa A, Mullen M, Berger D et al. The HIV integrase inhibitor GS-9137 demonstrates potent ARV activity in treatment-experienced patients. 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, February 2007. Abstract 143LB.
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections
    • Zolopa, A.1    Mullen, M.2    Berger, D.3
  • 10
    • 55049114155 scopus 로고    scopus 로고
    • The HIV integrase inhibitor elvitegravir (EVG/r) has potent and durable activity in treatment-experienced patients with active optimized background therapy (OBT)
    • Chicago, September, Abstract H-714
    • Zolopa AR, Lampiris H, Blick G et al. The HIV integrase inhibitor elvitegravir (EVG/r) has potent and durable activity in treatment-experienced patients with active optimized background therapy (OBT). 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, September 2007. Abstract H-714.
    • (2007) 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Zolopa, A.R.1    Lampiris, H.2    Blick, G.3
  • 11
    • 34248177765 scopus 로고    scopus 로고
    • Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
    • Los Angeles, February, Abstract 105aLB
    • Cooper D, Gatell J, Rockstroh J et al. Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, February 2007. Abstract 105aLB.
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections
    • Cooper, D.1    Gatell, J.2    Rockstroh, J.3
  • 12
    • 34248205567 scopus 로고    scopus 로고
    • Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
    • Los Angeles, February, Abstract 105bLB
    • Steigbigel R, Kumar P, Eron J et al. Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, February 2007. Abstract 105bLB.
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections
    • Steigbigel, R.1    Kumar, P.2    Eron, J.3
  • 13
    • 35648950291 scopus 로고    scopus 로고
    • Resistance to the HIV-integrase inhibitor raltegravir: Analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV-1 infection
    • for the P005 Study Team, Barbados, June, Abstract 8
    • Hazuda DJ, Miller MD, Nguyen BY, Zhao J for the P005 Study Team. Resistance to the HIV-integrase inhibitor raltegravir: analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV-1 infection. 16th International HIV Drug Resistance Workshop, Barbados, June 2007. Abstract 8.
    • (2007) 16th International HIV Drug Resistance Workshop
    • Hazuda, D.J.1    Miller, M.D.2    Nguyen, B.Y.3    Zhao, J.4
  • 14
    • 35648940077 scopus 로고    scopus 로고
    • Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase II study of elvitegravir (GS-9137)
    • Barbados, June, Abstract 9
    • McColl DJ, Fransen S, Gupta S et al. Resistance and cross-resistance to first generation integrase inhibitors: insights from a phase II study of elvitegravir (GS-9137). 16th International HIV Drug Resistance Workshop, Barbados, June 2007. Abstract 9.
    • (2007) 16th International HIV Drug Resistance Workshop
    • McColl, D.J.1    Fransen, S.2    Gupta, S.3
  • 15
    • 52149111109 scopus 로고    scopus 로고
    • First report of raltegravir (RAL, MK-0518) use after virological rebound on elvitegravir EVT, GS 9137, Treatment, and Prevention, Sydney, July, Abstract TUPEB032
    • DeJesus E, Cohen C, Elion R et al. First report of raltegravir (RAL, MK-0518) use after virological rebound on elvitegravir (EVT, GS 9137). 4th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention, Sydney, July 2007. Abstract TUPEB032.
    • (2007) 4th International AIDS Society Conference on HIV Pathogenesis
    • DeJesus, E.1    Cohen, C.2    Elion, R.3
  • 16
    • 52149087641 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. January 29, 2008; 1-128. Available at www.aidsinfo.nih.gov/ContentFiles/ AdultandAdolescentGL.pdf. Accessed 25th June 2008.
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. January 29, 2008; 1-128. Available at www.aidsinfo.nih.gov/ContentFiles/ AdultandAdolescentGL.pdf. Accessed 25th June 2008.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.