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Retroviral DNA integration directed by HIV integration protein in vitro
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Bushman FD, Fujiwara T, Craigie R. Retroviral DNA integration directed by HIV integration protein in vitro. Science, 1990, 249, 1555-1558.
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Bushman, F.D.1
Fujiwara, T.2
Craigie, R.3
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2
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34147136222
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Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
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Grinsztejn B, Nguyen BY, Katlama C et al. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet, 2007, 369, 1261-1269.
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Grinsztejn, B.1
Nguyen, B.Y.2
Katlama, C.3
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3
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43749098454
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48-week results from BENCHMRK-1, a phase III study or raltegravir in patients with failing antiretroviral therapy with triple-class resistant HIV-1
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Boston, February, Abstract 788
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Cooper DA, Gatell J, Rockstroh J et al. 48-week results from BENCHMRK-1, a phase III study or raltegravir in patients with failing antiretroviral therapy with triple-class resistant HIV-1. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 788.
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(2008)
15th Conference on Retroviruses and Opportunistic Infections
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Cooper, D.A.1
Gatell, J.2
Rockstroh, J.3
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4
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43749084994
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48-week results from BENCHMRK-2, a phase III study or raltegravir in patients with failing antiretroviral therapy with triple-class resistant HIV-1
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Boston, February, Abstract 789
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Steigbigel R, Kumar P, Eron J et al. 48-week results from BENCHMRK-2, a phase III study or raltegravir in patients with failing antiretroviral therapy with triple-class resistant HIV-1. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 789.
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(2008)
15th Conference on Retroviruses and Opportunistic Infections
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Steigbigel, R.1
Kumar, P.2
Eron, J.3
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5
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48949088324
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Outcomes of patients switched from enfuvirtide to raltegravir within a virologically suppressive regimen
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Boston, February, Abstract 799
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Harris M, Larsen G, Montaner J. Outcomes of patients switched from enfuvirtide to raltegravir within a virologically suppressive regimen. 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 2008. Abstract 799.
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(2008)
15th Conference on Retroviruses and Opportunistic Infections
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Harris, M.1
Larsen, G.2
Montaner, J.3
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6
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52149092106
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Retrospective analysis of a switch from enfuvirtide to raltegravir in patients with undetectable viral load: Efficacy at 12 weeks in a Montreal cohort
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Montreal, April
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Talbot A, Marcotte S, Thomas R et al. Retrospective analysis of a switch from enfuvirtide to raltegravir in patients with undetectable viral load: efficacy at 12 weeks in a Montreal cohort. 17th Annual Canadian Conference on HIV/AIDS Research, Montreal, April 2008.
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(2008)
17th Annual Canadian Conference on HIV/AIDS Research
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Talbot, A.1
Marcotte, S.2
Thomas, R.3
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7
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34748860363
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Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
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Markowitz M, Nguyen BY, Gotuzzo E et al. Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr 2007, 46, 125-133.
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Markowitz, M.1
Nguyen, B.Y.2
Gotuzzo, E.3
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8
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52149099604
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accessed 24th June 2008
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www.fda.gov/cder/foi/nda/2007/022145_ClinPharmR_P1.pdf accessed 24th June 2008.
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9
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34248199833
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The HIV integrase inhibitor GS-9137 demonstrates potent ARV activity in treatment-experienced patients
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Los Angeles, February, Abstract 143LB
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Zolopa A, Mullen M, Berger D et al. The HIV integrase inhibitor GS-9137 demonstrates potent ARV activity in treatment-experienced patients. 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, February 2007. Abstract 143LB.
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(2007)
14th Conference on Retroviruses and Opportunistic Infections
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Zolopa, A.1
Mullen, M.2
Berger, D.3
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10
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55049114155
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The HIV integrase inhibitor elvitegravir (EVG/r) has potent and durable activity in treatment-experienced patients with active optimized background therapy (OBT)
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Chicago, September, Abstract H-714
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Zolopa AR, Lampiris H, Blick G et al. The HIV integrase inhibitor elvitegravir (EVG/r) has potent and durable activity in treatment-experienced patients with active optimized background therapy (OBT). 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, September 2007. Abstract H-714.
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(2007)
47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
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Zolopa, A.R.1
Lampiris, H.2
Blick, G.3
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11
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34248177765
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Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
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Los Angeles, February, Abstract 105aLB
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Cooper D, Gatell J, Rockstroh J et al. Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, February 2007. Abstract 105aLB.
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(2007)
14th Conference on Retroviruses and Opportunistic Infections
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Cooper, D.1
Gatell, J.2
Rockstroh, J.3
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12
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34248205567
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Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
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Los Angeles, February, Abstract 105bLB
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Steigbigel R, Kumar P, Eron J et al. Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, February 2007. Abstract 105bLB.
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(2007)
14th Conference on Retroviruses and Opportunistic Infections
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Steigbigel, R.1
Kumar, P.2
Eron, J.3
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13
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35648950291
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Resistance to the HIV-integrase inhibitor raltegravir: Analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV-1 infection
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for the P005 Study Team, Barbados, June, Abstract 8
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Hazuda DJ, Miller MD, Nguyen BY, Zhao J for the P005 Study Team. Resistance to the HIV-integrase inhibitor raltegravir: analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV-1 infection. 16th International HIV Drug Resistance Workshop, Barbados, June 2007. Abstract 8.
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(2007)
16th International HIV Drug Resistance Workshop
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Hazuda, D.J.1
Miller, M.D.2
Nguyen, B.Y.3
Zhao, J.4
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14
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35648940077
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Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase II study of elvitegravir (GS-9137)
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Barbados, June, Abstract 9
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McColl DJ, Fransen S, Gupta S et al. Resistance and cross-resistance to first generation integrase inhibitors: insights from a phase II study of elvitegravir (GS-9137). 16th International HIV Drug Resistance Workshop, Barbados, June 2007. Abstract 9.
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(2007)
16th International HIV Drug Resistance Workshop
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McColl, D.J.1
Fransen, S.2
Gupta, S.3
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15
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52149111109
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First report of raltegravir (RAL, MK-0518) use after virological rebound on elvitegravir EVT, GS 9137, Treatment, and Prevention, Sydney, July, Abstract TUPEB032
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DeJesus E, Cohen C, Elion R et al. First report of raltegravir (RAL, MK-0518) use after virological rebound on elvitegravir (EVT, GS 9137). 4th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention, Sydney, July 2007. Abstract TUPEB032.
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(2007)
4th International AIDS Society Conference on HIV Pathogenesis
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DeJesus, E.1
Cohen, C.2
Elion, R.3
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16
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52149087641
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Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. January 29, 2008; 1-128. Available at www.aidsinfo.nih.gov/ContentFiles/ AdultandAdolescentGL.pdf. Accessed 25th June 2008.
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Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. January 29, 2008; 1-128. Available at www.aidsinfo.nih.gov/ContentFiles/ AdultandAdolescentGL.pdf. Accessed 25th June 2008.
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